Chuan He
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View article: Nasal-type NK/T-cell lymphoma with concurrent myocardial and central nervous system involvement: A rare case report
Nasal-type NK/T-cell lymphoma with concurrent myocardial and central nervous system involvement: A rare case report Open
Rationale: Extranodal NK/T-cell lymphoma primarily occurs in the nasopharynx, oropharynx and upper gastrointestinal tract. Involvement of the myocardium and central nervous system (CNS) is rare and poses significant diagnostic challenges. …
View article: Ultra-mild bisulfite outperforms existing methods for 5-methylcytosine detection with low input DNA
Ultra-mild bisulfite outperforms existing methods for 5-methylcytosine detection with low input DNA Open
We present Ultra-Mild Bisulfite Sequencing (UMBS-seq), a method for 5-methylcytosine (5mC) detection that minimizes DNA degradation and background noise. UMBS-seq outperforms conventional bisulfite and enzymatic methyl-sequencing (EM-seq) …
View article: N6-methyladenosine regulation of mRNA translation is essential for early human erythropoiesis
N6-methyladenosine regulation of mRNA translation is essential for early human erythropoiesis Open
N6-methyladenosine (m 6 A) is an abundant modification of mRNA with important regulatory roles in normal and malignant hematopoiesis. We previously reported that in human erythroid leukemia (HEL) cells, m 6 A mRNA marking selectively regul…
View article: Nuclear 2′- <i>O</i> -methylation regulates RNA splicing through its binding protein FUBP1
Nuclear 2′- <i>O</i> -methylation regulates RNA splicing through its binding protein FUBP1 Open
2′- O -methylation (N m ) is an abundant RNA modification exists on different mammalian RNA species. However, potential N m recognition by proteins has not been extensively explored. Here, we used RNA affinity purification, followed by mas…
View article: Single-base m <sup>6</sup> A epitranscriptomics reveals novel HIV-1 host interaction targets in primary CD4 <sup>+</sup> T cells
Single-base m <sup>6</sup> A epitranscriptomics reveals novel HIV-1 host interaction targets in primary CD4 <sup>+</sup> T cells Open
N 6 -methyladenosine (m 6 A) plays a critical role in regulating RNA Ostability, localization, and gene expression. m 6 A modification is also important for modulating the expression of viral and cellular genes during HIV-1 infection. Howe…
View article: Ultra-mild bisulfite outperforms existing methods for 5-methylcytosine detection with low input DNA
Ultra-mild bisulfite outperforms existing methods for 5-methylcytosine detection with low input DNA Open
We present Ultra-Mild Bisulfite Sequencing (UMBS-seq), a method for 5-methylcytosine (5mC) detection that minimizes DNA degradation and background noise. UMBS-seq outperforms conventional bisulfite and enzymatic methyl-sequencing (EM-seq) …
View article: Quantitative CRACI reveals transcriptome-wide distribution of RNA dihydrouridine at base resolution
Quantitative CRACI reveals transcriptome-wide distribution of RNA dihydrouridine at base resolution Open
Dihydrouridine (D) is an abundant RNA modification, yet its roles in mammals remain poorly understood due to limited detection methods. We even do not have a comprehensive profile of D site location and modification stoichiometry in tRNA. …
View article: Arginine methylation-dependent METTL14-SMN interaction regulates RNA m6A homeostasis
Arginine methylation-dependent METTL14-SMN interaction regulates RNA m6A homeostasis Open
N6-methyladenosine (m 6 A) homeostasis is essential for development, and its dysregulation is linked to cancers and neurological disorders. However, the mechanisms regulating m 6 A remain unclear. Here, we identify the survival of motoneur…
View article: Tumor Intrinsic METTL5 Modulates ATF4 Translation to Prevent T Cell‐Induced Ferroptosis in Ovarian Cancer
Tumor Intrinsic METTL5 Modulates ATF4 Translation to Prevent T Cell‐Induced Ferroptosis in Ovarian Cancer Open
Poor clinical responses to immune checkpoint blockade (ICB) observed in ovarian cancer (OC) highlight an unmet need to understand the mechanisms driving immune evasion in this disease. To address this, an integrative analysis is conducted …
View article: LINE1 RNA dysregulation impairs chromatin accessibility in C9ORF72- and TDP-43-linked ALS/FTD
LINE1 RNA dysregulation impairs chromatin accessibility in C9ORF72- and TDP-43-linked ALS/FTD Open
The long interspersed element-1 (LINE1) retrotransposon RNAs are abnormally elevated in various neurodegenerative disorders, but their pathogenic roles remain unclear. Here we investigated the mechanism of LINE1 RNA accumulation and its fu…
View article: Arsenic regulates ALKBH1 abundance and substrate specificity to promote translation and tumorigenicity
Arsenic regulates ALKBH1 abundance and substrate specificity to promote translation and tumorigenicity Open
The mechanisms that underlie arsenic tumorigenicity remain incompletely understood. Here, we show that arsenic regulates the abundance and the demethylase activity of ALKBH1, which, in turn, promotes arsenic-induced skin tumorigenesis. At …
View article: METTL3-mediated m<sup>6</sup>A modification of DNMT1 enhances ovarian cancer progression
METTL3-mediated m<sup>6</sup>A modification of DNMT1 enhances ovarian cancer progression Open
High-grade serous carcinoma (HGSC), the most lethal subtype of ovarian cancer, is often diagnosed at advanced stages owing to its asymptomatic progression and lack of early detection markers. In this study, we identified a critical oncogen…
View article: 5-hydroxymethylcytosine profiles in circulating cell-free DNA associate with disease status in patients with osteosarcoma
5-hydroxymethylcytosine profiles in circulating cell-free DNA associate with disease status in patients with osteosarcoma Open
5-hydroxymethylcytosine (5-hmC) is a marker of open chromatin and active gene expression. We profiled 5-hmC using plasma-derived cell-free DNA (cfDNA) from patients with osteosarcoma to assess its utility as a biomarker of disease status. …
View article: Zeaxanthin augments CD8+ effector T cell function and immunotherapy efficacy
Zeaxanthin augments CD8+ effector T cell function and immunotherapy efficacy Open
The detailed mechanisms underlying the regulatory significance of dietary components in modulating anti-tumor immunity remain largely unknown. Here, we apply a co-culture-based screening approach using a blood nutrient compound library and…
View article: FTO degrader impairs ribosome biogenesis and protein translation in acute myeloid leukemia
FTO degrader impairs ribosome biogenesis and protein translation in acute myeloid leukemia Open
Targeting ribosome biogenesis and protein translation has emerged as a promising avenue for cancer therapy. The fat mass and obesity-associated protein (FTO), an RNA N 6 -methyladenosine (m 6 A) eraser, has been identified as an oncogenic …
View article: Learning Unified User Quantized Tokenizers for User Representation
Learning Unified User Quantized Tokenizers for User Representation Open
Multi-source user representation learning plays a critical role in enabling personalized services on web platforms (e.g., Alipay). While prior works have adopted late-fusion strategies to combine heterogeneous data sources, they suffer fro…
View article: M^2VAE: Multi-Modal Multi-View Variational Autoencoder for Cold-start Item Recommendation
M^2VAE: Multi-Modal Multi-View Variational Autoencoder for Cold-start Item Recommendation Open
Cold-start item recommendation is a significant challenge in recommendation systems, particularly when new items are introduced without any historical interaction data. While existing methods leverage multi-modal content to alleviate the c…
View article: ALKBH1 Drives Tumorigenesis and Drug Resistance via tRNA-decoding Reprogramming and Codon-biased Translation
ALKBH1 Drives Tumorigenesis and Drug Resistance via tRNA-decoding Reprogramming and Codon-biased Translation Open
Cancer cells utilize codon-biased translation to fuel tumorigenesis and drug resistance; however, underlying mechanisms remain poorly understood. In this study, we show that ALKBH1 is overexpressed in acute myeloid leukemia (AML) and essen…
View article: Hydrogen Peroxide Electrosynthesis From Seawater
Hydrogen Peroxide Electrosynthesis From Seawater Open
Hydrogen peroxide (H 2 O 2 ) electrosynthesis via a two‐electron oxygen reduction reaction (2e – ORR) from seawater holds a promising perspective for the marine economy. However, the competitive 4e – ORR pathway and high concentration of C…
View article: Recessive epistasis of a synonymous mutation confers cucumber domestication through epitranscriptomic regulation
Recessive epistasis of a synonymous mutation confers cucumber domestication through epitranscriptomic regulation Open
Synonymous mutations, once known as "silent" mutations, are increasingly attracting the interest of biologists. Although they may affect transcriptional or post-transcriptional processes, their impact on biological traits remains under-inv…
View article: Inflammation-related 5-hydroxymethylation signatures as markers for clinical presentations of coronary artery disease
Inflammation-related 5-hydroxymethylation signatures as markers for clinical presentations of coronary artery disease Open
Our findings suggest that 5hmC modifications in cfDNA reflect CAD-related epigenetic changes and may serve as a promising biomarker for disease stratification. These results provide new insights into the epigenetic landscape of CAD and hig…