Explanipedia

Author Correction: Data-driven subtypes of polycystic ovary syndrome and their association with clinical outcomes Open

Yanzhi Du, Ziyi Yang, Junli Zhao, Xi Yuan, Daimin Wei , et al. · 2025

The threshold of estradiol level for fresh embryo transfer differs between blastocyst and cleavage‐stage embryo Open

Dingying Zhao, Huiying Xiao, Fang Yuan, Yanran Liu, Xue Shang , et al. · 2025

Introduction Ovarian stimulation can cause supraphysiological estradiol levels and adverse effects on endometrial receptivity. Since patients could undergo cleavage or blastocyst stage embryo transfer, the threshold value of peak estradiol…

Influence of COVID-19 on endocrine and metabolic profiles in women with pathological ovarian aging Open

Hui Jiang, Rongrong Zhang, Shan Meng, Tingting Meng, Wei Luo , et al. · 2025

Safety and efficacy of subcutaneous injection with HMI-115 versus placebo in endometriosis-associated pain in premenopausal women: a multicentre, double-blind, randomised, proof-of-concept phase 2 trial Open

Lan Zhu, Zi‐Jiang Chen, Haiyuan Liu, Guoyun Wang, Krzysztof Dynowski , et al. · 2025

Data-driven subtypes of polycystic ovary syndrome and their association with clinical outcomes Open

Xueying Gao, Shigang Zhao, Yanzhi Du, Ziyi Yang, Ye Tian , et al. · 2025

Polycystic ovary syndrome (PCOS) is a common and heterogeneous endocrine disorder that affects 11%-13% of women worldwide, with profound implications for fertility and long-term metabolic health. Here we identify four reproducible subtypes…

Maternal factor OTX2 regulates human embryonic genome activation and early development Open

Qiuyan Wang, Chuanxin Zhang, Yanna Dang, Jiaqi Sun, Zhuoning Zou , et al. · 2025

Human receptive endometrial assembloid for deciphering the implantation window Open

Yu Zhang, Rusong Zhao, Chaoyan Yang, Jinzhu Song, Peishu Liu , et al. · 2025

Human endometrial receptivity is a critical determinant of pregnancy success; however, in vivo studies of its features and regulation are particularly challenging due to ethical restriction. Recently, the development of human endometrial a…

Author response: Human receptive endometrial assembloid for deciphering the implantation window Open

Yu Zhang, Rusong Zhao, Chaoyan Yang, Jinzhu Song, Peishu Liu , et al. · 2025

Stress granule clearance mediated by V-ATPase-interacting protein NCOA7 mitigates ovarian aging Open

Ting Dong, Nianyu Li, Huirui Wang, Hui Zhu, Yinghui Gao , et al. · 2025

PPP6R3-mediated dephosphorylation regulates mRNA translation during spermatogonial differentiation Open

Qian Fang, Biyun Liu, Jie Cen, Tongtong Li, Shuhui Ji , et al. · 2025

Enrichment of decidual CD11c + CD8 + T cells with altered immune function in early pregnancy loss Open

Ling Guo, An-Liang Guo, Yaqiu Guo, Shuwen Han, Cameron Klein , et al. · 2025

Hypomethylation‐Triggered SERPINE1 (Serpin Family E Member 1) Exacerbates Polycystic Ovary Syndrome with Hyperandrogenism Induced by Circadian Disruption Open

Xueying Geng, Weiwei Chu, Shang Li, Xiying Zhou, Dongshuang Wang , et al. · 2025

Polycystic ovary syndrome (PCOS), a prevalent cause of female infertility, arises from complex interactions between genetic and environmental factors, with hyperandrogenism serving as a core pathological feature. While growing evidence lin…

Cover Image Open

Lili Cao, Jiayi Ren, Zining Kong, Mengchun Hu, Yaxuan Zhang , et al. · 2025

<span>HELQ</span> Maintains Genome Stability of Primordial Germ Cells by Inhibiting <span>LINE</span> ‐1 Expression Open

Lili Cao, Jiayi Ren, Zining Kong, Mengchun Hu, Yaxuan Zhang , et al. · 2025

The DNA helicase HELQ is involved in homologous recombination repair, interstrand cross‐link repair, and replication stress response. Its functional defects are associated with infertility and abnormal gametogenesis. However, the specific …

Alnustone Ameliorates Metabolic Dysfunction‐Associated Steatotic Liver Disease by Facilitating Mitochondrial Fatty Acid β‐Oxidation via Targeting Calmodulin Open

Shourui Hu, Xiaofan Liang, Yiming Qin, Yuxuan Li, Yue Liu , et al. · 2025

Metabolic dysfunction‐associated steatotic liver disease (MASLD), including its more severe manifestation metabolic dysfunction‐associated steatohepatitis (MASH), poses global public health threats with limited therapeutics. Here, the role…

P-782 Obstetric and Neonatal Outcomes following Freeze-all vs Fresh Embryo Transfer Strategies: An Individual Participant Data Meta-Analysis of Randomised Trials (INFORM) Open

Nicole Au, Rui Wang, Wei Deng, Lan N. Vuong, Anja Pinborg , et al. · 2025

Study question Do obstetric and neonatal outcomes following the first transfer differ between a freeze-all and a fresh embryo transfer strategy? Summary answer Compared to fresh embryo transfer, freeze-all strategy increases large for gest…

O-185 Natural ovulation regimen versus programmed regimen for endometrial preparation before frozen embryo transfer (FET) in ovulatory women: a randomized clinical trial Open

Ze Wang, Wei Deng, Yun Sun, Yuhong Guan, Fei Gong , et al. · 2025

Study question What is the optimal regimen for endometrial preparation before frozen embryo transfer in ovulatory women? Summary answer Compared with programmed regimen, natural ovulation regimen resulted in comparable live birth rate, but…

Recommendations for the management of GnRH‐ant for ovarian stimulation in the assistant reproductive process: Benefits and harms for different ovarian response population Open

Rong Li, Rui Yang, Junhao Yan, Yang Song, Yunxia Cao , et al. · 2025

Introduction: Gonadotropin‐releasing hormone antagonists (GnRH‐ant) are commonly used during controlled ovarian stimulation (COS) in the in vitro fertilization (IVF) process to prevent premature luteinization and to ensure follicles mature…

Female-specific associations of serum perfluoroalkyl and polyfluoroalkyl substances with sex hormonal/insulin dysregulation: An integrated population-based study Open

Li Yang, Junyu Zhai, Zi‐Jiang Chen, Yanzhi Du · 2025

Anti-tumor effect and immune-related mechanism study of compound aluminum sulfate injection in transplanted tumor-bearing mice Open

Zhenwei Shi, Zhifa Xia, Songtao Huang, Zi‐Jiang Chen, Fan Yin , et al. · 2025

This study investigates the antitumor and immunomodulatory effects of compound aluminum sulfate (CAS) solution in murine melanoma models. Using syngeneic B16-F10 and B16-OVA tumor models, we demonstrate that intratumoral CAS injection sign…

Three-dimensional genome structures of single mammalian sperm Open

Heming Xu, Yi Chi, Changjian Yin, Cheng Li, Yujie Chen , et al. · 2025

The three-dimensional (3D) organization of chromosomes is crucial for packaging a large mammalian genome into a confined nucleus and ensuring proper nuclear functions in somatic cells. However, the packaging of the much more condensed sper…

Intergenerational and transgenerational reproductive toxicity of polystyrene microplastics in female mice Open

Mengge Zhang, Yunde Dou, Han Zhao, Zi‐Jiang Chen · 2025

Evidence continues to emerge on the reproductive hazards induced by microplastics (MPs) in humans and animals. However, conclusive evidence for the reproductive toxicity of MPs in human contexts is still limited, and understanding the inte…

Efficacy of balloon stent or oral estrogen for adhesion prevention in septate uterus: A randomized clinical trial Open

Shan Deng, Zichen Zhao, Limin Feng, Xiaowu Huang, Sumin Wang , et al. · 2025

BDNF secreted by mesenchymal stem cells improves aged oocyte quality and development potential by activating the ERK1/2 pathway Open

Jing Zhou, Cheng Li, Xin Mi, Jiali Zhou, Caiyi Chen , et al. · 2025

These findings demonstrate that BDNF secreted by mesenchymal stem cells can improve the quality and development potential of oocytes from both aged mice and humans by activating the ERK1/2 signaling pathway, suggesting that it has the pote…

Targeted long-read sequencing enables higher diagnostic yield of ADPKD by accurate PKD1 genetic analysis Open

Qian Sun, Peiwen Xu, Aiping Mao, Sexin Huang, Jie Li , et al. · 2025

SHMT2 is essential for mammalian preimplantation embryonic development through de novo biosynthesis of nucleotide metabolites Open

Mingze Shi, Y. T. Huai, Tiantian Deng, Chuanxin Zhang, Jinzhu Song , et al. · 2025

Association of age at menarche and different causes of infertility: a retrospective study of 7634 women undergoing assisted reproductive technology Open

Miaomiao Ban, Jiejing Jiao, Jiayi Zhou, Linlin Cui, Huidan Wang , et al. · 2025

This study demonstrates a significant impact of AAM on endocrine-related infertility in women. Further research on the relationship between the onset of menarche and the pathogenesis of infertility is warranted.

Population-level analyses identify host and environmental variables influencing the vaginal microbiome Open

Lang Qin, Tianyong Sun, Xiao Li, Shigang Zhao, Zheng Liu , et al. · 2025

The vaginal microbiome is critical for the reproductive health of women, yet the differential impacts exerted by the host and by ambient environmental variables on the vaginal microbiome remain largely unknown. Here, we conducted a compreh…

Transgenerational inheritance of diabetes susceptibility in male offspring with maternal androgen exposure Open

Yuqing Zhang, Shourui Hu, Shan Han, Congcong Liu, Xiaofan Liang , et al. · 2025

Androgen exposure (AE) poses a profound health threat to women, yet its transgenerational impacts on male descendants remain unclear. Here, employing a large-scale mother-child cohort, we show that maternal hyperandrogenism predisposes son…

Frozen versus fresh embryo transfer in women with low prognosis for in vitro fertilisation treatment: pragmatic, multicentre, randomised controlled trial Open

Daimin Wei, Yun Sun, Han Zhao, Junhao Yan, Hong Zhou , et al. · 2025

Objective To test the hypothesis that a freeze-all strategy would increase the chance of live birth compared with fresh embryo transfer in women with low prognosis for in vitro fertilisation (IVF) treatment. Design Pragmatic, multicentre, …

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