Zhigang Cao
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View article: Escin inhibits PD-L1 expression by suppressing the p38 MAPK/ERK signalling pathways and synergistically enhances PD-1 inhibitor efficacy in hepatocellular carcinoma
Escin inhibits PD-L1 expression by suppressing the p38 MAPK/ERK signalling pathways and synergistically enhances PD-1 inhibitor efficacy in hepatocellular carcinoma Open
This study provides novel insights into the mechanism of action of escin in inhibiting HCC and confirms the potential of escin in conjunction with ICIs as a therapeutic approach to impede HCC progression.
View article: Relief of EGFR/FOS-downregulated miR-103a by loganin alleviates NF-kappaB-triggered inflammation and gut barrier disruption in colitis
Relief of EGFR/FOS-downregulated miR-103a by loganin alleviates NF-kappaB-triggered inflammation and gut barrier disruption in colitis Open
Due to the ever-rising global incidence rate of inflammatory bowel disease (IBD) and the lack of effective clinical treatment drugs, elucidating the detailed pathogenesis, seeking novel targets, and developing promising drugs are the top p…
View article: Regional divergence in the urban form-carbon emission nexus: a comparative analysis of linear and non-linear spatial modeling approaches for 286 Chinese cities
Regional divergence in the urban form-carbon emission nexus: a comparative analysis of linear and non-linear spatial modeling approaches for 286 Chinese cities Open
Urban areas account for over 70% of global CO 2 emissions. Recent studies show that urban morphology’s impact on carbon emissions is more complex than traditional linear models suggest, with critical implications for low-carbon urban plann…
View article: Three-Dimensional-Printed Meat Products with Lycopene-Functionalized Yeast Pickering Emulsions as Fat Replacer
Three-Dimensional-Printed Meat Products with Lycopene-Functionalized Yeast Pickering Emulsions as Fat Replacer Open
Due to the health-driven demand for fat replacers in meat products, Lycopene (Lyc)-loaded yeast protein (YP) high internal phase Pickering emulsions (HIPPEs) were explored as fat replacers for 3D-printed meat products. HIPPEs with varying …
View article: Rare metastasis of the urinary bladder from esophageal squamous cell carcinoma: a case report
Rare metastasis of the urinary bladder from esophageal squamous cell carcinoma: a case report Open
Background Squamous cell carcinoma (SCC) of the urinary bladder is rare, comprising less than 5% of all bladder cancers. There have been no previous reports of bladder SCC occurring as a metachronous metastatic tumor following curative res…
View article: Incorporating Uncertainty in Predictive Models Using Mobile Sensing and Clinical Data: A Case Study on Persistent Post-surgical Pain
Incorporating Uncertainty in Predictive Models Using Mobile Sensing and Clinical Data: A Case Study on Persistent Post-surgical Pain Open
Persistent postoperative pain (PPSP) is a significant concern in perioperative care, affecting patient quality of life and clinical outcomes. While traditional clinical data may capture patient-reported and objective physiological data in …
View article: Hiome Analysis Based on fsQCA: A Study on Sports Injury Factors in Adolescent Physical Training
Hiome Analysis Based on fsQCA: A Study on Sports Injury Factors in Adolescent Physical Training Open
In recent years, adolescent physical training has received more and more attention, but the risk of sports injury has also increased. Sports injuries not only affect adolescents’ physical health and exercise performance but may also negati…
View article: Osteoking exerts pro‑osteogenic and anti‑adipogenic effects in promoting bone fracture healing via EGF/EGFR/HDAC1/Wnt/β‑catenin signaling
Osteoking exerts pro‑osteogenic and anti‑adipogenic effects in promoting bone fracture healing via EGF/EGFR/HDAC1/Wnt/β‑catenin signaling Open
Bone fractures, as a global public health issue, lead to disability and reduce the quality of life for patients. Chinese patent drug Osteoking has efficacy in bone fracture therapy. However, its therapeutic properties and underlying mechan…
View article: Diagnostic values of glial fibrillary acidic protein, neuron-specific enolase and protein S100β for sepsis-associated encephalopathy
Diagnostic values of glial fibrillary acidic protein, neuron-specific enolase and protein S100β for sepsis-associated encephalopathy Open
Background To investigate the expressions of glial fibrillary acidic protein (GFAP), neuron-specific enolase (NSE) and protein S100β and their diagnostic values for sepsis-associated encephalopathy (SAE). Methods One hundred patients with …
View article: High-Risk Human Papillomavirus E7 Maintains Stemness Via APH1B In Cervical Cancer Stem-Cell Like Cells
High-Risk Human Papillomavirus E7 Maintains Stemness Via APH1B In Cervical Cancer Stem-Cell Like Cells Open
Shizhou Yang,1,* Tingting Chen,1,* Lu Huang,2 Shanshan Xu,1 Zhu Cao,1 Songfa Zhang,1 Junfen Xu,1 Yang Li,1 Yongfang Yue,1 Weiguo Lu,1,3 Xiaodong Cheng,1,3 Xing Xie1,3 1Department of Gynecologic Oncology, Women’s Hospital, Zhejiang Universi…
View article: ABCB1 polymorphism predicts the toxicity and clinical outcome of lung cancer patients with taxane‐based chemotherapy
ABCB1 polymorphism predicts the toxicity and clinical outcome of lung cancer patients with taxane‐based chemotherapy Open
Background Taxane‐based chemotherapy is widely used in lung cancer. ABCB1 have a role in the prediction of treatment response and toxicity of chemotherapy in solid tumors. In this retrospective study, we investigated ABCB1 polymorphism on …
View article: High expression of metabolic enzyme PFKFB4 is associated with poor prognosis of operable breast cancer
High expression of metabolic enzyme PFKFB4 is associated with poor prognosis of operable breast cancer Open
Together, our findings establish the prognostic value of metabolic enzyme PFKFB4 in patients with operable breast cancer.
View article: <p>The functions of microRNA-124 on bladder cancer</p>
The functions of microRNA-124 on bladder cancer Open
Background: To detect the expression of miR-124 in bladder cancer (BC) cell lines and tissue specimens and to analyze its association with the growth of the BC cells. Methods: Quantitative real-time polymerase chain reaction (qPCR) was app…
View article: MicroRNA‐493 is a prognostic factor in triple‐negative breast cancer
MicroRNA‐493 is a prognostic factor in triple‐negative breast cancer Open
Breast cancer is one of the most common malignant diseases in women. Triple‐negative breast cancer (TNBC) shows higher aggressiveness and recurrence rates than other subtypes, and there are no effective targets or tailored treatments for T…
View article: Xiaomao Guo: help cancer patients with precision medicine
Xiaomao Guo: help cancer patients with precision medicine Open
Xiaomao Guo, director of Fudan University Shanghai Cancer Center (FUSCC), director of Shanghai Proton and Heavy Ion Hospital (SPHIC, also Proton and Heavy Ion Center of FUSCC), professor, chief physician, doctoral tutor, and Shanghai Outst…
View article: AB070. Roles and mechanisms of soybean isoflavones in androgen-independent transformation of prostate cancer
AB070. Roles and mechanisms of soybean isoflavones in androgen-independent transformation of prostate cancer Open
The aims of this study were to investigate the impact of soybean isoflavones (SIFs) on the cellular oxidative stress levels in hormone-sensitive type (LNCap) and hormone-insensitive type (DU145) of prostate cancer, and to elucidate the mai…
View article: Positive expression of miR-361-5p indicates better prognosis for breast cancer patients
Positive expression of miR-361-5p indicates better prognosis for breast cancer patients Open
These results indicated that miR-361-5p expression is an independent predictive factor for better prognosis in BC.
View article: Downregulation of B7-H4 in the MHCC97-H hepatocellular carcinoma cell line by arsenic trioxide
Downregulation of B7-H4 in the MHCC97-H hepatocellular carcinoma cell line by arsenic trioxide Open
Arsenic trioxide (As2O3; ATO), a compound which is characterized by its ability to function as a potent anticancer agent, has been investigated in a variety of carcinomas. B7‑H4, a transmembrane protein, may inhibit the function of the T c…