Zihao Yuan
YOU?
Author Swipe
View article: DIET COMPOSITION AND TROPHIC NICHE OF FISH COMMUNITIES IN ERHAI LAKE: EVIDENCE FROM SIGNATURE FATTY ACID STUDIES
DIET COMPOSITION AND TROPHIC NICHE OF FISH COMMUNITIES IN ERHAI LAKE: EVIDENCE FROM SIGNATURE FATTY ACID STUDIES Open
View article: Harnessing GPT-4 for automated error detection in pathology reports: Implications for oncology diagnostics
Harnessing GPT-4 for automated error detection in pathology reports: Implications for oncology diagnostics Open
Objective Accurate pathology reports are crucial for the diagnosis and treatment planning of cancer patients. However, these reports are prone to errors due to time pressures, subjective interpretation, and inconsistencies among profession…
View article: Detection of Avian Influenza Virus in Pigeons
Detection of Avian Influenza Virus in Pigeons Open
Pigeons (Columba livia) are usually kept as free-ranging or racing birds, and they have direct contact with livestock, poultry, and humans. Therefore, they may have an important role in the ecology of influenza virus among various species.…
View article: Teleost GSDMEc regulates GSDMEa-mediated pyroptosis
Teleost GSDMEc regulates GSDMEa-mediated pyroptosis Open
Our results revealed the functions and interactive mechanism of teleost GSDME orthologs, and provided new insights into the regulation of pyroptosis in lower vertebrates.
View article: Web tension field action of a stainless steel section with stiffened web and folded flanges under bending and shear interaction
Web tension field action of a stainless steel section with stiffened web and folded flanges under bending and shear interaction Open
Compared with ordinary steels, stainless steels possess advantages such as robust corrosion resistance, beautiful appearance, and excellent ductility. This article investigated the performance of a novel C-shaped folded flange section stai…
View article: Vanadium-Dependent Haloperoxidase Gene Evolution in Brown Algae: Evidence for Horizontal Gene Transfer
Vanadium-Dependent Haloperoxidase Gene Evolution in Brown Algae: Evidence for Horizontal Gene Transfer Open
Compared with green plants, brown algae are characterized by their ability to accumulate iodine, contributing to their ecological adaptability in high-iodide coastal environments. Vanadium-dependent haloperoxidase (V-HPO) is the key enzyme…
View article: Efficacy and safety of immunotherapy in locally advanced or metastatic pulmonary lymphoepithelioma-like carcinoma: a multicenter retrospective study
Efficacy and safety of immunotherapy in locally advanced or metastatic pulmonary lymphoepithelioma-like carcinoma: a multicenter retrospective study Open
Background: Pulmonary lymphoepithelioma-like carcinoma (pLELC) is a rare subtype of non-small-cell lung cancer that predominantly affects younger, non-smoking individuals in southern and southeast Asia, where Epstein–Barr virus (EBV) preva…
View article: Integrated multi-approaches reveal unique metabolic mechanisms of Vestimentifera to adapt to deep sea
Integrated multi-approaches reveal unique metabolic mechanisms of Vestimentifera to adapt to deep sea Open
This study indicates a critical role of bacterial glycogen biosynthesis in the highly efficient symbiont - vestimentiferan cooperation. This study provides a new perspective for understanding the environmental adaptation strategies of vest…
View article: The Evolution and Biological Activity of Metazoan Mixed Lineage Kinase Domain-Like Protein (MLKL)
The Evolution and Biological Activity of Metazoan Mixed Lineage Kinase Domain-Like Protein (MLKL) Open
In mammals, mixed lineage kinase domain-like protein (MLKL) is the executor of necroptosis. MLKL comprises an N-terminal domain (NTD), which alone suffices to trigger necroptosis by forming pores in the plasma membrane, and a C-terminal do…
View article: Pyroptotic gasdermin exists in Mollusca and is vital to eliminating bacterial infection
Pyroptotic gasdermin exists in Mollusca and is vital to eliminating bacterial infection Open
View article: Pufferfish gasdermin Ea is a significant player in the defense against bacterial pathogens
Pufferfish gasdermin Ea is a significant player in the defense against bacterial pathogens Open
Gasdermins (GSDMs) are proteins cleaved by caspase (CASP) to trigger pyroptosis. In teleosts, pyroptosis is mediated by gasdermin E (GSDME). The Pufferfish, Takifugu rubripes , possesses two GSDME orthologs: named TrGSDMEa and TrGSDMEb. Tr…
View article: Characterization of the Apoptotic and Antimicrobial Activities of Two Initiator Caspases of Sea Cucumber Apostichopus japonicus
Characterization of the Apoptotic and Antimicrobial Activities of Two Initiator Caspases of Sea Cucumber Apostichopus japonicus Open
Caspase (CASP) is a protease family that plays a vital role in apoptosis, development, and immune response. Herein, we reported the identification and characterization of two CASPs, AjCASPX1 and AjCASPX2, from the sea cucumber Apostichopus…
View article: The molecular mechanism and evolutionary divergence of caspase 3/7-regulated gasdermin E activation
The molecular mechanism and evolutionary divergence of caspase 3/7-regulated gasdermin E activation Open
Caspase (CASP) is a family of proteases involved in cleavage and activation of gasdermin, the executor of pyroptosis. In humans, CASP3 and CASP7 recognize the same consensus motif DxxD, which is present in gasdermin E (GSDME). However, hum…
View article: Author Response: The molecular mechanism and evolutionary divergence of caspase 3/7-regulated gasdermin E activation
Author Response: The molecular mechanism and evolutionary divergence of caspase 3/7-regulated gasdermin E activation Open
Full text Figures and data Peer review Side by side Abstract eLife assessment eLife digest Introduction Results Discussion Materials and methods Data availability References Article and author information Metrics Abstract Caspase (CASP) is…
View article: The difference of the composition and digestive enzymes of gut microbiome in herbivorous blunt snout bream (Megalobrama amblycephala) and carnivorous largemouth bass (Micropterus salmoides)
The difference of the composition and digestive enzymes of gut microbiome in herbivorous blunt snout bream (Megalobrama amblycephala) and carnivorous largemouth bass (Micropterus salmoides) Open
Blunt snout bream (Megalobrama amblycephala) and largemouth bass (Micropterus salmoides) are a herbivorous and a carnivorous freshwater fish species respectively. These fish possess distinct intestinal microorganisms and digestive enzymes …
View article: Reviewer #1 (Public Review): The molecular mechanism and evolutionary divergence of caspase 3/7-regulated gasdermin E activation
Reviewer #1 (Public Review): The molecular mechanism and evolutionary divergence of caspase 3/7-regulated gasdermin E activation Open
Caspase (CASP) is a family of proteases involved in cleavage and activation of gasdermin, the executor of pyroptosis. In human, CASP3 and CASP7 recognize the same consensus motif DxxD, which is present in gasdermin E (GSDME). However, huma…
View article: Author Response: The molecular mechanism and evolutionary divergence of caspase 3/7-regulated gasdermin E activation
Author Response: The molecular mechanism and evolutionary divergence of caspase 3/7-regulated gasdermin E activation Open
View article: Reviewer #2 (Public Review): The molecular mechanism and evolutionary divergence of caspase 3/7-regulated gasdermin E activation
Reviewer #2 (Public Review): The molecular mechanism and evolutionary divergence of caspase 3/7-regulated gasdermin E activation Open
Caspase (CASP) is a family of proteases involved in cleavage and activation of gasdermin, the executor of pyroptosis. In human, CASP3 and CASP7 recognize the same consensus motif DxxD, which is present in gasdermin E (GSDME). However, huma…
View article: The molecular mechanism and evolutionary divergence of caspase 3/7-regulated gasdermin E activation
The molecular mechanism and evolutionary divergence of caspase 3/7-regulated gasdermin E activation Open
Caspase (CASP) is a family of proteases involved in cleavage and activation of gasdermin, the executor of pyroptosis. In human, CASP3 and CASP7 recognize the same consensus motif DxxD, which is present in gasdermin E (GSDME). However, huma…
View article: Carbon Microspheres with Cr(VI) Adsorption Performance were Prepared by In-situ Hydrothermal Carbonization Method
Carbon Microspheres with Cr(VI) Adsorption Performance were Prepared by In-situ Hydrothermal Carbonization Method Open
Biochar material is a renewable adsorbent widely used for treating contaminated wastewater. The hydrothermal carbon (HTC) were prepared from low polymeric sugars and low concentration glucose under hydrothermal carbonization reactions with…
View article: Baseline serum tumor markers predict the survival of patients with advanced non-small cell lung cancer receiving first-line immunotherapy: a multicenter retrospective study
Baseline serum tumor markers predict the survival of patients with advanced non-small cell lung cancer receiving first-line immunotherapy: a multicenter retrospective study Open
Background This study aimed to investigate the association between baseline serum tumor markers (STMs) (carcinoembryonic antigen [CEA], neuron-specific enolase [NSE], cytokeratin-19 fragment [CYFRA21-1], carbohydrate antigen 19–9 [CA19-9],…
View article: Reviewer #2 (Public Review): The molecular mechanism and evolutionary divergence of caspase 3/7-regulated gasdermin E activation
Reviewer #2 (Public Review): The molecular mechanism and evolutionary divergence of caspase 3/7-regulated gasdermin E activation Open
Cleavage of gasdermin, typically by caspase (CASP), is required for pyroptosis. In human, CASP3 and CASP7 recognize the same consensus motif DxxD, which is present in gasdermin E (GSDME), but only CASP3 cleaves GSDME. The underlying mechan…
View article: The molecular mechanism and evolutionary divergence of caspase 3/7-regulated gasdermin E activation
The molecular mechanism and evolutionary divergence of caspase 3/7-regulated gasdermin E activation Open
Caspase (CASP) is a family of proteases involved in cleavage and activation of gasdermin, the executor of pyroptosis. In humans, CASP3 and CASP7 recognize the same consensus motif DxxD, which is present in gasdermin E (GSDME). However, hum…
View article: Reviewer #1 (Public Review): The molecular mechanism and evolutionary divergence of caspase 3/7-regulated gasdermin E activation
Reviewer #1 (Public Review): The molecular mechanism and evolutionary divergence of caspase 3/7-regulated gasdermin E activation Open
Cleavage of gasdermin, typically by caspase (CASP), is required for pyroptosis. In human, CASP3 and CASP7 recognize the same consensus motif DxxD, which is present in gasdermin E (GSDME), but only CASP3 cleaves GSDME. The underlying mechan…
View article: The molecular mechanism and evolutionary divergence of caspase 3/7-regulated gasdermin E activation
The molecular mechanism and evolutionary divergence of caspase 3/7-regulated gasdermin E activation Open
Cleavage of gasdermin, typically by caspase (CASP), is required for pyroptosis. In human, CASP3 and CASP7 recognize the same consensus motif DxxD, which is present in gasdermin E (GSDME), but only CASP3 cleaves GSDME. The underlying mechan…
View article: Comparison of first-line immunotherapy efficacy between advanced lung squamous cell carcinoma and pulmonary lymphoepithelioma-like carcinoma: A propensity score matching multicenter study
Comparison of first-line immunotherapy efficacy between advanced lung squamous cell carcinoma and pulmonary lymphoepithelioma-like carcinoma: A propensity score matching multicenter study Open
Background: Compared with other lung squamous cell carcinomas (LUSC), pulmonary lymphoepithelioma-like carcinoma (pLELC) is closely associated with Epstein–Barr virus (EBV) infections with a unique molecular profile and immune microenviron…
View article: The molecular mechanism and evolutionary divergence of caspase 3/7-regulated gasdermin E activation
The molecular mechanism and evolutionary divergence of caspase 3/7-regulated gasdermin E activation Open
Caspase (CASP) is a family of proteases involved in cleavage and activation of gasdermin, the executor of pyroptosis. In human, CASP3 and CASP7 recognize the same consensus motif DxxD, which is present in gasdermin E (GSDME). However, huma…
View article: Integrated multi-approaches reveal unique metabolic mechanisms of Vestimentifera to adapt to deep-sea hydrothermal vents
Integrated multi-approaches reveal unique metabolic mechanisms of Vestimentifera to adapt to deep-sea hydrothermal vents Open
Vestimentiferans (Siboglinidae, Polychaeta) thrive in deep-sea hydrothermal vents and depend on chemosynthetic symbiosis for nutrition. Currently, the central carbon metabolisms, especially the sugar synthesis pathways, of vestimentiferans…
View article: Pyroptotic gasdermin exists in Mollusca and is vital to eliminating bacterial infection
Pyroptotic gasdermin exists in Mollusca and is vital to eliminating bacterial infection Open
Gasdermin (GSDM) is a family of proteins that execute pyroptosis in vertebrate. In invertebrate, pyroptotic GSDM was documented only in coral. Recent studies identified abundant GSDM structural homologs in Mollusca, but their functions are…
View article: Data from Disrupting LILRB4/APOE Interaction by an Efficacious Humanized Antibody Reverses T-cell Suppression and Blocks AML Development
Data from Disrupting LILRB4/APOE Interaction by an Efficacious Humanized Antibody Reverses T-cell Suppression and Blocks AML Development Open
Therapeutic strategies are urgently needed for patients with acute myeloid leukemia (AML). Leukocyte immunoglobulin-like receptor B4 (LILRB4), which suppresses T-cell activation and supports tissue infiltration of AML cells, represents an …