Zhongyu Zou
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View article: Nuclear 2′- <i>O</i> -methylation regulates RNA splicing through its binding protein FUBP1
Nuclear 2′- <i>O</i> -methylation regulates RNA splicing through its binding protein FUBP1 Open
2′- O -methylation (N m ) is an abundant RNA modification exists on different mammalian RNA species. However, potential N m recognition by proteins has not been extensively explored. Here, we used RNA affinity purification, followed by mas…
View article: 5-azacytosine induces cytotoxicity via 5-methylcytosine depletion on chromatin-associated RNA in leukemia
5-azacytosine induces cytotoxicity via 5-methylcytosine depletion on chromatin-associated RNA in leukemia Open
SUMMARY 5-azacytidine (5-azaC) is a DNA hypomethylating agent clinically used to improve outcomes in myeloid malignancies. However, 5-azaC treatment causes gene dysregulation inconsistent with DNA hypomethylation changes, suggesting altern…
View article: Quantitative RNA pseudouridine maps reveal multilayered translation control through plant rRNA, tRNA and mRNA pseudouridylation
Quantitative RNA pseudouridine maps reveal multilayered translation control through plant rRNA, tRNA and mRNA pseudouridylation Open
View article: 5-Azacytosine Induces Cytotoxicity&nbsp;via 5-Methylcytosine Depletion on Chromatin-Associated RNA in Leukemia
5-Azacytosine Induces Cytotoxicity via 5-Methylcytosine Depletion on Chromatin-Associated RNA in Leukemia Open
View article: Targeting DTX2/UFD1-mediated FTO degradation to regulate antitumor immunity
Targeting DTX2/UFD1-mediated FTO degradation to regulate antitumor immunity Open
Here, we show that vitamin E succinate (VES) acts as a degrader for the m 6 A RNA demethylase fat mass and obesity-associated protein (FTO), thus suppressing tumor growth and resistance to immunotherapy. FTO is ubiquitinated by its E3 liga…
View article: RNA m5C oxidation by TET2 regulates chromatin state and leukaemogenesis
RNA m5C oxidation by TET2 regulates chromatin state and leukaemogenesis Open
View article: m6A mRNA methylation by METTL14 regulates early pancreatic cell differentiation
m6A mRNA methylation by METTL14 regulates early pancreatic cell differentiation Open
View article: YTHDF1 mediates translational control by m6A mRNA methylation in adaptation to environmental challenges
YTHDF1 mediates translational control by m6A mRNA methylation in adaptation to environmental challenges Open
Animals adapt to environmental challenges with long-term changes at the behavioral, circuit, cellular, and synaptic levels which often require new protein synthesis. The discovery of reversible N6-methyladenosine (m 6 A) modifications of m…
View article: Zebrafish Mbd5 binds to RNA m5C and regulates histone deubiquitylation and gene expression in development metabolism and behavior
Zebrafish Mbd5 binds to RNA m5C and regulates histone deubiquitylation and gene expression in development metabolism and behavior Open
Complex biological processes are regulated by both genetic and epigenetic programs. One class of epigenetic modifications is methylation. Evolutionarily conserved methyl-CpG-binding domain (MBD)-containing proteins are known as readers of …
View article: Profiling of RNA-binding protein binding sites by in situ reverse transcription-based sequencing
Profiling of RNA-binding protein binding sites by in situ reverse transcription-based sequencing Open
View article: FMRP phosphorylation modulates neuronal translation through YTHDF1
FMRP phosphorylation modulates neuronal translation through YTHDF1 Open
View article: O-GlcNAcylation determines the translational regulation and phase separation of YTHDF proteins
O-GlcNAcylation determines the translational regulation and phase separation of YTHDF proteins Open
View article: Chemical Proteomic Discovery of Isotype‐Selective Covalent Inhibitors of the RNA Methyltransferase NSUN2
Chemical Proteomic Discovery of Isotype‐Selective Covalent Inhibitors of the RNA Methyltransferase NSUN2 Open
5‐Methylcytosine (m 5 C) is an RNA modification prevalent on tRNAs, where it can protect tRNAs from endonucleolytic cleavage to maintain protein synthesis. The NSUN family (NSUN1‐7 in humans) of RNA methyltransferases are capable of instal…
View article: m<sup>6</sup>A mRNA Methylation Regulates Early Pancreatic β-Cell Differentiation
m<sup>6</sup>A mRNA Methylation Regulates Early Pancreatic β-Cell Differentiation Open
SUMMARY N 6 -methyladenosine (m 6 A) is the most abundant chemical modification in mRNA, and plays important roles in human and mouse embryonic stem cell pluripotency, maintenance, and differentiation. We have recently reported, for the fi…
View article: A lncRNA from the FTO locus acts as a suppressor of the m6A writer complex and p53 tumor suppression signaling
A lncRNA from the FTO locus acts as a suppressor of the m6A writer complex and p53 tumor suppression signaling Open
N6-methyladenosine (m6A) of mRNAs modulated by the METTL3-METTL14-WTAP-RBM15 methyltransferase complex and m6A demethylases such as FTO play important roles in regulating mRNA stability, splicing, and trans…
View article: Exon architecture controls mRNA m <sup>6</sup> A suppression and gene expression
Exon architecture controls mRNA m <sup>6</sup> A suppression and gene expression Open
N 6 -methyladenosine (m 6 A) is the most abundant messenger RNA (mRNA) modification and plays crucial roles in diverse physiological processes. Using a massively parallel assay for m 6 A (MPm 6 A), we discover that m 6 A specificity is glo…
View article: The mechanism underlying redundant functions of the YTHDF proteins
The mechanism underlying redundant functions of the YTHDF proteins Open
The YTH N 6 -methyladenosine RNA binding proteins (YTHDFs) mediate the functional effects of N 6 -methyladenosine (m 6 A) on RNA. Recently, a report proposed that all YTHDFs work redundantly to facilitate RNA decay, raising questions about…
View article: Small-Molecule Inhibition of Mettl3 Suppresses Neuroblastoma Tumor Growth and Promotes Differentiation
Small-Molecule Inhibition of Mettl3 Suppresses Neuroblastoma Tumor Growth and Promotes Differentiation Open
View article: Additional file 2 of The mechanism underlying redundant functions of the YTHDF proteins
Additional file 2 of The mechanism underlying redundant functions of the YTHDF proteins Open
Additional file 2. It contains all processed data that was used to plot all the figures in this manuscript and YTHDF target definitions.
View article: New horizons of regulatory RNA
New horizons of regulatory RNA Open
View article: FMRP phosphorylation modulates neuronal translation through YTHDF1
FMRP phosphorylation modulates neuronal translation through YTHDF1 Open
Translation activation of local synaptic mRNAs is critical to learning and memory 1 -3 . Despite extensive studies on how phosphorylation of ribosomal proteins and translation factors enables timely response to exogenous stimuli 4, our kno…
View article: 5-methylcytosine (m <sup>5</sup> C) RNA modification controls the innate immune response to virus infection by regulating type I interferons
5-methylcytosine (m <sup>5</sup> C) RNA modification controls the innate immune response to virus infection by regulating type I interferons Open
5-methylcytosine (m 5 C) is one of the most prevalent modifications of RNA, playing important roles in RNA metabolism, nuclear export, and translation. However, the potential role of RNA m 5 C methylation in innate immunity remains elusive…
View article: FTO mediates LINE1 m <sup>6</sup> A demethylation and chromatin regulation in mESCs and mouse development
FTO mediates LINE1 m <sup>6</sup> A demethylation and chromatin regulation in mESCs and mouse development Open
N 6 -methyladenosine (m 6 A) is the most abundant internal modification on mammalian messenger RNA. It is installed by a writer complex and can be reversed by erasers such as the fat mass and obesity-associated protein FTO. Despite extensi…
View article: The mechanism underlying redundant functions of the YTHDF proteins
The mechanism underlying redundant functions of the YTHDF proteins Open
The YTH N 6 -methyladenosine RNA binding proteins (YTHDFs) mediate the functional effects of N 6 -methyladenosine (m 6 A) on RNA. Recently, a report proposed that all YTHDFs work redundantly to facilitate RNA decay, raising questions about…
View article: EGFR/SRC/ERK-stabilized YTHDF2 promotes cholesterol dysregulation and invasive growth of glioblastoma
EGFR/SRC/ERK-stabilized YTHDF2 promotes cholesterol dysregulation and invasive growth of glioblastoma Open
View article: Genetic analyses support the contribution of mRNA N6-methyladenosine (m6A) modification to human disease heritability
Genetic analyses support the contribution of mRNA N6-methyladenosine (m6A) modification to human disease heritability Open
View article: YTHDF2 promotes mitotic entry and is regulated by cell cycle mediators
YTHDF2 promotes mitotic entry and is regulated by cell cycle mediators Open
The N6-methyladenosine (m6A) modification regulates mRNA stability and translation. Here, we show that transcriptomic m6A modification can be dynamic and the m6A reader protein YTH N6-methyladenosine RNA binding protein 2 (YTHDF2) promotes…
View article: Metabolic Incorporation of Electron-Rich Ribonucleosides Enhanced APEX-Seq for Profiling Spatially Restricted Nascent Transcriptome
Metabolic Incorporation of Electron-Rich Ribonucleosides Enhanced APEX-Seq for Profiling Spatially Restricted Nascent Transcriptome Open