Ziang Wan
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View article: <scp>SNHG26</scp> Promotes Colorectal Cancer Progression via <scp>CDKN2A</scp> ‐Dependent Regulation of Cuproptosis and <scp>CD8</scp> + T Cell‐Mediated Immunity
<span>SNHG26</span> Promotes Colorectal Cancer Progression via <span>CDKN2A</span> ‐Dependent Regulation of Cuproptosis and <span>CD8</span> + T Cell‐Mediated Immunity Open
Long non‐coding RNAs ( lncRNAs ) play important roles in colorectal cancer (CRC) progression. However, the biological function and regulatory mechanism of small nucleolar RNA host gene 26 ( SNHG26 ) in CRC remain largely unexplored. SNHG26…
View article: Spin‐Deposited Ruddlesden–Popper Polycrystalline Perovskites for Large‐Area High‐Sensitivity Filterless Narrowband Photodetectors with Ultrafast Response Speed
Spin‐Deposited Ruddlesden–Popper Polycrystalline Perovskites for Large‐Area High‐Sensitivity Filterless Narrowband Photodetectors with Ultrafast Response Speed Open
Filterless perovskite narrowband photodetectors (PNPDs) are highly demanded in color and spectral discrimination, which are typically demonstrated by charge collection narrowing (CCN) effect of perovskite single crystals, showing a limited…
View article: A study on device physics of deep ultraviolet light emitting diodes leveraging machine learning
A study on device physics of deep ultraviolet light emitting diodes leveraging machine learning Open
An effective approach to optimizing the luminous performance of AlGaN-based DUV LEDs is demonstrated using machine learning. A CNN model predicts LOPD with high accuracy, revealing key features that influence LED performance.
View article: EEPD1 is identified as a predictor of prognosis and immune microenvironment through pan-cancer analysis and related to progression of colorectal cancer
EEPD1 is identified as a predictor of prognosis and immune microenvironment through pan-cancer analysis and related to progression of colorectal cancer Open
EEPD1 was dysregulated in human cancers and correlated with various cancer patient prognoses. The dysregulated EEPD1 expression can affect tumor-infiltrating immune cells and immunotherapy response. Therefore, EEPD1 could act as an oncogen…
View article: Herbal medicine and its impact on the gut microbiota in colorectal cancer
Herbal medicine and its impact on the gut microbiota in colorectal cancer Open
It is well-established that there are trillions of gut microbiota (GM) in the human gut. GM and its metabolites can reportedly cause cancer by causing abnormal immune responses. With the development of sequencing technology and the applica…
View article: Loss of exosomal micro-RNA-200b-3p from hypoxia cancer-associated fibroblasts reduces sensitivity to 5-flourouracil in colorectal cancer through targeting high-mobility group box 3
Loss of exosomal micro-RNA-200b-3p from hypoxia cancer-associated fibroblasts reduces sensitivity to 5-flourouracil in colorectal cancer through targeting high-mobility group box 3 Open
Hypoxia-mediated tumor progression is a major problem in colorectal cancer (CRC). MicroRNA (miR)-200b-3p can attenuate tumorigenesis in CRC, while exosomal miRNAs derived from cancer-associated fibroblasts (CAFs) can promote cancer progres…
View article: Identification of cuproptosis-related lncRNAs Prognostic Signature in Gastric cancer and Its Impact on the Tumor Microenvironment
Identification of cuproptosis-related lncRNAs Prognostic Signature in Gastric cancer and Its Impact on the Tumor Microenvironment Open
Background: There is extensive genetic and transcriptional heterogeneity in Gastric cancer (GC). Increasing evidence has demonstrated that cuproptosis could exert an important function in tumor progression. Long noncoding RNAs (lncRNAs)，wh…
View article: HMGB3 is a Potential Therapeutic Target by Affecting the Migration and Proliferation of Colorectal Cancer
HMGB3 is a Potential Therapeutic Target by Affecting the Migration and Proliferation of Colorectal Cancer Open
Colorectal cancer is one of the common malignant tumors in the digestive system, with high incidence and mortality rate. Therefore, there is an urgent need to identify and develop new molecular targets for colorectal cancer treatment. Prev…
View article: BHLHE41 Overexpression Alleviates the Malignant Behavior of Colon Cancer Cells Induced by Hypoxia via Modulating HIF-1α/EMT Pathway
BHLHE41 Overexpression Alleviates the Malignant Behavior of Colon Cancer Cells Induced by Hypoxia via Modulating HIF-1α/EMT Pathway Open
Objective. BHLHE41 has been shown to be a marker of tumorigenesis. Colon cancer (CC) is a common malignant tumor of colonic mucosa. This study mainly explored the mechanism of BHLHE41 in alleviating malignant behavior of hypoxia-induced CC…
View article: An Integrating of Clinical, Pathological, and Radiomic Approach to Predict the Microsatellite Instability in Rectal Carcinoma
An Integrating of Clinical, Pathological, and Radiomic Approach to Predict the Microsatellite Instability in Rectal Carcinoma Open
Objective: To develop an integrative model with clinical, pathological, and radiomic characteristics to predict the status of microsatellite instability (MSI) in rectal carcinoma (RC). Methods: A cohort of 788 RCs with 97 high MSI status (…
View article: TGF-β2 is a Prognostic Biomarker Correlated with Immune Cell Infiltration in Colorectal Cancer
TGF-β2 is a Prognostic Biomarker Correlated with Immune Cell Infiltration in Colorectal Cancer Open
Transforming growth factor-beta (TGF-β2) is an important cytokine regulating immune cell function. However, whether TGF-β2 controls the invasion of colorectal cancer (CRC) by immune cells is unknown. Therefore, we evaluated the expression …
View article: Schizandrin A exhibits potent anticancer activity in colorectal cancer cells by inhibiting heat shock factor 1
Schizandrin A exhibits potent anticancer activity in colorectal cancer cells by inhibiting heat shock factor 1 Open
Heat shock factor 1 (HSF1) is a powerful multifaceted oncogenic modifier that plays a role in maintaining the protein balance of cancer cells under various stresses. In recent studies, there have been reports of increased expression of HSF…
View article: MEIS2 promotes cell migration and invasion in colorectal cancer
MEIS2 promotes cell migration and invasion in colorectal cancer Open
Colorectal cancer (CRC) is one of the most common types of malignancy worldwide. Distant metastasis is a key cause of CRC-associated mortality. MEIS2 has been identified to be dysregulated in several types of human cancer. However, the mec…