Zian Zhang
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View article: Revealing the genetic basis of coat color in Tibetan sheep through selective sweep and transcriptomic analyses
Revealing the genetic basis of coat color in Tibetan sheep through selective sweep and transcriptomic analyses Open
Background and objective Coat color is an important economic trait in animal husbandry and plays a crucial role in the adaptability of animal. As a key economic trait in high-altitude areas, the genetic mechanisms regulating coat color in …
View article: The influence of severe knee varus and patellofemoral joint degeneration on outcomes following fixed-bearing medial robotic-assisted unicompartmental knee arthroplasty: a minimum of 18-month follow-up
The influence of severe knee varus and patellofemoral joint degeneration on outcomes following fixed-bearing medial robotic-assisted unicompartmental knee arthroplasty: a minimum of 18-month follow-up Open
This is the first study demonstrating that preoperative radiographic severe knee varus, mild-to-moderate PFJ OA, and malalignment of the PFJ do not adversely influence early outcomes after fixed-bearing medial RA-UKA. However, the relative…
View article: Pharmacological advances of the chlorogenic acids family: current insights and future research directions
Pharmacological advances of the chlorogenic acids family: current insights and future research directions Open
Phenolic acids are considered an important source for developing natural drugs due to their extensive biological activities. The chlorogenic acids (CGAs) family is the most widely distributed botanical drug in the phenolic acid group and i…
View article: Mapping the influence of inflammatory cytokines on gout risk: Insights from a comprehensive bidirectional Mendelian randomization analysis
Mapping the influence of inflammatory cytokines on gout risk: Insights from a comprehensive bidirectional Mendelian randomization analysis Open
Background The relationship between gout pathogenesis and inflammatory cytokine alterations remains uncertain, with inconsistent findings across studies. This study evaluated the causal links between gout and 41 inflammatory cytokines usin…
View article: Transcriptomic and flavor metabolomic exploration of the genetic basis of meat quality and flavor in Tibetan sheep
Transcriptomic and flavor metabolomic exploration of the genetic basis of meat quality and flavor in Tibetan sheep Open
This study systematically characterized the growth performance, meat quality, nutritional composition, and flavor profiles of three Tibetan sheep types. Through multi-omics analysis (transcriptome and metabolome), it uncovered the regulato…
View article: Study on the Corrosion Inhibition Mechanism of HEDP and Mechanical Performance Degradation of HSGPSW Under Tensile Stress
Study on the Corrosion Inhibition Mechanism of HEDP and Mechanical Performance Degradation of HSGPSW Under Tensile Stress Open
High-strength galvanized parallel steel wire (HSGPSW) is a primary load-bearing component in cable-supported bridge structures. However, due to both human and environmental factors, corrosion during its service life is often inevitable, an…
View article: Charge‐Guided Cartilage‐Penetrating Micro/Nanocarriers That Inhibit Piezo1 and Protect Cartilage to Alleviate Osteoarthritis
Charge‐Guided Cartilage‐Penetrating Micro/Nanocarriers That Inhibit Piezo1 and Protect Cartilage to Alleviate Osteoarthritis Open
Osteoarthritis (OA), characterized by progressive cartilage degeneration and chronic joint pain, represents a major global health challenge. While intra‐articular drug delivery is a common therapeutic approach, its efficacy is limited by p…
View article: The association between varus knee deformity and morphological changes in the foot and ankle in patients with end-stage varus knee osteoarthritis
The association between varus knee deformity and morphological changes in the foot and ankle in patients with end-stage varus knee osteoarthritis Open
View article: Isp Dynamic Teacher: Image Signal Process with Dynamic Class-Rebalanced and Iou-Threshold for Unsupervised Domain Adaptive Dark Object Detection
Isp Dynamic Teacher: Image Signal Process with Dynamic Class-Rebalanced and Iou-Threshold for Unsupervised Domain Adaptive Dark Object Detection Open
View article: Whole-genome resequencing to investigate the genetic diversity and mechanisms of plateau adaptation in Tibetan sheep
Whole-genome resequencing to investigate the genetic diversity and mechanisms of plateau adaptation in Tibetan sheep Open
Introduction Tibetan sheep, economically important animals on the Qinghai–Tibet Plateau, have diversified into numerous local breeds with unique characteristics through prolonged environmental adaptation and selective breeding. However, mo…
View article: Ferroptosis in Osteoarthritis: Current Understanding
Ferroptosis in Osteoarthritis: Current Understanding Open
Osteoarthritis (OA) is a prevalent degenerative disease in elderly people that is characterized by cartilage loss and abrasion, leading to joint pain and dysfunction. The aetiology of OA is complicated and includes abnormal mechanical stre…
View article: Robotic-assisted total hip arthroplasty outperforms manual technique in obese and overweight patients: a prospective comparative study
Robotic-assisted total hip arthroplasty outperforms manual technique in obese and overweight patients: a prospective comparative study Open
View article: Omega-3 fatty acids protect cartilage from acute injurie by reducing the mechanical sensitivity of chondrocytes
Omega-3 fatty acids protect cartilage from acute injurie by reducing the mechanical sensitivity of chondrocytes Open
View article: CT can enhance the measurement accuracy of radiographic anteversion of acetabular cup following total hip arthroplasty
CT can enhance the measurement accuracy of radiographic anteversion of acetabular cup following total hip arthroplasty Open
Background This study employed a novel method to measure radiographic anteversion (RA) of acetabular cups following total hip arthroplasty (THA) and validated its accuracy in comparison to traditional methods. The new method involves measu…
View article: Genome-Wide Association Analyses and Population Verification Highlight the Potential Genetic Basis of Horned Morphology during Polled Selection in Tibetan Sheep
Genome-Wide Association Analyses and Population Verification Highlight the Potential Genetic Basis of Horned Morphology during Polled Selection in Tibetan Sheep Open
The types and morphology of sheep horns have been extensively researched, yet the genetic foundation underlying the emergence of diverse horn characteristics during the breeding of polled Tibetan sheep has remained elusive. Genome-wide ass…
View article: A Comparative Study of Lower Limb Alignment between MAKO Robot-Assisted and Conventional Unicompartmental Knee Arthroplasty
A Comparative Study of Lower Limb Alignment between MAKO Robot-Assisted and Conventional Unicompartmental Knee Arthroplasty Open
Backgrounds: This retrospective study aims to comparatively analyze the lower limb alignment correction capabilities of MAKO robot-assisted surgery and conventional surgery. Methods Clinical data of 70 patients who underwent UKA treatment …
View article: A Comparative Analysis of the Impact of Import and Export Trade on the Economy Between China and the United States
A Comparative Analysis of the Impact of Import and Export Trade on the Economy Between China and the United States Open
Due to the continuous development of global trade globalization and the weakening of monopolistic policies by major powers, the current international trade pattern has undergone tremendous changes, which has also led to significant changes…
View article: A Comparative Analysis of the Impact of Import and Export Trade on the Economy Between China and the United States
A Comparative Analysis of the Impact of Import and Export Trade on the Economy Between China and the United States Open
Due to the continuous development of global trade globalization and the weakening of monopolistic policies by major powers, the current international trade pattern has undergone tremendous changes, which has also led to significant changes…
View article: Risk factor analysis and establishment of a nomogram model to predict blood loss during total knee arthroplasty
Risk factor analysis and establishment of a nomogram model to predict blood loss during total knee arthroplasty Open
Purpose The risk factors for excessive blood loss and transfusion during total knee arthroplasty (TKA) remain unclear. The present study aimed to determine the risk factors for excessive blood loss and establish a predictive model for post…
View article: Causal relationship between serum metabolites and juvenile idiopathic arthritis: a mendelian randomization study
Causal relationship between serum metabolites and juvenile idiopathic arthritis: a mendelian randomization study Open
Background Juvenile Idiopathic Arthritis (JIA) is a condition that occurs when individuals under the age of 16 develop arthritis that lasts for more than six weeks, and the cause is unknown. The development of JIA may be linked to serum me…
View article: ISP-Teacher:Image Signal Process with Disentanglement Regularization for Unsupervised Domain Adaptive Dark Object Detection
ISP-Teacher:Image Signal Process with Disentanglement Regularization for Unsupervised Domain Adaptive Dark Object Detection Open
Object detection in dark conditions has always been a great challenge due to the complex formation process of low-light images. Currently, the mainstream methods usually adopt domain adaptation with Teacher-Student architecture to solve th…
View article: Work in Progress: A Trio-Ethnography on Professional Identity Development of Internationally-Trained Minoritized Women Early-Career Researchers in Canada
Work in Progress: A Trio-Ethnography on Professional Identity Development of Internationally-Trained Minoritized Women Early-Career Researchers in Canada Open
Work in Progress (WIP): The experiences of internationally trained minoritized academic researchers in engineering and education tend to deviate from the dominant developmental model of the doctoral program and faculty preparation. Our res…
View article: A new designed full process coverage robot-assisted total hip arthroplasty: a multicentre randomized clinical trial
A new designed full process coverage robot-assisted total hip arthroplasty: a multicentre randomized clinical trial Open
Objective: To compare the effect of a new complete robot-assisted total hip arthroplasty (RA-THA) with that of the manual total hip arthroplasty (MTHA) and to verify the accuracy and safety of the former. Methods: Overall, 148 patients wer…
View article: Approximating complex 3D curves using origami spring structures
Approximating complex 3D curves using origami spring structures Open
Origami provides a versatile platform for creating intricate three-dimensional (3D) reconfigurable structures through folding techniques. However, the applications of origami patterns are restricted due to limited deformation modes and com…
View article: Accuracy and safety of a new robotic arm for both femoral and acetabular side in total hip arthroplasty: a cadaveric study
Accuracy and safety of a new robotic arm for both femoral and acetabular side in total hip arthroplasty: a cadaveric study Open
View article: Comparison in radiographic outcomes between robotic-assisted cruciate- retaining and posterior-stabilized total knee arthroplasty: a prospective randomized controlled study
Comparison in radiographic outcomes between robotic-assisted cruciate- retaining and posterior-stabilized total knee arthroplasty: a prospective randomized controlled study Open
Background Robotic-assisted total knee arthroplasty (RA-TKA) is currently increasingly used in the field of joint arthroplasty, with cruciate-retaining (CR) and posterior-stabilized (PS) prostheses currently being the most widely used pros…
View article: Ochronotic arthropathy effectively treated with total hip and total knee arthroplasty: a case report
Ochronotic arthropathy effectively treated with total hip and total knee arthroplasty: a case report Open
Ochronosis is a rare autosomal recessive disorder of tyrosine metabolism characterized by multilevel spinal degeneration and arthritis of large weight-bearing joints, which is referred to as ochronotic arthropathy. In this case report, we …
View article: Artificial intelligence planning and 3D printing augmented modules in the treatment of a complicated hip joint revision: a case report
Artificial intelligence planning and 3D printing augmented modules in the treatment of a complicated hip joint revision: a case report Open
Total hip revision with osseous defects can be very difficult. Artificial intelligence offers preoperative planning, real-time measurement, and intraoperative judgment, which can guide prothesis placement more accurately. Three-dimensional…
View article: Lymphotoxin<i>-</i>β Promotes Bone Colonization and Osteolytic Outgrowth of Indolent Bone Metastatic cells of Breast Cancer
Lymphotoxin<i>-</i>β Promotes Bone Colonization and Osteolytic Outgrowth of Indolent Bone Metastatic cells of Breast Cancer Open
SUMMARY Bone metastatic relapse is a lethal consequence of breast cancer, occurring years after initial diagnosis. By analyzing single-cell transcriptomes of bone-seeding tumor cells and in vivo barcoded cDNA library screening, LTβ (lympho…
View article: Accuracy and safety of a new Robotic arm for both femoral and acetabular side in Total Hip Arthroplasty: A Cadaveric Study
Accuracy and safety of a new Robotic arm for both femoral and acetabular side in Total Hip Arthroplasty: A Cadaveric Study Open
Background To investigate the accuracy and safety of a newly constructed robotic arm which can cover the whole process of THA, we performed a series of robot-assisted total hip replacement on the cadaver. Methods Fifteen frozen cadaveric s…