Guanyu Zhu
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View article: Invasive neurophysiology and whole brain connectomics for neural decoding in patients with brain implants
Invasive neurophysiology and whole brain connectomics for neural decoding in patients with brain implants Open
Brain-computer interface research can inspire closed-loop neuromodulation therapies, promising spatiotemporal precision for the treatment of brain disorders. Decoding dynamic patient states from brain signals with machine learning is requi…
View article: Deep brain stimulation surgical timing, outcomes, and prognostic factors in patients with Parkinson’s disease: A Chinese retrospective multicenter cohort study
Deep brain stimulation surgical timing, outcomes, and prognostic factors in patients with Parkinson’s disease: A Chinese retrospective multicenter cohort study Open
Background Deep brain stimulation (DBS) has been increasingly introduced for patients with Parkinson’s disease (PD). However, there has been extensive controversy regarding its surgical timing. This study aimed to evaluate surgical outcome…
View article: Realizing string-net condensation: Fibonacci anyon braiding for universal gates and sampling chromatic polynomials
Realizing string-net condensation: Fibonacci anyon braiding for universal gates and sampling chromatic polynomials Open
The remarkable complexity of a topologically ordered many-body quantum system is encoded in the characteristics of its anyons. Quintessential predictions emanating from this complexity employ the Fibonacci string net condensate (Fib SNC) a…
View article: Realizing string-net condensation: Fibonacci anyon braiding for universal gates and sampling chromatic polynomials
Realizing string-net condensation: Fibonacci anyon braiding for universal gates and sampling chromatic polynomials Open
The remarkable complexity of a topologically ordered many-body quantum system is encoded in the characteristics of its anyons. Quintessential predictions emanating from this complexity employ the Fibonacci string net condensate (Fib SNC) a…
View article: [Retracted] lncRNA‑MIAT regulates cell biological behaviors in gastric cancer through a mechanism involving the miR‑29a‑3p/HDAC4 axis
[Retracted] lncRNA‑MIAT regulates cell biological behaviors in gastric cancer through a mechanism involving the miR‑29a‑3p/HDAC4 axis Open
Following the publication of the above article, a concerned reader drew to the Editor's attention that, regarding the cell invasion assay data shown in Fig. 2B on p. 3469, the 'si‑NC (SGC7901)' and 'si‑NC (MGC803)' data panels appeared to …
View article: Subthalamic Nucleus Oscillatory Characteristics in Meige, Cervical Dystonia and Generalized Dystonia
Subthalamic Nucleus Oscillatory Characteristics in Meige, Cervical Dystonia and Generalized Dystonia Open
Objective Deep brain stimulation offers a unique opportunity to record neural activity of the basal ganglia. While much work in dystonia has focused on the globus pallidus internus, expanding research to investigate subthalamic nucleus (ST…
View article: Activation Metrics for Structural Connectivity Recruitment in Deep Brain Stimulation
Activation Metrics for Structural Connectivity Recruitment in Deep Brain Stimulation Open
Comparatively high excitability of myelinated fibers suggests that they represent a major mediator of deep brain stimulation effects. Such effects can be modeled using different levels of abstraction, ranging from simple electric field est…
View article: Activation metrics for structural connectivity recruitment in deep brain stimulation
Activation metrics for structural connectivity recruitment in deep brain stimulation Open
Comparatively high excitability of myelinated fibres suggests that they represent a major mediator of deep brain stimulation effects. Such effects can be modelled using different levels of abstraction, ranging from simple electric field es…
View article: Circuit-based Evidence and Practice of Neuromodulation for Obsessive-Compulsive Disorder: Towards the Optimal Neural Circuit
Circuit-based Evidence and Practice of Neuromodulation for Obsessive-Compulsive Disorder: Towards the Optimal Neural Circuit Open
Obsessive-Compulsive Disorder (OCD) is characterized by persistent intrusive thoughts and compulsive behaviors that are often resistant to traditional treatment methods such as medication and psychotherapy. Neuromodulation, targeting speci…
View article: Pallidal Versus Subthalamic Deep-Brain Stimulation for Generalized Isolated Dystonia: A Retrospective Study
Pallidal Versus Subthalamic Deep-Brain Stimulation for Generalized Isolated Dystonia: A Retrospective Study Open
Objectives: Deep-brain stimulation (DBS) has been used for the treatment of medically refractory dystonia with excellent results. In this study, we compared in detail the therapeutic advantages of two DBS targets for generalized isolated d…
View article: Pan‐cancer analysis of <scp>SERPINE1</scp> with a concentration on immune therapeutic and prognostic in gastric cancer
Pan‐cancer analysis of <span>SERPINE1</span> with a concentration on immune therapeutic and prognostic in gastric cancer Open
The serine protease inhibitor clade E member 1 (SERPINE1) is a key modulator of the plasminogen/plasminase system and has been demonstrated to promote tumor progression and metastasis in various tumours. However, although much literature h…
View article: Dopamine and deep brain stimulation accelerate the neural dynamics of volitional action in Parkinson's disease
Dopamine and deep brain stimulation accelerate the neural dynamics of volitional action in Parkinson's disease Open
The ability to initiate volitional action is fundamental to human behaviour. Loss of dopaminergic neurons in Parkinson's disease is associated with impaired action initiation, also termed akinesia. Both dopamine and subthalamic deep brain …
View article: Subthalamic and pallidal oscillations and their couplings reflect dystonia severity and improvements by deep brain stimulation
Subthalamic and pallidal oscillations and their couplings reflect dystonia severity and improvements by deep brain stimulation Open
Beyond pallidal theta power, subthalamic beta power, STN-GPi couplings in theta and beta bands, play a crucial role in understanding the pathophysiological mechanism of dystonia and developing optimal strategies for DBS.
View article: Comparison of children and adults in deep brain stimulation for Tourette Syndrome: a large-scale multicenter study of 102 cases with long-term follow-up
Comparison of children and adults in deep brain stimulation for Tourette Syndrome: a large-scale multicenter study of 102 cases with long-term follow-up Open
Background Deep brain stimulation (DBS) is a promising therapy for refractory Gilles de la Tourette syndrome (GTS). However, its long-term efficacy, safety, and recommended surgical age remain controversial, requiring evidence to compare d…
View article: Generalized sleep decoding with basal ganglia signals in multiple movement disorders
Generalized sleep decoding with basal ganglia signals in multiple movement disorders Open
Sleep disturbances profoundly affect the quality of life in individuals with neurological disorders. Closed-loop deep brain stimulation (DBS) holds promise for alleviating sleep symptoms, however, this technique necessitates automated slee…
View article: Contribution of basal ganglia activity to REM sleep disorder in Parkinson’s disease
Contribution of basal ganglia activity to REM sleep disorder in Parkinson’s disease Open
Background Rapid eye movement (REM) sleep behaviour disorder (RBD) is one of the most common sleep problems and represents a key prodromal marker in Parkinson’s disease (PD). It remains unclear whether and how basal ganglia nuclei, structu…
View article: Temporal interference stimulation targets deep primate brain
Temporal interference stimulation targets deep primate brain Open
Temporal interference (TI) stimulation, a novel non-invasive stimulation strategy, has recently been shown to modulate neural activity in deep brain regions of living mice. Yet, it is uncertain if this method is applicable to larger brains…
View article: Relationship between the College Student and the Campus Club: An Evolutionary Game Theory Analysis
Relationship between the College Student and the Campus Club: An Evolutionary Game Theory Analysis Open
In this paper, we use an evolutionary game theory approach to build a relationship model of students and clubs for the purpose of improving student enthusiasm for participating in club activities. First, the process of the model building i…
View article: The Related Factors and Effect of Electrode Displacement on Motor Outcome of Subthalamic Nuclei Deep Brain Stimulation in Parkinson’s Disease
The Related Factors and Effect of Electrode Displacement on Motor Outcome of Subthalamic Nuclei Deep Brain Stimulation in Parkinson’s Disease Open
Background: Previous studies have revealed the existence of electrode displacement during subthalamic nucleus deep brain stimulation (STN-DBS). However, the effect of electrode displacement on treatment outcomes is still unclear. In this s…
View article: Dopamine and DBS accelerate the neural dynamics of volitional action in Parkinson’s disease
Dopamine and DBS accelerate the neural dynamics of volitional action in Parkinson’s disease Open
The ability to initiate volitional action is fundamental to human behaviour. Loss of dopaminergic neurons in Parkinson’s disease is associated with impaired action initiation, also termed akinesia. Both dopamine and subthalamic deep brain …
View article: Pathological pallidal beta activity in Parkinson’s disease is sustained during sleep and associated with sleep disturbance
Pathological pallidal beta activity in Parkinson’s disease is sustained during sleep and associated with sleep disturbance Open
Parkinson’s disease (PD) is associated with excessive beta activity in the basal ganglia. Brain sensing implants aim to leverage this biomarker for demand-dependent adaptive stimulation. Sleep disturbance is among the most common non-motor…
View article: Pallidal activities during sleep and sleep decoding in dystonia, Huntington's, and Parkinson's disease
Pallidal activities during sleep and sleep decoding in dystonia, Huntington's, and Parkinson's disease Open
Our findings revealed strong sleep-stage dependent distinctions in pallidal oscillations in multiple movement disorders. Pallidal oscillatory features were sufficient for sleep stage decoding. These data may facilitate the development of a…
View article: Closed-Loop Adaptive Deep Brain Stimulation in Parkinson’s Disease: Procedures to Achieve It and Future Perspectives
Closed-Loop Adaptive Deep Brain Stimulation in Parkinson’s Disease: Procedures to Achieve It and Future Perspectives Open
Parkinson’s disease (PD) is a neurodegenerative disease with a heavy burden on patients, families, and society. Deep brain stimulation (DBS) can improve the symptoms of PD patients for whom medication is insufficient. However, current open…
View article: Complete Remission of a Patient With HER-2 amplification Gastric Cancer Treated With Sintilimab Combined With Trastuzumab
Complete Remission of a Patient With HER-2 amplification Gastric Cancer Treated With Sintilimab Combined With Trastuzumab Open
Background Gastric cancer (GC) is one of the most common malignant tumors in China and is also a major cause of cancer deaths worldwide, for which treatment strategies are extremely limited. Patients Susually lose the opportunity of therap…
View article: Association between Cognitive Impairment and Freezing of Gait in Patients with Parkinson’s Disease
Association between Cognitive Impairment and Freezing of Gait in Patients with Parkinson’s Disease Open
Background: Freezing of gait (FOG) is a common disabling symptom in Parkinson’s disease (PD). Cognitive impairment may contribute to FOG. Nevertheless, their correlations remain controversial. We aimed to investigate cognitive differences …