Ziyu Chen
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View article: Reply to the comment on “Clinicopathological features and prognostic value of CD276 expression in head and neck cancer: A meta-analysis”
Reply to the comment on “Clinicopathological features and prognostic value of CD276 expression in head and neck cancer: A meta-analysis” Open
View article: Sappanchalcone suppresses NSCLC by oxidative stress-driven DNA damage and ER stress activation through PIEZO1 modulation
Sappanchalcone suppresses NSCLC by oxidative stress-driven DNA damage and ER stress activation through PIEZO1 modulation Open
View article: Sex-specific role of body weight in mediating stress susceptibility through MeA Tac2-Nk3R signaling
Sex-specific role of body weight in mediating stress susceptibility through MeA Tac2-Nk3R signaling Open
Weight fluctuations, such as weight loss or gain, are hallmark features of major depression. However, the potential bidirectional relationship between body weight and depressive-like behaviors remains poorly understood. While the prevalenc…
View article: 977 The discovery and development of a cyno cross-reactive CD3 VHH antibody platform to optimize the development of T cell engagers for oncology and autoimmune diseases
977 The discovery and development of a cyno cross-reactive CD3 VHH antibody platform to optimize the development of T cell engagers for oncology and autoimmune diseases Open
View article: InstantSfM: Fully Sparse and Parallel Structure-from-Motion
InstantSfM: Fully Sparse and Parallel Structure-from-Motion Open
Structure-from-Motion (SfM), a method that recovers camera poses and scene geometry from uncalibrated images, is a central component in robotic reconstruction and simulation. Despite the state-of-the-art performance of traditional SfM meth…
View article: The complex interplay between diabetes mellitus and pancreatic carcinogenesis: deciphering multifactorial mechanisms and identifying emerging therapeutic vulnerabilities
The complex interplay between diabetes mellitus and pancreatic carcinogenesis: deciphering multifactorial mechanisms and identifying emerging therapeutic vulnerabilities Open
View article: An Eye-Tracking Study on the Impact of Green Consumption Values on the Purchase Intention of Bamboo Products Under the Background of “Replacing Plastic with Bamboo”
An Eye-Tracking Study on the Impact of Green Consumption Values on the Purchase Intention of Bamboo Products Under the Background of “Replacing Plastic with Bamboo” Open
Despite extensive research on green consumption, consumer purchase intentions for bamboo products under China’s “replacing plastic with bamboo” policy remain underexplored, given growing plastic pollution concerns. Research remains focused…
View article: TMEM158-mediated TGF-β signaling pathway modulates the sensitivity of TP53-deficient osteosarcoma to USP14 inhibitors
TMEM158-mediated TGF-β signaling pathway modulates the sensitivity of TP53-deficient osteosarcoma to USP14 inhibitors Open
Background Previous studies have demonstrated that the USP14 inhibitor IU1 and USP14/UCHL5 inhibitor b-AP15 can extend the survival period of TP53-deficient mice with spontaneous osteosarcoma (OS). However, the underlying molecular mechani…
View article: Aspects of harmonic emission in the attoclock
Aspects of harmonic emission in the attoclock Open
We study the emission of below-threshold harmonics from atoms in strong near-circular laser fields numerically and analytically. The calculated harmonic spectrum shows a double-plateau structure with two cutoffs. When the position of the s…
View article: Electrochemiluminescent devices: Structural composition, preparation process and applications for flexible/stretchable displays
Electrochemiluminescent devices: Structural composition, preparation process and applications for flexible/stretchable displays Open
View article: EZH2 in non-cancerous diseases: expanding horizons
EZH2 in non-cancerous diseases: expanding horizons Open
Enhancer of Zeste homolog 2 (EZH2), a histone methyltransferase within polycomb repressive complex 2 (PRC2), plays a crucial role in epigenetic regulation by silencing gene expression through trimethylation of histone 3 at lysine 27 (H3K27…
View article: Author Correction: Knockdown of LncRNA MEG3 promotes damage of vascular endothelial cells induced by vibration
Author Correction: Knockdown of LncRNA MEG3 promotes damage of vascular endothelial cells induced by vibration Open
View article: Knockdown of LncRNA MEG3 promotes damage of vascular endothelial cells induced by vibration
Knockdown of LncRNA MEG3 promotes damage of vascular endothelial cells induced by vibration Open
Hand-arm vibration syndrome (HAVS) is caused by long-term exposure to hand-transmitted vibration (HTV), and its pathogenesis has not been elucidated fully. We explored the molecular mechanism of HAVS and provided clues and a theoretical ba…
View article: DNA-encoded dynamic hydrogels for 3D bioprinted cartilage organoids
DNA-encoded dynamic hydrogels for 3D bioprinted cartilage organoids Open
View article: Single-Nucleus RNA Sequencing Reveals Cellular Transcriptome Features at Different Growth Stages in Porcine Skeletal Muscle
Single-Nucleus RNA Sequencing Reveals Cellular Transcriptome Features at Different Growth Stages in Porcine Skeletal Muscle Open
Porcine latissimus dorsi muscle (LDM) is a crucial source of pork products. Meat quality indicators, such as the proportion of muscle fibers and intramuscular fat (IMF) deposition, vary during the growth and development of pigs. Numerous s…
View article: Japans Lost Decades: The Impact of Deflation and Reflections on the Post-Covid Era
Japans Lost Decades: The Impact of Deflation and Reflections on the Post-Covid Era Open
This paper examines three pivotal events that shaped Japans economic development trajectory: the Asian financial crisis in 1997, the global financial crisis of GFC in 2008, and the health pandemic in 2020. These global crises revealed pote…
View article: The transcription factor FcMYB3 responds to 60Co γ-ray irradiation of axillary buds in Ficus carica L. by activating the expression of the NADPH oxidase, FcRbohD
The transcription factor FcMYB3 responds to 60Co γ-ray irradiation of axillary buds in Ficus carica L. by activating the expression of the NADPH oxidase, FcRbohD Open
Plant irradiation has been used to induce genetic variation in crop germplasm. However, the underlying mechanisms of plant responses to ionizing radiation stress are still unclear. In plants, reactive oxygen species (ROS) are produced with…
View article: Bioactive MgO/MgCO3/Polycaprolactone Multi-gradient Fibers Facilitate Peripheral Nerve Regeneration by Regulating Schwann Cell Function and Activating Wingless/Integrase-1 Signaling
Bioactive MgO/MgCO3/Polycaprolactone Multi-gradient Fibers Facilitate Peripheral Nerve Regeneration by Regulating Schwann Cell Function and Activating Wingless/Integrase-1 Signaling Open
Peripheral nerve defects present complex orthopedic challenges with limited efficacy of clinical interventions. The inadequate proliferation and dysfunction of Schwann cells within the nerve scaffold impede the effectiveness of nerve repai…
View article: A novel integrated testing strategy (ITS) for evaluating acute fish toxicity with new approach methodologies (NAMs)
A novel integrated testing strategy (ITS) for evaluating acute fish toxicity with new approach methodologies (NAMs) Open
Acute fish toxicity (AFT) tests are performed in aquatic risk assessments of chemical compounds globally. However, the specific endpoint of in vivo AFT is based on the lethal concentration 50 (LC50), which is a serious challenge…
View article: Histone H4K12 lactylation promotes malignancy progression in triple-negative breast cancer through SLFN5 downregulation
Histone H4K12 lactylation promotes malignancy progression in triple-negative breast cancer through SLFN5 downregulation Open
Lactylation, a newly identified post-translational modification, is uncertain in its implication in triple-negative breast cancer (TNBC). In this study, we analyzed 60 TNBC samples using immunohistochemical staining and revealed elevated l…
View article: Foundation models for bioinformatics
Foundation models for bioinformatics Open
Transformer‐based foundation models such as ChatGPTs have revolutionized our daily life and affected many fields including bioinformatics. In this perspective, we first discuss about the direct application of textual foundation models on b…
View article: Dynamics of single-nuclei transcriptomic profiling of adipose tissue from diverse anatomical locations during mouse aging process
Dynamics of single-nuclei transcriptomic profiling of adipose tissue from diverse anatomical locations during mouse aging process Open
View article: Research integrity in the era of artificial intelligence: Challenges and responses
Research integrity in the era of artificial intelligence: Challenges and responses Open
The application of artificial intelligence (AI) technologies in scientific research has significantly enhanced efficiency and accuracy but also introduced new forms of academic misconduct, such as data fabrication and text plagiarism using…
View article: Knockdown of lncRNA MEG3 promotes damage of vascular endothelial cells induced by vibration
Knockdown of lncRNA MEG3 promotes damage of vascular endothelial cells induced by vibration Open
Hand–arm vibration syndrome (HAVS) is caused by long-term exposure to hand-transmitted vibration (HTV), and its pathogenesis has not been elucidated fully. We explored the molecular mechanism of HAVS and provided clues and a theoretical ba…
View article: Building Haplotype‐Resolved 3D Genome Maps of Chicken Skeletal Muscle
Building Haplotype‐Resolved 3D Genome Maps of Chicken Skeletal Muscle Open
Haplotype‐resolved 3D chromatin architecture related to allelic differences in avian skeletal muscle development has not been addressed so far, although chicken husbandry for meat consumption has been prevalent feature of cultures on every…
View article: 13. Autologous Adipocyte Cell Therapy For Secondary Lymphedema
13. Autologous Adipocyte Cell Therapy For Secondary Lymphedema Open
Purpose: Secondary lymphedema is a chronic edematous condition associated with the methods to treat cancer leading to progressive swelling in extremities and chronic inflammatory response. Lymphedema is currently managed using physical app…
View article: 21. Rosiglitazone Decreases Fibrosis And Stimulates Adipogenesis From Locally Derived Precursors In Irradiated Skin
21. Rosiglitazone Decreases Fibrosis And Stimulates Adipogenesis From Locally Derived Precursors In Irradiated Skin Open
Purpose: Radiation-induced tissue injury occurs in over 90% of patients who receive radiation for cancer treatment. Adverse effects of radiation therapy include wound dehiscence, atrophy, fibrosis, ulceration, and partial or full-thickness…
View article: 04. Development Of A Bone Marrow-resident Cell Therapy For Tissue Repair During Genetic Heterotopic Ossification
04. Development Of A Bone Marrow-resident Cell Therapy For Tissue Repair During Genetic Heterotopic Ossification Open
Purpose: Fibrodysplasia Ossificans Progressiva (FOP) is a rare genetic disorder characterized by a R206H mutation in the ACVR1 receptor which causes progressive heterotopic ossification (HO) where muscle, tendons, and ligaments are slowly …
View article: Construction and validation of log odds of positive lymph nodes (LODDS)-based nomograms for predicting overall survival and cancer-specific survival in ovarian clear cell carcinoma patients
Construction and validation of log odds of positive lymph nodes (LODDS)-based nomograms for predicting overall survival and cancer-specific survival in ovarian clear cell carcinoma patients Open
Background Ovarian clear cell carcinoma (OCCC) is one of the special histologic subtypes of ovarian cancer. This study aimed to construct and validate log odds of positive lymph nodes (LODDS)-based nomograms for predicting the overall surv…
View article: Biomimetic nanocarriers loaded with temozolomide by cloaking brain-targeting peptides for targeting drug delivery system to promote anticancer effects in glioblastoma cells
Biomimetic nanocarriers loaded with temozolomide by cloaking brain-targeting peptides for targeting drug delivery system to promote anticancer effects in glioblastoma cells Open