Zhuobin Liang
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View article: Modular Nano-Scaffold Biocatalysis for Superior PET Depolymerization and Valorization
Modular Nano-Scaffold Biocatalysis for Superior PET Depolymerization and Valorization Open
The global crisis of polyethylene terephthalate (PET) waste demands innovative solutions for sustainable management. Current approaches are often inefficient, energy-intensive, and result in incomplete depolymerization. Here, we introduce …
View article: Impacts of graphene oxide contamination on a food web: Threats to somatic and reproductive health of organisms
Impacts of graphene oxide contamination on a food web: Threats to somatic and reproductive health of organisms Open
Contamination of aquatic food webs with nanomaterials poses a significant ecological and human health challenge. Ingestion of nanomaterials alongside food disrupts digestion and impairs physiological processes, with potential consequences …
View article: Human iPSCs-based modeling unveils chromatin remodeling induced by SETBP1 mutation as a potential initiating factor in GATA2 deficiency
Human iPSCs-based modeling unveils chromatin remodeling induced by SETBP1 mutation as a potential initiating factor in GATA2 deficiency Open
Patients with GATA2 deficiency are predisposed to developing myelodysplastic syndrome (MDS), which can progress to acute myeloid leukemia (AML). This progression is often associated with the acquisition of additional cytogenetic and somati…
View article: The FANCI/FANCD2 complex links DNA damage response to R-loop regulation through SRSF1-mediated mRNA export
The FANCI/FANCD2 complex links DNA damage response to R-loop regulation through SRSF1-mediated mRNA export Open
Fanconi anemia (FA) is characterized by congenital abnormalities, bone marrow failure, and cancer susceptibility. The central FA protein complex FANCI/FANCD2 (ID2) is activated by monoubiquitination and recruits DNA repair proteins for int…
View article: Metagenomics harvested genus-specific single-stranded DNA-annealing proteins improve and expand recombineering in <i>Pseudomonas</i> species
Metagenomics harvested genus-specific single-stranded DNA-annealing proteins improve and expand recombineering in <i>Pseudomonas</i> species Open
The widespread Pseudomonas genus comprises a collection of related species with remarkable abilities to degrade plastics and polluted wastes and to produce a broad set of valuable compounds, ranging from bulk chemicals to pharmaceuticals. …
View article: Recent advances in genome-scale engineering in Escherichia coli and their applications
Recent advances in genome-scale engineering in Escherichia coli and their applications Open
Owing to the rapid advancement of genome engineering technologies, the scale of genome engineering has expanded dramatically. Genome editing has progressed from one genomic alteration at a time that could only be employed in few species, t…
View article: Extracellular vesicles biogenesis, isolation, manipulation and genetic engineering for potential in vitro and in vivo therapeutics: An overview
Extracellular vesicles biogenesis, isolation, manipulation and genetic engineering for potential in vitro and in vivo therapeutics: An overview Open
The main goals of medicine consist of early detection and effective treatment of different diseases. In this regard, the rise of exosomes as carriers of natural biomarkers has recently attracted a lot of attention and managed to shed more …
View article: An overview on the reproductive toxicity of graphene derivatives: Highlighting the importance
An overview on the reproductive toxicity of graphene derivatives: Highlighting the importance Open
With the glorious discovery of graphene back in 2004, the field of nanotechnology was faced with a breakthrough that soon attracted the attention of many scientists from all over the world. Owing to its unique bidimensional structure and e…
View article: Optimization of Triarylpyridinone Inhibitors of the Main Protease of SARS-CoV-2 to Low-Nanomolar Antiviral Potency
Optimization of Triarylpyridinone Inhibitors of the Main Protease of SARS-CoV-2 to Low-Nanomolar Antiviral Potency Open
Non-covalent inhibitors of the main protease (Mpro) of SARS-CoV-2 having a pyridinone core were previously reported with IC50 values as low as 0.018 μM for inhibition of enzymatic activity and EC50 values as low as 0.8 μM for inhibition of…
View article: Potent Noncovalent Inhibitors of the Main Protease of SARS-CoV-2 from Molecular Sculpting of the Drug Perampanel Guided by Free Energy Perturbation Calculations
Potent Noncovalent Inhibitors of the Main Protease of SARS-CoV-2 from Molecular Sculpting of the Drug Perampanel Guided by Free Energy Perturbation Calculations Open
Starting from our previous finding of 14 known drugs as inhibitors of the main protease (Mpro) of SARS-CoV-2, the virus responsible for COVID-19, we have redesigned the weak hit perampanel to yield multiple noncovalent, nonpeptidic inhibit…
View article: Advanced eMAGE for highly efficient combinatorial editing of a stable genome
Advanced eMAGE for highly efficient combinatorial editing of a stable genome Open
Eukaryotic multiplex genome engineering (eMAGE) offers a powerful tool to generate precise combinatorial genome modifications in Saccharomyces cerevisiae . We optimize the design of synthetic oligonucleotides and enrichment of edited popul…
View article: RAD52 is required for RNA-templated recombination repair in post-mitotic neurons
RAD52 is required for RNA-templated recombination repair in post-mitotic neurons Open
It has been long assumed that post-mitotic neurons only utilize the error-prone non-homologous end-joining pathway to repair double-strand breaks (DSBs) associated with oxidative damage to DNA, given the inability of non-replicating neuron…
View article: Overhang polarity of chromosomal double-strand breaks impacts kinetics and fidelity of yeast non-homologous end joining
Overhang polarity of chromosomal double-strand breaks impacts kinetics and fidelity of yeast non-homologous end joining Open
Non-homologous end joining (NHEJ) is the main repair pathway for DNA double-strand breaks (DSBs) in cells with limited 5' resection. To better understand how overhang polarity of chromosomal DSBs affects NHEJ, we made site-specific 5'-over…
View article: Rejoining of DNA Double-Strand Breaks and Genome Stability: From Host-Pathogen Interactions to Break-Induced Mutagensis.
Rejoining of DNA Double-Strand Breaks and Genome Stability: From Host-Pathogen Interactions to Break-Induced Mutagensis. Open
An essential task for cell survival is the maintenance of genome stability despite various environmental and physiological stresses. These stresses, such as UV light and ionizing radiation, often damage DNA and result in various types of D…