Zhihong Hu
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View article: Total Retinal Pigment Epithelium Thickness and Reflectivity, in Relation to Histology and Vision, at the Aging-AMD Transition: ALSTAR2 Baseline
Total Retinal Pigment Epithelium Thickness and Reflectivity, in Relation to Histology and Vision, at the Aging-AMD Transition: ALSTAR2 Baseline Open
Reduced TRPET and TNRR in AMD and their correlation with RMDA are statistically significant due to the large sample. Whether they have practical utility for AMD detection will be learned from ongoing longitudinal studies. In ALSTAR2, non-R…
View article: Longitudinal Assessment of Area of Reticular Pseudodrusen in Eyes with Age-Related Macular Degeneration
Longitudinal Assessment of Area of Reticular Pseudodrusen in Eyes with Age-Related Macular Degeneration Open
View article: Machine Learning-Assisted Optical Characterization and Growth Modulation of Two-Dimensional Materials
Machine Learning-Assisted Optical Characterization and Growth Modulation of Two-Dimensional Materials Open
This review focuses on research on machine learning-enabled two-dimensional (2D) materials, exploring the progress and prospects of this interdisciplinary field. At a fundamental level, machine learning algorithms incorporate imaging syste…
View article: Automated Foveal Avascular Zone Segmentation in Optical Coherence Tomography Angiography Across Multiple Eye Diseases Using Knowledge Distillation
Automated Foveal Avascular Zone Segmentation in Optical Coherence Tomography Angiography Across Multiple Eye Diseases Using Knowledge Distillation Open
Optical coherence tomography angiography (OCTA) is a noninvasive imaging technique used to visualize retinal blood flow and identify changes in vascular density and enlargement or distortion of the foveal avascular zone (FAZ), which are in…
View article: Automated Detection and Biomarker Identification Associated with the Structural and Functional Progression of Glaucoma on Longitudinal Color Fundus Images
Automated Detection and Biomarker Identification Associated with the Structural and Functional Progression of Glaucoma on Longitudinal Color Fundus Images Open
The diagnosis of primary open-angle glaucoma (POAG) progression based on structural imaging such as color fundus photos (CFPs) is challenging due to the limited number of early biomarkers, as commonly determined by clinicians, and the inhe…
View article: Pathology and pharmacology of lung cancer, stomach cancer and colorectal cancer
Pathology and pharmacology of lung cancer, stomach cancer and colorectal cancer Open
Cancer, a term that strikes fear and concern in the hearts of millions around the globe, stands as one of the most formidable diseases of our time. It has been responsible for an alarming escalation in the number of fatalities annually, ca…
View article: Relating normal human cardiac development to the anatomical findings in the congenitally malformed heart
Relating normal human cardiac development to the anatomical findings in the congenitally malformed heart Open
A proper appreciation of cardiac development can now provide the necessary background to understand the anatomical findings in the congenitally malformed heart. We recently presented an account of human cardiac development based on reconst…
View article: Recurrent and Concurrent Prediction of Longitudinal Progression of Stargardt Atrophy and Geographic Atrophy towards Comparative Performance on Optical Coherence Tomography as on Fundus Autofluorescence
Recurrent and Concurrent Prediction of Longitudinal Progression of Stargardt Atrophy and Geographic Atrophy towards Comparative Performance on Optical Coherence Tomography as on Fundus Autofluorescence Open
Stargardt atrophy and geographic atrophy (GA) represent pivotal endpoints in FDA-approved clinical trials. Predicting atrophy progression is crucial for evaluating drug efficacy. Fundus autofluorescence (FAF), the standard 2D imaging modal…
View article: Probing Deposit-Driven Age-Related Macular Degeneration Via Thicknesses of Outer Retinal Bands and Choroid: ALSTAR2 Baseline
Probing Deposit-Driven Age-Related Macular Degeneration Via Thicknesses of Outer Retinal Bands and Choroid: ALSTAR2 Baseline Open
With AMD stages, the most consistent structural differences involve appearance of drusen and SDD, followed by RPE + BL thickness, and then thickness of photoreceptor inner and outer segments. Structural changes in the transition from aging…
View article: Recurrent and Concurrent Prediction of Longitudinal Progression of Stargardt Atrophy and Geographic Atrophy
Recurrent and Concurrent Prediction of Longitudinal Progression of Stargardt Atrophy and Geographic Atrophy Open
Stargardt disease and age-related macular degeneration are the leading causes of blindness in the juvenile and geriatric populations, respectively. The formation of atrophic regions of the macula is a hallmark of the end-stages of both dis…
View article: Potential Structural Biomarkers in 3D Images Validated by the First Functional Biomarker for Early Age-Related Macular Degeneration – ALSTAR2 Baseline
Potential Structural Biomarkers in 3D Images Validated by the First Functional Biomarker for Early Age-Related Macular Degeneration – ALSTAR2 Baseline Open
RMDA is correlated with the status of outer retinal bands in early and intermediate AMD eyes, particularly, the status of the IZ. This correlation is consistent with a previous analysis of only foveal B-scans and is biologically plausible …
View article: Progression of PROM1-Associated Retinal Degeneration as Determined by Spectral-Domain Optical Coherence Tomography Over a 24-Month Period
Progression of PROM1-Associated Retinal Degeneration as Determined by Spectral-Domain Optical Coherence Tomography Over a 24-Month Period Open
Significant thickness losses could be detected in outer retinal layers by SD-OCT over a 24-month period in patients with PROM1-associated retinal degeneration. Loss of thickness and/or intact area of such layers may serve as potential endp…
View article: Potential Structural Biomarkers in 3D Images Validated by the First Functional Biomarker for Early Age-Related Macular Degeneration - ALSTAR2 Baseline
Potential Structural Biomarkers in 3D Images Validated by the First Functional Biomarker for Early Age-Related Macular Degeneration - ALSTAR2 Baseline Open
Purpose While intermediate and late age-Related Macular Degeneration (AMD) have been widely investigated, rare studies were focused on the pathophysiologic mechanism of early AMD. Delayed rod-mediated dark adaptation (RMDA) is the first fu…
View article: Using Ensemble OCT-Derived Features beyond Intensity Features for Enhanced Stargardt Atrophy Prediction with Deep Learning
Using Ensemble OCT-Derived Features beyond Intensity Features for Enhanced Stargardt Atrophy Prediction with Deep Learning Open
Stargardt disease is the most common form of juvenile-onset macular dystrophy. Spectral-domain optical coherence tomography (SD-OCT) imaging provides an opportunity to directly measure changes to retinal layers due to Stargardt atrophy. Ge…
View article: Reverse engineering for reconstructing baseline features of dry age-related macular degeneration in optical coherence tomography
Reverse engineering for reconstructing baseline features of dry age-related macular degeneration in optical coherence tomography Open
View article: Automated segmentation and feature discovery of age-related macular degeneration and Stargardt disease via self-attended neural networks
Automated segmentation and feature discovery of age-related macular degeneration and Stargardt disease via self-attended neural networks Open
View article: Artificial intelligence-based strategies to identify patient populations and advance analysis in age-related macular degeneration clinical trials
Artificial intelligence-based strategies to identify patient populations and advance analysis in age-related macular degeneration clinical trials Open
View article: Automatic Segmentation in Multiple OCT Layers For Stargardt Disease Characterization Via Deep Learning
Automatic Segmentation in Multiple OCT Layers For Stargardt Disease Characterization Via Deep Learning Open
The automated algorithm's performance and the feature differences found using the algorithm's segmentation support the future applications of SD-OCT for the quantitative monitoring of Stargardt disease.
View article: Visualizing and understanding inherent features in <scp>SD‐OCT</scp> for the progression of age‐related macular degeneration using deconvolutional neural networks
Visualizing and understanding inherent features in <span>SD‐OCT</span> for the progression of age‐related macular degeneration using deconvolutional neural networks Open
To develop a convolutional neural network visualization strategy so that optical coherence tomography (OCT) features contributing to the evolution of age‐related macular degeneration (AMD) can be better determined. We have trained a U‐Net …
View article: Automated Retinal Layer Segmentation Using Graph-based Algorithm Incorporating Deep-learning-derived Information
Automated Retinal Layer Segmentation Using Graph-based Algorithm Incorporating Deep-learning-derived Information Open
Regular drusen, an accumulation of material below the retinal pigment epithelium (RPE), have long been established as a hallmark early feature of nonneovascular age-related macular degeneration (AMD). Advances in imaging have expanded the …
View article: Comparison of High Resolution and High Speed OCTA Axial Profiles in Normal Eyes
Comparison of High Resolution and High Speed OCTA Axial Profiles in Normal Eyes Open
View article: Functionally validated imaging endpoints in the Alabama study on early age-related macular degeneration 2 (ALSTAR2): design and methods
Functionally validated imaging endpoints in the Alabama study on early age-related macular degeneration 2 (ALSTAR2): design and methods Open
View article: Automated detection and classification of early AMD biomarkers using deep learning
Automated detection and classification of early AMD biomarkers using deep learning Open
View article: Longitudinal Change in Retinal Layer Thicknesses in Subjects with Proliferative Diabetic Retinopathy Treated with Intravitreal Afliberecept
Longitudinal Change in Retinal Layer Thicknesses in Subjects with Proliferative Diabetic Retinopathy Treated with Intravitreal Afliberecept Open
View article: Early Photoreceptor Alterations in OCT for Quantitative Prediction of Expansion and New Foci of Geographic Atrophy using Deep Learning
Early Photoreceptor Alterations in OCT for Quantitative Prediction of Expansion and New Foci of Geographic Atrophy using Deep Learning Open
View article: Impact of segmentation density on Spectral Domain Optical Coherence Tomography (SD-OCT) assessments in Geographic Atrophy
Impact of segmentation density on Spectral Domain Optical Coherence Tomography (SD-OCT) assessments in Geographic Atrophy Open
View article: Reproducibility of Measurements of Retinal Structural Parameters Using Optical Coherence Tomography in Stargardt Disease
Reproducibility of Measurements of Retinal Structural Parameters Using Optical Coherence Tomography in Stargardt Disease Open
ONL and TR thicknesses and the EZ intact area in the ETDRS inner ring hold potential as structural endpoints for STGD1 trials. Structure-function relationships need to be further established.
View article: Fluorescein Aqueous Angiography in Live Normal Human Eyes
Fluorescein Aqueous Angiography in Live Normal Human Eyes Open
Purpose: To evaluate aqueous humor outflow (AHO) in intact eyes of live human subjects during cataract surgery using fluorescein aqueous angiography. Methods: Aqueous angiography was performed in 8 live human subjects (56 to 86 y old; 2 me…
View article: Inter-Grader Repeatability of Geographic Atrophy Measurements from Infrared Reflectance Images
Inter-Grader Repeatability of Geographic Atrophy Measurements from Infrared Reflectance Images Open
View article: Impact of peripheral non-perfusion on macular retinal layer morphology in subjects with proliferative diabetic retinopathy
Impact of peripheral non-perfusion on macular retinal layer morphology in subjects with proliferative diabetic retinopathy Open