Zibo Chen
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View article: Decoupling ionic transfer kinetics via undercoordinated constraints for energy-efficient and high-quality zinc electrowinning
Decoupling ionic transfer kinetics via undercoordinated constraints for energy-efficient and high-quality zinc electrowinning Open
Zinc electrowinning (ZE), a carbon-intensive process, suffers from high energy consumption due to the parasitic hydrogen evolution reaction (HER) and poor deposit quality. Conventional adsorption-based additives fail to simultaneously deli…
View article: Multivalency Enables Signal Processing at Single Protein Level
Multivalency Enables Signal Processing at Single Protein Level Open
Synthetic signal processing in cells can be achieved through complex networks of molecules or simpler, single-molecule-based mechanisms. The latter approach stands out for its reduced genetic load and ease of delivery. Multivalent protein …
View article: CDK2 inhibition produces a persistent population of polyploid cancer cells
CDK2 inhibition produces a persistent population of polyploid cancer cells Open
Aneuploidy, a cancer hallmark, drives chromosomal instability, drug resistance, and clinically aggressive tumors. Cyclin-dependent kinase 2 (CDK2) antagonism with independent inhibitors or CDK2 knockdown triggered anaphase catastrophe. Thi…
View article: <i>De novo</i> design of inducibly assembling multi-component filaments
<i>De novo</i> design of inducibly assembling multi-component filaments Open
The design of multi-component nanomaterials is an outstanding challenge. Here, we describe the computational design of protein filaments with two or three distinct structural components that assemble into micron-scale, well-ordered fibers …
View article: Reduced graphene oxide-induced <i>in-situ</i> uniform growth of hydrated WO <sub>3</sub> film for enhanced electrochromic performance
Reduced graphene oxide-induced <i>in-situ</i> uniform growth of hydrated WO <sub>3</sub> film for enhanced electrochromic performance Open
View article: A synthetic protein-level neural network in mammalian cells
A synthetic protein-level neural network in mammalian cells Open
Artificial neural networks provide a powerful paradigm for nonbiological information processing. To understand whether similar principles could enable computation within living cells, we combined de novo–designed protein heterodimers and e…
View article: What can protein circuit design learn from DNA nanotechnology?
What can protein circuit design learn from DNA nanotechnology? Open
Protein circuit design is still in its infancy in terms of programmability. DNA nanotechnology, however, excels at this property and its community has created a myriad of circuits and assemblies following modular hierarchical design rules.…
View article: CDK2 inhibition disorders centrosome stoichiometry and alters cellular outcomes in aneuploid cancer cells
CDK2 inhibition disorders centrosome stoichiometry and alters cellular outcomes in aneuploid cancer cells Open
Cyclin-dependent Kinase 2 (CDK2) inhibition prevents supernumerary centrosome clustering. This causes multipolarity, anaphase catastrophe and apoptotic death of aneuploid cancers. This study elucidated how CDK2 antagonism affected centroso…
View article: A novel retinoic acid receptor-γ agonist antagonizes immune checkpoint resistance in lung cancers by altering the tumor immune microenvironment
A novel retinoic acid receptor-γ agonist antagonizes immune checkpoint resistance in lung cancers by altering the tumor immune microenvironment Open
View article: Data from A Novel CDK2/9 Inhibitor CYC065 Causes Anaphase Catastrophe and Represses Proliferation, Tumorigenesis, and Metastasis in Aneuploid Cancers
Data from A Novel CDK2/9 Inhibitor CYC065 Causes Anaphase Catastrophe and Represses Proliferation, Tumorigenesis, and Metastasis in Aneuploid Cancers Open
Cyclin-dependent kinase 2 (CDK2) antagonism inhibits clustering of excessive centrosomes at mitosis, causing multipolar cell division and apoptotic death. This is called anaphase catastrophe. To establish induced anaphase catastrophe as a …
View article: Supplementary Figures 1-6 from The Ubiquitin-Specific Peptidase USP18 Promotes Lipolysis, Fatty Acid Oxidation, and Lung Cancer Growth
Supplementary Figures 1-6 from The Ubiquitin-Specific Peptidase USP18 Promotes Lipolysis, Fatty Acid Oxidation, and Lung Cancer Growth Open
S1. USP18 regulates metabolism-related proteins by Reverse Phase Protein Array (RPPA) in A549 lung cancer cells. S2. This figure compares CellTiter-Glo assays and manual counting for lung cancer cell proliferation at day 3. S3. The mRNA ex…
View article: Figures S1-S6 from Tyrosine Threonine Kinase Inhibition Eliminates Lung Cancers by Augmenting Apoptosis and Polyploidy
Figures S1-S6 from Tyrosine Threonine Kinase Inhibition Eliminates Lung Cancers by Augmenting Apoptosis and Polyploidy Open
Figure S1: The structure of CFI-402257. Figure S2: TTK mRNA expression profiles in lung cancer cases with different smoking patterns, as shown in panel A. In this left panel N means no smoking history while Y indicates the presence of a sm…
View article: Supplemental Figure 1 from CT-707, a Novel FAK Inhibitor, Synergizes with Cabozantinib to Suppress Hepatocellular Carcinoma by Blocking Cabozantinib-Induced FAK Activation
Supplemental Figure 1 from CT-707, a Novel FAK Inhibitor, Synergizes with Cabozantinib to Suppress Hepatocellular Carcinoma by Blocking Cabozantinib-Induced FAK Activation Open
The combination of cabozantinib and CT-707 imposed minimal synergistic cytotoxicity against the human hepatocyte HL-7702 cells.
View article: Data from The Ubiquitin-Specific Peptidase USP18 Promotes Lipolysis, Fatty Acid Oxidation, and Lung Cancer Growth
Data from The Ubiquitin-Specific Peptidase USP18 Promotes Lipolysis, Fatty Acid Oxidation, and Lung Cancer Growth Open
Ubiquitin specific peptidase 18 (USP18), previously known as UBP43, is the IFN-stimulated gene 15 (ISG15) deconjugase. USP18 removes ISG15 from substrate proteins. This study reports that USP18-null mice (vs. wild-type mice) exhibited lowe…
View article: Supplementary figures from A Novel CDK2/9 Inhibitor CYC065 Causes Anaphase Catastrophe and Represses Proliferation, Tumorigenesis, and Metastasis in Aneuploid Cancers
Supplementary figures from A Novel CDK2/9 Inhibitor CYC065 Causes Anaphase Catastrophe and Represses Proliferation, Tumorigenesis, and Metastasis in Aneuploid Cancers Open
Supplementary figures
View article: Supplemental Figure 1 from CT-707, a Novel FAK Inhibitor, Synergizes with Cabozantinib to Suppress Hepatocellular Carcinoma by Blocking Cabozantinib-Induced FAK Activation
Supplemental Figure 1 from CT-707, a Novel FAK Inhibitor, Synergizes with Cabozantinib to Suppress Hepatocellular Carcinoma by Blocking Cabozantinib-Induced FAK Activation Open
The combination of cabozantinib and CT-707 imposed minimal synergistic cytotoxicity against the human hepatocyte HL-7702 cells.
View article: Supplementary table from A Novel CDK2/9 Inhibitor CYC065 Causes Anaphase Catastrophe and Represses Proliferation, Tumorigenesis, and Metastasis in Aneuploid Cancers
Supplementary table from A Novel CDK2/9 Inhibitor CYC065 Causes Anaphase Catastrophe and Represses Proliferation, Tumorigenesis, and Metastasis in Aneuploid Cancers Open
Supplementary table
View article: Data from CT-707, a Novel FAK Inhibitor, Synergizes with Cabozantinib to Suppress Hepatocellular Carcinoma by Blocking Cabozantinib-Induced FAK Activation
Data from CT-707, a Novel FAK Inhibitor, Synergizes with Cabozantinib to Suppress Hepatocellular Carcinoma by Blocking Cabozantinib-Induced FAK Activation Open
Hepatocellular carcinoma is among the leading causes of cancer-related deaths worldwide, and the development of new treatment regimens is urgently needed to improve therapeutic approach. In our study, we found that the combination of a Met…
View article: Data from CT-707, a Novel FAK Inhibitor, Synergizes with Cabozantinib to Suppress Hepatocellular Carcinoma by Blocking Cabozantinib-Induced FAK Activation
Data from CT-707, a Novel FAK Inhibitor, Synergizes with Cabozantinib to Suppress Hepatocellular Carcinoma by Blocking Cabozantinib-Induced FAK Activation Open
Hepatocellular carcinoma is among the leading causes of cancer-related deaths worldwide, and the development of new treatment regimens is urgently needed to improve therapeutic approach. In our study, we found that the combination of a Met…
View article: Supplementary figures from A Novel CDK2/9 Inhibitor CYC065 Causes Anaphase Catastrophe and Represses Proliferation, Tumorigenesis, and Metastasis in Aneuploid Cancers
Supplementary figures from A Novel CDK2/9 Inhibitor CYC065 Causes Anaphase Catastrophe and Represses Proliferation, Tumorigenesis, and Metastasis in Aneuploid Cancers Open
Supplementary figures
View article: Data from Tyrosine Threonine Kinase Inhibition Eliminates Lung Cancers by Augmenting Apoptosis and Polyploidy
Data from Tyrosine Threonine Kinase Inhibition Eliminates Lung Cancers by Augmenting Apoptosis and Polyploidy Open
The spindle assembly checkpoint maintains genomic integrity. A key component is tyrosine threonine kinase (TTK, also known as Mps1). TTK antagonism is hypothesized to cause genomic instability and cell death. Interrogating The Cancer Genom…
View article: Data from The Ubiquitin-Specific Peptidase USP18 Promotes Lipolysis, Fatty Acid Oxidation, and Lung Cancer Growth
Data from The Ubiquitin-Specific Peptidase USP18 Promotes Lipolysis, Fatty Acid Oxidation, and Lung Cancer Growth Open
Ubiquitin specific peptidase 18 (USP18), previously known as UBP43, is the IFN-stimulated gene 15 (ISG15) deconjugase. USP18 removes ISG15 from substrate proteins. This study reports that USP18-null mice (vs. wild-type mice) exhibited lowe…
View article: Supplementary table from A Novel CDK2/9 Inhibitor CYC065 Causes Anaphase Catastrophe and Represses Proliferation, Tumorigenesis, and Metastasis in Aneuploid Cancers
Supplementary table from A Novel CDK2/9 Inhibitor CYC065 Causes Anaphase Catastrophe and Represses Proliferation, Tumorigenesis, and Metastasis in Aneuploid Cancers Open
Supplementary table
View article: Figures S1-S6 from Tyrosine Threonine Kinase Inhibition Eliminates Lung Cancers by Augmenting Apoptosis and Polyploidy
Figures S1-S6 from Tyrosine Threonine Kinase Inhibition Eliminates Lung Cancers by Augmenting Apoptosis and Polyploidy Open
Figure S1: The structure of CFI-402257. Figure S2: TTK mRNA expression profiles in lung cancer cases with different smoking patterns, as shown in panel A. In this left panel N means no smoking history while Y indicates the presence of a sm…
View article: Supplementary Figures 1-6 from The Ubiquitin-Specific Peptidase USP18 Promotes Lipolysis, Fatty Acid Oxidation, and Lung Cancer Growth
Supplementary Figures 1-6 from The Ubiquitin-Specific Peptidase USP18 Promotes Lipolysis, Fatty Acid Oxidation, and Lung Cancer Growth Open
S1. USP18 regulates metabolism-related proteins by Reverse Phase Protein Array (RPPA) in A549 lung cancer cells. S2. This figure compares CellTiter-Glo assays and manual counting for lung cancer cell proliferation at day 3. S3. The mRNA ex…
View article: Data from A Novel CDK2/9 Inhibitor CYC065 Causes Anaphase Catastrophe and Represses Proliferation, Tumorigenesis, and Metastasis in Aneuploid Cancers
Data from A Novel CDK2/9 Inhibitor CYC065 Causes Anaphase Catastrophe and Represses Proliferation, Tumorigenesis, and Metastasis in Aneuploid Cancers Open
Cyclin-dependent kinase 2 (CDK2) antagonism inhibits clustering of excessive centrosomes at mitosis, causing multipolar cell division and apoptotic death. This is called anaphase catastrophe. To establish induced anaphase catastrophe as a …
View article: Data from Tyrosine Threonine Kinase Inhibition Eliminates Lung Cancers by Augmenting Apoptosis and Polyploidy
Data from Tyrosine Threonine Kinase Inhibition Eliminates Lung Cancers by Augmenting Apoptosis and Polyploidy Open
The spindle assembly checkpoint maintains genomic integrity. A key component is tyrosine threonine kinase (TTK, also known as Mps1). TTK antagonism is hypothesized to cause genomic instability and cell death. Interrogating The Cancer Genom…
View article: Optimizing decisions for post‐harvest ripening agricultural produce supply chain management: a dynamic quality‐based model
Optimizing decisions for post‐harvest ripening agricultural produce supply chain management: a dynamic quality‐based model Open
Fresh agricultural produce, which is characterized by post‐harvest ripening and is required for long‐term transportation in cross‐regional trade, is commonly harvested at the unripe stage and undergoes a routine process of natural ripening…
View article: Supplemental Methods from Multikinase Inhibitor CT-707 Targets Liver Cancer by Interrupting the Hypoxia-Activated IGF-1R–YAP Axis
Supplemental Methods from Multikinase Inhibitor CT-707 Targets Liver Cancer by Interrupting the Hypoxia-Activated IGF-1R–YAP Axis Open
Materials and Methods for Supplemental Figures
View article: Supplemental Tables from Multikinase Inhibitor CT-707 Targets Liver Cancer by Interrupting the Hypoxia-Activated IGF-1R–YAP Axis
Supplemental Tables from Multikinase Inhibitor CT-707 Targets Liver Cancer by Interrupting the Hypoxia-Activated IGF-1R–YAP Axis Open
Supplemental Table 1. The primer sequences for qRT-PCR assay Supplemental Table 2. The targeting sequences for siRNA Supplemental Table 3. The list of compounds for YAP-TEADs luciferase screening