Zhou‐Feng Chen
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View article: Distinct oxytocin signaling pathways synergistically mediate rescue-like behavior in mice
Distinct oxytocin signaling pathways synergistically mediate rescue-like behavior in mice Open
Spontaneous rescue behavior enhances the well-being and survival of social animals, yet the neural mechanisms underlying the recognition and response to conspecifics in need remain unclear. Here, we report that observer mice experience dis…
View article: Structures of human gastrin-releasing peptide receptors bound to antagonist and agonist for cancer and itch therapy
Structures of human gastrin-releasing peptide receptors bound to antagonist and agonist for cancer and itch therapy Open
Gastrin releasing peptide receptor (GRPR), a member of the bombesin (BBN) G protein-coupled receptors, is aberrantly overexpressed in several malignant tumors, including those of the breast, prostate, pancreas, lung, and central nervous sy…
View article: Molecular and neural basis of pleasant touch sensation
Molecular and neural basis of pleasant touch sensation Open
Pleasant touch provides emotional and psychological support that helps mitigate social isolation and stress. However, the underlying mechanisms remain poorly understood. Using a pleasant touch–conditioned place preference (PT-CPP) test, we…
View article: BNP facilitates NMB-encoded histaminergic itch via NPRC-NMBR crosstalk
BNP facilitates NMB-encoded histaminergic itch via NPRC-NMBR crosstalk Open
Histamine-dependent and -independent itch is conveyed by parallel peripheral neural pathways that express gastrin-releasing peptide (GRP) and neuromedin B (NMB), respectively, to the spinal cord of mice. B-type natriuretic peptide (BNP) ha…
View article: Author response: BNP facilitates NMB-encoded histaminergic itch via NPRC-NMBR crosstalk
Author response: BNP facilitates NMB-encoded histaminergic itch via NPRC-NMBR crosstalk Open
Article Figures and data Abstract Editor's evaluation eLife digest Introduction Results Discussion Materials and methods Data availability References Decision letter Author response Article and author information Metrics Abstract Histamine…
View article: BNP facilitates NMB-mediated histaminergic itch via NPRC-NMBR crosstalk
BNP facilitates NMB-mediated histaminergic itch via NPRC-NMBR crosstalk Open
B-type natriuretic peptide (BNP) binds to its two cognate receptors NPRA and NPRC, encoded by Npr1 and Npr3 , respectively, with equal potency and both are expressed in the spinal cord. Moreover, natriuretic peptides (NP) signal through th…
View article: GRP and NMB: distinct functions in itch transmission
GRP and NMB: distinct functions in itch transmission Open
One of the major challenges in the field is to understand how histaminergic and nonhistaminergic itch is encoded and transmitted from sensory neurons to the spinal cord, respectively. The question is of immerse importance because it concer…
View article: dmPFC-vlPAG projection neurons contribute to pain threshold maintenance and antianxiety behaviors
dmPFC-vlPAG projection neurons contribute to pain threshold maintenance and antianxiety behaviors Open
The dorsal medial prefrontal cortex (dmPFC) has been recognized as a key cortical area for nociceptive modulation. However, the underlying neural pathway and the function of specific cell types remain largely unclear. Here, we show that le…
View article: Exploration of sensory and spinal neurons expressing gastrin-releasing peptide in itch and pain related behaviors
Exploration of sensory and spinal neurons expressing gastrin-releasing peptide in itch and pain related behaviors Open
Gastrin-releasing peptide (GRP) functions as a neurotransmitter for non-histaminergic itch, but its site of action (sensory neurons vs spinal cord) remains controversial. To determine the role of GRP in sensory neurons, we generated a flox…
View article: Cross-talk between Human Spinal Cord μ-opioid Receptor 1Y Isoform and Gastrin-releasing Peptide Receptor Mediates Opioid-induced Scratching Behavior
Cross-talk between Human Spinal Cord μ-opioid Receptor 1Y Isoform and Gastrin-releasing Peptide Receptor Mediates Opioid-induced Scratching Behavior Open
Editor’s Perspective What We Already Know about This Topic What This Article Tells Us That Is New Background Although spinal opioids are safe and effective, pruritus is common and distressing. The authors previously demonstrated in mouse s…
View article: NPY2R signaling gates spontaneous and mechanical, but not thermal, pain transmission
NPY2R signaling gates spontaneous and mechanical, but not thermal, pain transmission Open
Neuropeptide Y signaling plays an important role in inhibiting chronic pain in the spinal cord of mice. However, little is known about the respective roles of two major neuropeptide Y receptors, Y1R and Y2R, in evoked and spontaneous pain …
View article: Exploration of Sensory and Spinal Neurons Expressing GRP in Itch and Pain
Exploration of Sensory and Spinal Neurons Expressing GRP in Itch and Pain Open
Gastrin-releasing peptide (GRP) is a putative itch-specific neurotransmitter, but definite evidence in the dorsal root ganglion (DRG) and spinal cord is lacking. We generated and validated a Grp -Cre knock-in ( Grp Cre-KI ) mouse line wher…
View article: Sedated gastroscopy improves detection of gastric polyps
Sedated gastroscopy improves detection of gastric polyps Open
The detection rate of gastric polyps (GPs) is low, improving the detection rate would be good. The present study aimed to evaluate the role of sedated gastroscopy in GP detection. The data of patients who underwent gastroscopic examination…
View article: Response to Comment on “Molecular and neural basis of contagious itch behavior in mice”
Response to Comment on “Molecular and neural basis of contagious itch behavior in mice” Open
Liljencrantz et al . report the failure of observing contagious itch behavior using mice injected with histamine as the demonstrators. Analysis of their results shows that the histamine model is limited by inadequate frequency and duration…