Zhongzhen Zhao
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View article: Quality Analysis of Raw Material and Products of Goat Bezoar (Houzao), a Mysterious Traditional Medicine
Quality Analysis of Raw Material and Products of Goat Bezoar (Houzao), a Mysterious Traditional Medicine Open
Background Goat bezoar (Houzao in Chinese, also called “monkey” bezoar or Caprae Calculus) is a valued traditional Chinese medicine (TCM) used in the treatment of pediatric cough for centuries. However, its undefined chemical composition h…
View article: Cordyceps caterpillar polysaccharide CCP activates innate immune responses via the TLR4/MyD88/p38 signaling pathway
Cordyceps caterpillar polysaccharide CCP activates innate immune responses via the TLR4/MyD88/p38 signaling pathway Open
Background and Purpose Cordyceps is a widely used traditional Chinese medicine due to its many health benefits, such as immune regulation. As Cordyceps’ major component, polysaccharides are of great attention serving as a potential drug or…
View article: Behavioral Prevention, Treatment, and Rehabilitation of Using Western and Chinese Medicines or Herbal Products among the Public in Response to COVID‐19 in Hong Kong: A Cross‐Sectional Study
Behavioral Prevention, Treatment, and Rehabilitation of Using Western and Chinese Medicines or Herbal Products among the Public in Response to COVID‐19 in Hong Kong: A Cross‐Sectional Study Open
The coronavirus disease 2019 (COVID‐19) pandemic occurred in Hong Kong for more than two years. This article conducted a cross‐sectional study for participants to investigate the behavioral prevention, treatment, and rehabilitation of usin…
View article: M cells of mouse and human Peyer's patches mediate the lymphatic absorption of an Astragalus hyperbranched heteroglycan
M cells of mouse and human Peyer's patches mediate the lymphatic absorption of an Astragalus hyperbranched heteroglycan Open
The gut cell wall is considered an impenetrable barrier to orally administrated polysaccharides. We recently reported a selective lymphatic route for Radix Astragali polysaccharide RAP to enter Peyer's patches (PPs) to trigger immune respo…
View article: Voyage of Ben Cao, Part II: Development of Chinese Medicinal Specimens in the British Museum
Voyage of Ben Cao, Part II: Development of Chinese Medicinal Specimens in the British Museum Open
1 Introduction In 2015, an on-site field investigation was conducted by the authors' research group to authenticate a batch of ancient Chinese medicinal decoction pieces that have been preserved in a rare collection at the Natural History …
View article: A lymphatic route for a hyperbranched heteroglycan from Radix Astragali to trigger immune responses after oral dosing
A lymphatic route for a hyperbranched heteroglycan from Radix Astragali to trigger immune responses after oral dosing Open
Gut barrier makes a huge research gap between in vivo and in vitro studies of orally bioactive polysaccharides: whether/how they contact the related cells in vivo. A hyperbranched heteroglycan RAP from Radix Astragali, exerting antitumor a…
View article: Correlation between quality and geographical origins of Leonuri Herba revealed by the qualitative fingerprint profiling and quantitative determination of chemical components
Correlation between quality and geographical origins of Leonuri Herba revealed by the qualitative fingerprint profiling and quantitative determination of chemical components Open
View article: Antifibrotic activities of Scutellariae Radix extracts and flavonoids: Comparative proteomics reveals distinct and shared mechanisms
Antifibrotic activities of Scutellariae Radix extracts and flavonoids: Comparative proteomics reveals distinct and shared mechanisms Open
View article: History of the Chinese Medicinal Gelatin
History of the Chinese Medicinal Gelatin Open
This article discusses the history of animal glue (gelatin) used in medical practice in China. In ancient times, gelatin was widely made from cowhide and has been found in excavations and wall paintings older than 2000 years in Egypt, Gree…
View article: Voyage of Ben Cao, Part I: Discovery of Kam Wah Chung, the Overlooked Chinese Medicine Museum in the United States
Voyage of Ben Cao, Part I: Discovery of Kam Wah Chung, the Overlooked Chinese Medicine Museum in the United States Open
1 Introduction Imagery of the Western United States typically evokes vast wheat fields, cowboys, and rolling mountain valleys. Few would associate the American West with Chinese medicine. This article describes a remote town called John Da…
View article: Correlation Between Quality and Geographical Origins of Leonuri Herba Revealed By the Qualitative Fingerprint Profiling and Quantitative Determination of Chemical Components
Correlation Between Quality and Geographical Origins of Leonuri Herba Revealed By the Qualitative Fingerprint Profiling and Quantitative Determination of Chemical Components Open
Background Leonuri Herba (Yimucao) is a very commonly Chinese herbs for treating menstrual and maternal diseases for thousands of years in China. However, the herb collected in different origins was easily found in the markets which induce…
View article: Analysis of historical changes in traditional Chinese medicine based on an Indonesian collection of Chinese materia medica from c. 1870
Analysis of historical changes in traditional Chinese medicine based on an Indonesian collection of Chinese materia medica from c. 1870 Open
View article: Comparative quality of the forms of decoction pieces evaluated by multidimensional chemical analysis and chemometrics: Poria cocos, a pilot study
Comparative quality of the forms of decoction pieces evaluated by multidimensional chemical analysis and chemometrics: Poria cocos, a pilot study Open
Many Chinese medicinal materials (CMMs) are parts of plants or fungi that have been processed into different physical forms, termed decoction pieces, that are typically boiled in water for consumption. One CMM may have several decoction pi…
View article: Correlation between Quality and Geographical Origins of Poria cocos Revealed by Qualitative Fingerprint Profiling and Quantitative Determination of Triterpenoid Acids
Correlation between Quality and Geographical Origins of Poria cocos Revealed by Qualitative Fingerprint Profiling and Quantitative Determination of Triterpenoid Acids Open
Poria cocos (Schw.) Wolf (PC) is a well-known saprophytic fungus, and its sclerotium without the epidermis (PCS) is widely used in traditional Chinese medicine and as a functional food in many countries. PCS is normally collected from mult…
View article: Integrating Targeted and Untargeted Metabolomics to Investigate the Processing Chemistry of Polygoni Multiflori Radix
Integrating Targeted and Untargeted Metabolomics to Investigate the Processing Chemistry of Polygoni Multiflori Radix Open
Polygoni Multiflori Radix (PMR, Heshouwu in Chinese), derived from the tuberous roots of Polygonum multiflorum Thunb., is a widely-used Chinese medicinal material. For traditional clinical use, raw PMR (RPMR) is processed by …
View article: Tissue-specific chemical profiling and quantitative analysis of bioactive components of Cinnamomum cassia by combining laser-microdissection with UPLC-Q/TOF–MS
Tissue-specific chemical profiling and quantitative analysis of bioactive components of Cinnamomum cassia by combining laser-microdissection with UPLC-Q/TOF–MS Open
View article: Tissue-Specific Analysis of Secondary Metabolites Creates a Reliable Morphological Criterion for Quality Grading of Polygoni Multiflori Radix
Tissue-Specific Analysis of Secondary Metabolites Creates a Reliable Morphological Criterion for Quality Grading of Polygoni Multiflori Radix Open
In commercial herbal markets, Polygoni Multiflori Radix (PMR, the tuberous roots of Polygonum multiflorum Thunb.), a commonly-used Chinese medicinal material, is divided into different grades based on morphological features of size and wei…
View article: Clarifying the origin of Houzao
Clarifying the origin of Houzao Open
Our study has clarified the origin of Indian Houzao, which can help to further develop Indian Houzao for the treatment of diseases.
View article: A concise classification of bencao (materia medica)
A concise classification of bencao (materia medica) Open
View article: Comprehensive quality evaluation and comparison of Angelica sinensis radix and Angelica acutiloba radix by integrated metabolomics and glycomics
Comprehensive quality evaluation and comparison of Angelica sinensis radix and Angelica acutiloba radix by integrated metabolomics and glycomics Open
Angelica radix (Danggui in Chinese) used in China and Japan is derived from two species of Angelica, namely Angelica sinensis and Angelica acutiloba, respectively. The differences in quality between A. sinensis radix (ASR) and A. acutiloba…
View article: A feasible and practical 1 H NMR analytical method for the quality control and quantification of bioactive principles in Lycii Fructus
A feasible and practical 1 H NMR analytical method for the quality control and quantification of bioactive principles in Lycii Fructus Open
Lycii Fructus, a solanaceous drug, is widely used as functional foods and in Traditional Chinese Medicine. Samples collected from different regions of China have been found to be not identical in chemical compositions which might affect th…
View article: The Original Source of Modern Research on Chinese Medicinal Materials: Bencao Texts
The Original Source of Modern Research on Chinese Medicinal Materials: Bencao Texts Open
According to ancient Chinese tradition, the mythological founder of Chinese herbal medicine, Shen Nong (the "Divine Husbandman"), was said to have "tried the hundred herbs by tasting them, encountering 70 toxicities
View article: Tissue-based metabolite profiling and qualitative comparison of two species of Achyranthes roots by use of UHPLC-QTOF MS and laser micro-dissection
Tissue-based metabolite profiling and qualitative comparison of two species of Achyranthes roots by use of UHPLC-QTOF MS and laser micro-dissection Open
View article: Comparison of chemical profiles between the root and aerial parts from three Bupleurum species based on a UHPLC-QTOF-MS metabolomics approach
Comparison of chemical profiles between the root and aerial parts from three Bupleurum species based on a UHPLC-QTOF-MS metabolomics approach Open
View article: Cannabis in Chinese Medicine: Are Some Traditional Indications Referenced in Ancient Literature Related to Cannabinoids?
Cannabis in Chinese Medicine: Are Some Traditional Indications Referenced in Ancient Literature Related to Cannabinoids? Open
Cannabis sativa L. (Cannabaceae) has a long history of utilization as a fiber and seed crop in China, and its achenes ("seeds") as well as other plant parts have been recorded in Chinese medical texts for nearly 2000 years. While th…
View article: Qualitative and quantitative characterization of secondary metabolites and carbohydrates in Bai-Hu-Tang using ultraperformance liquid chromatography coupled with quadrupole time-of-flight mass spectrometry and ultraperformance liquid chromatography coupled with photodiode array detector
Qualitative and quantitative characterization of secondary metabolites and carbohydrates in Bai-Hu-Tang using ultraperformance liquid chromatography coupled with quadrupole time-of-flight mass spectrometry and ultraperformance liquid chromatography coupled with photodiode array detector Open
Bai-Hu-Tang (BHT), a classic traditional Chinese medicine (TCM) formula used for clearing heat and promoting body fluid, consists of four traditional Chinese medicines, i.e., Gypsum Fibrosum (Shigao), Anemarrhenae Rhizoma (Zhimu), Glycyrrh…
View article: Tissue‐specific metabolite profiling of benzylisoquinoline alkaloids in the root of <scp> <i>Macleaya cordata</i> </scp> by combining laser microdissection with ultra‐high‐performance liquid chromatography/tandem mass spectrometry
Tissue‐specific metabolite profiling of benzylisoquinoline alkaloids in the root of <span> <i>Macleaya cordata</i> </span> by combining laser microdissection with ultra‐high‐performance liquid chromatography/tandem mass spectrometry Open
Rationale Tissue‐specific metabolite profiling helps to find trace alkaloids masked during organ analysis, which contributes to understanding the alkaloid biosynthetic pathways in vivo and evaluating the quality of medical plants by morpho…
View article: Rapid differentiation of Xihuangcao from the three Isodon species by UPLC-ESI-QTOF-MS/MS and chemometrics analysis
Rapid differentiation of Xihuangcao from the three Isodon species by UPLC-ESI-QTOF-MS/MS and chemometrics analysis Open
View article: Establishment of Platforms to Facilitate the Inheritance and Innovation of Chinese Medicinal Authentication (創刊100周年記念号)
Establishment of Platforms to Facilitate the Inheritance and Innovation of Chinese Medicinal Authentication (創刊100周年記念号) Open
View article: Ultrasound-Assisted Extraction May Not Be a Better Alternative Approach than Conventional Boiling for Extracting Polysaccharides from Herbal Medicines
Ultrasound-Assisted Extraction May Not Be a Better Alternative Approach than Conventional Boiling for Extracting Polysaccharides from Herbal Medicines Open
In clinical practice polysaccharides from herbal medicines are conventionally prepared by boiling water extraction (BWE), while ultrasound-assisted extraction (UAE) has often been used instead employed in laboratory research due to its str…