Zhen Zou
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View article: Genomic and insulin-mediated control of metabolic homeostasis by the mosquito ecdysone-induced gene E93
Genomic and insulin-mediated control of metabolic homeostasis by the mosquito ecdysone-induced gene E93 Open
Ecdysone-induced protein 93 (E93) is an adult specifier that governs insect pupal-adult conversion. It affects the reproductive transition in adult Aedes aegypti mosquitoes, the significant vectors of numerous devastating human diseases. H…
View article: Gene delivery in mosquitos with a vesicular stomatitis virus vector
Gene delivery in mosquitos with a vesicular stomatitis virus vector Open
Gain- and loss-of-function techniques are essential for comprehensive investigation of gene function. In mosquitoes, effective loss-of-function (LOF) methods such as RNA interference and gene knockout are available. However, convenient and…
View article: Insights on the sex determination, vector capacity and ecological biology from a chromosomal level genome of vector mosquito, Armigeres subulbatus
Insights on the sex determination, vector capacity and ecological biology from a chromosomal level genome of vector mosquito, Armigeres subulbatus Open
View article: Lysyl-tRNA synthetase orchestrates translation and hormone signaling during reproduction in Aedes aegypti mosquitoes
Lysyl-tRNA synthetase orchestrates translation and hormone signaling during reproduction in Aedes aegypti mosquitoes Open
View article: Dynamic assessment and zoning strategies for ecosystem health in Poyang lake urban agglomeration
Dynamic assessment and zoning strategies for ecosystem health in Poyang lake urban agglomeration Open
View article: Variations in the Bacterial Ecosystems of Mosquito Populations - Haikou and Sanya Cities, Hainan Province, China, 2019.
Variations in the Bacterial Ecosystems of Mosquito Populations - Haikou and Sanya Cities, Hainan Province, China, 2019. Open
This study revealed significant geographic differences in the midgut microbiota of mosquitoes from Haikou and Sanya, providing foundational data for understanding their potential impact on mosquito biology and disease transmission. While t…
View article: Evaluating Beauveria bassiana Strains for Insect Pest Control and Endophytic Colonization in Wheat
Evaluating Beauveria bassiana Strains for Insect Pest Control and Endophytic Colonization in Wheat Open
Certain entomopathogenic fungi, such as Beauveria bassiana, are highly pathogenic to arthropod pests and are able to colonize plant tissues, thereby enhancing both plant growth and disease resistance. This study assessed three B. bassiana …
View article: Haemaphysalis longicornis subolesin controls the infection and transmission of severe fever with thrombocytopenia syndrome virus
Haemaphysalis longicornis subolesin controls the infection and transmission of severe fever with thrombocytopenia syndrome virus Open
Severe fever with thrombocytopenia syndrome (SFTS) caused by the SFTS virus (SFTSV) is an emerging tick-borne disease with a high mortality rate. Haemaphysalis longicornis is the primary reservoir and vector of SFTSV. Here, we found that t…
View article: FEB-Cache: Frequency‑Guided Exposure Bias Reduction for Enhancing Diffusion Transformer Caching
FEB-Cache: Frequency‑Guided Exposure Bias Reduction for Enhancing Diffusion Transformer Caching Open
View article: Alterations in the salivary gland microbiota of <i>Haemaphysalis longicornis</i> during tick-to-host transmission of severe fever with thrombocytopenia syndrome virus
Alterations in the salivary gland microbiota of <i>Haemaphysalis longicornis</i> during tick-to-host transmission of severe fever with thrombocytopenia syndrome virus Open
Haemaphysalis longicornis serves as the primary tick vector for severe fever with thrombocytopenia syndrome virus (SFTSV), the etiological agent responsible for severe fever with thrombocytopenia syndrome (SFTS). Understanding alter…
View article: Gut symbiont-derived sphingosine modulates vector competence in Aedes mosquitoes
Gut symbiont-derived sphingosine modulates vector competence in Aedes mosquitoes Open
The main vectors of Zika virus (ZIKV) and dengue virus (DENV) are Aedes aegypti and Ae. albopictus, with Ae. aegypti being more competent. However, the underlying mechanisms remain unclear. Here, we find Ae. albopictus shows comparable vec…
View article: Protective effects of patchouli alcohol against DSS-induced ulcerative colitis
Protective effects of patchouli alcohol against DSS-induced ulcerative colitis Open
Patchouli alcohol (PA) is a widely used pharmaceutical ingredient in various Chinese traditional herbal medicine (THM) formulations, known for its modulatory effects on the gut microbiota. The present study investigated PA's anti-inflammat…
View article: High-quality reference genome of cowpea beetle Callosobruchus maculatus
High-quality reference genome of cowpea beetle Callosobruchus maculatus Open
View article: A three-dimensional immersed boundary method for accurate simulation of acoustic wavefields with complex surface topography
A three-dimensional immersed boundary method for accurate simulation of acoustic wavefields with complex surface topography Open
Irregular topography of the free surface significantly affects seismic wavefield modelling, especially when employing finite-difference methods on rectangular grids. These methods represent the free surface as discrete points, resulting in…
View article: Protein phosphatase <scp>SCP4</scp> regulates cartilage development and endochondral osteogenesis via <scp>FoxO3a</scp> dephosphorylation
Protein phosphatase <span>SCP4</span> regulates cartilage development and endochondral osteogenesis via <span>FoxO3a</span> dephosphorylation Open
The regulatory mechanisms involved in embryonic development are complex and yet remain unclear. SCP4 represents a novel nucleus‐resident phosphatase identified in our previous study. The primary aim of this study was to elucidate the funct…
View article: Ecdysone-controlled nuclear receptor ERR regulates metabolic homeostasis in the disease vector mosquito Aedes aegypti
Ecdysone-controlled nuclear receptor ERR regulates metabolic homeostasis in the disease vector mosquito Aedes aegypti Open
Hematophagous mosquitoes require vertebrate blood for their reproductive cycles, making them effective vectors for transmitting dangerous human diseases. Thus, high-intensity metabolism is needed to support reproductive events of female mo…
View article: The accumulation of modular serine protease mediated by a novel circRNA sponging miRNA increases Aedes aegypti immunity to fungus
The accumulation of modular serine protease mediated by a novel circRNA sponging miRNA increases Aedes aegypti immunity to fungus Open
View article: Leucine aminopeptidase1 controls egg deposition and hatchability in male Aedes aegypti mosquitoes
Leucine aminopeptidase1 controls egg deposition and hatchability in male Aedes aegypti mosquitoes Open
View article: Additional file 1 of The accumulation of modular serine protease mediated by a novel circRNA sponging miRNA increases Aedes aegypti immunity to fungus
Additional file 1 of The accumulation of modular serine protease mediated by a novel circRNA sponging miRNA increases Aedes aegypti immunity to fungus Open
Additional file 1: Table S1. Analysis of differentially expressed mRNAs response to B. bassiana infection in Ae. aegypti.
View article: Expressing Parasitoid Venom Protein VRF1 in an Entomopathogen <i>Beauveria bassiana</i> Enhances Virulence toward Cotton Bollworm <i>Helicoverpa armigera</i>
Expressing Parasitoid Venom Protein VRF1 in an Entomopathogen <i>Beauveria bassiana</i> Enhances Virulence toward Cotton Bollworm <i>Helicoverpa armigera</i> Open
Mycoinsecticides are essential for the development of integrated pest management as substitutes to chemical insecticides, but their usage is limited by their inferior virulence. Thus, genetically engineered bioinsecticides, including recom…
View article: Screening core genes and signaling pathways after SFTSV infection by integrated transcriptome profiling analysis
Screening core genes and signaling pathways after SFTSV infection by integrated transcriptome profiling analysis Open
A newly discovered tick-borne virus called the severe fever with thrombocytopenia syndrome virus (SFTSV) can cause the severe fever with thrombocytopenia syndrome (SFTS). The mortality and incidence rate of SFTS patients remain extremely h…
View article: Infection and transovarial transmission of severe fever with thrombocytopenia syndrome virus in <i>Rhipicephalus sanguineus</i> in Hainan Island, China
Infection and transovarial transmission of severe fever with thrombocytopenia syndrome virus in <i>Rhipicephalus sanguineus</i> in Hainan Island, China Open
Severe fever with thrombocytopenia syndrome virus (SFTSV) RNA level increased in female ticks after injection with SFTSV. Furthermore, SFTSV RNA was detected in the eggs and larvae that originated from the virus-infected female ticks.
View article: Hypofucosylation of Unc5b regulated by Fut8 enhances macrophage emigration and prevents atherosclerosis
Hypofucosylation of Unc5b regulated by Fut8 enhances macrophage emigration and prevents atherosclerosis Open
View article: OTU7B Modulates the Mosquito Immune Response to Beauveria bassiana Infection via Deubiquitination of the Toll Adaptor TRAF4
OTU7B Modulates the Mosquito Immune Response to Beauveria bassiana Infection via Deubiquitination of the Toll Adaptor TRAF4 Open
Insects use innate immunity to defend against microbial infection. The Toll pathway is a major immune signaling pathway that is associated with the antifungal immune response in mosquitoes.
View article: Two venom serpins from the parasitoid wasp Microplitis mediator inhibit the host prophenoloxidase activation and antimicrobial peptide synthesis
Two venom serpins from the parasitoid wasp Microplitis mediator inhibit the host prophenoloxidase activation and antimicrobial peptide synthesis Open
View article: Dual roles and evolutionary implications of P26/poxin in antagonizing intracellular cGAS-STING and extracellular melanization immunity
Dual roles and evolutionary implications of P26/poxin in antagonizing intracellular cGAS-STING and extracellular melanization immunity Open
View article: Ecdysone signaling mediates the trade-off between immunity and reproduction via suppression of amyloids in the mosquito Aedes aegypti
Ecdysone signaling mediates the trade-off between immunity and reproduction via suppression of amyloids in the mosquito Aedes aegypti Open
The balance between immunity and reproduction is essential for many key physiological functions. We report that to maintain an optimal fertility, 20-hydroxyecdysone (20E) and the ecdysone receptor (EcR) downregulate the immune deficiency (…
View article: A new scheme of wavefield decomposed elastic least-squares reverse time migration
A new scheme of wavefield decomposed elastic least-squares reverse time migration Open
Elastic least-squares reverse time migration (ELSRTM) describes the reflectivity of the underground media more accurately than acoustic LSRTM in theory while suffering from the P- and S-waves crosstalk artifacts. We propose a new wavefield…
View article: Proteomics reveals the hemolymph components of partially fed Hyalomma asiaticum ticks
Proteomics reveals the hemolymph components of partially fed Hyalomma asiaticum ticks Open
Hemolymph infection facilitates pathogen invasion of internal tick tissues. However, the overall protein composition of the hemolymph has not been analyzed for any tick species. Here, a gel based liquid chromatography tandem mass spectrome…
View article: Aedes aegypti CLIPB9 activates prophenoloxidase-3 in the presence of CLIPA14 after fungal infection
Aedes aegypti CLIPB9 activates prophenoloxidase-3 in the presence of CLIPA14 after fungal infection Open
Melanization is an integral part of the insect defense system and is often induced by pathogen invasion. Phenoloxidases (POs) are critical enzymes that catalyze melanin formation. PO3 is associated with the antifungal response of the mosqu…