Zhenjun Yang
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View article: THE SYMBIOSIS OF TAO AND ART: THEORETICAL RECONSTRUCTION OF TAOIST PHILOSOPHY IN CONTEMPORARY ART
THE SYMBIOSIS OF TAO AND ART: THEORETICAL RECONSTRUCTION OF TAOIST PHILOSOPHY IN CONTEMPORARY ART Open
This study is dedicated to examining the practical applicability of Taoist thought in contemporary art, systematically sorting out the core concepts of its theoretical system that have practical guidance significance, and exploring the pat…
View article: CXCL12 Promotes Peripheral Nerve Injury Repair by Inhibiting the Ferroptosis‒Inflammation Axis via the ERK/Nrf2 Pathway
CXCL12 Promotes Peripheral Nerve Injury Repair by Inhibiting the Ferroptosis‒Inflammation Axis via the ERK/Nrf2 Pathway Open
Peripheral nerve injury (PNI) is often limited by the activation of the ferroptosis‒inflammation axis. Although CXCL12 is a crucial neuroregenerative factor, the precise mechanism by which it promotes nerve repair through regulating this a…
View article: A Mannosylated peptidyl lipid CManDA doped into cytidinyl/cationic lipids efficiently delivers siG12Ss to lung cancer in vivo
A Mannosylated peptidyl lipid CManDA doped into cytidinyl/cationic lipids efficiently delivers siG12Ss to lung cancer in vivo Open
Gene therapy has attracted widespread attention in recent years, and one of the important delivery systems is the LNP. However, many LNPs have potential toxicity and accumulate in the liver. Here, we designed and synthesized a Gemini-type …
View article: Design and synthesis of nucleotidyl lipids and their application in the targeted delivery of siG12D for pancreatic cancer therapy
Design and synthesis of nucleotidyl lipids and their application in the targeted delivery of siG12D for pancreatic cancer therapy Open
Nucleic acid drugs are attracting significant attention as prospective therapeutics. However, their efficacy is hindered by challenges in penetrating cell membranes and reaching target tissues, limiting their applications. Nucleotidyl lipi…
View article: Design and Validation of a Short Novel Estradiol Aptamer and Exploration of Its Application in Sensor Technology
Design and Validation of a Short Novel Estradiol Aptamer and Exploration of Its Application in Sensor Technology Open
The specific and sensitive detection of 17β-estradiol (E2) is critical for diagnosing and treating numerous diseases, and aptamers have emerged as promising recognition probes for developing detection platforms. However, traditional long-s…
View article: Aptamer AS411 interacts with the KRAS promoter/hnRNP A1 complex and shows increased potency against drug-resistant lung cancer
Aptamer AS411 interacts with the KRAS promoter/hnRNP A1 complex and shows increased potency against drug-resistant lung cancer Open
Encapsulated by cytidinyl lipid, G-quadruplex based aptamer AS1411 etc. entered nucleus and targeted to KRAS promoter/hnRNP A1 complex, showed higher activity against drug-resistant lung cancer.
View article: Silicon-Based Micro-Calorimeter for Thermal Detection Using Single Thermocouple Structure
Silicon-Based Micro-Calorimeter for Thermal Detection Using Single Thermocouple Structure Open
View article: Correction: Aptamer AS1411 interacts with the KRAS promoter/hnRNP A1 complex and shows increased potency against drug-resistant lung cancer
Correction: Aptamer AS1411 interacts with the KRAS promoter/hnRNP A1 complex and shows increased potency against drug-resistant lung cancer Open
Correction for ‘Aptamer AS1411 interacts with the KRAS promoter/hnRNP A1 complex and shows increased potency against drug-resistant lung cancer’ by Yuejie Zhu et al. , RSC Med. Chem. , 2024, https://doi.org/10.1039/d3md00752a.
View article: Modified ASO conjugates encapsulated with cytidinyl/cationic lipids exhibit more potent and longer-lasting anti-HCC effects
Modified ASO conjugates encapsulated with cytidinyl/cationic lipids exhibit more potent and longer-lasting anti-HCC effects Open
View article: Optimization in Chemical Modification of Single-Stranded siRNA Encapsulated by Neutral Cytidinyl/Cationic Lipids
Optimization in Chemical Modification of Single-Stranded siRNA Encapsulated by Neutral Cytidinyl/Cationic Lipids Open
Single-stranded siRNA (ss-siRNA) refers to the antisense strand of siRNA, which plays the role of gene silencing. Since single-stranded RNA is unstable, the present study employed a homemade neutral cytidinyl/cationic lipid delivery system…
View article: Novel formulation of c-di-GMP with cytidinyl/cationic lipid reverses T cell exhaustion and activates stronger anti-tumor immunity
Novel formulation of c-di-GMP with cytidinyl/cationic lipid reverses T cell exhaustion and activates stronger anti-tumor immunity Open
Rationale: Cyclic dinucleotides (cDNs) are a promising class of immunotherapeutic agent targeting stimulator of interferon genes (STING). However, enzymatic instability and transmembrane barriers limit the extensive clinical applica…
View article: Rational preparation and application of a mRNA delivery system with cytidinyl/cationic lipid
Rational preparation and application of a mRNA delivery system with cytidinyl/cationic lipid Open
View article: Pathological Significance and Prognostic Roles of Indirect Bilirubin/Albumin Ratio in Hepatic Encephalopathy
Pathological Significance and Prognostic Roles of Indirect Bilirubin/Albumin Ratio in Hepatic Encephalopathy Open
Background and Aim: Hepatic encephalopathy (HE) is a neurological disease caused by severe liver disease. Early identification of the risk factor is beneficial to the prevention and treatment of HE. Free bilirubin has always been considere…
View article: Feasibility of cRGD conjugation at 5′-antisense strand of siRNA by phosphodiester linkage extension
Feasibility of cRGD conjugation at 5′-antisense strand of siRNA by phosphodiester linkage extension Open
View article: Selective Anti-melanoma Effect of Phosphothioated Aptamer Encapsulated by Neutral Cytidinyl/Cationic Lipids
Selective Anti-melanoma Effect of Phosphothioated Aptamer Encapsulated by Neutral Cytidinyl/Cationic Lipids Open
BC15-31 is a DNA aptamer that targets heterogeneous nuclear ribonucleoprotein A1 (hnRNP A1), which plays a crucial role in the process of pre-RNA maturation and is also essential for the rapid proliferation of tumor cells. In this research…
View article: Autophagy Induced by Proteasomal DUB Inhibitor NiPT Restricts NiPT-Mediated Cancer Cell Death
Autophagy Induced by Proteasomal DUB Inhibitor NiPT Restricts NiPT-Mediated Cancer Cell Death Open
Ubiquitin-proteasome system (UPS) and autophagy-lysosome pathway (ALP) are two major systems for protein quality control (PQC) in eukaryotic cells. Interconnectivity between these two pathways has been suggested, but the molecular detail o…
View article: Additional file 2 of Characterization of gut microbiota associated with clinical parameters in intrahepatic cholestasis of pregnancy
Additional file 2 of Characterization of gut microbiota associated with clinical parameters in intrahepatic cholestasis of pregnancy Open
Additional file 2. The total list of 638 KEGG Orthologs significantly different between ICP patients and controls.
View article: Additional file 3 of Characterization of gut microbiota associated with clinical parameters in intrahepatic cholestasis of pregnancy
Additional file 3 of Characterization of gut microbiota associated with clinical parameters in intrahepatic cholestasis of pregnancy Open
Additional file 3. The total list of 138 KEGG pathways significantly different between ICP patients and controls.
View article: Parkin facilitates proteasome inhibitor-induced apoptosis via suppression of NF-κB activity in hepatocellular carcinoma
Parkin facilitates proteasome inhibitor-induced apoptosis via suppression of NF-κB activity in hepatocellular carcinoma Open
The ubiquitin–proteasome system (UPS) is a tight homeostatic control mechanism of intracellular protein degradation and turnover involved in many human diseases. Proteasome inhibitors were initially developed as anticancer agents with pote…
View article: An oligonucleotide synthesizer based on a microreactor chip and an inkjet printer
An oligonucleotide synthesizer based on a microreactor chip and an inkjet printer Open
View article: Parkin Facilitates Proteasome Inhibitor-Induced Apoptosis via Suppression of NF-κB Activity in Hepatocellular Carcinoma
Parkin Facilitates Proteasome Inhibitor-Induced Apoptosis via Suppression of NF-κB Activity in Hepatocellular Carcinoma Open
View article: Development of Coupling Controlled Polymerizations by Adapter-ligation in Mate-pair Sequencing for Detection of Various Genomic Variants in One Single Assay
Development of Coupling Controlled Polymerizations by Adapter-ligation in Mate-pair Sequencing for Detection of Various Genomic Variants in One Single Assay Open
The diversity of disease presentations warrants one single assay for detection and delineation of various genomic disorders. Herein, we describe a gel-free and biotin-capture-free mate-pair method through coupling Controlled Polymerization…
View article: Annealing novel nucleobase-lipids with oligonucleotides or plasmid DNA based on H-bonding or π-π interaction: Assemblies and transfections
Annealing novel nucleobase-lipids with oligonucleotides or plasmid DNA based on H-bonding or π-π interaction: Assemblies and transfections Open
Lipid derivatives of nucleoside analogs have been highlighted for their potential for effective gene delivery. A novel class of nucleobase-lipids are rationally designed and readily synthesized, comprising thymine/cytosine, an ester/amide …
View article: Anticancer effects of combinational treatment with BRAFV600E siRNA and PI3K pathway inhibitors in melanoma cell lines harboring BRAFV600E
Anticancer effects of combinational treatment with BRAFV600E siRNA and PI3K pathway inhibitors in melanoma cell lines harboring BRAFV600E Open
In the present study, the anti-tumor effects of combination treatment with an siRNA targeting B-Raf proto-oncogene serine/threonine kinase (BRAF)V600E and phosphoinositide 3-kinase (PI3K) signaling pathway inhibitors was investi…
View article: Delivery Pathway Regulation of 3′,3″-Bis-Peptide-siRNA Conjugate via Nanocarrier Architecture Engineering
Delivery Pathway Regulation of 3′,3″-Bis-Peptide-siRNA Conjugate via Nanocarrier Architecture Engineering Open
View article: Transfection of 3′,3′′-bis-peptide-siRNA conjugate by cationic lipoplexes mixed with a neutral cytosin-1-yl-lipid
Transfection of 3′,3′′-bis-peptide-siRNA conjugate by cationic lipoplexes mixed with a neutral cytosin-1-yl-lipid Open
View article: Site-Specific Modification Using the 2′-Methoxyethyl Group Improves the Specificity and Activity of siRNAs
Site-Specific Modification Using the 2′-Methoxyethyl Group Improves the Specificity and Activity of siRNAs Open
View article: Reductive nanocomplex encapsulation of cRGD-siRNA conjugates for enhanced targeting to cancer cells
Reductive nanocomplex encapsulation of cRGD-siRNA conjugates for enhanced targeting to cancer cells Open
In this study, through covalent conjugation and lipid material entrapment, a combined modification strategy was established for effective delivery of small interfering RNA (siRNA). Single strands of siRNA targeting to BRAFV600E…
View article: The Bioactivity of D-/L-Isonucleoside- and 2′-Deoxyinosine-Incorporated Aptamer AS1411s Including DNA Replication/MicroRNA Expression
The Bioactivity of D-/L-Isonucleoside- and 2′-Deoxyinosine-Incorporated Aptamer AS1411s Including DNA Replication/MicroRNA Expression Open
View article: Alkylation of phosphorothioated thrombin binding aptamers improves the selectivity of inhibition of tumor cell proliferation upon anticoagulation
Alkylation of phosphorothioated thrombin binding aptamers improves the selectivity of inhibition of tumor cell proliferation upon anticoagulation Open