Explanipedia

Cellular signatures of hybrid immunity underpinning superior mucosal protection 2420 Open

Jinyi Tang, Panke Qu, Pei Li, Yajie Liu, Justin J. Taylor , et al. · 2025

Description Understanding mucosal immunity is vital for designing vaccines against respiratory viruses like SARS-CoV-2. Immunity resulting from vaccination followed by infection may offer superior mucosal protection, yet the underlying mec…

AgentSentinel: An End-to-End and Real-Time Security Defense Framework for Computer-Use Agents Open

Haitao Hu, Peng Chen, Yanpeng Zhao, Yuqi Chen · 2025

Large Language Models (LLMs) have been increasingly integrated into computer-use agents, which can autonomously operate tools on a user's computer to accomplish complex tasks. However, due to the inherently unstable and unpredictable natur…

The Identification of Gyrophoric Acid, a Phytochemical Derived from Lichen, as a Potent Inhibitor for Aggregation of Amyloid Beta Peptide: In Silico and Biochemical Evaluation Open

Meixia Yang, Haitao Hu, Jin Gao, Queenie Wing Sze Lai, Farkhod Eshboev , et al. · 2025

Alzheimer’s disease (AD) is characterized by amyloid-beta (Aβ) plaque accumulation and neurodegeneration. This study identified gyrophoric acid, a lichen-derived phenolic metabolite, as a dual-action Aβ42 inhibitor preventing aggregation a…

The Identification of Gyrophoric Acid, a Phytochemical Derived from Lichen, as a Potent Inhibitor for Aggregation of Amyloid Beta Peptide: In Silico and Biochemical Evaluation Open

Meixia Yang, Haitao Hu, Jin Gao, Queenie Wing Sze Lai, Farkhod Eshboev , et al. · 2025

Alzheimer’s disease (AD) is characterized by amyloid-beta (Aβ) plaque accumulation and neurodegeneration. This study identifies gyrophoric acid, a lichen-derived phenolic metabolite, as a dual-action Aβ42 inhibitor preventing aggregation a…

Water-absorbing bags for high-altitude aerial firefighting: Mathematical modeling and drop pattern analysis Open

Haoran Sun, Chengyun Wu, Dachuan Zhang, Yang Wu, Renyu Hu , et al. · 2025

In-situ investigation of shear force induced solution phase transformation of ABA-type tri-block copolymers Open

Jun Wang, Haofeng Sun, Zhijing Han, Mengjia Dou, Haitao Hu , et al. · 2025

UniMap: Type‐Level Integration Enhances Biological Preservation and Interpretability in Single‐Cell Annotation Open

Haitao Hu, Yue Guo, Fujing Ge, Hao Yin, Hao Zhang , et al. · 2025

Integrating single‐cell datasets from multiple studies provides a cost‐effective way to build comprehensive cell atlases, granting deeper insights into cellular characteristics across diverse biological systems. However, current data integ…

Water-Absorbing Bags for High-Altitude Aerial Firefighting: Mathematical Modeling and Drop Pattern Analysis Open

Haoran Sun, Chengyun Wu, Dachuan Zhang, Yang Wu, Renyu Hu , et al. · 2025

Numerical Model of Methanol Synthesis Process by Co2 Hydrogenation in Compact Reactor with Microchannels Open

Chenxi Pan, Liyu Zhang, Jia Yang, Jinbo Du, Haitao Hu · 2025

Numerical Model of Methanol Synthesis Process by Co2 Hydrogenation in Compact Reactor with Microchannels Open

Chenxi Pan, Liyu Zhang, Jinbo Du, Jia Yang, Haitao Hu · 2025

Glass transition-induced luminescence in ZIF-62 Open

S. F. Yu, Haitao Hu, Yichao Lin, Wen Yang, Ziqi Tian · 2025

Nanoporous ZIF-62 exhibits intense luminescence after the glass transition, due to the disordered rearrangement of ligands.

In-Situ Investigation of Shear Force Induced Phase Transformation of Aba-Type Tri-Block Copolymers Open

Hua Yang, Jun Wang, Haofeng Sun, Zhijing Han, Chunyong He , et al. · 2025

3d Numerical Simulation of Boiling Heat Transfer of Distributed Jet Array Impingement on Metal Foam-Covered Surface Open

Hui Yao, Rui Lei, Xuan Li, Haitao Hu · 2025

Modeling and simulation study of acoustic response for dual-membrane capacitive MEMS microphone Open

Siqi Hu, Haitao Hu, Wei Xue, Daehyeon Kang, Jing Xiao · 2024

As the micro-electro-mechanical systems (MEMS) technology matures, MEMS sensors have found widespread applications in mechatronics, robotics, and voice control. The high stability, high integration, and radio frequency interference resista…

Hepatic Macrophage Migration Inhibitory Factor Promotes Pancreatic Cancer Liver Metastasis in NAFLD Open

Qian Yu, Hui Song, Liang Zhu, Xiao-ya Shi, Haizhen Wang , et al. · 2024

How pathological livers shape tumors, thereby driving pancreatic ductal adenocarcinoma (PDAC) metastasis to the liver, is poorly understood. In the present study, we focus on examining key molecules implicated in this process and assessing…

Elasticity-controlled jamming criticality in soft composite solids Open

Yiqiu Zhao, Haitao Hu, Yulu Huang, Hanqing Liu, Caishan Yan , et al. · 2024

Enhancing Plant Photosynthesis using Carbon Dots as Light Converter and Photosensitizer Open

Haitao Hu, Wenbo Cheng, Xueyun Wang, Yang Yu, Xuemeng Yu , et al. · 2024

Improving photosynthetic efficiency is pivotal for CO 2 -based biomanufacturing and agriculture purposes. Despite the progress on photosynthetic biohybrids integrating biocatalysts with synthetic materials, nanomaterials with improved opti…

SynergyX: a multi-modality mutual attention network for interpretable drug synergy prediction Open

Yue Guo, Haitao Hu, Wenbo Chen, Hao Yin, Jian Wu , et al. · 2024

Discovering effective anti-tumor drug combinations is crucial for advancing cancer therapy. Taking full account of intricate biological interactions is highly important in accurately predicting drug synergy. However, the extremely limited …

Facilely Enhancing the Co2 Adsorption Capacity of Zeolites by Vacuum-Assisted Alkaline Treatment Open

Lihong Shui, Haitao Hu, Yaqi Wu, Ziqi Tian, Yunan Wang , et al. · 2024

Boiling Heat Transfer Characteristics of Distributed Jet Array Impingement on Metal Foam Covered Surface Open

Hui Yao, Xuan Li, Rui Lei, Haitao Hu, Huang Yonghua · 2024

Boiling Heat Transfer Characteristics of Confined Jet Impingement on Metal Foam with Different Structures Open

Hui Yao, Xuan Li, Rui Lei, Haitao Hu, Huang Yonghua · 2024

Numerical Analysis of Pool Boiling on Copper Foam in the Presence of External Circulation Open

Haitao Hu, Song Deng, Kun He, Side Ren · 2024

Next-Generation Vaccines Against COVID-19 Variants: Beyond the Spike Protein Open

Srinivasa Reddy Bonam, Haitao Hu · 2023

Vaccines are among the most effective medical countermeasures against infectious diseases. The current Coronavirus disease 2019 (COVID-19) pandemic, caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), has spurred the sc…

Recent Advances in the Lipid Nanoparticle-Mediated Delivery of mRNA Vaccines Open

K Swetha, Niranjan G. Kotla, Lakshmi Tunki, Arya Jayaraj, Suresh K. Bhargava , et al. · 2023

In the recent days, lipid nanoparticles have been successfully emerged as one of the most advanced technology for highly efficient in vivo delivery of exogenous mRNA, especially for delivery of COVID-19 vaccines. For the vaccines to be suc…

Multi-Layer Deep Sparse Representation for Biological Slice Image Inpainting Open

Haitao Hu, Hongmei Ma, Shuli Mei · 2023

Biological slices are an effective tool for studying the physiological structure and evolution mechanism of biological systems. However, due to the complexity of preparation technology and the presence of many uncontrollable factors during…

“Artificial Intelligence + Arbitration”: Research on the Implementation Path of Driven Intelligent Arbitration Open

Haitao Hu, Pinxiao Guan, Jiyao Lv, Yifan Xing, Linlin Li , et al. · 2022

With the advent of artificial intelligence technology and big data era, artificial intelligence technology continues to expand its application scope.Against this background, artificial intelligence law emerges.In China and beyond, the arti…

Protective effects of leonurine hydrochloride on pyroptosis in premature ovarian insufficiency via regulating NLRP3/GSDMD pathway Open

Yan-Nan Chi, Dong-Mei Hai, Lin Ma, Yanhong Cui, Haitao Hu , et al. · 2022

Intraperitoneal administration of leonurine hydrochloride prevents cyclophosphamide-induced premature ovarian insufficiency in mice by inhibiting NLRP3/GSDMD-mediated pyroptosis.

Non-monotonic Rheology and Stress Heterogeneity in confined Granular suspensions Open

Haitao Hu, Yiqiu Zhao, Weiwei Zhao, Xu Qin · 2022

We systematically investigated the impact of boundary confinement on the shear-thickening rheology of dense granular suspensions. Under highly confined conditions, dense suspensions were found to exhibit size-dependent or even rarely repor…

Viral Metagenomics Identifies a Novel Recombinant Murine Astrovirus from Rattus norvegicus in Jiangsu, China Open

Wang Li, Xin Li, Haitao Hu, Juan Xu, Jin Qian , et al. · 2022

Murine astrovirus (MuAstV) is widespread infection among wild and laboratory rats (Rattus norvegicus) and mice (Mus musculus). In this study, using viral metagenomics method, a near-complete genome of astrovirus isolate, named TZ-AST, was …

Analysis of low production coalbed methane wells and application of secondary reconstruction technologies Open

Yong Li, Haitao Hu, Yanbin Wang, Wenlong Han, Wu Xiang , et al. · 2022

Most coalbed methane reservoirs in China are of low porosity, low permeability and with extensive structural coals, which is difficult to be reformed, resulting in low single well gas production and recovery rates.It is the the key target …

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