Zhongying Yang
YOU?
Author Swipe
View article: Identification and rescue of congenital hyperinsulinism-associated ABCC8 mutations that impair KATP channel trafficking
Identification and rescue of congenital hyperinsulinism-associated ABCC8 mutations that impair KATP channel trafficking Open
ATP-sensitive potassium (KATP) channels composed of Kir6.2 and sulfonylurea receptor 1 (SUR1) couple glucose metabolism with insulin secretion in pancreatic β-cells. Loss-of-function mutations in the large regulatory SUR1 subuni…
View article: Identification and Rescue of Congenital Hyperinsulinism-Associated <i>ABCC8</i> Mutations that Impair K<sub>ATP</sub>Channel Trafficking
Identification and Rescue of Congenital Hyperinsulinism-Associated <i>ABCC8</i> Mutations that Impair K<sub>ATP</sub>Channel Trafficking Open
ATP-sensitive potassium (K ATP ) channels composed of Kir6.2 and sulfonylurea receptor 1 (SUR1) couple glucose metabolism with insulin secretion in pancreatic β-cells and are vital to glucose homeostasis. Loss-of-function mutations in SUR1…
View article: Hypnotic treatment improves sleep architecture and EEG disruptions and rescues memory deficits in a mouse model of fragile X syndrome
Hypnotic treatment improves sleep architecture and EEG disruptions and rescues memory deficits in a mouse model of fragile X syndrome Open
Fragile X syndrome (FXS) is associated with disrupted cognition and sleep abnormalities. Sleep loss negatively impacts cognitive function, and one untested possibility is that disrupted cognition in FXS is exacerbated by abnormal sleep. We…
View article: Sleep-dependent engram reactivation during hippocampal memory consolidation associated with subregion-specific biosynthetic changes
Sleep-dependent engram reactivation during hippocampal memory consolidation associated with subregion-specific biosynthetic changes Open
Post-learning sleep is essential for hippocampal memory processing, including contextual fear memory consolidation. We labeled context-encoding engram neurons in the hippocampal dentate gyrus (DG) and assessed reactivation of these neurons…
View article: Hypnotic treatment reverses NREM sleep disruption and EEG desynchronization in a mouse model of Fragile X syndrome to rescue memory consolidation deficits
Hypnotic treatment reverses NREM sleep disruption and EEG desynchronization in a mouse model of Fragile X syndrome to rescue memory consolidation deficits Open
Fragile X syndrome (FXS) is a highly-prevalent genetic cause of intellectual disability, associated with disrupted cognition and sleep abnormalities. Sleep loss itself negatively impacts cognitive function, yet the contribution of sleep lo…
View article: Hypnotic Treatment Reverses NREM Sleep Disruption and EEG Desynchronization in a Mouse Model of Fragile X Syndrome to Rescue Memory Consolidation Deficits
Hypnotic Treatment Reverses NREM Sleep Disruption and EEG Desynchronization in a Mouse Model of Fragile X Syndrome to Rescue Memory Consolidation Deficits Open
View article: Reactivation of memory-encoding dentate gyrus neurons during memory consolidation is associated with subregion-specific, learning- and sleep-mediated biosynthetic changes
Reactivation of memory-encoding dentate gyrus neurons during memory consolidation is associated with subregion-specific, learning- and sleep-mediated biosynthetic changes Open
Post-learning sleep plays an important role in hippocampal memory processing, including contextual fear memory (CFM) consolidation. Here, we used targeted recombination in activated populations (TRAP) to label context-encoding engram neuro…
View article: Sleep-dependent engram reactivation during hippocampal memory consolidation is associated with subregion-specific biosynthetic changes
Sleep-dependent engram reactivation during hippocampal memory consolidation is associated with subregion-specific biosynthetic changes Open
Post-learning sleep is essential for hippocampal memory processing, including contextual fear memory (CFM) consolidation. We used targeted recombination in activated populations (TRAP) to label context-encoding engram neurons in the hippoc…
View article: Localized islet nuclear enlargement hyperinsulinism (LINE-HI) due to <i>ABCC8</i> and <i>GCK</i> mosaic mutations
Localized islet nuclear enlargement hyperinsulinism (LINE-HI) due to <i>ABCC8</i> and <i>GCK</i> mosaic mutations Open
Objective Congenital hyperinsulinism (HI) is the most common cause of persistent hypoglycemia in children. In addition to typical focal or diffuse HI, some cases with diazoxide-unresponsive congenital HI have atypical pancreatic histology …
View article: Vascular K <sub>ATP</sub> channel structural dynamics reveal regulatory mechanism by Mg-nucleotides
Vascular K <sub>ATP</sub> channel structural dynamics reveal regulatory mechanism by Mg-nucleotides Open
Significance Vascular K ATP channels formed by the potassium channel Kir6.1 and its regulatory protein SUR2B maintain blood pressure in the physiological range. Overactivity of the channel due to genetic mutations in either Kir6.1 or SUR2B…
View article: Comparison of the effects of left atrial appendage closure and oral anticoagulants in preventing stroke in patients with non-valvular atrial fibrillation
Comparison of the effects of left atrial appendage closure and oral anticoagulants in preventing stroke in patients with non-valvular atrial fibrillation Open
Background: This study aims to analyze and evaluate the difference in efficacy between left atrial appendage closure (LAAC) and oral anticoagulants (OA) in preventing stroke in patients with non-valvular atrial fibrillation (NVAF) through …
View article: Vascular K<sub>ATP</sub> channel structural dynamics reveal regulatory mechanism by Mg-nucleotides
Vascular K<sub>ATP</sub> channel structural dynamics reveal regulatory mechanism by Mg-nucleotides Open
Vascular tone is dependent on smooth muscle K ATP channels comprising pore-forming Kir6.1 and regulatory SUR2B subunits, in which mutations cause Cantú syndrome. Unique among K ATP isoforms, they lack spontaneous activity and require Mg-nu…
View article: AKAP79/150 coordinates leptin-induced PKA signaling to regulate KATP channel trafficking in pancreatic β-cells
AKAP79/150 coordinates leptin-induced PKA signaling to regulate KATP channel trafficking in pancreatic β-cells Open
The adipocyte hormone leptin regulates glucose homeostasis both centrally and peripherally. A key peripheral target is the pancreatic β-cell, which secretes insulin upon glucose stimulation. Leptin is known to suppress glucose-stimulated i…
View article: AKAP79/150 coordinates leptin-induced PKA activation to regulate K<sub>ATP</sub>channel trafficking in pancreatic β-cells
AKAP79/150 coordinates leptin-induced PKA activation to regulate K<sub>ATP</sub>channel trafficking in pancreatic β-cells Open
The adipocyte hormone leptin regulates glucose homeostasis both centrally and peripherally. A key peripheral target is the pancreatic β-cell, which secretes insulin upon glucose stimulation. Leptin suppresses glucose-stimulated insulin sec…
View article: Leptin modulates pancreatic β-cell membrane potential through Src kinase–mediated phosphorylation of NMDA receptors
Leptin modulates pancreatic β-cell membrane potential through Src kinase–mediated phosphorylation of NMDA receptors Open
View article: CFTR trafficking mutations disrupt cotranslational protein folding by targeting biosynthetic intermediates
CFTR trafficking mutations disrupt cotranslational protein folding by targeting biosynthetic intermediates Open
View article: Mechanism of pharmacochaperoning in a mammalian KATP channel revealed by cryo-EM
Mechanism of pharmacochaperoning in a mammalian KATP channel revealed by cryo-EM Open
ATP-sensitive potassium (KATP) channels composed of a pore-forming Kir6.2 potassium channel and a regulatory ABC transporter sulfonylurea receptor 1 (SUR1) regulate insulin secretion in pancreatic β-cells to maintain glucose homeostasis. M…
View article: Author response: Mechanism of pharmacochaperoning in a mammalian KATP channel revealed by cryo-EM
Author response: Mechanism of pharmacochaperoning in a mammalian KATP channel revealed by cryo-EM Open
Article Figures and data Abstract Introduction Results Discussion Materials and methods Data availability References Decision letter Author response Article and author information Metrics Abstract ATP-sensitive potassium (KATP) channels co…
View article: Functional characterization of activating mutations in the sulfonylurea receptor 1 ( <i>ABCC8</i> ) causing neonatal diabetes mellitus in Asian Indian children
Functional characterization of activating mutations in the sulfonylurea receptor 1 ( <i>ABCC8</i> ) causing neonatal diabetes mellitus in Asian Indian children Open
The study shows the mechanisms by which five SUR1 mutations identified in Asian Indian NDM patients affect KATP channel function to cause the disease. The reduced ATP4- sensitivity caused by the D212Y and P254S mutati…
View article: Mechanism of pharmacochaperoning in KATP channels revealed by cryo-EM
Mechanism of pharmacochaperoning in KATP channels revealed by cryo-EM Open
ATP-sensitive potassium (K ATP ) channels composed of a pore-forming Kir6.2 potassium channel and a regulatory ABC transporter sulfonylurea receptor 1 (SUR1) regulate insulin secretion in pancreatic β-cells to maintain glucose homeostasis.…
View article: The Ribosome-Sec61 Translocon Complex Forms a Cytosolically Restricted Environment for Early Polytopic Membrane Protein Folding
The Ribosome-Sec61 Translocon Complex Forms a Cytosolically Restricted Environment for Early Polytopic Membrane Protein Folding Open
View article: Cotranslational Stabilization of Sec62/63 within the ER Sec61 Translocon Is Controlled by Distinct Substrate-Driven Translocation Events
Cotranslational Stabilization of Sec62/63 within the ER Sec61 Translocon Is Controlled by Distinct Substrate-Driven Translocation Events Open