Zhenhong Ni
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View article: Adaptive LongShort Equity Strategies with Salience Theory and Hidden Markov Regimes
Adaptive LongShort Equity Strategies with Salience Theory and Hidden Markov Regimes Open
This study bridges a gap in behavioral finance by integrating Salience Theory with Hidden Markov Models to develop adaptive long-short strategies. Existing salience-based approaches, while effective predictors of mispricing, remain static …
View article: Adult myopia progression in high myopes aged 18–25 years: evidence from a population-based cohort
Adult myopia progression in high myopes aged 18–25 years: evidence from a population-based cohort Open
Aims To investigate the prevalence and severity of adult myopia progression among highly myopic individuals aged 18–25 years, identify its associated factors and evaluate its association with pathologic myopia (PM). Methods We retrospectiv…
View article: Dietary fermented Artemisia argyi enhances growth performance, hepatic antioxidant activity, and intestinal health in Hongyu roosters
Dietary fermented Artemisia argyi enhances growth performance, hepatic antioxidant activity, and intestinal health in Hongyu roosters Open
View article: Atropine or Cyclopentolate to Diagnose Premyopia in Preschool Children
Atropine or Cyclopentolate to Diagnose Premyopia in Preschool Children Open
Importance Sufficient cycloplegia is essential for reliable refraction in preschool children. The choice of cycloplegic agent may affect refraction and diagnosis outcomes. Objective To evaluate the objective refraction outcomes after cyclo…
View article: Senescent macrophages induce ferroptosis in skeletal muscle and accelerate osteoarthritis-related muscle atrophy
Senescent macrophages induce ferroptosis in skeletal muscle and accelerate osteoarthritis-related muscle atrophy Open
Muscle atrophy around joints is a common issue for people with osteoarthritis (OA), but its causes are poorly understood. Here we demonstrate that chronic inflammation in quadriceps muscle coincides with OA in mice, characterized by an inc…
View article: Case Report: Mucoepidermoid carcinoma in rare locations: a report of two cases
Case Report: Mucoepidermoid carcinoma in rare locations: a report of two cases Open
Mucoepidermoid carcinoma (MEC) is a common malignancy of the salivary glands, accounting for 10-15% of salivary gland tumors. It mostly occurs in the salivary glands and very rarely in the lungs and mammary glands. The incidence of breast …
View article: A novel small cysteine‐rich protein, <scp>PbEL04</scp>, identified from <i>Plasmodiophora brassicae</i>, associates with <scp>AtSAMS2</scp> to regulate <i>Arabidopsis</i> clubroot resistance
A novel small cysteine‐rich protein, <span>PbEL04</span>, identified from <i>Plasmodiophora brassicae</i>, associates with <span>AtSAMS2</span> to regulate <i>Arabidopsis</i> clubroot resistance Open
SUMMARY Plasmodiophora brassicae is a devastating intracellular pathogen that causes clubroot disease in Brassicaceae plants, leading to significant economic losses in agriculture. Enhancing plant resistance against P. brassicae has become…
View article: Optimizing carotenoid cleavage dioxygenase 4 (CCD4) for enhanced β-ionone production in Nicotiana tabacum
Optimizing carotenoid cleavage dioxygenase 4 (CCD4) for enhanced β-ionone production in Nicotiana tabacum Open
View article: P032: Brown adipocytes are more capable than ASC in promoting breast cancer invasiveness through cell fusion
P032: Brown adipocytes are more capable than ASC in promoting breast cancer invasiveness through cell fusion Open
View article: The influence of policy advocacy and education on medical staff’s adaptation to diagnosis related groups payment reform in China: an analysis of the mediating effect of policy cognition
The influence of policy advocacy and education on medical staff’s adaptation to diagnosis related groups payment reform in China: an analysis of the mediating effect of policy cognition Open
Introduction In recent years, China has been carrying out the Diagnosis Related Groups (DRGs) payment reform, which has an impact not only on payment methods and medical expenses, but also on the behaviors of medical staff. Some of these b…
View article: A visible seedling‐stage screening system for the <i>Brassica napus</i> hybrid breeding by a novel hypocotyl length‐regulated gene <i>BnHL</i>
A visible seedling‐stage screening system for the <i>Brassica napus</i> hybrid breeding by a novel hypocotyl length‐regulated gene <i>BnHL</i> Open
Summary Rapeseed ( Brassica napus ) is a globally significant oilseed crop with strong heterosis performance. Recessive genic male sterility (RGMS) is one of the key approaches for utilizing heterosis in B. napus . However, this method fac…
View article: Mesenchymal stem cell–derived extracellular vesicles in joint diseases: Therapeutic effects and underlying mechanisms
Mesenchymal stem cell–derived extracellular vesicles in joint diseases: Therapeutic effects and underlying mechanisms Open
View article: Lopinavir enhances anoikis by remodeling autophagy in a circRNA-dependent manner
Lopinavir enhances anoikis by remodeling autophagy in a circRNA-dependent manner Open
Macroautophagy/autophagy-mediated anoikis resistance is crucial for tumor metastasis. As a key autophagy-related protein, ATG4B has been demonstrated to be a prospective anti-tumor target. However, the existing ATG4B inhibitors are still f…
View article: Environmental and Spatial Effects on Beak Morphology of the Purppleback Fling Suqid (Sthenoteuthis Oualaniensis) at Different Stages of Gonad Maturity in the Northwest Indian Ocean
Environmental and Spatial Effects on Beak Morphology of the Purppleback Fling Suqid (Sthenoteuthis Oualaniensis) at Different Stages of Gonad Maturity in the Northwest Indian Ocean Open
View article: CircPHKB decreases the sensitivity of liver cancer cells to sorafenib via miR-1234-3p/CYP2W1 axis
CircPHKB decreases the sensitivity of liver cancer cells to sorafenib via miR-1234-3p/CYP2W1 axis Open
Sorafenib is currently the first-line treatment for patients with advanced liver cancer, but its therapeutic efficacy declines significantly after a few months of treatment. Therefore, it is of great importance to investigate the regulator…
View article: A Novel Cargo Delivery System‐AnCar‐Exo<sup>LaIMTS</sup> Ameliorates Arthritis via Specifically Targeting Pro‐Inflammatory Macrophages
A Novel Cargo Delivery System‐AnCar‐Exo<sup>LaIMTS</sup> Ameliorates Arthritis via Specifically Targeting Pro‐Inflammatory Macrophages Open
Macrophages are heterogenic phagocytic cells that play distinct roles in physiological and pathological processes. Targeting different types of macrophages has shown potent therapeutic effects in many diseases. Although many approaches are…
View article: Supplementary Figure S5 from Metformin Synergizes with BCL-XL/BCL-2 Inhibitor ABT-263 to Induce Apoptosis Specifically in p53-Defective Cancer Cells
Supplementary Figure S5 from Metformin Synergizes with BCL-XL/BCL-2 Inhibitor ABT-263 to Induce Apoptosis Specifically in p53-Defective Cancer Cells Open
Metformin attenuates ABT-263-induced MCL-1, XIAP and SURVIVIN through neither transcriptional nor posttranslational regulation.
View article: Supplementary Figure S1 from Metformin Synergizes with BCL-XL/BCL-2 Inhibitor ABT-263 to Induce Apoptosis Specifically in p53-Defective Cancer Cells
Supplementary Figure S1 from Metformin Synergizes with BCL-XL/BCL-2 Inhibitor ABT-263 to Induce Apoptosis Specifically in p53-Defective Cancer Cells Open
The synergistic effect between metformin and ABT-263 is independent of the cell cycle changes and metformin sensitizes ABT-263 not via changing the levels of BCL-2, BCL-XL, cIAP1 and cIAP2.
View article: Supplementary Figures 1-13 from Sorafenib Sensitizes (−)-Gossypol-Induced Growth Suppression in Androgen-Independent Prostate Cancer Cells via Mcl-1 Inhibition and Bak Activation
Supplementary Figures 1-13 from Sorafenib Sensitizes (−)-Gossypol-Induced Growth Suppression in Androgen-Independent Prostate Cancer Cells via Mcl-1 Inhibition and Bak Activation Open
PDF file - 338K
View article: Data from Sorafenib Sensitizes (−)-Gossypol-Induced Growth Suppression in Androgen-Independent Prostate Cancer Cells via Mcl-1 Inhibition and Bak Activation
Data from Sorafenib Sensitizes (−)-Gossypol-Induced Growth Suppression in Androgen-Independent Prostate Cancer Cells via Mcl-1 Inhibition and Bak Activation Open
The natural BH3-mimetic (−)-gossypol shows promising efficacy in ongoing phase II/III clinical trials for human prostate cancer. Here, we show for the first time, that treatment with (−)-gossypol and multikinase inhibitor sorafenib synergi…
View article: Supplementary Figures 1-13 from Sorafenib Sensitizes (−)-Gossypol-Induced Growth Suppression in Androgen-Independent Prostate Cancer Cells via Mcl-1 Inhibition and Bak Activation
Supplementary Figures 1-13 from Sorafenib Sensitizes (−)-Gossypol-Induced Growth Suppression in Androgen-Independent Prostate Cancer Cells via Mcl-1 Inhibition and Bak Activation Open
PDF file - 338K
View article: Supplementary Figure S3 from Metformin Synergizes with BCL-XL/BCL-2 Inhibitor ABT-263 to Induce Apoptosis Specifically in p53-Defective Cancer Cells
Supplementary Figure S3 from Metformin Synergizes with BCL-XL/BCL-2 Inhibitor ABT-263 to Induce Apoptosis Specifically in p53-Defective Cancer Cells Open
Silencing or overexpressing the indicated genes in the presence of ABT-263 alone or the combination of metformin and ABT-263.
View article: Supplementary Figure S2 from Metformin Synergizes with BCL-XL/BCL-2 Inhibitor ABT-263 to Induce Apoptosis Specifically in p53-Defective Cancer Cells
Supplementary Figure S2 from Metformin Synergizes with BCL-XL/BCL-2 Inhibitor ABT-263 to Induce Apoptosis Specifically in p53-Defective Cancer Cells Open
Combination of metformin with ABT-263 had no significant growth inhibition effect on HEK-293 cells.
View article: Supplementary Figure S3 from Metformin Synergizes with BCL-XL/BCL-2 Inhibitor ABT-263 to Induce Apoptosis Specifically in p53-Defective Cancer Cells
Supplementary Figure S3 from Metformin Synergizes with BCL-XL/BCL-2 Inhibitor ABT-263 to Induce Apoptosis Specifically in p53-Defective Cancer Cells Open
Silencing or overexpressing the indicated genes in the presence of ABT-263 alone or the combination of metformin and ABT-263.
View article: Supplementary Figure Legend 14 from Sorafenib Sensitizes (−)-Gossypol-Induced Growth Suppression in Androgen-Independent Prostate Cancer Cells via Mcl-1 Inhibition and Bak Activation
Supplementary Figure Legend 14 from Sorafenib Sensitizes (−)-Gossypol-Induced Growth Suppression in Androgen-Independent Prostate Cancer Cells via Mcl-1 Inhibition and Bak Activation Open
PDF file - 49K
View article: Supplementary Figure Legend 14 from Sorafenib Sensitizes (−)-Gossypol-Induced Growth Suppression in Androgen-Independent Prostate Cancer Cells via Mcl-1 Inhibition and Bak Activation
Supplementary Figure Legend 14 from Sorafenib Sensitizes (−)-Gossypol-Induced Growth Suppression in Androgen-Independent Prostate Cancer Cells via Mcl-1 Inhibition and Bak Activation Open
PDF file - 49K
View article: Supplementary Figure S8 from Metformin Synergizes with BCL-XL/BCL-2 Inhibitor ABT-263 to Induce Apoptosis Specifically in p53-Defective Cancer Cells
Supplementary Figure S8 from Metformin Synergizes with BCL-XL/BCL-2 Inhibitor ABT-263 to Induce Apoptosis Specifically in p53-Defective Cancer Cells Open
Cotreatment with metformin and ABT-263 more remarkably elevates SASP components and p-ATM in p53-WT cancer cells compared to p53-defective cancer cells and the cotreatment increases p53 in p53-WT cancer cells.
View article: Supplementary Figure S8 from Metformin Synergizes with BCL-XL/BCL-2 Inhibitor ABT-263 to Induce Apoptosis Specifically in p53-Defective Cancer Cells
Supplementary Figure S8 from Metformin Synergizes with BCL-XL/BCL-2 Inhibitor ABT-263 to Induce Apoptosis Specifically in p53-Defective Cancer Cells Open
Cotreatment with metformin and ABT-263 more remarkably elevates SASP components and p-ATM in p53-WT cancer cells compared to p53-defective cancer cells and the cotreatment increases p53 in p53-WT cancer cells.
View article: Data from Metformin Synergizes with BCL-XL/BCL-2 Inhibitor ABT-263 to Induce Apoptosis Specifically in p53-Defective Cancer Cells
Data from Metformin Synergizes with BCL-XL/BCL-2 Inhibitor ABT-263 to Induce Apoptosis Specifically in p53-Defective Cancer Cells Open
p53 deficiency, a frequent event in multiple kinds of malignancies, decreases the sensitivity of diverse targeted chemotherapeutics including the BCL-XL/BCL-2 inhibitor ABT-263. Loss of p53 function can activate mTOR complex 1 (mTORC1), wh…
View article: Data from Metformin Synergizes with BCL-XL/BCL-2 Inhibitor ABT-263 to Induce Apoptosis Specifically in p53-Defective Cancer Cells
Data from Metformin Synergizes with BCL-XL/BCL-2 Inhibitor ABT-263 to Induce Apoptosis Specifically in p53-Defective Cancer Cells Open
p53 deficiency, a frequent event in multiple kinds of malignancies, decreases the sensitivity of diverse targeted chemotherapeutics including the BCL-XL/BCL-2 inhibitor ABT-263. Loss of p53 function can activate mTOR complex 1 (mTORC1), wh…