Z. Gu
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View article: Machine learning assisted CRCA multi-color fluorescent droplet imaging for high-sensitivity simultaneous detection of Maillard hazards
Machine learning assisted CRCA multi-color fluorescent droplet imaging for high-sensitivity simultaneous detection of Maillard hazards Open
Acrylamide and advanced glycation end products are two typical hazards produced simultaneously through the Maillard reaction of food. Traditional instrumental detection methods require specialized instrument operation, resulting in low det…
View article: Polyvinyl alcohol modified plant fiber hydrogel pressure and strain dual-model sensors for biomedical signal detection
Polyvinyl alcohol modified plant fiber hydrogel pressure and strain dual-model sensors for biomedical signal detection Open
Flexible and stretchable hydrogels have become promising materials for wearable biomedical devices used in continuous health monitoring. A simple and effective ball-milling method is proposed to create conductive, biocompatible polyvinyl a…
View article: Acute hypoxia suppresses blood glycolysis in saker falcons (<i>Falco cherrug</i>) via NR3C1-mediated repression of <i>HK1</i>: Evidence from hematological and epigenomic profiling
Acute hypoxia suppresses blood glycolysis in saker falcons (<i>Falco cherrug</i>) via NR3C1-mediated repression of <i>HK1</i>: Evidence from hematological and epigenomic profiling Open
Ongoing climate change is driving high-altitude bird species to occupy even higher elevations, yet physiological and regulatory responses enabling these transitions remain poorly understood. This study investigated acute hypoxic responses …
View article: A Simple and Effective Physical Ball‐Milling Strategy to Prepare Super‐Tough and Stretchable PVA@MXene@PPy Hydrogel for Flexible Capacitive Electronics
A Simple and Effective Physical Ball‐Milling Strategy to Prepare Super‐Tough and Stretchable PVA@MXene@PPy Hydrogel for Flexible Capacitive Electronics Open
Biomimetic flexible electronics for E‐skin have received increasing attention, due to their ability to sense various movements. However, the development of smart skin‐mimic material remains a challenge. Here, a simple and effective approac…
View article: Core-Shell Microneedle Gel for Self-Regulated Insulin Delivery
Core-Shell Microneedle Gel for Self-Regulated Insulin Delivery Open
A bioinspired glucose-responsive insulin delivery system for self-regulation of blood glucose levels is desirable for improving health and quality of life outcomes for patients with type 1 and advanced type 2 diabetes. Here we describe a p…
View article: Bioresponsive Microneedles with a Sheath Structure for H2O2 and pH Cascade-Triggered Insulin Delivery
Bioresponsive Microneedles with a Sheath Structure for H2O2 and pH Cascade-Triggered Insulin Delivery Open
Self-regulating glucose-responsive insulin delivery systems have great potential to improve clinical outcomes and quality of life among patients with diabetes. Herein, an H2O2-labile and positively charged amphiphilic diblock copolymer is …
View article: Charge-switchable polymeric complex for glucose-responsive insulin delivery in mice and pigs
Charge-switchable polymeric complex for glucose-responsive insulin delivery in mice and pigs Open
Glucose-responsive insulin delivery systems with robust responsiveness that has been validated in animal models, especially in large animal models, remain elusive. Here, we exploit a new strategy to form a micro-sized complex between a cha…
View article: Insulin-Responsive Glucagon Delivery for Prevention of Hypoglycemia
Insulin-Responsive Glucagon Delivery for Prevention of Hypoglycemia Open
Hypoglycemia, the state of abnormally low blood glucose level, is an acute complication of insulin and sulfonylurea therapy in diabetes management. Frequent insulin dosing and boluses during daily diabetes care leads to an increased risk o…
View article: Microneedle-array patches loaded with hypoxia-sensitive vesicles provide fast glucose-responsive insulin delivery
Microneedle-array patches loaded with hypoxia-sensitive vesicles provide fast glucose-responsive insulin delivery Open
The past year demonstrated how developing pharmacological solutions for better ways of insulin substitution and making those drugs commercially available for patients with all forms of diabetes are becoming more and more complex issues wor…
View article: Synthetic beta cells for fusion-mediated dynamic insulin secretion
Synthetic beta cells for fusion-mediated dynamic insulin secretion Open
Generating artificial pancreatic beta cells by using synthetic materials to mimic glucose-responsive insulin secretion in a robust manner holds promise for improving clinical outcomes in people with diabetes. Here, we describe the construc…
View article: Hypoxia and H2O2 Dual-Sensitive Vesicles for Enhanced Glucose-Responsive Insulin Delivery
Hypoxia and H2O2 Dual-Sensitive Vesicles for Enhanced Glucose-Responsive Insulin Delivery Open
A glucose-responsive closed-loop insulin delivery system mimicking pancreas activity without long-term side effect has the potential to improve diabetic patients' health and quality of life. Here, we developed a novel glucose-responsive in…
View article: Glucose-responsive insulin patch for the regulation of blood glucose in mice and minipigs
Glucose-responsive insulin patch for the regulation of blood glucose in mice and minipigs Open
20 h with patches of ~5 cm2). Under hyperglycaemic conditions, phenylboronic acid units within the polymeric matrix reversibly form glucose–boronate complexes that—owing to their increased negative charge—induce the swelling of the polymer…
View article: Red Blood Cells for Glucose-Responsive Insulin Delivery
Red Blood Cells for Glucose-Responsive Insulin Delivery Open
Glucose-responsive delivery of insulin mimicking the function of pancreatic β-cells to achieve meticulous control of blood glucose (BG) would revolutionize diabetes care. Here the authors report the development of a new glucose-responsive …