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View article: Design of Spider Web Biomimetic Structure Car Roof Handrails Based on Additive Manufacturing
Design of Spider Web Biomimetic Structure Car Roof Handrails Based on Additive Manufacturing Open
The combination of additive manufacturing technology and biomimetic structures plays an increasingly important role in the lightweight design of automotive parts. This work provides a lightweight design and manufacturing method for the spi…
View article: An SSR-Base Linkage Map Reveals QTLs for Floral-Related Traits in Nightlily (Hemerocallis citrina)
An SSR-Base Linkage Map Reveals QTLs for Floral-Related Traits in Nightlily (Hemerocallis citrina) Open
Nightlily (Hemerocallis citrina Baroni) is mainly cultivated for bud consumption with medicinal, nutritional, and economic value. Enhancing nightlily yield is one of the most significant breeding goals of modern agriculture of H. citrina b…
View article: Genome-Wide Identification of Watermelon Trihelix Genes and Their Expression Patterns Under Biotic and Abiotic Stresses
Genome-Wide Identification of Watermelon Trihelix Genes and Their Expression Patterns Under Biotic and Abiotic Stresses Open
Trihelix transcription factors (TFs) play crucial roles in plant growth, development, and environmental adaptation. However, there have been no systematic studies on the trihelix gene family in watermelon (Citrullus lanatus). A comprehensi…
View article: Single-cell atlas reveals the resistance of cortex cells to bacterial wilt in peanut roots
Single-cell atlas reveals the resistance of cortex cells to bacterial wilt in peanut roots Open
Peanut bacterial wilt (BW) is an extremely destructive soil-borne disease capable of causing yield losses exceeding 50%. However, the molecular mechanism underlying resistance to BW remains elusive. Here, we present the first single-cell e…
View article: Graph-based pangenome provides insights into structural variations and genetic basis of metabolic traits in potato
Graph-based pangenome provides insights into structural variations and genetic basis of metabolic traits in potato Open
Potato is the world's most important nongrain crop. In this study, to assess genetic diversity within the Petota section, 29 genomes from Petota and Etuberosum sections were newly de novo assembled and 248 accessions of wild potatoes, land…
View article: CD8+ T cells are necessary for improved sepsis survival induced by CD28 agonism in immunologically experienced mice
CD8+ T cells are necessary for improved sepsis survival induced by CD28 agonism in immunologically experienced mice Open
Introduction A hallmark of T cell dysregulation during sepsis is the downregulation of costimulatory molecules. CD28 is one of T cell costimulatory molecules significantly altered on memory T cells during sepsis. We recently showed that tr…
View article: Claudin-2 upregulation enhances intestinal permeability, immune activation, dysbiosis, and mortality in sepsis
Claudin-2 upregulation enhances intestinal permeability, immune activation, dysbiosis, and mortality in sepsis Open
Intestinal epithelial expression of the tight junction protein claudin-2, which forms paracellular cation and water channels, is precisely regulated during development and in disease. Here, we show that small intestinal epithelial claudin-…
View article: Dynamic <scp>N<sup>6</sup></scp>‐methyladenosine <scp>RNA</scp> modification regulates peanut resistance to bacterial wilt
Dynamic <span>N<sup>6</sup></span>‐methyladenosine <span>RNA</span> modification regulates peanut resistance to bacterial wilt Open
Summary N 6 ‐methyladenosine (m 6 A) is the most abundant mRNA modification in eukaryotes and is an important regulator of gene expression as well as many other critical biological processes. However, the characteristics and functions of m…
View article: A Novel Scoring System for Humane Endpoints in Mice with Cecal Ligation and Puncture-Induced Sepsis
A Novel Scoring System for Humane Endpoints in Mice with Cecal Ligation and Puncture-Induced Sepsis Open
Animal-based research is essential to the study of sepsis pathophysiology, diagnostics, and therapeutics. However, animal models of sepsis are often associated with high mortality because of the difficulty in predicting imminent death base…
View article: Nitric Oxide controls shoot meristem activity via regulation of DNA methylation
Nitric Oxide controls shoot meristem activity via regulation of DNA methylation Open
Despite the importance of Nitric Oxide (NO) as signaling molecule in both plant and animal development 1–7 , the regulatory mechanisms downstream of NO remain largely unclear. Here, we show that NO is involved in Arabidopsis shoot stem cel…
View article: CHRONIC ETHANOL USE WORSENS GUT PERMEABILITY AND ALTERS TIGHT JUNCTION EXPRESSION IN A MURINE SEPSIS MODEL
CHRONIC ETHANOL USE WORSENS GUT PERMEABILITY AND ALTERS TIGHT JUNCTION EXPRESSION IN A MURINE SEPSIS MODEL Open
Alcohol use disorder is associated with increased mortality in septic patients. Murine studies demonstrate that ethanol/sepsis is associated with changes in gut integrity. This study examined intestinal permeability after ethanol/sepsis an…
View article: Genetic basis of expression and splicing underlying spike architecture in wheat (<i>Triticum aestivum</i>L.)
Genetic basis of expression and splicing underlying spike architecture in wheat (<i>Triticum aestivum</i>L.) Open
Introduction Wheat is one of the most important staple crops worldwide, and an important source of human protein and mineral element intake. Continuously increasing stable production of wheat is critical for global food security under the …
View article: MYOSIN LIGHT CHAIN KINASE DELETION WORSENS LUNG PERMEABILITY AND INCREASES MORTALITY IN PNEUMONIA-INDUCED SEPSIS
MYOSIN LIGHT CHAIN KINASE DELETION WORSENS LUNG PERMEABILITY AND INCREASES MORTALITY IN PNEUMONIA-INDUCED SEPSIS Open
Increased epithelial permeability in sepsis is mediated via disruptions in tight junctions, which are closely associated with the perijunctional actin-myosin ring. Genetic deletion of myosin light chain kinase (MLCK) reverses sepsis-induce…
View article: Additional file 3 of Chromatin accessibility illuminates single-cell regulatory dynamics of rice root tips
Additional file 3 of Chromatin accessibility illuminates single-cell regulatory dynamics of rice root tips Open
Additional file 3: Table S10: Enriched TF motifs in differential ACRs upon heat stress for each cluster. (XLS 403 kb)
View article: Additional file 2 of Chromatin accessibility illuminates single-cell regulatory dynamics of rice root tips
Additional file 2 of Chromatin accessibility illuminates single-cell regulatory dynamics of rice root tips Open
Additional file 2: Table S2: Marker genes of each cluster. Table S3: ACRs of each cluster for Normal and HS. Table S4: List of genes with open chromatin accessibility but low/no expression. Table S5: List of genes with close chromatin acce…
View article: Chromosome-level reference genome of tetraploid <i>Isoetes sinensis</i> provides insights into evolution and adaption of lycophytes
Chromosome-level reference genome of tetraploid <i>Isoetes sinensis</i> provides insights into evolution and adaption of lycophytes Open
Background The Lycophyta species are the extant taxa most similar to early vascular plants that were once abundant on Earth. However, their distribution has greatly diminished. So far, the absence of chromosome-level assembled lycophyte ge…
View article: The RIPK3 Scaffold Regulates Lung Inflammation During <i>Pseudomonas Aeruginosa</i> Pneumonia
The RIPK3 Scaffold Regulates Lung Inflammation During <i>Pseudomonas Aeruginosa</i> Pneumonia Open
RIPK3 (receptor-interacting protein kinase 3) activity triggers cell death via necroptosis, whereas scaffold function supports protein binding and cytokine production. To determine if RIPK3 kinase or scaffold domains mediate pathology duri…
View article: Junctional adhesion molecule-A deletion increases phagocytosis and improves survival in a murine model of sepsis
Junctional adhesion molecule-A deletion increases phagocytosis and improves survival in a murine model of sepsis Open
Expression of the tight junction-associated protein junctional adhesion molecule-A (JAM-A) is increased in sepsis, although the significance of this is unknown. Here, we show that septic JAM-A -/- mice have increased gut permeability, yet …
View article: FIONA1‐Mediated m<sup>6</sup>A Modification Regulates the Floral Transition in <i>Arabidopsis</i>
FIONA1‐Mediated m<sup>6</sup>A Modification Regulates the Floral Transition in <i>Arabidopsis</i> Open
N 6 ‐methyladenosine (m 6 A) mRNA modification represents the most widespread form of internal modifications in eukaryotic mRNAs. In the model plant Arabidopsis thaliana , those known methyltransferases mainly deposit m 6 A at their target…
View article: TIGIT modulates sepsis-induced immune dysregulation in mice with preexisting malignancy
TIGIT modulates sepsis-induced immune dysregulation in mice with preexisting malignancy Open
TIGIT is a recently identified coinhibitory receptor that is upregulated in the setting of cancer and functionally contributes to the impairment of antitumor immunity. However, its role during sepsis is unknown. Because patients with cance…
View article: Anti-TIGIT differentially affects sepsis survival in immunologically experienced versus previously naive hosts
Anti-TIGIT differentially affects sepsis survival in immunologically experienced versus previously naive hosts Open
Mounting evidence suggests that the balance of T cell costimulatory and coinhibitory signals contributes to mortality during sepsis. Here, we identified a critical role of the coinhibitory molecule T cell Ig and ITIM domain (TIGIT) in regu…
View article: Membrane Permeant Inhibitor of Myosin Light Chain Kinase Worsens Survival in Murine Polymicrobial Sepsis
Membrane Permeant Inhibitor of Myosin Light Chain Kinase Worsens Survival in Murine Polymicrobial Sepsis Open
Sepsis-induced intestinal hyperpermeability is mediated by disruption of the epithelial tight junction, which is closely associated with the peri-junctional actin-myosin ring. Genetic deletion of myosin light chain kinase (MLCK) reverses i…