Zhiyao Deng
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View article: Exploration of oxidative stress-related molecular signature for clear cell renal cell carcinoma
Exploration of oxidative stress-related molecular signature for clear cell renal cell carcinoma Open
View article: N-Homocysteinylation of HMGB1/2 Promotes Corpus Cavernosum Endothelial Senescence in Erectile Dysfunction
N-Homocysteinylation of HMGB1/2 Promotes Corpus Cavernosum Endothelial Senescence in Erectile Dysfunction Open
Homocysteine (Hcy) is an age-related risk factor for erectile dysfunction (ED), with enhanced vascular toxicity in middle-aged and elderly individuals. However, folate-based Hcy-lowering therapies have shown limited efficacy, necessitating…
View article: Prediction of clear cell renal cell carcinoma prognosis based on an immunogenomic landscape analysis
Prediction of clear cell renal cell carcinoma prognosis based on an immunogenomic landscape analysis Open
Immune cell infiltration and tumor-related immune molecules play key roles in tumorigenesis and tumor progression. The influence of immune interactions on the molecular characteristics and prognosis of clear cell renal cell carcinoma (ccRC…
View article: Multi-omic profiling of clear cell renal cell carcinoma identifies metabolic reprogramming associated with disease progression
Multi-omic profiling of clear cell renal cell carcinoma identifies metabolic reprogramming associated with disease progression Open
Clear cell renal cell carcinoma (ccRCC) is a complex disease with remarkable immune and metabolic heterogeneity. Here we perform genomic, transcriptomic, proteomic, metabolomic and spatial transcriptomic and metabolomic analyses on 100 pat…
View article: Identification and validation of an individualized metabolic prognostic signature for predicting the biochemical recurrence of prostate cancer based on the immune microenvironment
Identification and validation of an individualized metabolic prognostic signature for predicting the biochemical recurrence of prostate cancer based on the immune microenvironment Open
View article: A novel cuproptosis pattern and tumor immune microenvironment characterization in urothelial carcinoma of the bladder
A novel cuproptosis pattern and tumor immune microenvironment characterization in urothelial carcinoma of the bladder Open
Background Urothelial carcinoma of the bladder (UCB) is the most prevalent malignant tumor of the urinary system worldwide, which has a significant recurrence rate despite multiple treatment options available. As a unique and novel copper-…
View article: Circular RNA EPHA3 suppresses progression and metastasis in prostate cancer through the miR-513a-3p/BMP2 axis
Circular RNA EPHA3 suppresses progression and metastasis in prostate cancer through the miR-513a-3p/BMP2 axis Open
View article: Prediction of clear cell renal cell carcinoma prognosis based on an immunogenomic landscape analysis
Prediction of clear cell renal cell carcinoma prognosis based on an immunogenomic landscape analysis Open
Immune-cell infiltration and tumor-related immune molecules play a key role in tumorigenesis and progression. It remains to be systematically studied how immune interactions influence clear cell renal cell carcinoma (ccRCC) molecular chara…
View article: Erectile dysfunction and exosome therapy
Erectile dysfunction and exosome therapy Open
Erectile dysfunction (ED), as a common male disease, can seriously reduce the life quality of men and their partners. With the improvement of human living standards, ED is considered to be an important health issue that plagues men. Howeve…
View article: Additional file 4 of Circular RNA EPHA3 suppresses progression and metastasis in prostate cancer through the miR-513a-3p/BMP2 axis
Additional file 4 of Circular RNA EPHA3 suppresses progression and metastasis in prostate cancer through the miR-513a-3p/BMP2 axis Open
Additional file 4: The 58 differentially expressed genes (DEGs) were screened and regulated in both PC-3 and DU145 cells after transfected circEPHA3 lentivirus.
View article: Human umbilical cord mesenchymal stem cells ameliorate erectile dysfunction in rats with diabetes mellitus through the attenuation of ferroptosis
Human umbilical cord mesenchymal stem cells ameliorate erectile dysfunction in rats with diabetes mellitus through the attenuation of ferroptosis Open
View article: Human umbilical cord mesenchymal stem cells ameliorate erectile dysfunction in rats with diabetes mellitus through the attenuation of ferroptosis
Human umbilical cord mesenchymal stem cells ameliorate erectile dysfunction in rats with diabetes mellitus through the attenuation of ferroptosis Open
Background: Erectile dysfunction (ED), as one of the most prevalent consequences in male diabetic patients, has a serious impact on men's physical and mental health, and the treatment effect of diabetic mellitus erectile dysfunction (DMED)…
View article: Evaluation of mid- and long-term impact of COVID-19 on male fertility through evaluating semen parameters
Evaluation of mid- and long-term impact of COVID-19 on male fertility through evaluating semen parameters Open
The sperm quality of COVID-19 recovered patients improved after a recovery time of nearly half a year, while the total sperm number showed an improvement after a recovery time of about 150 days. COVID-19 patients should pay close attention…
View article: A Mid-to-Long Term Comprehensive Evaluation of Psychological Distress and Erectile Function in COVID-19 Recovered Patients
A Mid-to-Long Term Comprehensive Evaluation of Psychological Distress and Erectile Function in COVID-19 Recovered Patients Open
Background The psychological and sexual health of different populations are negatively affected during the coronavirus disease 2019 (COVID-19) pandemic. However, little is known about psychological distress and erectile function of male re…
View article: Development of an Individualized Ubiquitin Prognostic Signature for Clear Cell Renal Cell Carcinoma
Development of an Individualized Ubiquitin Prognostic Signature for Clear Cell Renal Cell Carcinoma Open
Clear cell renal cell carcinoma (ccRCC) is a common tumor type in genitourinary system and has a poor prognosis. Ubiquitin dependent modification systems have been reported in a variety of malignancies and have influenced tumor genesis and…
View article: Exploration of Redox‐Related Molecular Patterns and the Redox Score for Prostate Cancer
Exploration of Redox‐Related Molecular Patterns and the Redox Score for Prostate Cancer Open
Redox homeostasis is the key to cell survival, and its imbalance can promote the occurrence and progression of tumors. However, it remains unclear whether these redox‐related genes (RRGs) have potential roles in the tumor microenvironment,…
View article: A Mitochondrial Dysfunction and Oxidative Stress Pathway‐Based Prognostic Signature for Clear Cell Renal Cell Carcinoma
A Mitochondrial Dysfunction and Oxidative Stress Pathway‐Based Prognostic Signature for Clear Cell Renal Cell Carcinoma Open
Mitochondria not only are the main source of ATP synthesis but also regulate cellular redox balance and calcium homeostasis. Its dysfunction can lead to a variety of diseases and promote cancer and metastasis. In this study, we aimed to ex…