Qin Zhang
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View article: Hybrid untargeted and targeted RNA sequencing facilitates genotype-phenotype associations at single-cell resolution
Hybrid untargeted and targeted RNA sequencing facilitates genotype-phenotype associations at single-cell resolution Open
Long-read scRNA-seq has enabled simultaneous, unbiased identification of transcriptomic variants and expression profiling. However, it often suffers from limited read coverage, which constrains its ability to link genotype and phenotype at…
View article: A comprehensive analysis of supermere, exomere, and extracellular vesicle isolation and cargo in colorectal cancer
A comprehensive analysis of supermere, exomere, and extracellular vesicle isolation and cargo in colorectal cancer Open
Biofluids contain a heterogeneous mixture of extracellular vesicles and non-vesicular nanoparticles (including exomeres and supermeres) that transport a diverse array of proteins, RNA, and lipids. Our previous efforts to characterize the c…
View article: GREEN INNOVATIVE WORK BEHAVIOR AND SMES’ BUSINESS SUSTAINABILITY: A CONCEPTUAL FRAMEWORK
GREEN INNOVATIVE WORK BEHAVIOR AND SMES’ BUSINESS SUSTAINABILITY: A CONCEPTUAL FRAMEWORK Open
Given the aggravation of global environmental problems and the promotion of sustainable development strategies, corporate green innovation has become an important way to enhance corporate competitiveness and promote social responsibility. …
View article: Comparison of single-cell long-read and short-read transcriptome sequencing via cDNA molecule matching: quality evaluation of the MAS-ISO-seq approach
Comparison of single-cell long-read and short-read transcriptome sequencing via cDNA molecule matching: quality evaluation of the MAS-ISO-seq approach Open
Single-cell RNA sequencing is used for profiling gene expression differences between cells. It can be performed with short reads, which provide high-throughput and high-quality information at the gene level, or with long reads, which provi…
View article: CSEANet: Cross-Stage Enhanced Aggregation Network for Detecting Surface Bolt Defects in Railway Steel Truss Bridges
CSEANet: Cross-Stage Enhanced Aggregation Network for Detecting Surface Bolt Defects in Railway Steel Truss Bridges Open
The accurate detection of surface bolt defects in railway steel truss bridges plays a vital role in maintaining structural integrity. Conventional manual inspection techniques require extensive labor and introduce subjective assessments, f…
View article: Harnessing Photo‐Energy Conversion in Nanomaterials for Precision Theranostics
Harnessing Photo‐Energy Conversion in Nanomaterials for Precision Theranostics Open
The rapidly advancing field of theranostics aims to integrate therapeutic and diagnostic functionalities into a single platform for precision medicine, enabling the simultaneous treatment and monitoring of diseases. Photo‐energy conversion…
View article: In vivo quantification of viscoelastic property alterations in oral submucous fibrosis using optical coherence elastography
In vivo quantification of viscoelastic property alterations in oral submucous fibrosis using optical coherence elastography Open
Quantitative analysis of viscoelastic alterations in oral submucous fibrosis (OSF) provides crucial insights for monitoring disease progression and preventing malignant transformation. We developed a piezoelectric-based optical coherence e…
View article: Enhancer transcription profiling reveals an enhancer RNA-driven ferroptosis and new therapeutic opportunities in prostate cancer
Enhancer transcription profiling reveals an enhancer RNA-driven ferroptosis and new therapeutic opportunities in prostate cancer Open
Enhancer RNAs (eRNAs), a subclass of non-coding RNAs transcribed from enhancer regions, have emerged as critical regulators of gene expression; however, their functional roles in prostate cancer remain largely unexplored. In this study, we…
View article: Nuclear factor erythroid 2‐related factor 2 ameliorates disordered glucose and lipid metabolism in liver: Involvement of gasdermin D in regulating pyroptosis
Nuclear factor erythroid 2‐related factor 2 ameliorates disordered glucose and lipid metabolism in liver: Involvement of gasdermin D in regulating pyroptosis Open
Background The epidemic of metabolic dysfunction‐associated fatty liver disease linked to excessive high‐fat diet (HFD) consumption has sparked widespread public concern. Nuclear factor erythroid 2‐related factor 2 (NRF2) has been reported…
View article: Blebbisomes are large, organelle-rich extracellular vesicles with cell-like properties
Blebbisomes are large, organelle-rich extracellular vesicles with cell-like properties Open
View article: Lon protease 1-mediated metabolic reprogramming promotes the progression of prostate cancer
Lon protease 1-mediated metabolic reprogramming promotes the progression of prostate cancer Open
View article: Application of lacrimal gland ultrasonography in the evaluation of chronic ocular graft-versus-host-disease
Application of lacrimal gland ultrasonography in the evaluation of chronic ocular graft-versus-host-disease Open
Objective To investigate the effectiveness of lacrimal gland ultrasonography in the assessment of chronic ocular graft-versus-host-disease (oGVHD) after allogeneic hematopoietic stem cell transplantation (allo-HSCT) and to establish the co…
View article: Multifunctional biomass materials based on electroless plating
Multifunctional biomass materials based on electroless plating Open
View article: What Determines Rural Residents’ Intention and Behavior Towards Clean Energy Use? Evidence from Northwest China
What Determines Rural Residents’ Intention and Behavior Towards Clean Energy Use? Evidence from Northwest China Open
Two United Nations Sustainable Development Goals highlight that energy supply, conversion, transmission, and consumption are primary contributors to climate change, accounting for 60% of global greenhouse gas emissions. Exploring the influ…
View article: Nuclear Factor I Family Members are Key Transcription Factors Regulating Gene Expression
Nuclear Factor I Family Members are Key Transcription Factors Regulating Gene Expression Open
View article: A biomimetic upconversion nanoreactors for near-infrared driven H2 release to inhibit tauopathy in Alzheimer's disease therapy
A biomimetic upconversion nanoreactors for near-infrared driven H2 release to inhibit tauopathy in Alzheimer's disease therapy Open
View article: High-density lipoprotein cholesterol level and risk of muscle strength decline and sarcopenia in older adults
High-density lipoprotein cholesterol level and risk of muscle strength decline and sarcopenia in older adults Open
We present the first longitudinal evidence that very high HDL-C level was associated with a significantly higher risk of muscle strength decline and developing sarcopenia in older adults. It is essential to monitor the muscle health of old…
View article: Effect of occupational stress and resilience on insomnia among nurses during COVID-19 in China: a structural equation modelling analysis
Effect of occupational stress and resilience on insomnia among nurses during COVID-19 in China: a structural equation modelling analysis Open
Objectives To explore the effects of occupational stress and resilience on insomnia among Chinese nurses during the COVID-19 pandemic. Design, settings and participants A quantitative description study. The data were collected via a cross-…
View article: Prognostic significance of CT-determined sarcopenia in older patients with advanced squamous cell lung cancer treated with programmed death-1 inhibitors
Prognostic significance of CT-determined sarcopenia in older patients with advanced squamous cell lung cancer treated with programmed death-1 inhibitors Open
Sarcopenia has been associated with higher toxicity induced by anti-cancer treatments and shorter survival in patients with squamous cell lung carcinoma (SqCLC). Over the past few decades, immune checkpoint inhibitors (ICIs) significantly …
View article: Viscoelasticity quantification of cancerous tongue using intraoral optical coherence elastography: a preliminary study
Viscoelasticity quantification of cancerous tongue using intraoral optical coherence elastography: a preliminary study Open
Quantifying the biomechanical properties of the tongue is significant for early diagnosis of tongue carcinoma. Therefore, an intraoral optical coherence elastography system based on a miniature probe was proposed here to evaluate the visco…
View article: Comparison of Single-cell Long-read and Short-read Transcriptome Sequencing of Patient-derived Organoid Cells of ccRCC: Quality Evaluation of the MAS-ISO-seq Approach
Comparison of Single-cell Long-read and Short-read Transcriptome Sequencing of Patient-derived Organoid Cells of ccRCC: Quality Evaluation of the MAS-ISO-seq Approach Open
Single-cell RNA sequencing is used in profiling gene expression differences between cells. Short-read sequencing platforms provide high throughput and high-quality information at the gene-level, but the technique is hindered by limited rea…
View article: The role of cholesterol metabolism in lung cancer
The role of cholesterol metabolism in lung cancer Open
Elevated serum cholesterol metabolism is associated with a reduced risk of lung cancer. Disrupted cholesterol metabolism is evident in both lung cancer patients and tumor cells. Inhibiting tumor cell cholesterol uptake or biosynthesis path…
View article: Quantitative Evaluation of Biomechanical Properties of the Tongue Using a Shaker-Based Optical Coherence Elastography System
Quantitative Evaluation of Biomechanical Properties of the Tongue Using a Shaker-Based Optical Coherence Elastography System Open
Biomechanical properties of the tongue play a significant role in maintaining its normal physiological state. Although some techniques have been used to evaluate the tongue’s elasticity, they are limited in clinical detection because of lo…
View article: 208P Identification of BCOR mutation as a novel predictor of immunotherapy efficacy in gastrointestinal tumors
208P Identification of BCOR mutation as a novel predictor of immunotherapy efficacy in gastrointestinal tumors Open
View article: 877P ROS1 mutations as potential negative predictor for response of immunotherapy in patient with head and neck cancer
877P ROS1 mutations as potential negative predictor for response of immunotherapy in patient with head and neck cancer Open
The c-ros oncogene 1 (ROS1) gene has aroused great research interest for its role as an oncogenic driver of malignancies, as well as its untapped potential for novel therapeutic target. Despite the success of targeted therapy in ROS1-rearr…
View article: 633P Genomic alterations in SPEN predict outcome of immune checkpoint therapy in gastrointestinal cancer
633P Genomic alterations in SPEN predict outcome of immune checkpoint therapy in gastrointestinal cancer Open
View article: 884P Prognostic value and immune characteristics of LGALS1 in head and neck squamous cell carcinoma
884P Prognostic value and immune characteristics of LGALS1 in head and neck squamous cell carcinoma Open
View article: 1644P The mutation landscape and evolution pattern of liver or peritoneal metastasis in pancreatic cancer
1644P The mutation landscape and evolution pattern of liver or peritoneal metastasis in pancreatic cancer Open
View article: Attitudes and demands on medical statistical education during the COVID-19 pandemic among undergraduates-postgraduates-teachers: A cross-sectional study in eastern China
Attitudes and demands on medical statistical education during the COVID-19 pandemic among undergraduates-postgraduates-teachers: A cross-sectional study in eastern China Open
Global coronavirus disease 2019 pandemic leads to the soaring demand for medical statistical applications, bringing a great challenge to medical education at universities worldwide. The purpose of our study is to investigate medical studen…
View article: Mechanical manipulation of cancer cell tumorigenicity via heat shock protein signaling
Mechanical manipulation of cancer cell tumorigenicity via heat shock protein signaling Open
Biophysical cues of rigid tumor matrix play a critical role in cancer cell malignancy. We report that stiffly confined cancer cells exhibit robust growth of spheroids in the stiff hydrogel that exerts substantial confining stress on the ce…