Zhongju Shi
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View article: Targeted delivery of the GPX4 activator via HUCMSC-derived exosomes inhibits ferroptosis in spinal cord injury
Targeted delivery of the GPX4 activator via HUCMSC-derived exosomes inhibits ferroptosis in spinal cord injury Open
View article: Interferon regulatory factor 4–releasing 3D-printed scaffolds enhance spinal cord repair by modulating macrophage polarization
Interferon regulatory factor 4–releasing 3D-printed scaffolds enhance spinal cord repair by modulating macrophage polarization Open
Three-dimensional (3D)-printed hydrogel scaffolds are widely used in spinal cord injury repair, with gelatin methacrylate being particularly favored owing to its excellent biocompatibility. However, traditional scaffolds have a small conta…
View article: Ferroptosis suppressor protein 1 regulated oligodendrocytes ferroptosis rescued by idebenone in spinal cord injury
Ferroptosis suppressor protein 1 regulated oligodendrocytes ferroptosis rescued by idebenone in spinal cord injury Open
Ferroptosis has been demonstrated to be involved in the progression of spinal cord injury (SCI). Ferroptosis suppressor protein 1 (FSP1) can inhibit ferroptosis in parallel with Glutathione peroxidase 4 (GPX4). However, the role of FSP1 in…
View article: Analysis and experimental validation of genes and their transcription factor prediction in contused rat spinal cord at the intermediate phase
Analysis and experimental validation of genes and their transcription factor prediction in contused rat spinal cord at the intermediate phase Open
The intermediate phase of spinal cord injury (SCI) serves as an important target site for therapeutic mediation of SCI. However, there is a lack of insight into the mechanism of the intermediate phase of SCI. The present study aimed to inv…
View article: Systematic analysis of co-expression network and gene expression profile of differentially expressed lncRNA-mRNA one week after spinal cord injury
Systematic analysis of co-expression network and gene expression profile of differentially expressed lncRNA-mRNA one week after spinal cord injury Open
Spinal cord injury (SCI) is a severe event that occurs in the central nervous system (CNS). Long noncoding RNAs (lncRNAs) have already been proven to play key roles in different diseases of the CNS. Nevertheless, the roles of messenger RNA…
View article: Multiple mechanisms of curcumin targeting spinal cord injury
Multiple mechanisms of curcumin targeting spinal cord injury Open
Spinal cord injury (SCI) is an irreversible disease process with a high disability and mortality rate. After primary spinal cord injury, the secondary injury may occur in sequence, which is composed of ischemia and hypoxia, excitotoxicity,…
View article: Programmed cell death in spinal cord injury pathogenesis and therapy
Programmed cell death in spinal cord injury pathogenesis and therapy Open
Spinal cord injury (SCI) always leads to functional deterioration due to a series of processes including cell death. In recent years, programmed cell death (PCD) is considered to be a critical process after SCI, and various forms of PCD we…
View article: Microglia-organized scar-free spinal cord repair in neonatal mice
Microglia-organized scar-free spinal cord repair in neonatal mice Open
View article: Bioinformatic identification of key candidate genes and pathways in axon regeneration after spinal cord injury in zebrafish
Bioinformatic identification of key candidate genes and pathways in axon regeneration after spinal cord injury in zebrafish Open
Zebrafish and human genomes are highly homologous; however, despite this genomic similarity, adult zebrafish can achieve neuronal proliferation, regeneration and functional restoration within 6-8 weeks after spinal cord injury, whereas hum…
View article: Correction to: c-Jun Amino-Terminal Kinase is Involved in Valproic Acid-Mediated Neuronal Differentiation of Mouse Embryonic NSCs and Neurite Outgrowth of NSC-Derived Neurons
Correction to: c-Jun Amino-Terminal Kinase is Involved in Valproic Acid-Mediated Neuronal Differentiation of Mouse Embryonic NSCs and Neurite Outgrowth of NSC-Derived Neurons Open
View article: Highlights for the 10th Annual Conference of the International Association of Neurorestoratology
Highlights for the 10th Annual Conference of the International Association of Neurorestoratology Open
The 10th annual conference of the International Association of Neurorestoratology (IANR) was held on Sept. 28-30, 2017. Here main promising topics were summarized, such as, memorial of Professor Geoffrey Raisman—Life Honorary President of …
View article: Epidemiological Features of Spinal Cord Injury in China: A Systematic Review
Epidemiological Features of Spinal Cord Injury in China: A Systematic Review Open
Background: Spinal cord injury (SCI) is a severe condition that disrupts patients' physiological, mental, and social well-being state and exerts great financial burden on patients, their families and social healthcare system. This r…
View article: The emerging role of long non‐coding <scp>RNA</scp> in spinal cord injury
The emerging role of long non‐coding <span>RNA</span> in spinal cord injury Open
Spinal cord injury ( SCI ) is a significant health burden worldwide which causes permanent neurological deficits, and there are approximately 17,000 new cases each year. However, there are no effective and current treatments that lead to f…
View article: Identification and Verification of Candidate Genes Regulating Neural Stem Cells Behavior Under Hypoxia
Identification and Verification of Candidate Genes Regulating Neural Stem Cells Behavior Under Hypoxia Open
Background/Aims: Neural stem cells (NSCs) reside in a hypoxic environment, and hypoxia plays an important role in their development and differentiation. This study aimed to explore the underlying mechanisms by which hypoxia affects NSC beh…
View article: Stem cell-based therapies to treat spinal cord injury: a review
Stem cell-based therapies to treat spinal cord injury: a review Open
Zhongju Shi,1,2 Hongyun Huang,3 Shiqing Feng1,2 1Department of Orthopaedics, Tianjin Medical University General Hospital, 2Institute of Neurology, Key Laboratory of Post-Neuroinjury Neuro-Repair and Regeneration in Central Nervous System, …
View article: Exploring the key genes and pathways of osteosarcoma with pulmonary metastasis using a gene expression microarray
Exploring the key genes and pathways of osteosarcoma with pulmonary metastasis using a gene expression microarray Open
Osteosarcoma is a common and highly malignant tumour in children and teenagers that is characterized by drug resistance and high metastatic potential. Patients often develop pulmonary metastasis and have a low survival rate. However, the m…
View article: The roles of microRNAs in spinal cord injury
The roles of microRNAs in spinal cord injury Open
Background and purpose: Spinal cord injury (SCI) involves serious damage that can result in abnormal or absent motor and sensory functions and a disruption of autonomic function, and a series of pathological reactions occur after th…
View article: Exploring the key genes and pathways in enchondromas using a gene expression microarray
Exploring the key genes and pathways in enchondromas using a gene expression microarray Open
Enchondromas are the most common primary benign osseous neoplasms that occur in the medullary bone; they can undergo malignant transformation into chondrosarcoma. However, enchondromas are always undetected in patients, and the molecular m…
View article: c-Jun Amino-Terminal Kinase is Involved in Valproic Acid-Mediated Neuronal Differentiation of Mouse Embryonic NSCs and Neurite Outgrowth of NSC-Derived Neurons
c-Jun Amino-Terminal Kinase is Involved in Valproic Acid-Mediated Neuronal Differentiation of Mouse Embryonic NSCs and Neurite Outgrowth of NSC-Derived Neurons Open
Valproic acid (VPA), an anticonvulsant and mood-stabilizing drug, can induce neuronal differentiation, promote neurite extension and exert a neuroprotective effect in central nervous system (CNS) injuries; however, comparatively little is …
View article: Long non-coding RNA NONMMUG014387 promotes Schwann cell proliferation after peripheral nerve injury
Long non-coding RNA NONMMUG014387 promotes Schwann cell proliferation after peripheral nerve injury Open
Schwann cells play a critical role in peripheral nerve regeneration through dedifferentiation and proliferation. In a previous study, we performed microarray analysis of the sciatic nerve after injury. Accordingly, we predicted that long n…
View article: Effectiveness of Teriparatide on Fracture Healing: A Systematic Review and Meta-Analysis
Effectiveness of Teriparatide on Fracture Healing: A Systematic Review and Meta-Analysis Open
This analysis showed that administration of teriparatide following fracture lacked the effectiveness for fracture healing. Moreover, teriparatide administration had no apparent adverse effects. These results should be interpreted with caut…
View article: The Effectiveness of Transforaminal Versus Caudal Routes for Epidural Steroid Injections in Managing Lumbosacral Radicular Pain
The Effectiveness of Transforaminal Versus Caudal Routes for Epidural Steroid Injections in Managing Lumbosacral Radicular Pain Open
Epidural steroid injection (ESI) is one of the most commonly used treatments for radiculopathy. Previous studies have described the effectiveness of ESI in the management of radiculopathy. However, controversy exists regarding the route th…