Zhongzhong Ji
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View article: Effects of attractions and social attributes on peoples’ usage intention and media dependence towards chatbot: The mediating role of parasocial interaction and emotional support
Effects of attractions and social attributes on peoples’ usage intention and media dependence towards chatbot: The mediating role of parasocial interaction and emotional support Open
Purpose It is important to explore the relationship between humans and chatbots to improve human–robot interaction in the era of artificial intelligence. This study aims to explore the effects of attractions and social attributes of chatbo…
View article: HPOseq: a deep ensemble model for predicting the protein-phenotype relationships based on protein sequences
HPOseq: a deep ensemble model for predicting the protein-phenotype relationships based on protein sequences Open
View article: PBRM1 deficiency enhances PD1 immunotherapeutic sensitivity via chromosomal accessibility in colorectal cancer
PBRM1 deficiency enhances PD1 immunotherapeutic sensitivity via chromosomal accessibility in colorectal cancer Open
Rationale: Tumor cell epigenetics, especially chromosome accessibility, has been reported to be closely related to the tumor immune landscape and immunotherapy. However, the exact mechanism remains unknown. Methods: Whole-exo…
View article: BIRC5 knockdown ameliorates hepatocellular carcinoma progression via regulating PPARγ pathway and cuproptosis
BIRC5 knockdown ameliorates hepatocellular carcinoma progression via regulating PPARγ pathway and cuproptosis Open
BIRC5 silencing attenuated HCC through blocking PPARγ pathway and regulating cuproptosis, which may offer therapeutic implications against HCC.
View article: ADORA2A-driven proline synthesis triggers epigenetic reprogramming in neuroendocrine prostate and lung cancers
ADORA2A-driven proline synthesis triggers epigenetic reprogramming in neuroendocrine prostate and lung cancers Open
Cell lineage plasticity is one of the major causes for the failure of targeted therapies in various cancers. However, the driver and actionable drug targets in promoting cancer cell lineage plasticity are scarcely identified. Here, we foun…
View article: IL‐1β Is an Androgen‐Responsive Target in Macrophages for Immunotherapy of Prostate Cancer
IL‐1β Is an Androgen‐Responsive Target in Macrophages for Immunotherapy of Prostate Cancer Open
Great attention is paid to the role of androgen receptor (AR) as a central transcriptional factor in driving the growth of prostate cancer (PCa) epithelial cells. However, the understanding of the role of androgen in PCa‐infiltrated immune…
View article: Data from WNT/β-Catenin Directs Self-Renewal Symmetric Cell Division of hTERT<sup>high</sup> Prostate Cancer Stem Cells
Data from WNT/β-Catenin Directs Self-Renewal Symmetric Cell Division of hTERT<sup>high</sup> Prostate Cancer Stem Cells Open
Cancer stem-like cells (CSC) drive cancer progression and recurrence. Self-renewal expansion of CSC is achieved through symmetric cell division, yet how external stimuli affect intracellular regulatory programs of CSC division modes and st…
View article: Supplementary Figures from Blockade of β-Catenin–Induced CCL28 Suppresses Gastric Cancer Progression via Inhibition of Treg Cell Infiltration
Supplementary Figures from Blockade of β-Catenin–Induced CCL28 Suppresses Gastric Cancer Progression via Inhibition of Treg Cell Infiltration Open
Supplementary data of in vitro cell line experiments, human stomach tumor database/sample analysis and animal experiments.
View article: Supplementary Table 2 from WNT/β-Catenin Directs Self-Renewal Symmetric Cell Division of hTERT<sup>high</sup> Prostate Cancer Stem Cells
Supplementary Table 2 from WNT/β-Catenin Directs Self-Renewal Symmetric Cell Division of hTERT<sup>high</sup> Prostate Cancer Stem Cells Open
Supplementary Table 2: Primer sequences used in the qRT-PCR experiment
View article: Supplementary Data from Numb<sup>−/low</sup> Enriches a Castration-Resistant Prostate Cancer Cell Subpopulation Associated with Enhanced Notch and Hedgehog Signaling
Supplementary Data from Numb<sup>−/low</sup> Enriches a Castration-Resistant Prostate Cancer Cell Subpopulation Associated with Enhanced Notch and Hedgehog Signaling Open
Supplementary Mehods, Materials, figures and tables Figure S1. Immunofluorescent staining of Numb in PCa tissues. Figure S2. Classical Wnt signaling was not affected by Numb in PCa cells. Figure S3. The mRNA levels of Hes1 and GLI1 negativ…
View article: Data from WNT/β-Catenin Directs Self-Renewal Symmetric Cell Division of hTERT<sup>high</sup> Prostate Cancer Stem Cells
Data from WNT/β-Catenin Directs Self-Renewal Symmetric Cell Division of hTERT<sup>high</sup> Prostate Cancer Stem Cells Open
Cancer stem-like cells (CSC) drive cancer progression and recurrence. Self-renewal expansion of CSC is achieved through symmetric cell division, yet how external stimuli affect intracellular regulatory programs of CSC division modes and st…
View article: Supplementary Fig 4 related to Fig 4 from WNT/β-Catenin Directs Self-Renewal Symmetric Cell Division of hTERT<sup>high</sup> Prostate Cancer Stem Cells
Supplementary Fig 4 related to Fig 4 from WNT/β-Catenin Directs Self-Renewal Symmetric Cell Division of hTERT<sup>high</sup> Prostate Cancer Stem Cells Open
Supplementary Fig 4 related to Fig 4: hTERThigh PCa cells exhibit three distinct cell division modes in a Numb-dsRed segregation context
View article: Supplementary Fig 1 related to Fig 1 from WNT/β-Catenin Directs Self-Renewal Symmetric Cell Division of hTERT<sup>high</sup> Prostate Cancer Stem Cells
Supplementary Fig 1 related to Fig 1 from WNT/β-Catenin Directs Self-Renewal Symmetric Cell Division of hTERT<sup>high</sup> Prostate Cancer Stem Cells Open
Supplementary Fig 1 related to Fig 1: hTERT expression in PCa specimens and FACS sorted hTERT-/low and hTERThigh PCa cells
View article: Supplementary Materials and Methods from WNT/β-Catenin Directs Self-Renewal Symmetric Cell Division of hTERT<sup>high</sup> Prostate Cancer Stem Cells
Supplementary Materials and Methods from WNT/β-Catenin Directs Self-Renewal Symmetric Cell Division of hTERT<sup>high</sup> Prostate Cancer Stem Cells Open
Supplementary Materials and Methods
View article: Supplementary Fig 5 related to Fig 5 from WNT/β-Catenin Directs Self-Renewal Symmetric Cell Division of hTERT<sup>high</sup> Prostate Cancer Stem Cells
Supplementary Fig 5 related to Fig 5 from WNT/β-Catenin Directs Self-Renewal Symmetric Cell Division of hTERT<sup>high</sup> Prostate Cancer Stem Cells Open
Supplementary Fig 5 related to Fig 5: The Effects of WNT ligands and WNT inhibitors on SCD I, SCD II and ACD ratio of hTERThigh LNCaP cells
View article: Supplementary Table 2 from WNT/β-Catenin Directs Self-Renewal Symmetric Cell Division of hTERT<sup>high</sup> Prostate Cancer Stem Cells
Supplementary Table 2 from WNT/β-Catenin Directs Self-Renewal Symmetric Cell Division of hTERT<sup>high</sup> Prostate Cancer Stem Cells Open
Supplementary Table 2: Primer sequences used in the qRT-PCR experiment
View article: Supplementary Fig 4 related to Fig 4 from WNT/β-Catenin Directs Self-Renewal Symmetric Cell Division of hTERT<sup>high</sup> Prostate Cancer Stem Cells
Supplementary Fig 4 related to Fig 4 from WNT/β-Catenin Directs Self-Renewal Symmetric Cell Division of hTERT<sup>high</sup> Prostate Cancer Stem Cells Open
Supplementary Fig 4 related to Fig 4: hTERThigh PCa cells exhibit three distinct cell division modes in a Numb-dsRed segregation context
View article: Supplementary Fig 1 related to Fig 1 from WNT/β-Catenin Directs Self-Renewal Symmetric Cell Division of hTERT<sup>high</sup> Prostate Cancer Stem Cells
Supplementary Fig 1 related to Fig 1 from WNT/β-Catenin Directs Self-Renewal Symmetric Cell Division of hTERT<sup>high</sup> Prostate Cancer Stem Cells Open
Supplementary Fig 1 related to Fig 1: hTERT expression in PCa specimens and FACS sorted hTERT-/low and hTERThigh PCa cells
View article: Supplementary Fig 2 related to Fig 2 from WNT/β-Catenin Directs Self-Renewal Symmetric Cell Division of hTERT<sup>high</sup> Prostate Cancer Stem Cells
Supplementary Fig 2 related to Fig 2 from WNT/β-Catenin Directs Self-Renewal Symmetric Cell Division of hTERT<sup>high</sup> Prostate Cancer Stem Cells Open
Supplementary Fig 2 related to Fig 2: hTERT promotes xenograft tumor growth and EMT of PCa cells
View article: Data from Blockade of β-Catenin–Induced CCL28 Suppresses Gastric Cancer Progression via Inhibition of Treg Cell Infiltration
Data from Blockade of β-Catenin–Induced CCL28 Suppresses Gastric Cancer Progression via Inhibition of Treg Cell Infiltration Open
Dysregulation of Wnt/β-catenin signaling is frequently observed in human gastric cancer. Elucidation of the tumor immune microenvironment is essential for understanding tumorigenesis and for the development of immunotherapeutic strategies.…
View article: Supplementary Fig 7 related to Fig 7 from WNT/β-Catenin Directs Self-Renewal Symmetric Cell Division of hTERT<sup>high</sup> Prostate Cancer Stem Cells
Supplementary Fig 7 related to Fig 7 from WNT/β-Catenin Directs Self-Renewal Symmetric Cell Division of hTERT<sup>high</sup> Prostate Cancer Stem Cells Open
Supplementary Fig 7 related to Fig 7: Validation of beta-catenin knockdown efficiency in PCa cells
View article: Supplementary Fig 8 working model from WNT/β-Catenin Directs Self-Renewal Symmetric Cell Division of hTERT<sup>high</sup> Prostate Cancer Stem Cells
Supplementary Fig 8 working model from WNT/β-Catenin Directs Self-Renewal Symmetric Cell Division of hTERT<sup>high</sup> Prostate Cancer Stem Cells Open
Supplementary Fig 8 working model: Schematic model of hTERThigh PCSCs cell division modes modulated by WNT/beta-catenin
View article: hTERT-/low and hTERThigh PCa cell division modes from WNT/β-Catenin Directs Self-Renewal Symmetric Cell Division of hTERT<sup>high</sup> Prostate Cancer Stem Cells
hTERT-/low and hTERThigh PCa cell division modes from WNT/β-Catenin Directs Self-Renewal Symmetric Cell Division of hTERT<sup>high</sup> Prostate Cancer Stem Cells Open
hTERT-/low and hTERThigh PCa cell division modes from WNT/β-Catenin Directs Self-Renewal Symmetric Cell Division of hTERThigh Prostate Cancer Stem Cells
View article: Data from Blockade of β-Catenin–Induced CCL28 Suppresses Gastric Cancer Progression via Inhibition of Treg Cell Infiltration
Data from Blockade of β-Catenin–Induced CCL28 Suppresses Gastric Cancer Progression via Inhibition of Treg Cell Infiltration Open
Dysregulation of Wnt/β-catenin signaling is frequently observed in human gastric cancer. Elucidation of the tumor immune microenvironment is essential for understanding tumorigenesis and for the development of immunotherapeutic strategies.…
View article: Supplementary Table 1 from WNT/β-Catenin Directs Self-Renewal Symmetric Cell Division of hTERT<sup>high</sup> Prostate Cancer Stem Cells
Supplementary Table 1 from WNT/β-Catenin Directs Self-Renewal Symmetric Cell Division of hTERT<sup>high</sup> Prostate Cancer Stem Cells Open
Supplementary Table 1: Antibodies and proteins used in the present study
View article: Supplementary Figures from Blockade of β-Catenin–Induced CCL28 Suppresses Gastric Cancer Progression via Inhibition of Treg Cell Infiltration
Supplementary Figures from Blockade of β-Catenin–Induced CCL28 Suppresses Gastric Cancer Progression via Inhibition of Treg Cell Infiltration Open
Supplementary data of in vitro cell line experiments, human stomach tumor database/sample analysis and animal experiments.
View article: Supplementary Fig 3 related to Fig 3 from WNT/β-Catenin Directs Self-Renewal Symmetric Cell Division of hTERT<sup>high</sup> Prostate Cancer Stem Cells
Supplementary Fig 3 related to Fig 3 from WNT/β-Catenin Directs Self-Renewal Symmetric Cell Division of hTERT<sup>high</sup> Prostate Cancer Stem Cells Open
Supplementary Fig 3 related to Fig 3: hTERT enhances the holoclone formation capacity of PCa cells
View article: Data from Numb<sup>−/low</sup> Enriches a Castration-Resistant Prostate Cancer Cell Subpopulation Associated with Enhanced Notch and Hedgehog Signaling
Data from Numb<sup>−/low</sup> Enriches a Castration-Resistant Prostate Cancer Cell Subpopulation Associated with Enhanced Notch and Hedgehog Signaling Open
Purpose: To elucidate the role and molecular mechanism of Numb in prostate cancer and the functional contribution of Numb−/low prostate cancer cells in castration resistance.Experimental Design: The expression of N…
View article: Supplementary Fig 6 related to Fig 6 from WNT/β-Catenin Directs Self-Renewal Symmetric Cell Division of hTERT<sup>high</sup> Prostate Cancer Stem Cells
Supplementary Fig 6 related to Fig 6 from WNT/β-Catenin Directs Self-Renewal Symmetric Cell Division of hTERT<sup>high</sup> Prostate Cancer Stem Cells Open
Supplementary Fig 6 related to Fig 6: PCa tissues with elevated WNT signaling activation express higher level of hTERT
View article: Data from Numb<sup>−/low</sup> Enriches a Castration-Resistant Prostate Cancer Cell Subpopulation Associated with Enhanced Notch and Hedgehog Signaling
Data from Numb<sup>−/low</sup> Enriches a Castration-Resistant Prostate Cancer Cell Subpopulation Associated with Enhanced Notch and Hedgehog Signaling Open
Purpose: To elucidate the role and molecular mechanism of Numb in prostate cancer and the functional contribution of Numb−/low prostate cancer cells in castration resistance.Experimental Design: The expression of N…