Ziwen Fan
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View article: Association of leukocyte composition ratios from blood methylation with cancer mortality outcomes
Association of leukocyte composition ratios from blood methylation with cancer mortality outcomes Open
View article: Machine learning method based on radiomics help differentiate posterior pituitary tumors from pituitary neuroendocrine tumors and craniopharyngioma
Machine learning method based on radiomics help differentiate posterior pituitary tumors from pituitary neuroendocrine tumors and craniopharyngioma Open
Posterior pituitary tumors (PPTs) are rare neoplasms, but easily misdiagnosed as pituitary neuroendocrine tumor (PitNET) and craniopharyngioma. This study aimed to differentiate PPTs from PitNET and craniopharyngioma using a machine learni…
View article: A Hybrid Framework Combining Autoregression and Common Factors for Matrix Time Series Modeling
A Hybrid Framework Combining Autoregression and Common Factors for Matrix Time Series Modeling Open
Matrix-valued time series are increasingly common in economics and finance, but existing approaches such as matrix autoregressive and dynamic matrix factor models often impose restrictive assumptions and fail to capture complex dependencie…
View article: The Role of the Major Histocompatibility Complex Region on Chromosome 6 in Skin Atrophy: A Mendelian Randomization Study
The Role of the Major Histocompatibility Complex Region on Chromosome 6 in Skin Atrophy: A Mendelian Randomization Study Open
Background Skin atrophy (SA) is a pathological condition marked by the thinning of the skin, decreased elasticity, and reduced functionality, often arising from aging, chronic glucocorticoid use, or autoimmune diseases. Objective This stud…
View article: Pyogenic liver abscess and sepsis caused by mixed anaerobic bacteria in an immunocompetent adult: a case report
Pyogenic liver abscess and sepsis caused by mixed anaerobic bacteria in an immunocompetent adult: a case report Open
Background Anaerobic bacterial communities in the digestive tract play an important role in digestive tract infections and aspiration pneumonia. However, ectopic infections originating from these communities are uncommon. Case report We pr…
View article: Tracking DNA Methylation Based Biological Age Longitudinal Analyses in a Cohort of Community-Dwelling Older Adults
Tracking DNA Methylation Based Biological Age Longitudinal Analyses in a Cohort of Community-Dwelling Older Adults Open
View article: Matrix Time Series Modeling: A Hybrid Framework Combining Autoregression and Common Factors
Matrix Time Series Modeling: A Hybrid Framework Combining Autoregression and Common Factors Open
View article: Machine learning method based on radiomics help differentiate posterior pituitary tumors from pituitary adenomas and craniopharyngioma
Machine learning method based on radiomics help differentiate posterior pituitary tumors from pituitary adenomas and craniopharyngioma Open
Objectives Posterior pituitary tumors (PPTs) are rare neoplasms, but easily misdiagnosed as pituitary adenoma and craniopharyngioma. This study aimed to differentiate PPTs from pituitary adenoma and craniopharyngioma using a machine learni…
View article: Smoking‐independent <scp>DNA</scp> methylation markers for lung cancer risk: External validation in a large population‐based cohort study
Smoking‐independent <span>DNA</span> methylation markers for lung cancer risk: External validation in a large population‐based cohort study Open
Smoking‐associated epigenetic changes have been linked to lung cancer (LC) risk; however, the role of epigenetic alterations independent of smoking is yet to be fully understood. This study aimed to validate 16 previously reported CpG site…
View article: Developing survival prediction models in colorectal cancer using epigenome-wide DNA methylation data from whole blood
Developing survival prediction models in colorectal cancer using epigenome-wide DNA methylation data from whole blood Open
While genome-wide association studies are valuable in identifying CRC survival predictors, the benefit of adding blood DNA methylation (blood-DNAm) to clinical features, including the TNM system, remains unclear. In a multi-site population…
View article: The Safety Profile of Vitamin D Supplements Using Real-World Data from 445,493 Participants of the UK Biobank: Slightly Higher Hypercalcemia Prevalence but Neither Increased Risks of Kidney Stones nor Atherosclerosis
The Safety Profile of Vitamin D Supplements Using Real-World Data from 445,493 Participants of the UK Biobank: Slightly Higher Hypercalcemia Prevalence but Neither Increased Risks of Kidney Stones nor Atherosclerosis Open
Background: Potential calcium-related adverse events of vitamin D supplement use have not been addressed in large-scale, real-world data so far. Methods: Leveraging data from the UK Biobank, encompassing 445,493 individuals aged 40–69, we …
View article: Safety Profile of Vitamin D Supplements Using Real-World Data from 445,493 Participants of the UK Biobank: Slightly Higher Hypercalcemia Prevalence but Neither Increased Risks of Kidney Stones nor Atherosclerosis
Safety Profile of Vitamin D Supplements Using Real-World Data from 445,493 Participants of the UK Biobank: Slightly Higher Hypercalcemia Prevalence but Neither Increased Risks of Kidney Stones nor Atherosclerosis Open
Background: Potential calcium-related adverse events of vitamin D supplement use have not been addressed in large-scale, real-world data so far. Methods: Leveraging data from the UK Biobank, encompassing 445,493 individuals aged 40-69, we …
View article: DNA methylation-based biomarkers and prediction models for the survival of patients with colorectal cancer: systematic review and external validation study
DNA methylation-based biomarkers and prediction models for the survival of patients with colorectal cancer: systematic review and external validation study Open
Background DNA methylation biomarkers (e.g., methylation level at CpG sites) have the potential to improve prognostic accuracy for patients with colorectal cancer (CRC). We identified existing DNA methylation-based prognostic biomarkers an…
View article: DNA methylation-based biomarkers and prediction models for the survival of patients with colorectal cancer: systematic review and external validation study
DNA methylation-based biomarkers and prediction models for the survival of patients with colorectal cancer: systematic review and external validation study Open
Objectives To identify existing DNA methylation-based prognostic biomarkers and prediction models for colorectal cancer (CRC) prognosis and to validate them in a large external cohort. Design Systematic review and external validation study…
View article: Machine learning in the identification of prognostic DNA methylation biomarkers among patients with cancer: a systematic review of epigenome-wide studies
Machine learning in the identification of prognostic DNA methylation biomarkers among patients with cancer: a systematic review of epigenome-wide studies Open
Summary Background DNA methylation biomarkers have great potential in improving prognostic classification systems for patients with cancer. Machine learning (ML)-based analytic techniques might help overcome the challenges of analyzing hig…
View article: MR imaging characteristics of slow- and rapid-growing meningiomas: a cohort study of 165 cases
MR imaging characteristics of slow- and rapid-growing meningiomas: a cohort study of 165 cases Open
Introduction : The growth rate of meningiomas varies greatly (0.01 to 2.58 cm 3 /year).An inappropriate ‘wait and see’ treatment strategy, such as a follow-up interval of MRI longer than 2 years, for rapid growing meningioma (RGM) may seri…
View article: Identifying biomarkers associated with tumor growth rate: a longitudinal preoperative magnetic resonance imaging follow-up of low-grade gliomas
Identifying biomarkers associated with tumor growth rate: a longitudinal preoperative magnetic resonance imaging follow-up of low-grade gliomas Open
The status of biomarkers is significantly associated with the tumor growth rate in LGGs.
View article: Interactions Between Immunomodulatory Biomaterials and Immune Microenvironment: Cues for Immunomodulation Strategies in Tissue Repair
Interactions Between Immunomodulatory Biomaterials and Immune Microenvironment: Cues for Immunomodulation Strategies in Tissue Repair Open
The foreign body response (FBR) caused by biomaterials can essentially be understood as the interaction between the immune microenvironment and biomaterials, which has severely impeded the application of biomaterials in tissue repair. This…
View article: Image-Based Differentiation of Intracranial Metastasis From Glioblastoma Using Automated Machine Learning
Image-Based Differentiation of Intracranial Metastasis From Glioblastoma Using Automated Machine Learning Open
Purpose The majority of solitary brain metastases appear similar to glioblastomas (GBMs) on magnetic resonance imaging (MRI). This study aimed to develop and validate an MRI-based model to differentiate intracranial metastases from GBMs us…
View article: Ischemic Infarction of Pituitary Apoplexy: A Retrospective Study of 46 Cases From a Single Tertiary Center
Ischemic Infarction of Pituitary Apoplexy: A Retrospective Study of 46 Cases From a Single Tertiary Center Open
Objective Ischemic infarction of pituitary apoplexy (PA) is a rare type of pituitary apoplexy. This study aims to characterize ischemic PA via clinical presentations, imaging data, histopathological manifestations, and focus on the managem…
View article: Preoperative Radiomics Analysis of 1p/19q Status in WHO Grade II Gliomas
Preoperative Radiomics Analysis of 1p/19q Status in WHO Grade II Gliomas Open
Purpose The present study aimed to preoperatively predict the status of 1p/19q based on radiomics analysis in patients with World Health Organization (WHO) grade II gliomas. Methods This retrospective study enrolled 157 patients with WHO g…
View article: Radiomics Features Predict Telomerase Reverse Transcriptase Promoter Mutations in World Health Organization Grade II Gliomas via a Machine-Learning Approach
Radiomics Features Predict Telomerase Reverse Transcriptase Promoter Mutations in World Health Organization Grade II Gliomas via a Machine-Learning Approach Open
The detection of mutations in telomerase reverse transcriptase promoter (p TERT ) is important since preoperative diagnosis of p TERT status helps with evaluating prognosis and determining the surgical strategy. Here, we aimed to establish…
View article: [Investigation of sleep disturbance and related factors in patients with primary Sjögren's syndrome].
[Investigation of sleep disturbance and related factors in patients with primary Sjögren's syndrome]. Open
The incidence of sleep disorder in the pSS patients was higher, which was closely related to the course of disease, anxiety, depression and other factors. It is critical to assess and manage comprehensively the disease.
View article: Association of tumor growth rates with molecular biomarker status: a longitudinal study of high-grade glioma
Association of tumor growth rates with molecular biomarker status: a longitudinal study of high-grade glioma Open
To determine the association of molecular biomarkers with tumor growth in patients with high-grade gliomas (HGGs), the tumor growth rates and molecular biomarker status in 109 patients with HGGs were evaluated. Mean tumor diameter was asse…
View article: 0718 Hypoxemia and Pulmonary Hypertension in Patients with Concomitant Restrictive Ventilatory Defect and Sleep Apnea: The Overlap Syndrome
0718 Hypoxemia and Pulmonary Hypertension in Patients with Concomitant Restrictive Ventilatory Defect and Sleep Apnea: The Overlap Syndrome Open
Introduction Patients with severe restrictive ventilatory defect (RVD) have hypoxemia and a high risk of pulmonary hypertension (PHTN). Sleep apnea (SA) aggravates the severity of nocturnal desaturation significantly. The aim of this study…
View article: 微小乳頭サブタイプの手順特異的予後影響は小型肺腺癌における切除戦略を導く可能性がある:多施設研究【JST・京大機械翻訳】
微小乳頭サブタイプの手順特異的予後影響は小型肺腺癌における切除戦略を導く可能性がある:多施設研究【JST・京大機械翻訳】 Open
View article: Procedure-specific prognostic impact of micropapillary subtype may guide resection strategy in small-sized lung adenocarcinomas: a multicenter study
Procedure-specific prognostic impact of micropapillary subtype may guide resection strategy in small-sized lung adenocarcinomas: a multicenter study Open
Background: Limited resection has gradually become an acceptable treatment for lung adenocarcinomas (ADCs) presenting as ground-glass nodules (GGNs). However, its role in lung ADCs presenting as pure solid nodules (PSN) remains unclear. In…
View article: Three-dimensional printing of navigational template in localization of pulmonary nodule: A pilot study
Three-dimensional printing of navigational template in localization of pulmonary nodule: A pilot study Open
View article: [Mononuclear cells of umbilical cord blood differentiation to granulocyte cell in vitro].
[Mononuclear cells of umbilical cord blood differentiation to granulocyte cell in vitro]. Open
Objective: To explore an optimal method for granulocyte cell production from umbilical cord blood mononuclear cells. Methods: Erythrocytes were precipitated by hydroxyethyl starch. Mononuclear cells were isolated through Fico…