Yun Chen
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View article: HMGB2 Promotes Cardiomyocyte Proliferation and Heart Regeneration Through MTA2‐Driven Metabolic Reprogramming
HMGB2 Promotes Cardiomyocyte Proliferation and Heart Regeneration Through MTA2‐Driven Metabolic Reprogramming Open
The neonatal heart possesses the unique ability to regenerate post‐injury. Underlying related mechanisms and reactivation of this process are crucial for regeneration medicine. Using quantitative proteomics with tandem mass tag labeling, R…
View article: CSAD inhibits excessive inflammation during viral infections through the NF-κB signaling pathway
CSAD inhibits excessive inflammation during viral infections through the NF-κB signaling pathway Open
Studies have shown that 129 mice generate more severe inflammatory responses than C57BL/6 (B6) mice shortly after influenza virus infection. However, the mechanisms for regulation of the magnitudes and kinetics of innate immune responses i…
View article: Preference of Chinese clinical researchers to participate in international clinical research training: a cross-sectional study
Preference of Chinese clinical researchers to participate in international clinical research training: a cross-sectional study Open
View article: NETs accelerate aortic valve calcification by promoting M1 macrophage polarization through the TLR9 signaling pathway
NETs accelerate aortic valve calcification by promoting M1 macrophage polarization through the TLR9 signaling pathway Open
Neutrophil extracellular traps (NETs) are positively correlated with the severity of calcific aortic valve disease (CAVD). This study aims to elucidate the mechanism by which NETs contribute to CAVD. The CAVD mice model was established by …
View article: Single-Cell Atlas of Spleen Remodeling Reveals Macrophage Subset-Driven ASFV Pathogenesis
Single-Cell Atlas of Spleen Remodeling Reveals Macrophage Subset-Driven ASFV Pathogenesis Open
African swine fever virus (ASFV) causes global swine outbreaks, but its cellular pathogenesis is poorly understood. Using single-cell RNA data from ASFV-infected pig spleens across four timepoints, we identified macrophages as the primary …
View article: CircRNA ZFR promotes cell progression by regulating miR-96a-5p/SLC1A1 axis in hepatocellular carcinoma
CircRNA ZFR promotes cell progression by regulating miR-96a-5p/SLC1A1 axis in hepatocellular carcinoma Open
View article: Single-cell multiome and enhancer connectome of human retinal pigment epithelium and choroid nominate pathogenic variants in age-related macular degeneration
Single-cell multiome and enhancer connectome of human retinal pigment epithelium and choroid nominate pathogenic variants in age-related macular degeneration Open
SUMMARY Age-related macular degeneration (AMD) is a leading cause of vision loss worldwide. Genome-wide association studies (GWAS) of AMD have identified dozens of risk loci that may house disease targets. However, variants at these loci a…
View article: Tubular epithelial cell-derived Flt3L is required for type 1 conventional dendritic cell (cDC1) activation and expansion in promoting the recovery in acute kidney injury
Tubular epithelial cell-derived Flt3L is required for type 1 conventional dendritic cell (cDC1) activation and expansion in promoting the recovery in acute kidney injury Open
Flt3L is upregulated in both humans and mice during IRI-induced AKI and is likely produced by tubular epithelial cells. It mainly promotes the expansion and activation of kidney cDC1 cells, thereby reducing the severity of AKI in mice. The…
View article: Willingness of Chinese Clinical Researchers to Participate in International Clinical Research Training: A Cross-Sectional Study
Willingness of Chinese Clinical Researchers to Participate in International Clinical Research Training: A Cross-Sectional Study Open
Background The reform of medical education in China, particularly the emphasis on lifelong learning, has transformed its structure and content, prioritizing the integration of clinical research with practice. However, limited access to res…
View article: SCO6564, a novel 3-ketoacyl acyl carrier protein synthase III, contributes in fatty acid synthesis in Streptomyces coelicolor
SCO6564, a novel 3-ketoacyl acyl carrier protein synthase III, contributes in fatty acid synthesis in Streptomyces coelicolor Open
The genus Streptomyces comprises gram-positive bacteria that produce large numbers of secondary metabolites, which have promising commercial applications and deserve extensive study. Most bacteria synthesize fatty acids using a type II fat…
View article: Detection of single-cell enzyme activity by single-time-point stable isotope probing-mass spectrometry
Detection of single-cell enzyme activity by single-time-point stable isotope probing-mass spectrometry Open
Development of a single-time-point stable isotope probing-mass spectrometry (SIP-MS) assay for revealing enzyme activity heterogeneity in single cells.
View article: The Role of Co-Ion Transport in Selectrodialysis for Mono/Divalent Anion Separation
The Role of Co-Ion Transport in Selectrodialysis for Mono/Divalent Anion Separation Open
View article: TSI: A Multi-View Representation Learning Approach for Time Series Forecasting
TSI: A Multi-View Representation Learning Approach for Time Series Forecasting Open
As the growing demand for long sequence time-series forecasting in real-world applications, such as electricity consumption planning, the significance of time series forecasting becomes increasingly crucial across various domains. This is …
View article: Toxicity Study of Silica Nanoparticles Following 94-Day Repeated Oral Administration in Sprague Dawley Rats
Toxicity Study of Silica Nanoparticles Following 94-Day Repeated Oral Administration in Sprague Dawley Rats Open
This study was designed to investigate the toxic response of Sprague Dawley (SD) rats following oral administration of different doses of silica nanoparticles (SiNPs) for 94 consecutive days, as well as the recovery after 30 days of withdr…
View article: Correction: Resistance to FGFR1-targeted therapy leads to autophagy via TAK1/AMPK activation in gastric cancer
Correction: Resistance to FGFR1-targeted therapy leads to autophagy via TAK1/AMPK activation in gastric cancer Open
View article: Identification prognostic features related to sphingolipid metabolism and experimental validation of TRIM47 in hepatocellular carcinoma
Identification prognostic features related to sphingolipid metabolism and experimental validation of TRIM47 in hepatocellular carcinoma Open
Background: The specific impact of sphingolipid metabolism on developing hepatocellular Carcinoma (HCC) remains unclear. This study aims to explore the relationship between sphingolipid metabolism and HCC prognosis, immune response,…
View article: Proteomic Analysis Revealed the Potential Role of MAGE-D2 in the Therapeutic Targeting of Triple-Negative Breast Cancer
Proteomic Analysis Revealed the Potential Role of MAGE-D2 in the Therapeutic Targeting of Triple-Negative Breast Cancer Open
View article: 715TiP ARTS-021-1001: Phase I/II study of ARTS-021, a potent, oral administrated, selective CDK2 inhibitor, in advanced or metastatic solid tumors
715TiP ARTS-021-1001: Phase I/II study of ARTS-021, a potent, oral administrated, selective CDK2 inhibitor, in advanced or metastatic solid tumors Open
View article: YBX1 as an oncogenic factor in T-cell acute lymphoblastic leukemia
YBX1 as an oncogenic factor in T-cell acute lymphoblastic leukemia Open
Y-box-binding protein 1 (YBX1), a member of the RNA-binding protein family, is a critical regulator of cell survival in various solid tumors and acute myeloid leukemia. However, the function of YBX1 in T-cell acute lymphoblastic leukemia (…
View article: Low‑dose anlotinib combined with EGFR‑TKI can be used as an alternative for EGFR‑TKI‑resistant non‑small cell lung cancer in elderly patients
Low‑dose anlotinib combined with EGFR‑TKI can be used as an alternative for EGFR‑TKI‑resistant non‑small cell lung cancer in elderly patients Open
The current treatment options for epidermal growth factor receptor (EGFR) mutation-positive lung cancer in the elderly with tyrosine kinase inhibitor (TKI) resistance are limited. Although chemotherapy combined with vascular endothelial gr…
View article: <scp>WDR54</scp> exerts oncogenic roles in T‐cell acute lymphoblastic leukemia
<span>WDR54</span> exerts oncogenic roles in T‐cell acute lymphoblastic leukemia Open
WDR54 has been recently identified as a novel oncogene in colorectal and bladder cancers. However, the expression and function of WDR54 in T‐cell acute lymphoblastic leukemia (T‐ALL) were not reported. In this study, we investigated the ex…
View article: Design, synthesis and pharmacological evaluation of 2,3-dihydrobenzofuran IRAK4 inhibitors for the treatment of diffuse large B-cell lymphoma
Design, synthesis and pharmacological evaluation of 2,3-dihydrobenzofuran IRAK4 inhibitors for the treatment of diffuse large B-cell lymphoma Open
View article: Single-cell metabolic fingerprints discover a cluster of circulating tumor cells with distinct metastatic potential
Single-cell metabolic fingerprints discover a cluster of circulating tumor cells with distinct metastatic potential Open
Circulating tumor cells (CTCs) are recognized as direct seeds of metastasis. However, CTC count may not be the “best” indicator of metastatic risk because their heterogeneity is generally neglected. In this study, we develop a molecular ty…
View article: Supplemental information from Smoothened Promotes Glioblastoma Radiation Resistance Via Activating USP3-Mediated Claspin Deubiquitination
Supplemental information from Smoothened Promotes Glioblastoma Radiation Resistance Via Activating USP3-Mediated Claspin Deubiquitination Open
Supplemental information
View article: Supplemental information from Smoothened Promotes Glioblastoma Radiation Resistance Via Activating USP3-Mediated Claspin Deubiquitination
Supplemental information from Smoothened Promotes Glioblastoma Radiation Resistance Via Activating USP3-Mediated Claspin Deubiquitination Open
Supplemental information
View article: Constructed Tumor-Targeted and MMP-2 Biocleavable Antibody Conjugated Silica Nanoparticles for Efficient Cancer Therapy
Constructed Tumor-Targeted and MMP-2 Biocleavable Antibody Conjugated Silica Nanoparticles for Efficient Cancer Therapy Open
Antibody-drug conjugates (ADC) are an inevitable trend in the development of modern "precision medicine". The goal of this work is to produce enzyme-responsive antibody nanoparticle-loaded medication (FMSN-Dox-H2-AE01) based on the EGFR an…
View article: Evaluation of Chitosan-Oleuropein Nanoparticles on the Durability of Dentin Bonding
Evaluation of Chitosan-Oleuropein Nanoparticles on the Durability of Dentin Bonding Open
Altogether, the CONPs had the potential to act as a dentin primer, which could effectively improve the dentin-resin binding durability.
View article: Structural N-Glycoproteomics Characterization of Cell-Surface N-Glycosylation of MCF-7/ADR Cancer Stem Cells
Structural N-Glycoproteomics Characterization of Cell-Surface N-Glycosylation of MCF-7/ADR Cancer Stem Cells Open
View article: Pemetrexed induces ROS generation and cellular senescence by attenuating TS-mediated thymidylate metabolism to reverse gefitinib resistance in non-small cell lung cancer
Pemetrexed induces ROS generation and cellular senescence by attenuating TS-mediated thymidylate metabolism to reverse gefitinib resistance in non-small cell lung cancer Open
Epidermal growth factor receptor tyrosine kinase inhibitors (EGFR-TKIs) are strongly recommended for non-small cell lung carcinoma (NSCLC) patients harboring active EGFR mutations, while drug resistance inevitably makes exploring the resis…
View article: Smoking Status and Cognitive Function in a National Sample of Older Adults
Smoking Status and Cognitive Function in a National Sample of Older Adults Open
Aims To examine the correlation between smoking status and different domains of cognitive function in elderly Americans. Methods We used data from the 2011 to 2014 U.S. National Health and Nutrition Examination Survey (NHANES). Participant…