Zhongyang Sun
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View article: Preliminary exploration of safety and efficiency of external traction fixation in early-stage treatment of severe lower leg injuries--A retrospective cohort study
Preliminary exploration of safety and efficiency of external traction fixation in early-stage treatment of severe lower leg injuries--A retrospective cohort study Open
Background: Staged treatment is commonly used for severe limb injuries, and optimizing early stabilization is crucial for successful definitive surgery. Calcaneal traction and external skeletal fixation are widely applied; however, both ha…
View article: Efficacy and Safety of Poly‐<scp>l</scp>‐Lactic Acid for Correction of Midfacial Volume Loss and Contour Defects: A Prospective, Multicenter, Randomized, Parallel‐Controlled, Evaluator‐Blinded, Superiority Trial
Efficacy and Safety of Poly‐<span>l</span>‐Lactic Acid for Correction of Midfacial Volume Loss and Contour Defects: A Prospective, Multicenter, Randomized, Parallel‐Controlled, Evaluator‐Blinded, Superiority Trial Open
Background Poly‐ l ‐lactic acid (PLLA) is widely used in esthetic medicine due to its excellent biocompatibility and biodegradability. This study aimed to evaluate the effectiveness and safety of PLLA facial filler in correcting midfacial …
View article: Local Sustained‐Release of Triamcinolone‐Acetonide‐Loaded Regenerated Silk Fibroin Formulations for the Inhibition of Scar Hyperplasia in Rabbit Ears
Local Sustained‐Release of Triamcinolone‐Acetonide‐Loaded Regenerated Silk Fibroin Formulations for the Inhibition of Scar Hyperplasia in Rabbit Ears Open
To investigate the safety, efficacy, and underlying mechanisms of triamcinolone‐acetonide‐loaded silk fibroin formulations in inhibiting scar hyperplasia in rabbit ears. This study employed molecular induction self‐assembly and high‐energy…
View article: Global burden of disease for musculoskeletal disorders in all age groups, from 2024 to 2050, and a bibliometric-based survey of the status of research in geriatrics, geriatric orthopedics, and geriatric orthopedic diseases
Global burden of disease for musculoskeletal disorders in all age groups, from 2024 to 2050, and a bibliometric-based survey of the status of research in geriatrics, geriatric orthopedics, and geriatric orthopedic diseases Open
DALY in older adults over 70 years of age accounts for a significant portion of the disease burden of musculoskeletal disorders. Possible future research hotspots in geriatric orthopedics and geriatric bone diseases include three direction…
View article: Pretreatment with a modified St. Thomas' solution in patients with severe upper limb injuries: Four case reports
Pretreatment with a modified St. Thomas' solution in patients with severe upper limb injuries: Four case reports Open
Inflammatory myofibroblastic tumor (IMT) of the biliary tract is rare, and often difficult to diagnose or to distinguish from other tumors due to its atypical clinical presentation and nonspecific radiological features. Histologically, IMT…
View article: Inhibitory effects of Formononetin on CoCrMo particle-induced osteoclast activation and bone loss through downregulating NF-κB and MAPK signaling
Inhibitory effects of Formononetin on CoCrMo particle-induced osteoclast activation and bone loss through downregulating NF-κB and MAPK signaling Open
Wear particle-induced osteoclast over-activation is a major contributor to periprosthetic osteolysis and aseptic loosening, which can cause pathological bone loss and destruction. Hence, inhibiting excessive osteoclast-resorbing activity i…
View article: Jujuboside A Exhibits an Antiepileptogenic Effect in the Rat Model via Protection against Traumatic Epilepsy-Induced Oxidative Stress and Inflammatory Responses
Jujuboside A Exhibits an Antiepileptogenic Effect in the Rat Model via Protection against Traumatic Epilepsy-Induced Oxidative Stress and Inflammatory Responses Open
Traumatic brain injuries (TBI) are the greatest source of death in trauma, and post-traumatic epilepsy (PTE) is one of the common complications of TBI. Oxidative stress and inflammatory responses play an important role in the process of PT…
View article: Enteropathogenic Escherichia coli Mediates CoCrMo Particle-Induced Peri-Implant Osteolysis by Increasing Peripheral 5-HT
Enteropathogenic Escherichia coli Mediates CoCrMo Particle-Induced Peri-Implant Osteolysis by Increasing Peripheral 5-HT Open
The human gut microbiota has been proven to have great effects on the regulation of bone health. However, the association between gut microbiota and particle-induced osteolysis, which is the primary cause of aseptic loosening, is still unk…
View article: Individualized Modeling Differential Ratio Method for Judging the Degree of Lower Extremity Long Bone Healing
Individualized Modeling Differential Ratio Method for Judging the Degree of Lower Extremity Long Bone Healing Open
Background: There are no recognized quantitative diagnostic criteria, which is one of the difficulties faced in trauma orthopedics. The purpose of this study is to quantitatively evaluate the degree of bone healing after internal fracture …
View article: MiR‐103‐3p targets the m<sup>6</sup>A methyltransferase METTL14 to inhibit osteoblastic bone formation
MiR‐103‐3p targets the m<sup>6</sup>A methyltransferase METTL14 to inhibit osteoblastic bone formation Open
Impaired osteoblast function is involved in osteoporosis, and microRNA (miRNA) dysregulation may cause abnormal osteoblast osteogenic activity. However, the influence of miRNA on osteoblast activity and the underlying mechanisms remain elu…
View article: Bilobalide protects against ischemia/reperfusion-induced oxidative stress and inflammatory responses via the MAPK/NF-κB pathways in rats
Bilobalide protects against ischemia/reperfusion-induced oxidative stress and inflammatory responses via the MAPK/NF-κB pathways in rats Open
Background Clinically, skeletal muscle ischemia/reperfusion injury is a life-threatening syndrome that is often caused by skeletal muscle damage and is characterized by oxidative stress and inflammatory responses. Bilobalide has been found…
View article: miR‐181c‐5p mediates simulated microgravity‐induced impaired osteoblast proliferation by promoting cell cycle arrested in the G<sub>2</sub> phase
miR‐181c‐5p mediates simulated microgravity‐induced impaired osteoblast proliferation by promoting cell cycle arrested in the G<sub>2</sub> phase Open
Impaired osteoblast proliferation plays fundamental roles in microgravity‐induced bone loss, and cell cycle imbalance may result in abnormal osteoblast proliferation. However, whether microgravity exerts an influence on the cell cycle in o…
View article: Osteoblast-targeted delivery of miR-33-5p attenuates osteopenia development induced by mechanical unloading in mice
Osteoblast-targeted delivery of miR-33-5p attenuates osteopenia development induced by mechanical unloading in mice Open
A growing body of evidence has revealed that microRNAs (miRNAs) play crucial roles in regulating osteoblasts and bone metabolism. However, the effects of miRNAs in osteoblast mechanotransduction remain to be defined. In this study, we inve…
View article: Effect of blue light on proliferation of human retinal pigment epithelial cells
Effect of blue light on proliferation of human retinal pigment epithelial cells Open
AIM: To investigate the influence and mechanism of blue light on the proliferation of human retinal pigment epithelial cells. METHODS: Cells were divided into two groups, including blue light group and control group. The 35W white light la…
View article: Simulated microgravity inhibits L-type calcium channel currents partially by the up-regulation of miR-103 in MC3T3-E1 osteoblasts
Simulated microgravity inhibits L-type calcium channel currents partially by the up-regulation of miR-103 in MC3T3-E1 osteoblasts Open
L-type voltage-sensitive calcium channels (LTCCs), particularly Cav1.2 LTCCs, play fundamental roles in cellular responses to mechanical stimuli in osteoblasts. Numerous studies have shown that mechanical loading promotes bone formation, w…