Zhiguo Xiong
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View article: The expression, regulation, and function of human endogenous retroviruses in genitourinary cancers
The expression, regulation, and function of human endogenous retroviruses in genitourinary cancers Open
Human endogenous retroviruses (HERVs), constituting approximately 8% of the human genome, represent genomic remnants of ancestral retroviral infections that colonized the germline through evolutionary processes. While most HERVs remain epi…
View article: Clinicopathological features and prognostic factors of clear cell papillary renal cell tumor: a retrospective population-based analysis
Clinicopathological features and prognostic factors of clear cell papillary renal cell tumor: a retrospective population-based analysis Open
Our study demonstrated the highly favorable outcomes in ccpRCT patients with low potential of lymph node invasion, metastasis, or disease specific death, and surgery is associated with improved outcomes.
View article: Deferred Versus Upfront Cytoreductive Nephrectomy in MetaStatic Renal Cell Carcinoma: Comparative Survival Analysis in the Immunotherapy Era
Deferred Versus Upfront Cytoreductive Nephrectomy in MetaStatic Renal Cell Carcinoma: Comparative Survival Analysis in the Immunotherapy Era Open
Background: The optimal timing of cytoreductive nephrectomy (CN) in metastatic renal cell carcinoma (mRCC) remains a subject of debate, particularly in the immunotherapy era. This study compares survival outcomes between deferred CN (dCN) …
View article: Mouse models for enteral and parenteral nutrition after surgery
Mouse models for enteral and parenteral nutrition after surgery Open
Background This study aims to establish a mouse model with different nutritional support modalities [enteral nutrition (EN) and parenteral nutrition] after abdominal surgery, providing a stable and effective animal model for further study …
View article: Serum ATIC Expression as a Novel Diagnostic and Prognostic Biomarker in Multiple Myeloma Patients
Serum ATIC Expression as a Novel Diagnostic and Prognostic Biomarker in Multiple Myeloma Patients Open
This study found that serum ATIC expression levels were significantly upregulated in MM patients, which is closely related to comorbidities, disease progression, renal dysfunction, and poor prognosis.
View article: Laparoscopic versus open surgery for rectal neuroendocrine tumors: a multicenter real-world study
Laparoscopic versus open surgery for rectal neuroendocrine tumors: a multicenter real-world study Open
Laparoscopic surgery was associated with improved postoperative outcomes and oncologic prognosis for patients with rectal neuroendocrine tumors ≤ 4 cm; it can serve as a safe and feasible option for radical surgery of rectal neuroendocrine…
View article: The impact of transanal drainage tube on the incidence of anastomotic leakage and small bowel obstruction in radical surgery (Dixon) for rectal cancer: a retrospective cohort study
The impact of transanal drainage tube on the incidence of anastomotic leakage and small bowel obstruction in radical surgery (Dixon) for rectal cancer: a retrospective cohort study Open
TDT is a safer, more effective, and more economical surgery for preventing postoperative complications.
View article: Laparoscopic Versus Open Surgery for Rectal Neuroendocrine Tumors: A Multicenter Real-World Study
Laparoscopic Versus Open Surgery for Rectal Neuroendocrine Tumors: A Multicenter Real-World Study Open
Background Due to the lack of large sample evidence-based medical studies, the surgical approach for radical resection of rectal neuroendocrine tumors is controversial. Methods We retrospectively collected the medical records of rectal neu…
View article: Long-term outcomes of 1–2 cm rectal neuroendocrine tumors after local excision or radical resection: A population-based multicenter study
Long-term outcomes of 1–2 cm rectal neuroendocrine tumors after local excision or radical resection: A population-based multicenter study Open
R-NETs measuring 1-2 cm generally have a favorable prognosis, and there is no difference in postoperative survival between LE and RR. For patients without lymph node metastasis, LE should be the preferred choice; however, for patients with…
View article: Local Excision Versus Radical Resection for Grade 2 Rectal Neuroendocrine Tumors: A Multicenter Propensity Score-Matched Analysis
Local Excision Versus Radical Resection for Grade 2 Rectal Neuroendocrine Tumors: A Multicenter Propensity Score-Matched Analysis Open
BACKGROUND: Studies on grade 2 rectal neuroendocrine tumors are limited, and the optimal treatment for these tumors is not well established. OBJECTIVE: We aimed to compare the oncologic results of local excision versus radical resection fo…
View article: Clinical evaluation of a multitarget fecal immunochemical test‐sDNA test for colorectal cancer screening in a high‐risk population: a prospective, multicenter clinical study
Clinical evaluation of a multitarget fecal immunochemical test‐sDNA test for colorectal cancer screening in a high‐risk population: a prospective, multicenter clinical study Open
Colorectal cancer (CRC) is a major malignancy threatening the health of people in China and screening could be effective for preventing the occurrence and reducing the mortality of CRC. We conducted a multicenter, prospective clinical stud…
View article: International guideline on natural orifice specimen extraction surgery (NOSES) for colorectal cancer (2023 version)
International guideline on natural orifice specimen extraction surgery (NOSES) for colorectal cancer (2023 version) Open
Purpose In recent years, natural orifice specimen extraction surgery (NOSES) has gained widespread attention as an alternative approach. Although the safety and feasibility of NOSES have been well documented, many questions remain open for…
View article: Current Status and Exploration of Digestive Tract Reconstruction After Totally Laparoscopic Radical Gastrectomy for Gastric Cancer
Current Status and Exploration of Digestive Tract Reconstruction After Totally Laparoscopic Radical Gastrectomy for Gastric Cancer Open
Digestive tract reconstruction is one of the key operations of gastric cancer surgery. Its quality directly affects the occurrence of postoperative complications and long-term nutritional status and quality of life. Reasonable selection of…
View article: Feasibility of quantification based on novel evaluation with stool DNA and fecal immunochemical test for colorectal cancer detection
Feasibility of quantification based on novel evaluation with stool DNA and fecal immunochemical test for colorectal cancer detection Open
Background Stool DNA (sDNA) tests and fecal immunochemical test (FIT) are used for the detection of colorectal cancer (CRC). Here we performed a novel evaluation using sDNA and FIT to assess their performance in CRC screening and monitorin…
View article: A Comparison of the Short-Term Clinical Effects Between Totally Laparoscopic Radical Gastrectomy With Modified Roux-en-Y Anastomosis and Laparoscopic-Assisted Radical Gastrectomy With Roux-en-Y Anastomosis
A Comparison of the Short-Term Clinical Effects Between Totally Laparoscopic Radical Gastrectomy With Modified Roux-en-Y Anastomosis and Laparoscopic-Assisted Radical Gastrectomy With Roux-en-Y Anastomosis Open
Objective: To compare the short-term clinical effects between totally laparoscopic radical gastrectomy with modified Roux-en-Y anastomosis, and laparoscopic-assisted radical gastrectomy with Roux-en-Y anastomosis; to explore the safety, fe…
View article: International consensus on natural orifice specimen extraction surgery (NOSES) for colorectal cancer
International consensus on natural orifice specimen extraction surgery (NOSES) for colorectal cancer Open
In recent years, natural orifice specimen extraction surgery (NOSES) in the treatment of colorectal cancer has attracted widespread attention. The potential benefits of NOSES including reduction in postoperative pain and wound complication…