Zhongshi Wu
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View article: A closed-loop bioelectronic patch for intelligent blood pressure management
A closed-loop bioelectronic patch for intelligent blood pressure management Open
Cardiovascular diseases remain a leading cause of mortality due to passive and delayed drug interventions. This study introduces an intelligent blood pressure management system (BPMS) for real-time monitoring and adaptive intervention thro…
View article: Integrated bioinformatics identifies ferroptosis biomarkers and therapeutic targets in idiopathic pulmonary arterial hypertension
Integrated bioinformatics identifies ferroptosis biomarkers and therapeutic targets in idiopathic pulmonary arterial hypertension Open
View article: Application of fibrobronchoscopy-guided aortic suspension in pediatric patients with bronchial compression resulting from repair of coarctation of the aorta: a case report
Application of fibrobronchoscopy-guided aortic suspension in pediatric patients with bronchial compression resulting from repair of coarctation of the aorta: a case report Open
View article: Prediction of the ideal length of insertion to monitor left atrial pressures in pediatric open-heart surgery: a retrospective cohort study
Prediction of the ideal length of insertion to monitor left atrial pressures in pediatric open-heart surgery: a retrospective cohort study Open
Height was identified as the most significant individual predictor of ideal length in this study. The newly developed formula, L = 5.0 + 0.1 × height (cm), is feasible and can be utilized to determine the optimal depth of the catheter to m…
View article: Reverse Potts shunt in severe pulmonary hypertension: A 20-year retrospective review
Reverse Potts shunt in severe pulmonary hypertension: A 20-year retrospective review Open
Pulmonary arterial hypertension (PAH) is a multifactorial heterogeneous condition characterized by elevated pulmonary artery pressure, leading to increased right ventricular afterload and ultimately resulting in right heart failure. Despit…
View article: Identifying potential ferroptosis-related biomarkers and therapeutic targets for IPAH by integrative bioinformatics approaches
Identifying potential ferroptosis-related biomarkers and therapeutic targets for IPAH by integrative bioinformatics approaches Open
Background: Idiopathic pulmonary arterial hypertension (IPAH), a rare and devastating pulmonary vascular disorder, is characterized by cellular proliferation and vascular remodeling. Although previous studies have underscored that ferropto…
View article: A rare morphology of the cardiac fibroma in a child: a case report
A rare morphology of the cardiac fibroma in a child: a case report Open
Here we report a rare morphology of a cardiac fibroma in a child. A 2-year and 8-month-old toddler came for “chronic constipation” and was found to have a heart murmur on cardiac auscultation. Further transthoracic echocardiography suggest…
View article: Identifying potential ferroptosis-related biomarkers and therapeutic targets for Idiopathic Pulmonary Hypertension in the context of predictive, preventive, and personalized medicine by integrative bioinformatics approaches
Identifying potential ferroptosis-related biomarkers and therapeutic targets for Idiopathic Pulmonary Hypertension in the context of predictive, preventive, and personalized medicine by integrative bioinformatics approaches Open
Background: Idiopathic pulmonary arterial hypertension (IPAH), a rare and devastating pulmonary vascular disorder, is characterized by cellular proliferation and vascular remodeling. Although previous studies have underscored that ferropto…
View article: Optimal depth for left atrial pressure monitoring in pediatric open-heart surgery
Optimal depth for left atrial pressure monitoring in pediatric open-heart surgery Open
Background Monitoring the left atrial pressure (LAP) is an important perioperative management tool for maintaining adequate cardiac output. This study aimed to devise a simple formula of left atrial catheterization to quantify the LAP in i…
View article: Comparison between the modified Blalock-Taussig shunt and right ventricular outflow tract stent in the palliative treatment for tetralogy of Fallot.
Comparison between the modified Blalock-Taussig shunt and right ventricular outflow tract stent in the palliative treatment for tetralogy of Fallot. Open
RVOT stent would have good surgical outcomes used in TOF patients with low weight and severe comorbidities. It also leads to an higher postoperative oxygen saturation and better promotion of pulmonary artery growth with RVOT stent compared…
View article: Prenatal diagnosis, management, and outcomes of fetuses with tetralogy of Fallot in China after prenatal counseling: a prospective cohort study
Prenatal diagnosis, management, and outcomes of fetuses with tetralogy of Fallot in China after prenatal counseling: a prospective cohort study Open
Objective The study aimed to monitor fetuses with tetralogy of Fallot (TOF) after prenatal counseling and how it influenced the decision of parents to terminate the pregnancy. Methods Fetuses with isolated TOF diagnosed between January 201…
View article: Free-aldehyde neutralized and oligohyaluronan loaded bovine pericardium with improved anti-calcification and endothelialization for bioprosthetic heart valves
Free-aldehyde neutralized and oligohyaluronan loaded bovine pericardium with improved anti-calcification and endothelialization for bioprosthetic heart valves Open
The number of patients with valvular heart disease is increasing yearly, and valve replacement is the most effective treatment, during which bioprosthetic heart valves (BHVs) are the most widely used. Commercial BHVs are mainly prepared wi…
View article: Preliminary study of improving immune tolerance in vivo of bioprosthetic heart valves through a novel antigenic removal method
Preliminary study of improving immune tolerance in vivo of bioprosthetic heart valves through a novel antigenic removal method Open
The durability of bioprosthetic heart valves is always compromised by the inherent antigenicity of biomaterials. Decellularization has been a promising approach to reducing the immunogenicity of biological valves. However, current methods …
View article: Right ventricular outflow tract stenting promotes pulmonary artery development in tetralogy of fallot
Right ventricular outflow tract stenting promotes pulmonary artery development in tetralogy of fallot Open
Background Right ventricular outflow tract (RVOT) stenting seems to be suggested as a promising treatment option and an alternative to modified Blalock-Taussig shunt (mBTS) in the initial palliation of patients with Fallot-type lesions in …
View article: Multifunctional nanoparticle-VEGF modification for tissue-engineered vascular graft to promote sustained anti-thrombosis and rapid endothelialization
Multifunctional nanoparticle-VEGF modification for tissue-engineered vascular graft to promote sustained anti-thrombosis and rapid endothelialization Open
Purpose: The absence of a complete endothelial cell layer is a well-recognized reason leading to small-diameter tissue-engineered vascular graft failure. Here we reported a multifunctional system consisting of chitosan (CS), Arg-Glu-Asp-Va…
View article: Expert Consensus on Nutritional Support for Children with Congenital Heart Disease (2023 Edition)
Expert Consensus on Nutritional Support for Children with Congenital Heart Disease (2023 Edition) Open
The second edition of the expert consensus on pediatric nutrition was formed based on a global update of pediatric nutrition guidelines or consensus worldwide, the management of congenital heart disease, and the results of multi-center cli…
View article: Vascular endothelial growth factor attenuates neointimal hyperplasia of decellularized small-diameter vascular grafts by modulating the local inflammatory response
Vascular endothelial growth factor attenuates neointimal hyperplasia of decellularized small-diameter vascular grafts by modulating the local inflammatory response Open
Small-diameter vascular grafts (diameter <6 mm) are in high demand in clinical practice. Neointimal hyperplasia, a common complication after implantation of small-diameter vascular grafts, is one of the common causes of graft failure. M…
View article: The hybrid crosslinking method improved the stability and anti-calcification properties of the bioprosthetic heart valves
The hybrid crosslinking method improved the stability and anti-calcification properties of the bioprosthetic heart valves Open
The bioprosthetic heart valves (BHVs) are the best option for the treatment of valvular heart disease. Glutaraldehyde (Glut) is commonly used as the golden standard reagent for the crosslinking of BHVs. However, the obvious defects of Glut…
View article: Decellularized bovine jugular vein and hand-sewn ePTFE valved conduit for right ventricular outflow tract reconstruction in children undergoing Ross procedure
Decellularized bovine jugular vein and hand-sewn ePTFE valved conduit for right ventricular outflow tract reconstruction in children undergoing Ross procedure Open
Background The Ross procedure is recommended as an optimal aortic valve replacement (AVR) in children and young adults due to several advantages. Nevertheless, multiple reconstructions of the right ventricular outflow tract (RVOT) with new…
View article: A proteomics analysis of neointima formation on decellularized vascular grafts reveals regenerative alterations in protein signature running head: Proteomics analysis of neointima formation
A proteomics analysis of neointima formation on decellularized vascular grafts reveals regenerative alterations in protein signature running head: Proteomics analysis of neointima formation Open
Background: Neointima formation contributes to vascular grafts stenosis and thrombosis. It is a complex reaction that plays a significant role in the performance of vascular grafts. Despite its critical implications, little is known about …
View article: A Novel Crosslinking Method for Improving the Anti-Calcification Ability and Extracellular Matrix Stability in Transcatheter Heart Valves
A Novel Crosslinking Method for Improving the Anti-Calcification Ability and Extracellular Matrix Stability in Transcatheter Heart Valves Open
More than 200,000 patients with aortic diseases worldwide undergo surgical valve replacement each year, and transcatheter heart valves (THV) have been more widely used than ever before. However, THV made by the glutaraldehyde (Glut) crossl…
View article: Comparison of biodegradable and durable polymer drug-eluting stents in acute coronary syndrome: a meta-analysis
Comparison of biodegradable and durable polymer drug-eluting stents in acute coronary syndrome: a meta-analysis Open
Objective To compare the safety and effectiveness between biodegradable polymer drug-eluting stents (BP-DES) and durable polymer drug-eluting stents (DP-DES) in patients with acute coronary syndrome (ACS). Design Meta-analysis of randomise…
View article: Improved Cytocompatibility and Reduced Calcification of Glutaraldehyde-Crosslinked Bovine Pericardium by Modification With Glutathione
Improved Cytocompatibility and Reduced Calcification of Glutaraldehyde-Crosslinked Bovine Pericardium by Modification With Glutathione Open
Bioprosthetic heart valves (BHVs) used in clinics are fabricated via glutaraldehyde (GLUT) crosslinking, which results in cytotoxicity and causes eventual valve calcification after implantation into the human body; therefore, the average l…
View article: Photooxidation and Pentagalloyl Glucose Cross-Linking Improves the Performance of Decellularized Small-Diameter Vascular Xenograft In Vivo
Photooxidation and Pentagalloyl Glucose Cross-Linking Improves the Performance of Decellularized Small-Diameter Vascular Xenograft In Vivo Open
Small-diameter vascular grafts have a significant need in peripheral vascular surgery and procedures of coronary artery bypass graft (CABG); however, autografts are not always available, synthetic grafts perform poorly, and allografts and …
View article: Surgery for Primary Cardiac Tumors in Children: Successful Management of Large Fibromas
Surgery for Primary Cardiac Tumors in Children: Successful Management of Large Fibromas Open
Background Pediatric primary cardiac tumors (PCTs) are rare. Its clinical features and prognoses are not well defined. The management of asymptomatic patients with cardiac fibromas remains controversial. Objective We aimed to examine our e…
View article: Clinical factors affecting the early postoperative prognosis of infants suffering surgery for congenital heart diseases: A single-center experience of 511 patients.
Clinical factors affecting the early postoperative prognosis of infants suffering surgery for congenital heart diseases: A single-center experience of 511 patients. Open
Surgical treatment for infants (<3 months) with CHD is still a challenge, particularly for infants with complex CHD and weight under 4.0 kg. We can improve the prognosis of CHD treatment in infants by establishing the integrated model of p…
View article: Hand-sewn expanded polytetrafluoroethylene valved conduit for right ventricular outflow tract reconstruction.
Hand-sewn expanded polytetrafluoroethylene valved conduit for right ventricular outflow tract reconstruction. Open
Hand-sewn ePTFE valved conduit is feasible for RVOT reconstruction. It is a promising material for RVOT reconstruction which can effectively meet clinical need. In our experience, the ePTFE valved conduit is simple to manufacture with sati…
View article: An extremely rare malignant Dabska tumour in right atria for a premature neonate
An extremely rare malignant Dabska tumour in right atria for a premature neonate Open
View article: Yak Pericardium as an Alternative Biomaterial for Transcatheter Heart Valves
Yak Pericardium as an Alternative Biomaterial for Transcatheter Heart Valves Open
Transcatheter aortic valve implantation (TAVI) has received much attention and development in the past decade due to its lower risk of complication and infections compared to a traditional open thoracotomy. However, the current commercial …
View article: Conduits for Right Ventricular Outflow Tract Reconstruction in Infants and Young Children
Conduits for Right Ventricular Outflow Tract Reconstruction in Infants and Young Children Open
Purpose of Review: Right ventricular outflow tract (RVOT) reconstruction remains a challenge due to the lack of an ideal conduit. Data and experience are accumulating with each passing day. Therefore, it is necessary to review this topic f…