Ziwei Huang
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View article: Metabolomic Signatures of Extreme Old Age: Findings from the New England Centenarian Study
Metabolomic Signatures of Extreme Old Age: Findings from the New England Centenarian Study Open
The New England Centenarian Study (NECS) provides a unique resource for the study of extreme human longevity (EL). To gain insight into biological pathways related to EL, chronological age and survival, we used an untargeted serum metabolo…
View article: Discovery of a potent covalent inhibitor that unusually distorts the catalytic dyad of SARS-CoV-2 main protease
Discovery of a potent covalent inhibitor that unusually distorts the catalytic dyad of SARS-CoV-2 main protease Open
Proteases are versatile therapeutic targets for a wide variety of human diseases, including cancer, cardiovascular diseases, and infections by viruses, bacteria, and parasites. The main protease (M pro ) of severe acute respiratory syndrom…
View article: Neutrophil infiltration and microglial shifts in sepsis induced preterm brain injury: pathological insights
Neutrophil infiltration and microglial shifts in sepsis induced preterm brain injury: pathological insights Open
Preterm sepsis is a major contributor to brain injury and long-term neurodevelopmental impairments, but its molecular mechanisms remain poorly understood. This study integrated clinical and experimental approaches to investigate the pathol…
View article: Photocrosslinkable Biomaterials for 3D Bioprinting: Mechanisms, Recent Advances, and Future Prospects
Photocrosslinkable Biomaterials for 3D Bioprinting: Mechanisms, Recent Advances, and Future Prospects Open
Constructing scaffolds with the desired structures and functions is one of the main goals of tissue engineering. Three-dimensional (3D) bioprinting is a promising technology that enables the personalized fabrication of devices with regulat…
View article: GDF2 and BMP10 coordinate liver cellular crosstalk to maintain liver health
GDF2 and BMP10 coordinate liver cellular crosstalk to maintain liver health Open
The liver is the largest solid organ in the body and is primarily composed of hepatocytes (HCs), endothelial cells (ECs), Kupffer cells (KCs), and hepatic stellate cells (HSCs), which spatially interact and cooperate with each other to mai…
View article: Author response: GDF2 and BMP10 coordinate liver cellular crosstalk to maintain liver health
Author response: GDF2 and BMP10 coordinate liver cellular crosstalk to maintain liver health Open
View article: Author response: BMP9 and BMP10 coordinate liver cellular crosstalk to maintain liver health
Author response: BMP9 and BMP10 coordinate liver cellular crosstalk to maintain liver health Open
View article: BMP9 and BMP10 coordinate liver cellular crosstalk to maintain liver health
BMP9 and BMP10 coordinate liver cellular crosstalk to maintain liver health Open
The liver is the largest solid organ in the body and is primarily composed of HCs, ECs, KCs, and HSCs, which spatially interact and cooperate with each other to maintain liver homeostasis. However, the complexity and molecular mechanisms u…
View article: Xinbao pill attenuated water retention by regulating the CaSR/AQP2 pathway in LAD-induced chronic heart failure rats
Xinbao pill attenuated water retention by regulating the CaSR/AQP2 pathway in LAD-induced chronic heart failure rats Open
Our study revealed that XBP improved water retention against CHF via promoting CaSR/p38-MAPK-mediated AQP2 ubiquitination and regulating CaSR/CREB-mediated AQP2 transcription.
View article: Chemokines and lymphocyte homing in Sjögren’s syndrome
Chemokines and lymphocyte homing in Sjögren’s syndrome Open
Sjögren’s syndrome (SS) is a chronic systemic autoimmune disease that typically presents with lymphocyte, dendritic cell, and macrophage infiltration of exocrine gland ducts and the formation of ectopic germinal centers. The interactions o…
View article: Author response: BMP9 and BMP10 coordinate liver cellular crosstalk to maintain liver health
Author response: BMP9 and BMP10 coordinate liver cellular crosstalk to maintain liver health Open
The liver is the largest solid organ in the body and is primarily composed of HCs, ECs, KCs, and HSCs, which spatially interact and cooperate with each other to maintain liver homeostasis. However, the complexity and molecular mechanisms u…
View article: Reviewer #1 (Public Review): BMP9 and BMP10 coordinate liver cellular crosstalk to maintain liver health
Reviewer #1 (Public Review): BMP9 and BMP10 coordinate liver cellular crosstalk to maintain liver health Open
The liver is the largest solid organ in the body and is primarily composed of HCs, ECs, KCs, and HSCs, which spatially interact and cooperate with each other to maintain liver homeostasis. However, the complexity and molecular mechanisms u…
View article: Reviewer #2 (Public Review): BMP9 and BMP10 coordinate liver cellular crosstalk to maintain liver health
Reviewer #2 (Public Review): BMP9 and BMP10 coordinate liver cellular crosstalk to maintain liver health Open
The liver is the largest solid organ in the body and is primarily composed of HCs, ECs, KCs, and HSCs, which spatially interact and cooperate with each other to maintain liver homeostasis. However, the complexity and molecular mechanisms u…
View article: A novel bystander effect in tamoxifen treatment: PPIB derived from ER+ cells attenuates ER− cells via endoplasmic reticulum stress-induced apoptosis
A novel bystander effect in tamoxifen treatment: PPIB derived from ER+ cells attenuates ER− cells via endoplasmic reticulum stress-induced apoptosis Open
Tamoxifen (TAM) is the frontline therapy for estrogen receptor-positive (ER+) breast cancer in premenopausal women that interrupts ER signaling. As tumors with elevated heterogeneity, amounts of ER-negative (ER−) cells are present in ER+ b…
View article: DISTANCE-BASED ANALYSIS OF LONGEVITY-RELATED METABOLOMIC PROFILES
DISTANCE-BASED ANALYSIS OF LONGEVITY-RELATED METABOLOMIC PROFILES Open
Longevity is a complex multifactorial trait with many interacting determinants. Identifying each determinant is complicated given that the marginal effect of any one of them may be small. Contemporary high-throughput biomedical assays, suc…
View article: circRARS synergises with IGF2BP3 to regulate RNA methylation recognition to promote tumour progression in renal cell carcinoma
circRARS synergises with IGF2BP3 to regulate RNA methylation recognition to promote tumour progression in renal cell carcinoma Open
As the most prominent RNA modification, N6‐methyladenosine (m 6 A) participates in the regulation of tumour initiation and progression. Circular RNAs (circRNAs) also play crucial roles in ubiquitous life processes. Whether circRNAs are req…
View article: SERUM METABOLOMICS SIGNATURES OF EXTREME OLD AGE AND LONGEVITY
SERUM METABOLOMICS SIGNATURES OF EXTREME OLD AGE AND LONGEVITY Open
A total of 1,495 chemicals including 1,213 compounds of known identity and 282 compounds of unknown structural identity were profiled in serum samples collected at enrollment at Metabolon, Inc. from the blood serum of 213 subjects, includi…
View article: Biological and mutational analyses of CXCR4–antagonist interactions and design of new antagonistic analogs
Biological and mutational analyses of CXCR4–antagonist interactions and design of new antagonistic analogs Open
The chemokine receptor CXCR4 has become an attractive therapeutic target for HIV-1 infection, hematopoietic stem cell mobilization, and cancer metastasis. A wide variety of synthetic antagonists of CXCR4 have been developed and studied for…
View article: Elucidation of the α-Ketoamide Inhibition Mechanism: Revealing the Critical Role of the Electrostatic Reorganization Effect of Asp17 in the Active Site of the 20S Proteasome
Elucidation of the α-Ketoamide Inhibition Mechanism: Revealing the Critical Role of the Electrostatic Reorganization Effect of Asp17 in the Active Site of the 20S Proteasome Open
The 20S proteasome is an attractive drug target for the development of anticancer agents because it plays an important role in cellular protein degradation. It has a threonine residue that can act as a nucleophile to attack inhibitors with…
View article: CXCR4 Recognition by L- and D-Peptides Containing the Full-Length V3 Loop of HIV-1 gp120
CXCR4 Recognition by L- and D-Peptides Containing the Full-Length V3 Loop of HIV-1 gp120 Open
Human immunodeficiency virus-1 (HIV-1) recognizes one of its principal coreceptors, CXC chemokine receptor 4 (CXCR4), on the host cell via the third variable loop (V3 loop) of HIV-1 envelope glycoprotein gp120 during the viral entry proces…
View article: Discovery of Potential Inhibitors of SARS-CoV-2 Main Protease by a Transfer Learning Method
Discovery of Potential Inhibitors of SARS-CoV-2 Main Protease by a Transfer Learning Method Open
The COVID-19 pandemic caused by SARS-CoV-2 remains a global public health threat and has prompted the development of antiviral therapies. Artificial intelligence may be one of the strategies to facilitate drug development for emerging and …
View article: Investigation of the stability and gastrointestinal digestion of camellia oleifera oil bodies as a natural delivery system for curcumin
Investigation of the stability and gastrointestinal digestion of camellia oleifera oil bodies as a natural delivery system for curcumin Open
We extracted Camellia oleifera oil bodies (COOB) from Camellia oleifera seeds (COS) to evaluate the function of oil bodies in delivering lipophilic bioactive compounds. Curcumin was loaded into COOB by pH shift method to form Curcumin- Cam…
View article: Preparation and evaluation of a temperature-responsive methylcellulose/polyvinyl alcohol hydrogel for stem cell encapsulation
Preparation and evaluation of a temperature-responsive methylcellulose/polyvinyl alcohol hydrogel for stem cell encapsulation Open
Cell delivery therapy holds great prospects in regenerative medicine. However, low cell survival and retention are still the main problems in current studies. To address these challenges, a temperature-sensitive hydrogel suitable for cell …
View article: Potential Therapeutic Strategies for Skeletal Muscle Atrophy
Potential Therapeutic Strategies for Skeletal Muscle Atrophy Open
The maintenance of muscle homeostasis is vital for life and health. Skeletal muscle atrophy not only seriously reduces people’s quality of life and increases morbidity and mortality, but also causes a huge socioeconomic burden. To date, no…
View article: The gut microbiota modulates responses to anti–PD-1 and chemotherapy combination therapy and related adverse events in patients with advanced solid tumors
The gut microbiota modulates responses to anti–PD-1 and chemotherapy combination therapy and related adverse events in patients with advanced solid tumors Open
Background Immune checkpoint inhibitors (ICIs) targeting programmed cell death protein 1 (PD-1) have been widely used in treating different malignancies. Several studies have reported that the gut microbiota modulates the response and adve…
View article: HIV-1 gp120-CXCR4 recognition probed with synthetic nanomolar affinity D-peptides containing fragments of gp120 V3 loop
HIV-1 gp120-CXCR4 recognition probed with synthetic nanomolar affinity D-peptides containing fragments of gp120 V3 loop Open
View article: Restoring the epigenetically silenced lncRNA COL18A1-AS1 represses ccRCC progression by lipid browning via miR-1286/KLF12 axis
Restoring the epigenetically silenced lncRNA COL18A1-AS1 represses ccRCC progression by lipid browning via miR-1286/KLF12 axis Open
Abnormal accumulation of lipids has been highlighted in the progression of clear cell renal cell carcinoma (ccRCC). However, the underlying mechanism remains unclear. Emerging evidence suggests long noncoding RNAs (lncRNAs) participate in …
View article: Synergistic inhibition of hepatitis C virus infection by a novel microtubule inhibitor in combination with daclatasvir
Synergistic inhibition of hepatitis C virus infection by a novel microtubule inhibitor in combination with daclatasvir Open
View article: Fast and Effective Prediction of the Absolute Binding Free Energies of Covalent Inhibitors of SARS-CoV-2 Main Protease and 20S Proteasome
Fast and Effective Prediction of the Absolute Binding Free Energies of Covalent Inhibitors of SARS-CoV-2 Main Protease and 20S Proteasome Open
The COVID-19 pandemic has been a public health emergency with continuously evolving deadly variants around the globe. Among many preventive and therapeutic strategies, the design of covalent inhibitors targeting the main protease (Mpr…
View article: Inverse Colloidal Crystal Polymer Coating with Monolayer Ordered Pore Structure
Inverse Colloidal Crystal Polymer Coating with Monolayer Ordered Pore Structure Open
A functional lens coating, based on the structure of inversed colloidal photonic crystals, is proposed. The color-reflecting colloidal crystal was first prepared by self-assembly of nano-colloids and was infiltrated by adhesive polymer sol…