Zhengxue Quan
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View article: Next-generation suturing: Moisture-pressurized and ultrasonic synthesis of Cu–Ag–Al nanorods for antibacterial dental and dialysis applications
Next-generation suturing: Moisture-pressurized and ultrasonic synthesis of Cu–Ag–Al nanorods for antibacterial dental and dialysis applications Open
View article: The RNA-Binding Protein RBMX Mediates the Immunosuppressive Microenvironment of Osteosarcoma by Regulating CD8+T Cells
The RNA-Binding Protein RBMX Mediates the Immunosuppressive Microenvironment of Osteosarcoma by Regulating CD8+T Cells Open
Background: The progression of osteosarcoma is closely related to the immune microenvironment. Related studies have found that the RNA-binding motif protein, X-linked (RBMX), plays a regulatory role in modulating the biological characteris…
View article: Electrochemical Synthesis of Biomass-Derived Aromatic N-Heterocycles by Using Ni-Based Hierarchical Nanosheets Catalysts
Electrochemical Synthesis of Biomass-Derived Aromatic N-Heterocycles by Using Ni-Based Hierarchical Nanosheets Catalysts Open
View article: MUC1 and CREB3 are Hub Ferroptosis Suppressors for Nucleus Pulposus and Annulus Fibrosus Degeneration by Integrated Bioinformatics and Experimental Verification
MUC1 and CREB3 are Hub Ferroptosis Suppressors for Nucleus Pulposus and Annulus Fibrosus Degeneration by Integrated Bioinformatics and Experimental Verification Open
MUC1 and CREB3 were considered novel biomarkers for NP and AF ferroptosis, respectively. Drug and ceRNA networks were constructed for future drug development and investigation of new mechanisms of ferroptosis.
View article: A novel nanohydroxyapatite/polyamide 66 strut for reducing subsidence after one-level anterior cervical corpectomy and fusion: a finite-element study
A novel nanohydroxyapatite/polyamide 66 strut for reducing subsidence after one-level anterior cervical corpectomy and fusion: a finite-element study Open
View article: Inhibiting DNA methyltransferase DNMT3B confers protection against ferroptosis in nucleus pulposus and ameliorates intervertebral disc degeneration via upregulating SLC40A1
Inhibiting DNA methyltransferase DNMT3B confers protection against ferroptosis in nucleus pulposus and ameliorates intervertebral disc degeneration via upregulating SLC40A1 Open
Epigenetic changes are important considerations for degenerative diseases. DNA methylation regulates crucial genes by epigenetic mechanism, impacting cell function and fate. DNA presents hypermethylation in degenerated nucleus pulposus (NP…
View article: RARRES2 is involved in the “lock-and-key” interactions between osteosarcoma stem cells and tumor-associated macrophages
RARRES2 is involved in the “lock-and-key” interactions between osteosarcoma stem cells and tumor-associated macrophages Open
View article: Incidence and risk factors associated with superior segmented facet joint violation in posterior approach lumbar interbody fusion
Incidence and risk factors associated with superior segmented facet joint violation in posterior approach lumbar interbody fusion Open
Objective: To investigate the incidence and risk factors of superior-segmented facet joint violation (FJV) during pedicle screw placement in posterior approach lumbar interbody fusion (PLIF). Study type: Retrospective study. Methods: A tot…
View article: Retrospective analysis of 10 cases with esophageal fistula after anterior surgery for cervical spine fracture
Retrospective analysis of 10 cases with esophageal fistula after anterior surgery for cervical spine fracture Open
The occurrence of esophageal fistula is associated with surgical procedures, esophageal injury, and implant compression. Esophagography and endoscopy are the primary diagnostic methods, while incision exploration after ingestion of food mi…
View article: Sinomenine Ameliorates IL-1β-Induced Intervertebral Disc Degeneration in Rats Through Suppressing Inflammation and Oxidative Stress via Keap1/Nrf2/NF-κB Signaling Pathways
Sinomenine Ameliorates IL-1β-Induced Intervertebral Disc Degeneration in Rats Through Suppressing Inflammation and Oxidative Stress via Keap1/Nrf2/NF-κB Signaling Pathways Open
SN can prevent IL-1β-induced apoptosis of NPCs and ameliorate IDD by activating the Keap1/Nrf2 pathway and inhibiting the NF-κB signaling pathway.
View article: Femoral Anteversion Measured by the Surgical Transepicondylar Axis Is Correlated with the Tibial Tubercle–Roman Arch Distance in Patients with Lateral Patellar Dislocation
Femoral Anteversion Measured by the Surgical Transepicondylar Axis Is Correlated with the Tibial Tubercle–Roman Arch Distance in Patients with Lateral Patellar Dislocation Open
Background and Objectives: Various predisposing factors for lateral patellar dislocation (LPD) have been identified, but the relation between femoral rotational deformity and the tibial tubercle–Roman arch (TT-RA) distance remains elusive.…
View article: Prediction of Subsequent Contralateral Patellar Dislocation after First-Time Dislocation Based on Patellofemoral Morphologies
Prediction of Subsequent Contralateral Patellar Dislocation after First-Time Dislocation Based on Patellofemoral Morphologies Open
The subsequent dislocation of a contralateral patellofemoral joint sometimes occurs after a first-time lateral patellar dislocation (LPD). However, the anatomic risk factors for subsequent contralateral LPD remain elusive. This study inclu…
View article: Role of ferroptosis-associated genes in ankylosing spondylitis and immune cell infiltration
Role of ferroptosis-associated genes in ankylosing spondylitis and immune cell infiltration Open
Ankylosing spondylitis (AS) is a chronic progressive autoimmune disease with insidious onset, high rates of disability among patients, unknown pathogenesis, and no effective treatment. Ferroptosis is a novel type of regulated cell death th…
View article: Targeting Ferroptosis Holds Potential for Intervertebral Disc Degeneration Therapy
Targeting Ferroptosis Holds Potential for Intervertebral Disc Degeneration Therapy Open
Intervertebral disc degeneration (IVDD) is a common pathological condition responsible for lower back pain, which can significantly increase economic and social burdens. Although considerable efforts have been made to identify potential me…
View article: The surgical management trends of osteoporotic vertebral compression fractures: 5-year experience in one institution
The surgical management trends of osteoporotic vertebral compression fractures: 5-year experience in one institution Open
Osteoporotic vertebral compression fractures (OVCFs) have gradually become a health threat to elderly individuals. Treatment options are controversial, and many challenges remain. Our study aimed to investigate the management trends of OVC…
View article: Comparison of the Outcomes between <scp>AO</scp> Type <scp>B2</scp> Thoracolumbar Fracture with and without Disc Injury after Posterior Surgery
Comparison of the Outcomes between <span>AO</span> Type <span>B2</span> Thoracolumbar Fracture with and without Disc Injury after Posterior Surgery Open
Objective The type AO B2 thoracolumbar fracture is a kind of flexion‐distraction injury and the effect of disc injury on treatment results of patients with B2 fracture remains unclear. The objective of the current study was to compare and …
View article: Correction to: Homologous targeting nanoparticles for enhanced PDT against osteosarcoma HOS cells and the related molecular mechanisms
Correction to: Homologous targeting nanoparticles for enhanced PDT against osteosarcoma HOS cells and the related molecular mechanisms Open
View article: Causal associations of circulating adiponectin with cardiometabolic diseases and osteoporotic fracture
Causal associations of circulating adiponectin with cardiometabolic diseases and osteoporotic fracture Open
Circulating adiponectin shows some relationships with the occurrence of cardiometabolic diseases and osteoporotic fracture, but little is known about their causal associations. This two-sample Mendelian randomization (MR) study aims to exp…
View article: [Transvertebral space and under the pedicle osteotomy for thoracolumbar kyphosis caused by old osteoporotic vertebral compression fracture].
[Transvertebral space and under the pedicle osteotomy for thoracolumbar kyphosis caused by old osteoporotic vertebral compression fracture]. Open
Transvertebral space and under the pedicle osteotomy is an effective way to treat thoracolumbar kyphosis caused by old OVCF with less trauma, shorter operation time, and less intraoperative blood loss. Patients can obtain good orthopedic r…
View article: bFGF-incorporated composite biomaterial for bone regeneration
bFGF-incorporated composite biomaterial for bone regeneration Open
View article: Homologous targeting nanoparticles for enhanced PDT against osteosarcoma HOS cells and the related molecular mechanisms
Homologous targeting nanoparticles for enhanced PDT against osteosarcoma HOS cells and the related molecular mechanisms Open
View article: Clinical results of a lamina with spinous process and an iliac graft as bone grafts in the surgical treatment of single-segment lumbar pyogenic spondylodiscitis: a retrospective cohort study
Clinical results of a lamina with spinous process and an iliac graft as bone grafts in the surgical treatment of single-segment lumbar pyogenic spondylodiscitis: a retrospective cohort study Open
View article: Theaflavin‐3,3′‐Digallate Plays a ROS‐Mediated Dual Role in Ferroptosis and Apoptosis via the MAPK Pathway in Human Osteosarcoma Cell Lines and Xenografts
Theaflavin‐3,3′‐Digallate Plays a ROS‐Mediated Dual Role in Ferroptosis and Apoptosis via the MAPK Pathway in Human Osteosarcoma Cell Lines and Xenografts Open
Globally, osteosarcoma (OS) is the most prevalent form of primary bone cancer in children and adolescents. Traditional neoadjuvant chemotherapy regimens have reached a bottleneck; thus, OS survivors have unsatisfactory outcomes. Theaflavin…
View article: Causal Roles of Sleep Duration in Osteoporosis and Cardiometabolic Diseases: A Mendelian Randomization Study
Causal Roles of Sleep Duration in Osteoporosis and Cardiometabolic Diseases: A Mendelian Randomization Study Open
Sleep duration suggests some association with osteoporosis and cardiometabolic diseases, but it is unknown if these associations are causal or confounded. In this two‐sample Mendelian randomization (MR) study, we included the largest genom…
View article: Elevated intraspinal pressure in traumatic spinal cord injury is a promising therapeutic target
Elevated intraspinal pressure in traumatic spinal cord injury is a promising therapeutic target Open
The currently recommended management for acute traumatic spinal cord injury aims to reduce the incidence of secondary injury and promote functional recovery. Elevated intraspinal pressure (ISP) likely plays an important role in the process…
View article: Causal Effect of Serum Magnesium on Osteoporosis and Cardiometabolic Diseases
Causal Effect of Serum Magnesium on Osteoporosis and Cardiometabolic Diseases Open
Serum magnesium is associated with osteoporosis and cardiometabolic diseases, but their causal associations remain elusive. We used the two-sample Mendelian randomization (MR) study to explore the causal roles of serum magnesium on osteopo…
View article: The CT assessment of uncovertebral joints degeneration in a healthy population
The CT assessment of uncovertebral joints degeneration in a healthy population Open
View article: Clinical Outcomes of Fracture Haemorrhage Aspiration for Percutaneous Vertebroplasty in Treating Osteoporotic Vertebral Compression Fractures
Clinical Outcomes of Fracture Haemorrhage Aspiration for Percutaneous Vertebroplasty in Treating Osteoporotic Vertebral Compression Fractures Open
Compared with traditional surgical methods, bone haemorrhage aspiration could improve the diffusion degree of bone cement and reduce the height loss and deformity of injured vertebrae. This method provides a feasible new scheme for improvi…
View article: Enhancement of the bone-implant interface by applying a plasma-sprayed titanium coating on nanohydroxyapatite/polyamide66 implants in a rabbit model
Enhancement of the bone-implant interface by applying a plasma-sprayed titanium coating on nanohydroxyapatite/polyamide66 implants in a rabbit model Open
View article: Systematic Influence of Circulating Bilirubin Levels on Osteoporosis
Systematic Influence of Circulating Bilirubin Levels on Osteoporosis Open
Observational studies report some association between circulating bilirubin levels and osteoporosis, but it is unknown if this association is causal or confounded. In this two-sample Mendelian randomization (MR) study, we included a large …