Zihui Deng
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View article: Research advances in the function and anti-aging effects of nicotinamide mononucleotide
Research advances in the function and anti-aging effects of nicotinamide mononucleotide Open
Aging and age-related ailments have emerged as critical challenges and great burdens within the global contemporary society. Addressing these concerns is an imperative task, with the aims of postponing the aging process and finding effecti…
View article: Ameliorative effects of mesenchymal stromal cells on senescence associated phenotypes in naturally aged rats
Ameliorative effects of mesenchymal stromal cells on senescence associated phenotypes in naturally aged rats Open
Background Aging is a multifaceted process that affects all organ systems. With the increasing trend of population aging, aging-related diseases have resulted in significant medical challenges and socioeconomic burdens. Mesenchymal stromal…
View article: Immunotherapy in the context of sepsis-induced immunological dysregulation
Immunotherapy in the context of sepsis-induced immunological dysregulation Open
Sepsis is a clinical syndrome caused by uncontrollable immune dysregulation triggered by pathogen infection, characterized by high incidence, mortality rates, and disease burden. Current treatments primarily focus on symptomatic relief, la…
View article: Ameliorative Effects of Mesenchymal Stem Cells on Senescence Associated Phenotypes in Naturally Aged Rats
Ameliorative Effects of Mesenchymal Stem Cells on Senescence Associated Phenotypes in Naturally Aged Rats Open
Background Aging is a multifaceted process that affects all organ systems. With the increasing trend of population aging, age-related diseases have resulted in significant medical challenges and socioeconomic burdens. Mesenchymal stem cell…
View article: The Study on the Regulation of Th Cells by Mesenchymal Stem Cells Through the JAK-STAT Signaling Pathway to Protect Naturally Aged Sepsis Model Rats
The Study on the Regulation of Th Cells by Mesenchymal Stem Cells Through the JAK-STAT Signaling Pathway to Protect Naturally Aged Sepsis Model Rats Open
Sepsis is the leading cause of death among patients, especially elderly patients, in intensive care units worldwide. In this study, we established a sepsis model using naturally aged rats and injected 5×10 6 umbilical cord-derived MSCs via…
View article: Protective and Immunomodulatory Effects of Mesenchymal Stem Cells on Multiorgan Injury in Rats with Heatstroke
Protective and Immunomodulatory Effects of Mesenchymal Stem Cells on Multiorgan Injury in Rats with Heatstroke Open
View article: The Study on the Regulation of Th Cells by MSCs Through the JAK-STAT Signaling Pathway to Protect Naturally Aged Sepsis Model Rats
The Study on the Regulation of Th Cells by MSCs Through the JAK-STAT Signaling Pathway to Protect Naturally Aged Sepsis Model Rats Open
Background: Sepsis is the leading cause of death among patients, especially elderly patients, in intensive care units worldwide. However, there is no effective treatment for sepsis in the aging population. Therefore, we designed such a stu…
View article: Functions of Monocytes and Macrophages and the Associated Effective Molecules and Mechanisms at the Early Stage of Atherosclerosis.
Functions of Monocytes and Macrophages and the Associated Effective Molecules and Mechanisms at the Early Stage of Atherosclerosis. Open
Monocytes did not directly participate in lipid metabolism before differentiation into macrophages at the early stage in vitro. Furthermore, noncoding RNAs and ceRNA networks might play important roles in regulating the lipid metabolism of…
View article: Mesenchymal stem cells regulate activation of microglia cells to improve hippocampal injury of heat stroke rats
Mesenchymal stem cells regulate activation of microglia cells to improve hippocampal injury of heat stroke rats Open
Heat stroke is a severe systemic inflammatory response disease caused by high fever, mainly with nervous system damage. Mesenchymal stem cells (MSCs) are currently believed to have anti-inflammation and immunomodulatory effects. Therefore,…
View article: Regulation of Inflammatory Cytokine Storms by Mesenchymal Stem Cells
Regulation of Inflammatory Cytokine Storms by Mesenchymal Stem Cells Open
Mesenchymal stem cells (MSCs) have been widely used in preclinical and clinical trials for various diseases and have shown great potential in the treatment of sepsis and coronavirus disease (COVID-19). Inflammatory factors play vital roles…
View article: The Study on the Regulation of Th Cells by Mesenchymal Stem Cells Through the JAK-STAT Signaling Pathway to Protect Naturally Aged Sepsis Rats
The Study on the Regulation of Th Cells by Mesenchymal Stem Cells Through the JAK-STAT Signaling Pathway to Protect Naturally Aged Sepsis Rats Open
View article: Protective effect and mechanism of mesenchymal stem cells on heat stroke induced intestinal injury
Protective effect and mechanism of mesenchymal stem cells on heat stroke induced intestinal injury Open
Heat stroke (HS) is considered to be a severe systemic inflammatory reaction disease that is caused by high fever. The mortality of HS is high worldwide due to the lack of effective treatments. Presently, mesenchymal stem cells (MSCs) have…
View article: Mesenchymal stem cells regulate activation of microglia cells to improve hippocampal nerve damage of heat stroke rats
Mesenchymal stem cells regulate activation of microglia cells to improve hippocampal nerve damage of heat stroke rats Open
Background Heat stroke (HS) is a severe systemic inflammatory response disease caused by high fever, mainly with nervous system damage. Currently, mesenchymal stem cells (MSCs) have inflammation and immunomodulatory effects. Therefore, we …
View article: Mesenchymal Stem Cells Regulate Activation of Microglia Cells to Improve Hippocampal Nerve Damage of Heat Stroke Rats
Mesenchymal Stem Cells Regulate Activation of Microglia Cells to Improve Hippocampal Nerve Damage of Heat Stroke Rats Open
Background: Heat stroke (HS) is a severe systemic inflammatory response disease caused by high fever, mainly with nervous system damage. Currently, mesenchymal stem cells (MSCs) have inflammation and immunomodulatory effects. Therefore, we…
View article: Mesenchymal Stem Cells Provide Neuroprotection by Regulating Heat Stroke-Induced Brain Inflammation
Mesenchymal Stem Cells Provide Neuroprotection by Regulating Heat Stroke-Induced Brain Inflammation Open
Heat stroke (HS) is the most acute type of heat illness accompanied with serious central nervous system (CNS) dysfunction. Despite the pathological process being clearly studied, effective treatment is deficient. Currently, mesenchymal ste…
View article: A fluorine-doped MnFe2O4 nanorod/carbon composite as an anode material for high-performance lithium-ion batteries
A fluorine-doped MnFe2O4 nanorod/carbon composite as an anode material for high-performance lithium-ion batteries Open
View article: Mesenchymal stem cells ameliorate myocardial fibrosis in diabetic cardiomyopathy via the secretion of prostaglandin E2
Mesenchymal stem cells ameliorate myocardial fibrosis in diabetic cardiomyopathy via the secretion of prostaglandin E2 Open
Background Diabetic cardiomyopathy (DCM) is a cardiac complication of long-term uncontrolled diabetes and is characterized by myocardial fibrosis and abnormal cardiac function. Mesenchymal stem cells (MSCs) are multipotent cells with immun…
View article: Mesenchymal stem cells promote type 2 macrophage polarization to ameliorate the myocardial injury caused by diabetic cardiomyopathy
Mesenchymal stem cells promote type 2 macrophage polarization to ameliorate the myocardial injury caused by diabetic cardiomyopathy Open
Our results suggested that MSC infusions can protect against cardiac injury in DCM rats. The underlying mechanisms may include MSC-enhanced M2 macrophage polarization via the COX-2-PGE2 pathway.
View article: Role of ultrasonographic features and quantified BRAFV600E mutation in lymph node metastasis in Chinese patients with papillary thyroid carcinoma
Role of ultrasonographic features and quantified BRAFV600E mutation in lymph node metastasis in Chinese patients with papillary thyroid carcinoma Open
View article: Infusion of adipose‑derived mesenchymal stem cells inhibits skeletal muscle mitsugumin 53 elevation and thereby alleviates insulin resistance in type 2 diabetic rats
Infusion of adipose‑derived mesenchymal stem cells inhibits skeletal muscle mitsugumin 53 elevation and thereby alleviates insulin resistance in type 2 diabetic rats Open
It is widely accepted that infusion of mesenchymal stem cells (MSCs) ameliorates hyperglycemia by alleviating insulin resistance in rats with type 2 diabetes mellitus (T2D). However, the detailed underlying mechanisms are not clearly defin…