Junzi Wu
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View article: Flavonoid-containing copolymers can act as both extended-release excipients and active pharmaceutical ingredients for the treatment of diabetes
Flavonoid-containing copolymers can act as both extended-release excipients and active pharmaceutical ingredients for the treatment of diabetes Open
This study focuses on multifaceted applications of plant-based natural products in the treatment of diabetes, specifically aiming to use flavonoids as both active ingredients and extended-release excipients for drug delivery. Three flavono…
View article: Nickel nanoparticles: a novel platform for cancer-targeted delivery and multimodal therapy
Nickel nanoparticles: a novel platform for cancer-targeted delivery and multimodal therapy Open
Traditional cancer treatment methods often encounter limitations, such as poor targeting, low bioavailability, and high systemic toxicity. These challenges have led researchers to explore alternative therapeutic strategies. Nickel nanopart…
View article: Multifunctional investigation of “drug–excipient unification” of natural polysaccharide nanocarriers: A new paradigm from drug delivery to adjuvant therapy
Multifunctional investigation of “drug–excipient unification” of natural polysaccharide nanocarriers: A new paradigm from drug delivery to adjuvant therapy Open
The concept of “drug–excipient unification” involves replacing or reducing traditional excipients with components that possess pharmacological activity, thereby simultaneously enhancing therapeutic efficacy and reducing toxicity. This conc…
View article: Effects of Melatonin-Loaded Poly(N-vinylcaprolactam) Transdermal Gel on Sleep Quality
Effects of Melatonin-Loaded Poly(N-vinylcaprolactam) Transdermal Gel on Sleep Quality Open
The rapid pace of modern life has contributed to a significant decline in sleep quality, which has become an urgent global public health issue. Melatonin, an endogenous hormone that regulates circadian rhythms, is vital in maintaining norm…
View article: Diverse-Origin Exosomes Therapeutic Strategies for Diabetic Wound Healing
Diverse-Origin Exosomes Therapeutic Strategies for Diabetic Wound Healing Open
Diabetic wounds represent a pressing clinical challenge in the medical field. Compared to healthy individuals, patients with diabetes present with various complications, including abnormal blood sugar levels, microcirculation disorders, an…
View article: Acid-Unlocked Two-Layer Ca-Loaded Nanoplatform to Interfere With Mitochondria for Synergistic Tumor Therapy
Acid-Unlocked Two-Layer Ca-Loaded Nanoplatform to Interfere With Mitochondria for Synergistic Tumor Therapy Open
The acid two-step unlocking nanoplatform is a therapeutic modality that combines calcium storm and oxidative damage. The mode triggers apoptosis leading to ICD of tumor cells. The material induces cycle blockade during treatment to inhibit…
View article: Prediction Method for Mechanical Characteristic Parameters of Weak Components of 110 kV Transmission Tower under Ice-Covered Condition Based on Finite Element Simulation and Machine Learning
Prediction Method for Mechanical Characteristic Parameters of Weak Components of 110 kV Transmission Tower under Ice-Covered Condition Based on Finite Element Simulation and Machine Learning Open
Icing on transmission lines may cause damage to tower components and even lead to structural failure. Aiming at the lack of research on predicting mechanical characteristic parameters of weak components of transmission towers, and the cumb…
View article: Pharmacology of bioactive compounds from plant extracts for improving non-alcoholic fatty liver disease through endoplasmic reticulum stress modulation: A comprehensive review
Pharmacology of bioactive compounds from plant extracts for improving non-alcoholic fatty liver disease through endoplasmic reticulum stress modulation: A comprehensive review Open
This review underscores the role of ER stress in NAFLD and the potential of plant bioactive compounds in treating this condition. The molecular mechanisms by which plant bioactive compounds interact with their ER stress targets provide a b…
View article: Research Progress on Stimulus-Responsive Polymer Nanocarriers for Cancer Treatment
Research Progress on Stimulus-Responsive Polymer Nanocarriers for Cancer Treatment Open
As drug carriers for cancer treatment, stimulus-responsive polymer nanomaterials are a major research focus. These nanocarriers respond to specific stimulus signals (e.g., pH, redox, hypoxia, enzymes, temperature, and light) to precisely c…
View article: Ice-Covered Warning System and Terminal Application Based on Beidou Technology
Ice-Covered Warning System and Terminal Application Based on Beidou Technology Open
Disaster prevention and mitigation are one of the most prominent industrial applications of Beidou. Through the Beidou system’s short message and location reporting functions, it can realize disaster early warning, disaster rescue command …
View article: Establishment and Application of Management Evaluation System for Transmission Line Icing Monitoring Terminal
Establishment and Application of Management Evaluation System for Transmission Line Icing Monitoring Terminal Open
The transmission line icing on-line monitoring device, which integrates many functions, such as line icing thickness monitoring, wire tension, micro weather, and image/video monitoring, can realize real-time icing condition monitoring of t…
View article: Increased expression levels of DLX5 inhibit the development of the nervous system
Increased expression levels of DLX5 inhibit the development of the nervous system Open
Introduction: Preeclampsia (PE) is a hypertensive disorder of pregnancy (HDP). DLX5 plays an important role in the migration and differentiation of subglobus pallidus precursor cells. Material and methods: We established a zebrafish line e…
View article: Nanomaterials Respond to Lysosomal Function for Tumor Treatment
Nanomaterials Respond to Lysosomal Function for Tumor Treatment Open
The safety and efficacy of tumor treatment are difficult problems to address. Recently, lysosomes have become an important target for tumor treatment because of their special environment and function. Nanoparticles have unique physicochemi…
View article: Recent advances of the nanocomposite hydrogel as a local drug delivery for diabetic ulcers
Recent advances of the nanocomposite hydrogel as a local drug delivery for diabetic ulcers Open
Diabetic ulcer is a serious complication of diabetes. Compared with that of healthy people, the skin of patients with a diabetic ulcer is more easily damaged and difficult to heal. Without early intervention, the disease will become increa…
View article: Platelet-Activating Factor Promotes the Development of Non-Alcoholic Fatty Liver Disease
Platelet-Activating Factor Promotes the Development of Non-Alcoholic Fatty Liver Disease Open
Non-alcoholic fatty liver disease (NAFLD) is a multifaceted clinicopathological syndrome characterised by excessive hepatic lipid accumulation that causes steatosis, excluding alcoholic factors. Platelet-activating factor (PAF), a biologic…
View article: Cu2+-Chelating Mesoporous Silica Nanoparticles for Synergistic Chemotherapy/Chemodynamic Therapy
Cu2+-Chelating Mesoporous Silica Nanoparticles for Synergistic Chemotherapy/Chemodynamic Therapy Open
In this study, a pH-responsive controlled-release mesoporous silica nanoparticle (MSN) formulation was developed. The MSNs were functionalized with a histidine (His)-tagged targeting peptide (B3int) through an amide bond, and loaded with a…
View article: Biomineralized Bimetallic Oxide Nanotheranostics for Multimodal Imaging-Guided Combination Therapy: Erratum
Biomineralized Bimetallic Oxide Nanotheranostics for Multimodal Imaging-Guided Combination Therapy: Erratum Open
[This corrects the article DOI: 10.7150/thno.40715.].
View article: Novel glucose-responsive nanoparticles based on p-hydroxyphenethyl anisate and 3-acrylamidophenylboronic acid reduce blood glucose and ameliorate diabetic nephropathy
Novel glucose-responsive nanoparticles based on p-hydroxyphenethyl anisate and 3-acrylamidophenylboronic acid reduce blood glucose and ameliorate diabetic nephropathy Open
An insulin delivery system that self-regulates blood sugar levels, mimicking the human pancreas, can improve hyperglycaemia. At present, a glucose-responsive insulin delivery system combining AAPBA with long-acting slow release biomaterial…
View article: Nanoparticles prepared from pterostilbene reduce blood glucose and improve diabetes complications
Nanoparticles prepared from pterostilbene reduce blood glucose and improve diabetes complications Open
Background Diabetes complications are the leading cause of mortality in diabetic patients. The common complications are decline in antioxidant capacity and the onset of micro-inflammation syndrome. At present, glucose-responsive nanopartic…
View article: Nanoparticles Prepared From Pterostilbene (PTE): A New Strategy for Reducing Blood Glucose and Improving Diabetic Complications
Nanoparticles Prepared From Pterostilbene (PTE): A New Strategy for Reducing Blood Glucose and Improving Diabetic Complications Open
Aim: New envisions are put forward on the cross application of plant extracts and biomaterials, especially new conjectures are put forward on glucose lowering nanodrug delivery systems.Study design and methods: In this study, pterostilbene…
View article: Bioresponsive Functional Phenylboronic Acid-Based Delivery System as an Emerging Platform for Diabetic Therapy
Bioresponsive Functional Phenylboronic Acid-Based Delivery System as an Emerging Platform for Diabetic Therapy Open
The glucose-sensitive self-adjusting drug delivery system simulates the physiological model of the human pancreas-secreting insulin and then precisely regulates the release of hypoglycemic drugs and controls the blood sugar. Thus, it has g…
View article: Corrigendum: Eupafolin Suppresses Esophagus Cancer Growth by Targeting T-LAK Cell-Originated Protein Kinase Protein Kinase
Corrigendum: Eupafolin Suppresses Esophagus Cancer Growth by Targeting T-LAK Cell-Originated Protein Kinase Protein Kinase Open
[This corrects the article .].
View article: Biomineralized Bimetallic Oxide Nanotheranostics for Multimodal Imaging-Guided Combination Therapy
Biomineralized Bimetallic Oxide Nanotheranostics for Multimodal Imaging-Guided Combination Therapy Open
The hypoxia of the tumor microenvironment (TME) often hinders the effectiveness of cancer treatments, especially O2-dependent photodynamic therapy (PDT). Methods: An integrated iridium oxide (IrO2)-manganese dioxide (MnO2) nanotheranostic …
View article: Eupafolin Suppresses Esophagus Cancer Growth by Targeting T-LAK Cell-Originated Protein Kinase
Eupafolin Suppresses Esophagus Cancer Growth by Targeting T-LAK Cell-Originated Protein Kinase Open
Eupafolin is the main bioactive component extracted from the traditional Chinese medicine Ay Tsao (Artemisia vulgaris L.), and its anti-tumor activity has had been studied in previous researches. T-LAK cell-originated protein kinase (TOPK)…
View article: <p>Glucose-Sensitive Nanoparticles Based On Poly(3-Acrylamidophenylboronic Acid-Block-N-Vinylcaprolactam) For Insulin Delivery</p>
Glucose-Sensitive Nanoparticles Based On Poly(3-Acrylamidophenylboronic Acid-Block-N-Vinylcaprolactam) For Insulin Delivery Open
Our research suggested that these p(AAPBA-b-NVCL) nanoparticles might have the potential to be applied in a delivery system for insulin or other hypoglycemic proteins.
View article: A chitosan-based cascade-responsive drug delivery system for triple-negative breast cancer therapy
A chitosan-based cascade-responsive drug delivery system for triple-negative breast cancer therapy Open
Background It is extremely difficult to develop targeted treatments for triple-negative breast (TNB) cancer, because these cells do not express any of the key biomarkers usually exploited for this goal. Results In this work, we develop a s…
View article: <p>Biodegradable nanotheranostics with hyperthermia-induced bubble ability for ultrasound imaging–guided chemo-photothermal therapy</p>
Biodegradable nanotheranostics with hyperthermia-induced bubble ability for ultrasound imaging–guided chemo-photothermal therapy Open
Therefore, such "all-in-one" PHDP nanoparticles with satisfactory biocompatibility and biodegradability, hyperthermia-induced bubble ability and simultaneous US imaging performance hold great potential for cancer nanotheranostics.