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View article: Rationale for Incorporating Short-Term Endpoints in Interim Futility Analysis of Phase 3 Oncology Trials: A Simulation Study
Rationale for Incorporating Short-Term Endpoints in Interim Futility Analysis of Phase 3 Oncology Trials: A Simulation Study Open
Background: Futility analysis is a critical component of phase III oncology trials, enabling early termination of ineffective treatments to save resources and time. However, these interim analyses are often challenged by insufficient data …
View article: MeP Induces Metabolic Disorder and Liver Damage at Human-Relevant Exposure Levels: Role of the Gut Microbiota
MeP Induces Metabolic Disorder and Liver Damage at Human-Relevant Exposure Levels: Role of the Gut Microbiota Open
Methylparaben (MeP) is a widely used preservative found in many consumer products that leads to extensive human exposure. Despite some health concerns, our understanding of MeP's effects on metabolic homeostasis remains limited. This study…
View article: Combined LFS and ConvLSTM to forecast marine heatwaves: a case study
Combined LFS and ConvLSTM to forecast marine heatwaves: a case study Open
View article: A retrospective analysis of unprotected ultraviolet tolerance and influencing factors in 1036 participants evaluating the efficacy of cosmetic sunscreen products
A retrospective analysis of unprotected ultraviolet tolerance and influencing factors in 1036 participants evaluating the efficacy of cosmetic sunscreen products Open
Objective: To more rapidly and accurately obtain minimal erythema dose (MED) and minimal persistent pigment dose (MPPD) values in sun protection testing, we conducted a retrospective exploration of previous test data. Methods: This retrosp…
View article: High plant diversity alleviates the negative effects of nitrogen deposition on soil nitrogen cycling multifunctionality
High plant diversity alleviates the negative effects of nitrogen deposition on soil nitrogen cycling multifunctionality Open
Introduction Changes in plant diversity and increased atmospheric nitrogen deposition independently influence soil nitrogen cycling in terrestrial ecosystems. However, the interactive effects of plant diversity and nitrogen deposition on s…
View article: A Bibliometric Analysis and Systematic Review of Research Advances in In Situ Gel Drug Delivery Systems from 2003 to 2023
A Bibliometric Analysis and Systematic Review of Research Advances in In Situ Gel Drug Delivery Systems from 2003 to 2023 Open
Objective: We aimed analyze research trends in in situ gel drug delivery systems. Methods: Studies from 2003 to 2023 were systematically obtained from the Web of Science database and analyzed using VOSviewer software to evaluate publicatio…
View article: Thermal-hydraulic-mechanical-chemical multiphysics coupling for geothermal energy development
Thermal-hydraulic-mechanical-chemical multiphysics coupling for geothermal energy development Open
View article: Exposure to carcinogenic primary aromatic amines and associated health risks among the Chinese general population: A nationwide biomonitoring study
Exposure to carcinogenic primary aromatic amines and associated health risks among the Chinese general population: A nationwide biomonitoring study Open
Primary aromatic amines (PAAs) are a class of chemicals that are produced in large quantities and used widely. However, studies on internal exposure levels of these chemicals in the general population in China are limited. This study prese…
View article: The Logic of Pan-securitization: A Investigation of the EU’s Resilience Construction Policy
The Logic of Pan-securitization: A Investigation of the EU’s Resilience Construction Policy Open
View article: Improving the Catalytic Activity and Thermostability of Mariniflexile Fucanivorans Fucoidanase by Rational Design
Improving the Catalytic Activity and Thermostability of Mariniflexile Fucanivorans Fucoidanase by Rational Design Open
View article: Characteristics and Mechanisms of Spring Tidal Mixing and Sediment Transport in a Microtidal Funnel-Shaped Estuary
Characteristics and Mechanisms of Spring Tidal Mixing and Sediment Transport in a Microtidal Funnel-Shaped Estuary Open
Information about estuarine mixing and its control of sediment transport is crucial to elucidating the dynamics and evolution of estuaries. Here, the microtidal and funnel-shaped Zhenhai Estuary, located in the southwestern Pearl River Del…
View article: Impact of Anthropogenic Activities on Sedimentary Records in the Lingdingyang Estuary of the Pearl River Delta, China
Impact of Anthropogenic Activities on Sedimentary Records in the Lingdingyang Estuary of the Pearl River Delta, China Open
High-intensity anthropogenic activities have greatly altered the estuarine-shelf depositional processes of sediments, and the intensity and frequency of the impacts of human interventions have far exceeded the natural development of estuar…
View article: Au24Cd Nanoenzyme Coating for Enhancing Electrochemical Sensing Performance of Metal Wire Microelectrodes
Au24Cd Nanoenzyme Coating for Enhancing Electrochemical Sensing Performance of Metal Wire Microelectrodes Open
Dopamine (DA), ascorbic acid (AA), and uric acid (UA) are crucial neurochemicals, and their abnormal levels are involved in various neurological disorders. While electrodes for their detection have been developed, achieving the sensitivity…
View article: Using a Leroux-prior-based conditional autoregression-based strategy to map the short-term association between temperature and bacillary dysentery and its attributable burden in China
Using a Leroux-prior-based conditional autoregression-based strategy to map the short-term association between temperature and bacillary dysentery and its attributable burden in China Open
Background In China, bacillary dysentery (BD) is the third most frequently reported infectious disease, with the greatest annual incidence rate of 38.03 cases per 10,000 person-years. It is well acknowledged that temperature is associated …
View article: Elevated accumulation and distinct migration patterns of neonicotinoids compared to traditional insecticides in South China typical orchard
Elevated accumulation and distinct migration patterns of neonicotinoids compared to traditional insecticides in South China typical orchard Open
The global insecticide market is undergoing significant changes, witnessing a surge in neonicotinoids (NEOs) usage, alongside the persistent application of traditional insecticides, such as organophosphates (OPs), carbamates (CMs) and pyre…
View article: Pu-erh tea theabrownin improves the ovarian function and gut microbiota in laying hens
Pu-erh tea theabrownin improves the ovarian function and gut microbiota in laying hens Open
Studies have reported that theabrownin can moderate the lipid metabolism and intestinal microbiota, thereby affecting the health of humans and model animals, however the research on laying hens is scarce. The present study aimed to investi…
View article: Human Exposure Levels of Volatile Organic Compounds in E-waste Recycling Area: Get Insight into Impacts of Manipulation Mode and Associations with Oxidative Stress Markers
Human Exposure Levels of Volatile Organic Compounds in E-waste Recycling Area: Get Insight into Impacts of Manipulation Mode and Associations with Oxidative Stress Markers Open
There is currently a dearth of evidence regarding the impact of the manipulation mode on human occupational exposure to volatile organic compounds (VOCs) originating from e-waste dismantling. Therefore, 11 VOC metabolites (mVOCs) and four …
View article: From Plastic Waste to Treasure: Selective Upcycling through Catalytic Technologies (Adv. Energy Mater. 41/2023)
From Plastic Waste to Treasure: Selective Upcycling through Catalytic Technologies (Adv. Energy Mater. 41/2023) Open
Plastics Upcycling Innovative catalytic technologies for plastics upcycling into high-value chemicals and fuels are recognized as a pivotal approach in realizing a sustainable carbon cycle. In article number 2302008, Pengfei Wang, Sihui Zh…
View article: A review of sources, pathways, and toxic effects of human exposure to benzophenone ultraviolet light filters
A review of sources, pathways, and toxic effects of human exposure to benzophenone ultraviolet light filters Open
Benzophenone ultraviolet light filters (BPs) are high-production-volume chemicals extensively used in personal care products, leading to widespread human exposure. Given their estrogenic properties, the potential health risks associated wi…
View article: Effects of a lotion containing probiotic ferment lysate as the main functional ingredient on enhancing skin barrier: a randomized, self-control study
Effects of a lotion containing probiotic ferment lysate as the main functional ingredient on enhancing skin barrier: a randomized, self-control study Open
View article: Issue Information
Issue Information Open
Aim and scopeThe aim of the journal since its inception has been the accurate and fast presentation of new data in reproductive immunology.As reproductive immunology evolved from an initially laboratory oriented science toward increasing c…
View article: A New GFSv15 based Climate Model Large Ensemble and Its Application to Understanding Climate Variability, and Predictability
A New GFSv15 based Climate Model Large Ensemble and Its Application to Understanding Climate Variability, and Predictability Open
Data and analysis scripts for figures of Journal article (A New GFSv15 based Climate Model Large Ensemble and Its Application to Understanding Climate Variability, and Predictability)
View article: A New GFSv15 based Climate Model Large Ensemble and Its Application to Understanding Climate Variability, and Predictability
A New GFSv15 based Climate Model Large Ensemble and Its Application to Understanding Climate Variability, and Predictability Open
Data and analysis scripts for figures of Journal article (A New GFSv15 based Climate Model Large Ensemble and Its Application to Understanding Climate Variability, and Predictability)
View article: A New GFSv15 based Climate Model Large Ensemble and Its Application to Understanding Climate Variability, and Predictability
A New GFSv15 based Climate Model Large Ensemble and Its Application to Understanding Climate Variability, and Predictability Open
Data and analysis scripts for figures of Journal article (A New GFSv15 based Climate Model Large Ensemble and Its Application to Understanding Climate Variability, and Predictability)
View article: Insights into Free and Conjugated Forms of Neonicotinoid Insecticides in Human Serum and Their Association with Oxidative Stress
Insights into Free and Conjugated Forms of Neonicotinoid Insecticides in Human Serum and Their Association with Oxidative Stress Open
Following exposure, neonicotinoid insecticides (NEOs) can be metabolized by both Phase I and Phase II reactions catalyzed by human cytochrome P450 enzymes. However, toxicities of parent NEOs and their metabolites are still unclear, and lit…
View article: Changing on the Concentrations of Neonicotinoids in Rice and Drinking Water through Heat Treatment Process
Changing on the Concentrations of Neonicotinoids in Rice and Drinking Water through Heat Treatment Process Open
Neonicotinoids (NEOs) have become the most widely used insecticides in the world since the mid-1990s. According to Chinese dietary habits, rice and water are usually heated before being consumed, but the information about the alteration th…
View article: Changing on the Concentrations of Neonicotinoids in Rice and Drinking Water through Heat Treatment Process
Changing on the Concentrations of Neonicotinoids in Rice and Drinking Water through Heat Treatment Process Open
Neonicotinoids (NEOs) have become the most widely used insecticides in the world since the mid-1990s. According to Chinese dietary habits, rice and water are usually heated before being consumed, but the information about the alteration th…
View article: Issue Information
Issue Information Open
Aim and scopeThe aim of the journal since its inception has been the accurate and fast presentation of new data in reproductive immunology.As reproductive immunology evolved from an initially laboratory oriented science toward increasing c…
View article: Quantitative Identification of the Co-Exposure Effects of E-Waste Pollutants on Human Oxidative Stress by Explainable Machine Learning
Quantitative Identification of the Co-Exposure Effects of E-Waste Pollutants on Human Oxidative Stress by Explainable Machine Learning Open
View article: Changing on the Concentrations of Neonicotinoids in Rice and Drinking Water Through Heating Treatment Process: An Unusual Increase in Imidacloprid
Changing on the Concentrations of Neonicotinoids in Rice and Drinking Water Through Heating Treatment Process: An Unusual Increase in Imidacloprid Open