Jingwen Zhou
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View article: In Vivo and In Vitro Mechanisms of Equol Synthesis and Key Influencing Factors: A Critical Review
In Vivo and In Vitro Mechanisms of Equol Synthesis and Key Influencing Factors: A Critical Review Open
Background: Equol exists in two enantiomers of S-equol and R-equol. The results of cell and animal experiments, as well as clinical trials, have supported its protective effects on menopausal symptoms, aging, and cardiovascular diseases, e…
View article: Soluble E-Cadherin Facilitates Pre-Metastatic Niche Hyperpermeability Via Rac2
Soluble E-Cadherin Facilitates Pre-Metastatic Niche Hyperpermeability Via Rac2 Open
Aim or purpose: Lung metastasis is the main cause of mortality in salivary adenoid cystic carcinoma (SACC). Preventing vascular barrier leakiness in the pre-metastatic niche is a key strategy for inhibiting metastasis. Stable bounded of ZO…
View article: Computational Design of PtM (M = Au, Ir, Pd, Rh, and Ru) Binary Alloys for Enhanced Ammonia Oxidation Electrocatalysis
Computational Design of PtM (M = Au, Ir, Pd, Rh, and Ru) Binary Alloys for Enhanced Ammonia Oxidation Electrocatalysis Open
The electrochemical ammonia oxidation reaction (AOR) shows considerable potential for its applications in waste removal and the production of clean energy. While Pt remains the most investigated catalyst for this reaction, its limitations …
View article: SoM-1K: A Thousand-Problem Benchmark Dataset for Strength of Materials
SoM-1K: A Thousand-Problem Benchmark Dataset for Strength of Materials Open
Foundation models have shown remarkable capabilities in various domains, but their performance on complex, multimodal engineering problems remains largely unexplored. We introduce SoM-1K, the first large-scale multimodal benchmark dataset …
View article: CRISPR‐DNA Polymerase Assisted Targeted Mutagenesis for Regulable Laboratory Evolution
CRISPR‐DNA Polymerase Assisted Targeted Mutagenesis for Regulable Laboratory Evolution Open
Targeted hypermutation tools are useful for engineering proteins and pathways, and exploring the evolutionary landscapes. However, existing targeted hypermutation tools for genomic loci mostly exhibit restricted mutation windows and limite…
View article: Antimicrobial Resistance Characteristics of Staphylococcus aureus Isolated From Both Tertiary Hospitals, One Western Medicine Hospital and One Traditional Chinese Medicine Hospital, in Shanghai, China From 2014-2023
Antimicrobial Resistance Characteristics of Staphylococcus aureus Isolated From Both Tertiary Hospitals, One Western Medicine Hospital and One Traditional Chinese Medicine Hospital, in Shanghai, China From 2014-2023 Open
STCMH had lower MRSA prevalence and S. aureus resistance rates than SGH, and TCM-antibiotic combination therapy might promote bacterial clearance, suggesting TCM's potential in combating antimicrobial resistance, which needs further multic…
View article: Combination of enzyme engineering and quorum sensing system for efficient de novo biosynthesis of β-arbutin in Escherichia coli
Combination of enzyme engineering and quorum sensing system for efficient de novo biosynthesis of β-arbutin in Escherichia coli Open
β-Arbutin is a plant-derived glycoside with various biological activities, which has been applied in pharmaceuticals and whitening cosmetics. Uneven carbon flux distribution and the low catalytic efficiency of arbutin synthase limit the bi…
View article: Saccharomyces boulardii and Bifidobacterium co-treatment for antibiotic associated diarrhea in pediatrics: a multicenter efficacy and safety study
Saccharomyces boulardii and Bifidobacterium co-treatment for antibiotic associated diarrhea in pediatrics: a multicenter efficacy and safety study Open
Background Recent or ongoing use of antibiotics causes diarrhea. Probiotic yogurt is generally used in antibiotic-induced diarrhea as adjuvant therapy. In recent times, there have been no clear recommendations or guidelines for the course …
View article: Development of precise genome editing and multi-copy integration tools in Hansenula polymorpha DL-1
Development of precise genome editing and multi-copy integration tools in Hansenula polymorpha DL-1 Open
Hansenula polymorpha DL-1 is a thermotolerant yeast capable of utilizing multiple renewable carbon sources, making it a promising microbial cell factory for sustainable manufacturing. However, advanced metabolic engineering efforts have be…
View article: On-treatment serum albumin levels can predict 28-day mortality and guide albumin infusion in sepsis patients
On-treatment serum albumin levels can predict 28-day mortality and guide albumin infusion in sepsis patients Open
Background As the most abundant protein in plasma, albumin (ALB) presents close association with prognosis of septic patients. Whereas, the benefit and the target level of ALB infusion remain controversial. Methods We conducted a retrospec…
View article: Efficient Synthesis of High-Active Myoglobin and Hemoglobin by Reconstructing the Mitochondrial Heme Synthetic Pathway in Engineered Saccharomyces cerevisiae
Efficient Synthesis of High-Active Myoglobin and Hemoglobin by Reconstructing the Mitochondrial Heme Synthetic Pathway in Engineered Saccharomyces cerevisiae Open
Currently, various types of myoglobins and hemoglobins are widely used in the fields of food additives and biocatalytic applications. However, the limited availability of heme constrains the biosynthesis of these high-activity hemoproteins…
View article: Fast and accurate active alignment of camera lenses with physics-informed deep learning
Fast and accurate active alignment of camera lenses with physics-informed deep learning Open
As optical systems become increasingly complex, accurate and fast alignment is becoming more critical. Active alignment (AA) techniques dynamically optimize optical positioning using real-time image quality feedback, ensuring better perfor…
View article: GRLGRN: graph representation-based learning to infer gene regulatory networks from single-cell RNA-seq data
GRLGRN: graph representation-based learning to infer gene regulatory networks from single-cell RNA-seq data Open
The experimental results and case studies illustrate the considerable performance of GRLGRN in predicting gene interactions and provide interpretability for the prediction tasks, such as identifying hub genes in the network and uncovering …
View article: Artificial intelligence in traditional Chinese medicine: advances in multi-metabolite multi-target interaction modeling
Artificial intelligence in traditional Chinese medicine: advances in multi-metabolite multi-target interaction modeling Open
Traditional Chinese Medicine (TCM) utilizes multi-metabolite and multi-target interventions to address complex diseases, providing advantages over single-target therapies. However, the active metabolites, therapeutic targets, and especiall…
View article: Production of cultivated meat with stably proliferated porcine muscle stem cells and edible scaffolds
Production of cultivated meat with stably proliferated porcine muscle stem cells and edible scaffolds Open
To achieve large-scale production of high-quality cultivated meat, it is crucial to develop a culture system that efficiently expands muscle stem cells (MuSCs) while maintaining their differentiation potential, as well as an edible scaffol…
View article: Identification of two new flavone 4′-O-methyltransferases and their application in de novo biosynthesis of (2S)-hesperetin in Yarrowia lipolytica
Identification of two new flavone 4′-O-methyltransferases and their application in de novo biosynthesis of (2S)-hesperetin in Yarrowia lipolytica Open
Methyltransferases are pivotal enzymes in the biosynthesis of methylated flavonoids, including (2S)-hesperetin. However, existing flavonoid 4'-O-methyltransferase (F4'OMT) enzymes typically exhibit low substrate specificity and catalytic e…
View article: Precise Engineering and Efficient Biosynthesis of Robust and High‐Activity Human Haemoglobin for Artificial Oxygen Carriers
Precise Engineering and Efficient Biosynthesis of Robust and High‐Activity Human Haemoglobin for Artificial Oxygen Carriers Open
Recombinant human haemoglobin (rHb) is a tetramer protein with heme as cofactors, which have extensive applications in the fields of biomaterials and biomedical therapeutics. However, due to the poor structural stability, the dissociation …
View article: Construction of a Plasmid-Free Escherichia coli Strain with Enhanced Heme Supply to Produce Active Hemoglobins
Construction of a Plasmid-Free Escherichia coli Strain with Enhanced Heme Supply to Produce Active Hemoglobins Open
Background: Heme is an important cofactor and plays crucial roles in the correct folding of hemoproteins. The synthesis of heme can be enhanced by the plasmid-based expression of heme biosynthetic genes. However, plasmid-based expression i…
View article: Lipogenic enzyme FASN promotes mutant p53 accumulation and gain-of-function through palmitoylation
Lipogenic enzyme FASN promotes mutant p53 accumulation and gain-of-function through palmitoylation Open
The tumor-suppressive function of p53 is frequently disrupted by mutations in cancers. Missense mutant p53 (mutp53) protein often stabilizes and accumulates to high levels in cancers to promote tumorigenesis through the gain-of-function (G…
View article: Modifications of Constitutive Promoter to Large-Scale Synthesize Porcine Myoglobin in Komagataella phaffii
Modifications of Constitutive Promoter to Large-Scale Synthesize Porcine Myoglobin in Komagataella phaffii Open
Myoglobin (MG) is a heme-binding protein and can be used as a color and flavor additive for artificial meat. After the selection of stable constitutive expression, although the synthesis of porcine myoglobin (pMG) was achieved through the …