Zihong Liang
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View article: The efficacy and safety of fingolimod plus standardized treatment versus standardized treatment alone for acute ischemic stroke: A systematic review and meta‐analysis
The efficacy and safety of fingolimod plus standardized treatment versus standardized treatment alone for acute ischemic stroke: A systematic review and meta‐analysis Open
Acute ischemic stroke (AIS) is the most common type of stroke. Fingolimod is a sphingosine analog that acts on sphingosine‐1‐phosphate receptors (S1PR). Recently, the safety and efficacy of fingolimod in both patients with intracerebral he…
View article: Agomelatine might be more appropriate for elderly, depressed, type 2 diabetes mellitus patients than paroxetine/fluoxetine
Agomelatine might be more appropriate for elderly, depressed, type 2 diabetes mellitus patients than paroxetine/fluoxetine Open
Agomelatine was a novel and melatonergic antidepressant. The present study was conducted to find out whether age was an important factor for agomelatine in treating depressed type 2 diabetes mellitus (T2DM) patients. In total, 193 depresse…
View article: <p>Diterpene Ginkgolides Exert an Antidepressant Effect Through the NT3-TrkA and Ras-MAPK Pathways</p>
Diterpene Ginkgolides Exert an Antidepressant Effect Through the NT3-TrkA and Ras-MAPK Pathways Open
These findings provide novel insight into the mechanisms underlying the antidepressant action of DG, and should help advance the development of new therapeutic strategies for depression.
View article: <p>Efficacy of ginkgo biloba extract as augmentation of venlafaxine in treating post-stroke depression</p>
Efficacy of ginkgo biloba extract as augmentation of venlafaxine in treating post-stroke depression Open
These results demonstrated that the ginkgo biloba extract was a good augmentation of venlafaxine in treating PSD and should be further investigated.
View article: <p>Urinary biomarkers for diagnosing poststroke depression in patients with type 2 diabetes mellitus</p>
Urinary biomarkers for diagnosing poststroke depression in patients with type 2 diabetes mellitus Open
Our results could be helpful for future development of an objective method to diagnose T2DM patients with PSD and provide novel ideas to study the pathogenesis of depression.
View article: A Pattern-Based Method for Medical Entity Recognition From Chinese Diagnostic Imaging Text
A Pattern-Based Method for Medical Entity Recognition From Chinese Diagnostic Imaging Text Open
Background: The identification of medical entities and relations from electronic medical records is a fundamental research issue for medical informatics. However, the task of extracting valuable knowledge from these records is chall…
View article: Diterpene Ginkgolides Exert an Antidepressive Effect Through the NT3-TrkA and Ras-MAPK Pathways
Diterpene Ginkgolides Exert an Antidepressive Effect Through the NT3-TrkA and Ras-MAPK Pathways Open
View article: Ginkgo biloba extract and its diterpene ginkgolide constituents ameliorate the metabolic disturbances caused by recombinant tissue plasminogen activator in rat prefrontal cortex
Ginkgo biloba extract and its diterpene ginkgolide constituents ameliorate the metabolic disturbances caused by recombinant tissue plasminogen activator in rat prefrontal cortex Open
Our results provide important novel mechanistic insights into the adverse effects of rtPA and offer directions for future exploration on the thrombolytic effects of rtPA combined with the administration of DG or GBE for the treatment of ac…
View article: Metabolite-related antidepressant action of diterpene ginkgolides in the prefrontal cortex
Metabolite-related antidepressant action of diterpene ginkgolides in the prefrontal cortex Open
These findings demonstrate that DG has antidepressant-like, but not anxiolytic-like, effects in mice, suggesting that it might have therapeutic potential for the treatment of major depressive disorder.
View article: Insight into the metabolic mechanism of Diterpene Ginkgolides on antidepressant effects for attenuating behavioural deficits compared with venlafaxine
Insight into the metabolic mechanism of Diterpene Ginkgolides on antidepressant effects for attenuating behavioural deficits compared with venlafaxine Open
Depression is a severe and chronic mental disorder, affecting about 322 million individuals worldwide. A recent study showed that diterpene ginkgolides (DG) have antidepressant-like effects on baseline behaviours in mice. Here, we examined…
View article: Inhibitory effects of vitamin E on osteocyte apoptosis and DNA oxidative damage in bone marrow hemopoietic cells at early stage of steroid-induced femoral head necrosis
Inhibitory effects of vitamin E on osteocyte apoptosis and DNA oxidative damage in bone marrow hemopoietic cells at early stage of steroid-induced femoral head necrosis Open
Apoptosis and DNA oxidative damage serve significant roles in the pathogenesis of steroid‑induced femoral head necrosis. Vitamin E demonstrates anti‑apoptotic and anti‑oxidant properties. Therefore, the present study investigated the effec…
View article: Brain region-specific metabolite networks regulate antidepressant effects of venlafaxine
Brain region-specific metabolite networks regulate antidepressant effects of venlafaxine Open
Administration of venlafaxine significantly altered the metabolic profiles of both the hippocampus and prefrontal cortex and the altered metabolites had significant brain region specificities.
View article: Recombinant Tissue Plasminogen Activator Induces Neurological Side Effects Independent on Thrombolysis in Mechanical Animal Models of Focal Cerebral Infarction: A Systematic Review and Meta-Analysis
Recombinant Tissue Plasminogen Activator Induces Neurological Side Effects Independent on Thrombolysis in Mechanical Animal Models of Focal Cerebral Infarction: A Systematic Review and Meta-Analysis Open
This meta-analysis reveals rtPA can lead to neurological side effects besides thrombolysis in mechanical animal stroke, which may account for clinical exacerbation for stroke patients that do not achieve vascular recanalization with rtPA.