Liang Yu
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View article: Targeting tumor-infiltrating regulatory T cells: combining CD47 and PD-L1 inhibition via a novel aptamer-siRNA chimera
Targeting tumor-infiltrating regulatory T cells: combining CD47 and PD-L1 inhibition via a novel aptamer-siRNA chimera Open
Tumor-infiltrating regulatory T (Treg) cells contribute to immune evasion and are associated with poor prognosis in solid tumors. While CD47 blockade has demonstrated efficacy in hematologic malignancies, its application in solid tumors is…
View article: The trilateral crosstalk of TGF β1-ROS-Nrf2 axis in fibrosis: Decoding mechanistic networks for precision therapeutics
The trilateral crosstalk of TGF β1-ROS-Nrf2 axis in fibrosis: Decoding mechanistic networks for precision therapeutics Open
Fibrosis, a hallmark pathological process in numerous chronic diseases, is characterized by the excessive accumulation of extracellular matrix (ECM) components, primarily driven by activated myofibroblasts. This dysregulated tissue remodel…
View article: Targeting LRBA triggers CTLA4 degradation and antitumor immunity for cancer immunotherapy
Targeting LRBA triggers CTLA4 degradation and antitumor immunity for cancer immunotherapy Open
The lipopolysaccharide-responsive beige-like anchor protein (LRBA) deficiency causes severe autoimmune diseases and cytotoxic T-lymphocyte-associated protein 4 (CTLA4) loss in humans. However, the impact of LRBA on antitumor immunity remai…
View article: Transcranial focused ultrasound induces source localizable cortical activation in resting state humans when applied concurrently with transcranial electric stimulation
Transcranial focused ultrasound induces source localizable cortical activation in resting state humans when applied concurrently with transcranial electric stimulation Open
The effects of transcranial focused ultrasound (tFUS) on the human brain are poorly understood. Currently, the field is at odds with whether tFUS is subthreshold modulating the brain’s excitability towards other stimuli, producing suprathr…
View article: Iron metabolism dysregulation: a novel perspective on B-cell lymphomagenesis, drug resistance and targeted therapy
Iron metabolism dysregulation: a novel perspective on B-cell lymphomagenesis, drug resistance and targeted therapy Open
Iron is a trace element indispensable for fundamental cellular processes, whose metabolism is regulated homeostatically at both systemic and cellular levels. Crucial components of iron metabolism comprise: transferrin receptor 1 (TfR1)-med…
View article: Leveraging Transfection Dose Streamlines the Establishment of a Chinese Hamster Ovary Cell Targeted Integration System
Leveraging Transfection Dose Streamlines the Establishment of a Chinese Hamster Ovary Cell Targeted Integration System Open
Targeted integration (TI) expression system has emerged as an alternative to random integration in cell line development (CLD) involved in biologics development and manufacturing. A key element of a robust TI CLD system is the construction…
View article: Pathogenesis, Host Resistance and Integrated Management of Sugarcane Smut Caused by <i>Sporisorium scitamineum</i> : A Comprehensive Review
Pathogenesis, Host Resistance and Integrated Management of Sugarcane Smut Caused by <i>Sporisorium scitamineum</i> : A Comprehensive Review Open
Sugarcane smut, caused by the fungus Sporisorium scitamineum , is a devastating disease that threatens sugar production, leading to significant yield losses. The pathogen disrupts sugarcane growth by forming whip‐like structures filled wit…
View article: Recent advances in the interaction of ferroptosis and immune-mediated inflammation in cardiovascular disease: mechanisms and therapeutic potential
Recent advances in the interaction of ferroptosis and immune-mediated inflammation in cardiovascular disease: mechanisms and therapeutic potential Open
Ferroptosis is an iron-dependent form of programmed cell death primarily characterized by the inactivation of glutathione peroxidase 4 (GPX4), accumulation of lipid peroxides (LPO), and disruption of intracellular antioxidant defenses. Rec…
View article: Identification of potential bladder cancer drug targets through Mendelian randomization and molecular docking
Identification of potential bladder cancer drug targets through Mendelian randomization and molecular docking Open
Bladder cancer is a common and lethal malignancy with high treatment costs due to frequent recurrence and prolonged therapy. Despite therapeutic advances, many patients develop drug-resistant metastatic disease, underscoring the need for n…
View article: Trade-Offs and Synergies Among Habitat, Water, and Carbon Services Driven by Urbanization: A Spatiotemporal Analysis of the Chang-Zhu-Tan City Cluster
Trade-Offs and Synergies Among Habitat, Water, and Carbon Services Driven by Urbanization: A Spatiotemporal Analysis of the Chang-Zhu-Tan City Cluster Open
Understanding the evolution of ecosystem services (ESs) is crucial for sustainable development in rapidly urbanizing regions. This study quantifies the spatiotemporal evolution of habitat quality (HQ), water yield (WY), and carbon storage …
View article: Potassium Sorbate Triggers Kidney Injury via Dysregulated Intercellular Communication: A Study Combining Network Toxicology, Machine Learning, Molecular Docking, and Single‐Cell RNA Sequencing
Potassium Sorbate Triggers Kidney Injury via Dysregulated Intercellular Communication: A Study Combining Network Toxicology, Machine Learning, Molecular Docking, and Single‐Cell RNA Sequencing Open
Acute kidney injury (AKI) is a clinically significant syndrome, characterized by high mortality rates and the potential for progression to chronic kidney disease. Potassium sorbate (PS), a widely‐used food preservative with a high safety p…
View article: Protective effects of Angelica sinensis polysaccharide on chemotherapy-injured rats with premature ovarian insufficiency and its impact on gut microbiota
Protective effects of Angelica sinensis polysaccharide on chemotherapy-injured rats with premature ovarian insufficiency and its impact on gut microbiota Open
Objective This study aimed to investigate the therapeutic effects and action mechanisms of Angelica sinensis polysaccharides (ASP) on a chemotherapy-induced premature ovarian insufficiency (POI) rat model along with screening for the optim…
View article: Prediction of the Ki-67 proliferation index in lung adenocarcinoma using an interpretable CT-based deep learning radiomics model: a two-center study
Prediction of the Ki-67 proliferation index in lung adenocarcinoma using an interpretable CT-based deep learning radiomics model: a two-center study Open
Purpose To develop an interpretable computed tomography (CT)-based deep learning radiomics (DLR) model that integrates deep learning (DL) and radiomics features to predict the preoperative Ki-67 proliferation index in lung adenocarcinoma. …
View article: Efficient n‐Doping of Organic Semiconductors via a Broadly Applicable Nucleophilic‐Attack Mechanism
Efficient n‐Doping of Organic Semiconductors via a Broadly Applicable Nucleophilic‐Attack Mechanism Open
The development of efficient and broadly applicable n‐doping strategies for organic semiconductors (OSCs) is crucial for advancing the performance of various organic electronic devices. Here, a novel nucleophilic‐attack n‐doping mechanism …
View article: Unraveling the mechanism of tetracycline-induced renal injury: an evaluation of drug safety based on network toxicology and molecular dynamics simulations
Unraveling the mechanism of tetracycline-induced renal injury: an evaluation of drug safety based on network toxicology and molecular dynamics simulations Open
Background Tetracyline, a widely used antibiotic, is associated with nephrotoxicity, though its underlying mechanisms require further investigation. Methods We investigated the toxicological process of tetracycline-induced renal injury usi…
View article: Haematological toxicities with targeted drugs in tumors: A systematic review and network meta-analysis of randomized controlled trials
Haematological toxicities with targeted drugs in tumors: A systematic review and network meta-analysis of randomized controlled trials Open
Objective: Tumor-targeted drug monotherapy or chemotherapy is becoming increasingly important in cancer treatment, yet the concomitant issue of hematological toxicities is gradually gaining attention. Existing studies lack a comprehensive …
View article: Exploring the anti-AML mechanisms of compound zhebei granule via integrated network pharmacology, transcriptomic sequencing, and experimental validation
Exploring the anti-AML mechanisms of compound zhebei granule via integrated network pharmacology, transcriptomic sequencing, and experimental validation Open
Background: Acute myeloid leukemia (AML) is a hematologic malignancy with a poor prognosis. In recent years, the clinical application of the Bcl-2 inhibitor Venetoclax (VEN) has significantly improved remission rates and short-term surviva…
View article: Independent and joint associations of sleep quality and physical activity with glycaemic control in patients with type 2 diabetes mellitus
Independent and joint associations of sleep quality and physical activity with glycaemic control in patients with type 2 diabetes mellitus Open
Background Although determinants of glycaemic control in type 2 diabetes mellitus (T2DM) have been extensively investigated, the joint influence of sleep quality and physical activity (PA) remains insufficiently studied. We aimed to examin…
View article: Effective determination of pre-chronic obstructive pulmonary disease by symptoms and CT features: a multicenter cross-sectional study
Effective determination of pre-chronic obstructive pulmonary disease by symptoms and CT features: a multicenter cross-sectional study Open
Our diagnostic models can identify pre-COPD among symptomatic patients with existing CT.
View article: Paraneoplastic Pemphigus Unveiling Occult Lung Adenocarcinoma: A Rituximab‐Responsive Case With Diagnostic and Therapeutic Implications
Paraneoplastic Pemphigus Unveiling Occult Lung Adenocarcinoma: A Rituximab‐Responsive Case With Diagnostic and Therapeutic Implications Open
Paraneoplastic pemphigus (PNP) is a rare autoimmune disorder typically associated with hematologic or squamous cell malignancies. Its association with lung adenocarcinoma (LUAD) is exceptionally uncommon, with only sporadic cases reported.…
View article: Study on Motion Performance and Mooring Tension Response of 16 MW Tension Leg Platform Floating Wind Turbine Under Extreme Environmental Conditions
Study on Motion Performance and Mooring Tension Response of 16 MW Tension Leg Platform Floating Wind Turbine Under Extreme Environmental Conditions Open
This paper presents a 16 MW typhoon-resistant Tension Leg Platform floating offshore wind turbine (TLP FOWT) designed for the South China Sea. The survivability of the TLP FOWT under extreme environmental conditions is investigated through…