Explanipedia

Research trends in cervical cancer brachytherapy: a bibliometric analysis Open

Shuilan Bao, Yiren Wang, Yiheng Hu, Sheng Lin, Youhua Wang , et al. · 2025

With medical imaging informatics advancing, research on cervical cancer brachytherapy has become increasingly profound. Recently, areas such as image-guided-adaptive-brachytherapy, effective biological dose, and radionecrosis have attracte…

Clinicopathologic features of superficial esophageal squamous cell carcinoma in different infiltrative growth pattern Open

Xingshun Qi, Zhongyuan Zuo, Bin Yu, Huimin Zhang, Xiujie Cui , et al. · 2025

Introduction Superficial esophageal squamous cell carcinoma (SESCC) is defined as neoplastic lesions limited to the mucosa or submucosa regardless of the nodal status. The infiltrative growth pattern (INF) has been implicated in tumor aggr…

Comparison of clinical and pathological characteristics between early gastric cardiac cancer and early gastric non-cardiac cancer Open

Bin Yu, Honglei Wu, Shuai Li, Daoyu Tao, Zhongyuan Zuo , et al. · 2025

Background Previous studies primarily focused on advanced-stage gastric cancer have identified significant differences between gastric cardiac cancer (GCC) and gastric non-cardiac cancer (GNCC) in clinical, pathological, and molecular phen…

SERS nanotags for ultrasensitive and dual biomarker detection of breast cancer Open

Huiying Hou, Junqi Zhao, Zhongyuan Zuo, Song Li, Xiao Han , et al. · 2025

Sensitive and simultaneous detection of breast cancer 1 (BRCA1) and breast cancer 2 (BRCA2) is of significance for the early diagnosis of breast cancers, but it still challenges conventional methods. Herein, we developed a novel surface-en…

Case Report: A rare case of early esophageal basaloid squamous cell carcinoma with ductal differentiation Open

Xingshun Qi, Zhongyuan Zuo, Guangchun Li, Xiujie Cui, Honglei Wu · 2025

Background Early esophageal basaloid squamous cell carcinoma (EBSCC) with ductal differentiation is a rare variant of esophageal cancer (EC), for which the clinical behavior, endoscopic features and diagnostic criteria are not fully elucid…

Electromotility can be disassociated from gating charge movement in outer hair cells of conditional alpha2 spectrin knockout mice Open

Jun-Ping Bai, Micheal Stankewitch, Jie Yang, Winston Tan, Zhongyuan Zuo , et al. · 2025

Electromotility in mammalian outer hair cells (OHC) is the mechanism underlying cochlear amplification. It is brought about by the piezoelectric-like property of the membrane protein prestin (Slc26a5) that lies in the OHCs lateral plasma m…

Bibliometric analysis of 100 most highly cited publications on endoscopic submucosal dissection in early gastric cancer Open

Zhongyuan Zuo, Jinfeng Qi, Shihao Shi, Honglei Wu · 2025

Endoscopic and clinicopathological features of early gastric papillary adenocarcinoma Open

Zhongyuan Zuo, Xingshun Qi, Xiujie Cui, Bin Yu, Huimin Zhang , et al. · 2024

Objectives Gastric papillary adenocarcinoma (GPA), a well-differentiated gastric adenocarcinoma, is associated with a worse prognosis compared to other differentiated gastric adenocarcinomas. Therefore, there is an urgent need to character…

Cdk8/CDK19 promotes mitochondrial fission through Drp1 phosphorylation and can phenotypically suppress pink1 deficiency in Drosophila Open

Jenny Zhe Liao, Hyunglok Chung, Claire R. Y. Shih, Kenneth Kin Lam Wong, Debdeep Dutta , et al. · 2024

Cdk8 in Drosophila is the orthologue of vertebrate CDK8 and CDK19 . These proteins have been shown to modulate transcriptional control by RNA polymerase II. We found that neuronal loss of Cdk8 severely reduces fly lifespan and causes bang …

A defect in mitochondrial fatty acid synthesis impairs iron metabolism and causes elevated ceramide levels Open

Debdeep Dutta, Oguz Kanca, Seul Kee Byeon, Paul C. Marcogliese, Zhongyuan Zuo , et al. · 2023

Daam2 phosphorylation by CK2α negatively regulates Wnt activity during white matter development and injury Open

Chih‐Yen Wang, Zhongyuan Zuo, Ju-Yeon Jo, Kyoung In Kim, Christine Madamba , et al. · 2023

Wnt signaling plays an essential role in developmental and regenerative myelination in the central nervous system. The Wnt signaling pathway is composed of multiple regulatory layers; thus, how these processes are coordinated to orchestrat…

Very-long-chain fatty acids induce glial-derived sphingosine-1-phosphate synthesis, secretion, and neuroinflammation Open

Hyunglok Chung, Qi Ye, Ye-Jin Park, Zhongyuan Zuo, Jung-Wan Mok , et al. · 2023

Loss of Mitochondrial Enoyl CoA Reductase causes elevated ceramide levels and impairs iron metabolism Open

Debdeep Dutta, Oguz Kanca, Seul Kee Byeon, Paul C. Marcogliese, Zhongyuan Zuo , et al. · 2023

In most eukaryotic cells fatty acid synthesis occurs in the cytoplasm as well as in mitochondria. However, the relative contribution of mitochondrial fatty acid synthesis (mtFAS) to the cellular lipidome of metazoans is ill-defined. Hence,…

CK2α-dependent regulation of Wnt activity governs white matter development and repair Open

Chih‐Yen Wang, Zhongyuan Zuo, Kyoung In Kim, Hugo J. Bellen, Hyun Kyoung Lee · 2023

Wnt signaling plays an essential role in developmental and regenerative myelination in the CNS. The Wnt signaling pathway is comprised of multiple regulatory layers; thus, how these processes are coordinated to orchestrate oligodendrocyte …

Exploring therapeutic strategies for infantile neuronal axonal dystrophy (INAD/PARK14) Open

Guang Lin, Burak Tepe, Geoff McGrane, Regine Tipon, Gist F. Croft , et al. · 2023

Infantile neuroaxonal dystrophy (INAD) is caused by recessive variants in PLA2G6 and is a lethal pediatric neurodegenerative disorder. Loss of the Drosophila homolog of PLA2G6 , leads to ceramide accumulation, lysosome expansion, and mitoc…

Two neuronal peptides encoded from a single transcript regulate mitochondrial complex III in Drosophila Open

Justin A. Bosch, Berrak Uğur, Israel Pichardo‐Casas, Jordan Rabasco, Felipe Escobedo , et al. · 2022

Naturally produced peptides (<100 amino acids) are important regulators of physiology, development, and metabolism. Recent studies have predicted that thousands of peptides may be translated from transcripts containing small open-reading f…

Neuronal activity induces glucosylceramide that is secreted via exosomes for lysosomal degradation in glia Open

Liping Wang, Guang Lin, Zhongyuan Zuo, Yarong Li, Seul Kee Byeon , et al. · 2022

Recessive variants in GBA1 cause Gaucher disease, a prevalent form of lysosome storage disease. GBA1 encodes a lysosomal enzyme that hydrolyzes glucosylceramide (GlcCer) into glucose and ceramide. Its loss causes lysosomal dysfunction and …

An expanded toolkit for Drosophila gene tagging using synthesized homology donor constructs for CRISPR-mediated homologous recombination Open

Oguz Kanca, Jonathan Zirin, Yanhui Hu, Burak Tepe, Debdeep Dutta , et al. · 2022

Previously, we described a large collection of Drosophila strains that each carry an artificial exon containing a T2AGAL4 cassette inserted in an intron of a target gene based on CRISPR-mediated homologous recombination. These alleles perm…

Loss of IRF2BPL impairs neuronal maintenance through excess Wnt signaling Open

Paul C. Marcogliese, Debdeep Dutta, Shrestha Sinha Ray, Nghi Dang, Zhongyuan Zuo , et al. · 2022

De novo truncations in Interferon Regulatory Factor 2 Binding Protein Like ( IRF2BPL ) lead to severe childhood-onset neurodegenerative disorders. To determine how loss of IRF2BPL causes neural dysfunction, we examined its function in Dros…

Very Long-Chain Fatty Acids Induce Glial-Derived Sphingosine-1-Phosphate Synthesis, Secretion, and Neuroinflammation Open

Hyunglok Chung, Qi Ye, Ye-Jin Park, Zhongyuan Zuo, Oguz Kanca , et al. · 2022

An expanded toolkit for Drosophila gene tagging using synthesized homology donor constructs for CRISPR mediated homologous recombination Open

Oguz Kanca, Jonathan Zirin, Yanhui Hu, Burak Tepe, Debdeep Dutta , et al. · 2021

Previously, we described a large collection of Drosophila strains that each carry an artificial exon containing a T2AGAL4 cassette inserted in an intron of a target gene based on CRISPR-mediated homologous recombination (Lee et al ., 2018)…

Low doses of the organic insecticide spinosad trigger lysosomal defects, ROS driven lipid dysregulation and neurodegeneration in flies Open

Felipe Martelli, Zhongyuan Zuo, Julia Wang, Ching‐On Wong, Nicholas E. Karagas , et al. · 2021

The plight of insect populations around the world and the threats it poses to agriculture and ecosystems has thrown insecticide use into the spotlight. Spinosad is an organic insecticide, considered less harmful to beneficial insects than …

Minimum Alveolar Concentration-Awake of Sevoflurane is Decreased in Patients with Parkinson’s Disease: An Up-and-Down Sequential Allocation Trial Open

Chongzhe Yang, Feiwu Kang, Wei Meng, M. Dong, Xuemei Huang , et al. · 2021

Chengwei Yang,1,* Fang Kang,1,* Wenjun Meng,1 Meirong Dong,1 Xiang Huang,1 Sheng Wang,1 Zhiyi Zuo,2 Juan Li1 1Department of Anesthesiology, The First Affiliated Hospital of USTC, Division of Life Sciences and Medicine, University of Scienc…

TFEB/Mitf links impaired nuclear import to autophagolysosomal dysfunction in C9-ALS Open

Kathleen M. Cunningham, Kirstin Maulding, Kai Ruan, Mümine Şentürk, Jonathan C. Grima , et al. · 2020

Disrupted nucleocytoplasmic transport (NCT) has been implicated in neurodegenerative disease pathogenesis; however, the mechanisms by which disrupted NCT causes neurodegeneration remain unclear. In a Drosophila screen, we identified ref(2)…

Author response: TFEB/Mitf links impaired nuclear import to autophagolysosomal dysfunction in C9-ALS Open

Kathleen M. Cunningham, Kirstin Maulding, Kai Ruan, Mümine Şentürk, Jonathan C. Grima , et al. · 2020

Low doses of the neonicotinoid insecticide imidacloprid induce ROS triggering neurological and metabolic impairments in <i>Drosophila</i> Open

Felipe Martelli, Zhongyuan Zuo, Julia Wang, Ching‐On Wong, Nicholas E. Karagas , et al. · 2020

Significance Intense insecticide usage is suggested to be a significant contributor to the observed decline of insect populations around the world. Beneficial insects play essential roles in food production and ecosystem health. It is ther…

PCN10 ORAL H2RA for Taxane Hypersensitivity Prevention: A Pharmacokinetic-Guided Decision Open

Ann‐Lii Cheng, E. Yip, Janice Tsang, P Chan, Anthony Choi , et al. · 2020

The Daam2–VHL–Nedd4 axis governs developmental and regenerative oligodendrocyte differentiation Open

Xiaoyun Ding, Ju-Yeon Jo, Chih‐Yen Wang, Carlo D. Cristobal, Zhongyuan Zuo , et al. · 2020

Dysregulation of the ubiquitin–proteasomal system (UPS) enables pathogenic accumulation of disease-driving proteins in neurons across a host of neurological disorders. However, whether and how the UPS contributes to oligodendrocyte dysfunc…

Two neuronal peptides encoded from a single transcript regulate mitochondrial complex III in <i>Drosophila</i> Open

Justin A. Bosch, Berrak Uğur, Israel Pichardo‐Casas, Jorden Rabasco, Felipe Escobedo , et al. · 2020

Summary Naturally produced peptides (<100 amino acids) are important regulators of physiology, development, and metabolism. Recent studies have predicted that thousands of peptides may be translated from transcripts containing small open r…

TFEB/Mitf links impaired nuclear import to autophagolysosomal dysfunction in C9-ALS Open

Kathleen M. Cunningham, Ke Zhang, Kai Ruan, Kirstin Maulding, Mümine Şentürk , et al. · 2020

Disrupted nucleocytoplasmic transport (NCT) has been implicated in neurodegenerative disease pathogenesis; however, the mechanisms by which impaired NCT causes neurodegeneration remain unclear. In a Drosophila screen, we identified Ref(2)p…

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