Yan Zhuang
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View article: Night shift work increases the risk of developing irritable bowel syndrome: a prospective cohort study in the UK Biobank
Night shift work increases the risk of developing irritable bowel syndrome: a prospective cohort study in the UK Biobank Open
Background Irritable bowel syndrome (IBS) is a functional gastrointestinal disorder associated with a substantial disease burden. Night shift work has become increasingly common and is related to various human diseases. This study investig…
View article: Geographic disparities in inpatient service in primary care and patients' choice of first point of consultation: a linked cross-sectional survey and administrative data analysis in Shaanxi of China
Geographic disparities in inpatient service in primary care and patients' choice of first point of consultation: a linked cross-sectional survey and administrative data analysis in Shaanxi of China Open
Our findings suggest that inpatient service in primary care enhancement exhibits heterogeneous effects on FPC rates across China's geographic and socioeconomic strata. Policy prioritization should focus on targeted interventions in underse…
View article: Machine learning integration with multi-omics data constructs a robust prognostic model and identifies PTGES3 as a therapeutic target for precision oncology in lung adenocarcinoma
Machine learning integration with multi-omics data constructs a robust prognostic model and identifies PTGES3 as a therapeutic target for precision oncology in lung adenocarcinoma Open
Background Lung adenocarcinoma is the most prevalent lung cancer type, with a 5-year survival rate for advanced patients below 20%. This study aims to develop a risk model to guide treatment for these patients. Materials and methods RNA-se…
View article: Screening for individuals with postpartum depression by an attenuated and delayed niacin skin flushing response: a case control study
Screening for individuals with postpartum depression by an attenuated and delayed niacin skin flushing response: a case control study Open
Background Postpartum depression (PPD) affects maternal mental health extensively and is challenged by the lack of objective diagnostic methods. This study aimed to explore the characteristics of niacin skin flush response, a diagnostic ma…
View article: Integration of autophagy-related genes and immune dysregulation reveals a prognostic landscape in multiple myeloma
Integration of autophagy-related genes and immune dysregulation reveals a prognostic landscape in multiple myeloma Open
Background Autophagy is a self-renewal mechanism in which cells degrade damaged organelles or abnormal proteins through lysosomes. This process eliminates harmful components within the cell and maintains energy homeostasis. Multiple myelom…
View article: Strengthening financial protection through multitiered health coverage: evidence from 667 055 low-income households in China
Strengthening financial protection through multitiered health coverage: evidence from 667 055 low-income households in China Open
Introduction Low-income households face disproportionate out-of-pocket hardship when accessing healthcare, undermining equity and universal health coverage. To address these challenges, China implemented a three-tiered health coverage syst…
View article: Impact of chemical reactions on convective and diffusive transport of dissolved CO2 in saline aquifers
Impact of chemical reactions on convective and diffusive transport of dissolved CO2 in saline aquifers Open
View article: Plasma Soluble ST2 as a Prognostic Biomarker for Cardiovascular Events and Mortality in COVID-19 Patients
Plasma Soluble ST2 as a Prognostic Biomarker for Cardiovascular Events and Mortality in COVID-19 Patients Open
Background: Coronavirus disease 2019 (COVID-19) is frequently complicated by cardiovascular involvement. Soluble growth stimulation-expressed gene 2 (sST2) is a promising cardiovascular biomarker, but its prognostic value in COVID-19 remai…
View article: Investigation of structural, electronic, mechanical, and optical properties of Nd-based oxide-perovskites NdXO<sub>3</sub> (X = Ge, Zr, Sc): A DFT study
Investigation of structural, electronic, mechanical, and optical properties of Nd-based oxide-perovskites NdXO<sub>3</sub> (X = Ge, Zr, Sc): A DFT study Open
This study comprehensively investigated simple cubic oxide perovskite’s structural, electronic, including total and partial density of states, optical and mechanical properties. We also performed the charge density, electron density differ…
View article: Differential expression of capecitabine-related metabolic enzymes in hepatocellular carcinoma and its clinical value: a retrospective cohort study
Differential expression of capecitabine-related metabolic enzymes in hepatocellular carcinoma and its clinical value: a retrospective cohort study Open
View article: 146 | PHASE 1/2 STUDIES OF DZD8586 IN CLL/SLL PATIENTS AFTER COVALENT OR NON‐COVALENT BTK INHIBITORS AND BTK DEGRADERS
146 | PHASE 1/2 STUDIES OF DZD8586 IN CLL/SLL PATIENTS AFTER COVALENT OR NON‐COVALENT BTK INHIBITORS AND BTK DEGRADERS Open
View article: The association between lipid accumulation products and bone mineral density in U.S. Adults, a nationally representative cross-sectional study
The association between lipid accumulation products and bone mineral density in U.S. Adults, a nationally representative cross-sectional study Open
LAP (lipid accumulation products) is a new indicator that estimates lipid overaccumulation and central obesity in our bodies. Nevertheless, the relationship of LAP with bone mineral density (BMD) has not been well established. This study a…
View article: 5-O-Methylvisammioside inhibits HMGB1-induced Angiogenesis of hepatocellular carcinoma through RAGE/MEK/ERK signaling pathway
5-O-Methylvisammioside inhibits HMGB1-induced Angiogenesis of hepatocellular carcinoma through RAGE/MEK/ERK signaling pathway Open
5-O-Methylvisammioside (5OMV), a flavonol compound derived from the traditional Chinese medicine plant Saposhnikovia divaricat , has been shown to inhibit vasospasm induced by High Mobility Group Box 1 (HMGB1) protein. However, its therape…
View article: Leveraging a disulfidptosis-based signature to characterize heterogeneity and optimize treatment in multiple myeloma
Leveraging a disulfidptosis-based signature to characterize heterogeneity and optimize treatment in multiple myeloma Open
Background Disulfidptosis is an emerging type of programmed cell death related to ROS accumulation and aberrant disulfide bond formation. Multiple myeloma (MM) is the second most prevalent hematologic malignancy characterized by a high syn…
View article: WITHDRAWN: hsa-miR-4498 and hsa-miR-95-5p in plasma exosomes as potential early biomarkers for metabolic bone disease of prematurity
WITHDRAWN: hsa-miR-4498 and hsa-miR-95-5p in plasma exosomes as potential early biomarkers for metabolic bone disease of prematurity Open
View article: Detection and co-occurrence of Acanthamoeba and Klebsiella pneumoniae in freshwater river systems of Taichung, Taiwan
Detection and co-occurrence of Acanthamoeba and Klebsiella pneumoniae in freshwater river systems of Taichung, Taiwan Open
This research demonstrates that Acanthamoeba and K. pneumoniae are both prevalent in the freshwater ecosystems of Taichung, Taiwan, with notable instances of co-occurrence. Although environmental parameters such as temperature and pH did n…
View article: Characteristic analysis and surgical exploration for acetabular roof fractures: Multicenter retrospective cohort study
Characteristic analysis and surgical exploration for acetabular roof fractures: Multicenter retrospective cohort study Open
Background Acetabular roof was a crucial structure for maintaining the stability of hip joint; however, its important role was not especially emphasized in the Letournel-Judet classification system. Acetabular roof was segmented into the r…
View article: Formononetin Affects Polarization of M2 Macrophages Through the Jak2/Stat3 Pathway in Hcc
Formononetin Affects Polarization of M2 Macrophages Through the Jak2/Stat3 Pathway in Hcc Open
View article: Novel Histopathology-DNA Methylation Combined Approach for Predicting Lymph Node Metastasis in Papillary Thyroid Carcinoma: A Prospective Study with Superior Performance
Novel Histopathology-DNA Methylation Combined Approach for Predicting Lymph Node Metastasis in Papillary Thyroid Carcinoma: A Prospective Study with Superior Performance Open
View article: The Novel Navigation‐Assisted Surgery Increases Financial Burden of Patients Suffering Tile Types B and C Pelvic Fractures in China
The Novel Navigation‐Assisted Surgery Increases Financial Burden of Patients Suffering Tile Types B and C Pelvic Fractures in China Open
Background Studies demonstrating whether patients with pelvic fractures can benefit from robotic technology in terms of financial burden are lacking. This study was aimed at comparing the financial burden of navigation‐assisted and convent…
View article: Investigation of Mechanical Response Characteristics of 3D-Printed Composite Energetic Material with Advanced Grid Structures
Investigation of Mechanical Response Characteristics of 3D-Printed Composite Energetic Material with Advanced Grid Structures Open
View article: A study of the changing characteristics and influencing factors of holiday visitor vitality in Urban parks: The case of Fuzhou, China
A study of the changing characteristics and influencing factors of holiday visitor vitality in Urban parks: The case of Fuzhou, China Open
The vitality of urban parks reflects the intensity of green space utilization, gauging visitors’ overall perception of the parks, facilitating integrated park management, and ensuring the parks’ sustainable development. But, the park’s spa…
View article: Thymosin α1 reverses oncolytic adenovirus-induced M2 polarization of macrophages to improve antitumor immunity and therapeutic efficacy
Thymosin α1 reverses oncolytic adenovirus-induced M2 polarization of macrophages to improve antitumor immunity and therapeutic efficacy Open
View article: Fibrinogen dysfunction and fibrinolysis state in patients with hepatitis B-related cirrhosis
Fibrinogen dysfunction and fibrinolysis state in patients with hepatitis B-related cirrhosis Open
Sialylation of fibrinogen is one of the main causes of modifications of fibrinogen in patients with hepatitis B-related cirrhosis. The polymerization and fibrinolysis functions of fibrinogen are impaired. The degree of impaired fibrinolysi…
View article: Dynamic observation and risk factors analysis of deep vein thrombosis after hip fracture
Dynamic observation and risk factors analysis of deep vein thrombosis after hip fracture Open
Objective To dynamically observe the occurrence of deep vein thrombosis (DVT) after a hip fracture and analyze of the risk factors affecting the dynamic alteration of DVT. Methods Data of patients with hip fractures from January 1, 2017 to…
View article: Identification and validation of a platelet-related signature for predicting survival and drug sensitivity in multiple myeloma
Identification and validation of a platelet-related signature for predicting survival and drug sensitivity in multiple myeloma Open
Background: Significant progress has been achieved in the management of multiple myeloma (MM) by implementing high-dose therapy and stem cell transplantation. Moreover, the prognosis of patients has been enhanced due to the introduction of…
View article: Assessing the causal relationship between CRP,IL-1α, IL-1β, and IL-6 levels and intervertebral discdegeneration: a two-sample Mendelianrandomization study
Assessing the causal relationship between CRP,IL-1α, IL-1β, and IL-6 levels and intervertebral discdegeneration: a two-sample Mendelianrandomization study Open
Growing research has suggested an association between chronic inflammation and Intervertebral disc degeneration (IVDD),but whether there is a causal effect remains unknown. This study adopted two-sample Mendelian randomization (MR) approac…
View article: Risk analysis of air pollutants and types of anemia: a UK Biobank prospective cohort study
Risk analysis of air pollutants and types of anemia: a UK Biobank prospective cohort study Open
Background: Previous studies have suggested that exposure to air pollutants may be associated with specific blood indicators or anemia in certain populations. However, there is insufficient epidemiological data and prospective evidence to …
View article: Intrinsic Mechanism of Water-Shale Interaction Induced Structural Changes
Intrinsic Mechanism of Water-Shale Interaction Induced Structural Changes Open
View article: Mechanism of Microfracture Propagation Under Force-Chemical Coupling Conditions Considering Dissolution
Mechanism of Microfracture Propagation Under Force-Chemical Coupling Conditions Considering Dissolution Open