Zhuojun He
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View article: Bacteriophage therapy targeting microbiome in HIV/AIDS
Bacteriophage therapy targeting microbiome in HIV/AIDS Open
Despite antiretroviral therapy (ART) effectively suppressing viral replication and reducing transmission risk, human immunodeficiency virus (HIV) infection still sustains cycles of chronic inflammation, immune dysfunction, and dysbiosis of…
View article: Antibacterial Cu-doped cotton textile against respiratory pathogens for preventing hospital-acquired infections
Antibacterial Cu-doped cotton textile against respiratory pathogens for preventing hospital-acquired infections Open
Respiratory pathogens transmitted via clinical textiles represent a major source of hospital-acquired infections, yet current antibacterial fabric strategies are limited by poor durability and weak bacterial inhibition. Here, we reported a…
View article: Ultra-sensitive in situ detection of intracellular Mycobacterium tuberculosis with CRISPR/Cas12a
Ultra-sensitive in situ detection of intracellular Mycobacterium tuberculosis with CRISPR/Cas12a Open
Mycobacterium tuberculosis ( Mtb ) invades and survives inside macrophages, evading detection and resisting antibiotic treatment, which results in severe clinical consequences such as fatal respiratory failure and systemic inflammation. Ra…
View article: Development of a novel cholesterol tag-based system for trans-membrane transport of protein drugs
Development of a novel cholesterol tag-based system for trans-membrane transport of protein drugs Open
The main technological difficulties of developing an intracellular (transmembrane) transport system for protein drugs lie in two points: i) overcoming the barriers in the cellular membrane, and ii) loading enough protein drugs, and particu…
View article: Devising novel near-infrared aggregation-induced-emission luminogen labeling for point-of-care diagnosis of <i>Mycobacterium tuberculosis </i>
Devising novel near-infrared aggregation-induced-emission luminogen labeling for point-of-care diagnosis of <i>Mycobacterium tuberculosis </i> Open
Detecting and appropriately diagnosing a Mycobacterium tuberculosis infection remains technologically difficult because the pathogen commonly hides in macrophages in a dormant state. Described here is novel near-infrared aggregation-induce…
View article: A cytoderm metabolic labeling AIEgen for rapid detection and intracellular ablation of Mycobacterium tuberculosis
A cytoderm metabolic labeling AIEgen for rapid detection and intracellular ablation of Mycobacterium tuberculosis Open
Latent Mycobacterium tuberculosis (Mtb) shielded in macrophages is hard to detect and eradicate, causing lethal respiratory failure and systemic inflammation. Here, we synthesize an aggregation-induced emission luminogen (AIEgen) with meta…