Zijun Ouyang
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View article: Progress in Research on the Mechanism of GABA in Improving Sleep
Progress in Research on the Mechanism of GABA in Improving Sleep Open
Sleep disorders represent a growing global health concern with significant socio-economic impacts. GABA, a natural bioactive compound abundant in various fermented foods, especially probiotic-fermented foods, has garnered increasing attent…
View article: T Cell‐Specific Deficiency of Src Homology 2‐Containing Protein Tyrosine Phosphatase 2 Ameliorates Psoriasis and Colitis by Promoting Treg Differentiation
T Cell‐Specific Deficiency of Src Homology 2‐Containing Protein Tyrosine Phosphatase 2 Ameliorates Psoriasis and Colitis by Promoting Treg Differentiation Open
Psoriasis and ulcerative colitis are both autoimmune diseases with complex pathogenesis characterized by immune disorders. Src homology 2‐containing protein tyrosine phosphatase 2 (SHP2) is a non‐receptor protein tyrosine phosphatase that …
View article: Research Progress on the Mechanism of Action and Screening Methods of Probiotics for Lowering Blood Lipid Levels
Research Progress on the Mechanism of Action and Screening Methods of Probiotics for Lowering Blood Lipid Levels Open
Hyperlipidemia is one of the most prevalent metabolic disorders worldwide. It is a significant risk factor for a range of cardiovascular diseases, including acute pancreatitis, fatty liver disease, atherosclerosis, and coronary heart disea…
View article: Marine Natural Products in Inflammation‐Related Diseases: Opportunities and Challenges
Marine Natural Products in Inflammation‐Related Diseases: Opportunities and Challenges Open
In recent decades, the potentiality of marine natural products (MNPs) in the medical field has been increasingly recognized. Natural compounds derived from marine microorganisms, algae, and invertebrates have shown significant promise for …
View article: NANOG-conjugated Toll-Like Receptor 7 Agonist Suppresses Tumor Growth in Testicular Embryonic Carcinoma
NANOG-conjugated Toll-Like Receptor 7 Agonist Suppresses Tumor Growth in Testicular Embryonic Carcinoma Open
Background Induced pluripotent stem cells (iPSCs) present gene expression profiles similar to cancer cells. Thus, the iPSCs could be used as a cancer vaccine. However, the iPSCs-based vaccines might lead to tumorigenesis, and strategies to…
View article: Celastrol directly targets LRP1 to inhibit fibroblast-macrophage crosstalk and ameliorates psoriasis progression
Celastrol directly targets LRP1 to inhibit fibroblast-macrophage crosstalk and ameliorates psoriasis progression Open
Psoriasis is an incurable chronic inflammatory disease that requires new interventions. Here, we found that fibroblasts exacerbate psoriasis progression by promoting macrophage recruitment via CCL2 secretion by single-cell multi-omi…
View article: Properties of exohiss waves during different level of geomagnetic activity
Properties of exohiss waves during different level of geomagnetic activity Open
Exohiss are broadband, structureless whistler-mode waves outside the plasmapause. In our work, using the data sets detected by the EMFISIS suite aboard Van Allen Probe A, from 1st January 2013 to 30th June 2017, the exohiss waves are categ…
View article: Study on Overpressure and Seismic Waves of Large-Scale Vapor Cloud Explosions and Rapid Prediction Method
Study on Overpressure and Seismic Waves of Large-Scale Vapor Cloud Explosions and Rapid Prediction Method Open
View article: EGCG inhibits ferroptosis to ameliorate APAP-induced liver injury by suppressing NEDD8 and stabilizing HUWE1 in vivo and in vitro
EGCG inhibits ferroptosis to ameliorate APAP-induced liver injury by suppressing NEDD8 and stabilizing HUWE1 in vivo and in vitro Open
Excessive consumption of acetaminophen (APAP) has emerged as the primary culprit behind drug-induced liver injury (DILI), with N-acetylcysteine serving as the principal antidote. However, use of N-acetylcysteine is limited to the early sta…
View article: The Molecular Mechanism by Which Falwd1-Like Mediates the Specific Accumulation of Cyanidin in Pink/White Strawberry Through Enhancing the Transcriptional Activation of Faf3'H by Famyb10
The Molecular Mechanism by Which Falwd1-Like Mediates the Specific Accumulation of Cyanidin in Pink/White Strawberry Through Enhancing the Transcriptional Activation of Faf3'H by Famyb10 Open
View article: Traditional Chinese Medicine Shi-Bi-Man ameliorates psoriasis via inhibiting IL-23/Th17 axis and CXCL16-mediated endothelial activation
Traditional Chinese Medicine Shi-Bi-Man ameliorates psoriasis via inhibiting IL-23/Th17 axis and CXCL16-mediated endothelial activation Open
Background Psoriasis is a chronic inflammatory genetic disease, mainly manifesting in the skin. Conventional therapies, such as glucocorticosteroids and corticosteroids, have adverse effects that limit drug use. Hence, it is imperative to …
View article: Miao sour soup alleviates DSS-induced colitis in mice: modulation of gut microbiota and intestinal barrier function
Miao sour soup alleviates DSS-induced colitis in mice: modulation of gut microbiota and intestinal barrier function Open
Miao sour soup (MSS), a daily fermented food in Guizhou, China, is rich in microorganisms with various beneficial activities, including anti-inflammatory and antioxidant activities.
View article: Traditional Chinese medicine Shi-Bi-Man ameliorates psoriasis via inhibiting IL-23/Th17 axis and CXCL16-mediated endothelial activation
Traditional Chinese medicine Shi-Bi-Man ameliorates psoriasis via inhibiting IL-23/Th17 axis and CXCL16-mediated endothelial activation Open
Background Psoriasis is a chronic inflammatory genetic disease, mainly manifesting in the skin. Conventional therapies, such as glucocorticosteroids and corticosteroids, have adverse effects that limit drug use. Hence, it is imperative to …
View article: Adipokine chemerin overexpression in trophoblasts leads to dyslipidemia in pregnant mice: implications for preeclampsia
Adipokine chemerin overexpression in trophoblasts leads to dyslipidemia in pregnant mice: implications for preeclampsia Open
Background The adipokine chemerin regulates adipogenesis and the metabolic function of both adipocytes and liver. Chemerin is elevated in preeclamptic women, and overexpression of chemerin in placental trophoblasts induces preeclampsia-lik…
View article: Blockade of dual immune checkpoint inhibitory signals with a CD47/PD-L1 bispecific antibody for cancer treatment
Blockade of dual immune checkpoint inhibitory signals with a CD47/PD-L1 bispecific antibody for cancer treatment Open
Background: Even though PD-1/PD-L1 is an identified key "don't find me" signal to active adaptive immune system for cancer treatment, the overall response rate (ORR) for all cancer patients is still limited. Other effective therapeu…
View article: New opportunities and challenges of natural products research: When target identification meets single-cell multiomics
New opportunities and challenges of natural products research: When target identification meets single-cell multiomics Open
View article: Tyrosine phosphatase SHP2 exacerbates psoriasis‐like skin inflammation in mice via ERK5‐dependent NETosis
Tyrosine phosphatase SHP2 exacerbates psoriasis‐like skin inflammation in mice via ERK5‐dependent NETosis Open
Psoriasis is a chronic inflammatory skin disease, often accompanied by increased infiltration of immune cells, especially neutrophils. However, the detailed mechanism of the neutrophil function in psoriasis progression remains unclear. Her…
View article: SHP2 allosteric inhibitor TK-453 alleviates psoriasis-like skin inflammation in mice via inhibition of IL-23/Th17 axis
SHP2 allosteric inhibitor TK-453 alleviates psoriasis-like skin inflammation in mice via inhibition of IL-23/Th17 axis Open
View article: A combined Globo H-OCT4-T7 immunotherapy restrains colorectal tumor growth
A combined Globo H-OCT4-T7 immunotherapy restrains colorectal tumor growth Open
Background: Malignant tumors express multiple common markers that might constitute targets for tumor immunotherapy. Methods: Here we performed antigen epitope screening and molecular docking to design a new combination vaccine based on cov…
View article: Rotating magnetic field ameliorates experimental autoimmune encephalomyelitis by promoting T cell peripheral accumulation and regulating the balance of Treg and Th1/Th17
Rotating magnetic field ameliorates experimental autoimmune encephalomyelitis by promoting T cell peripheral accumulation and regulating the balance of Treg and Th1/Th17 Open
Multiple sclerosis (MS) is an autoimmune disease characterized by T cell infiltration and demyelination of the central nervous system (CNS). Experimental autoimmune encephalomyelitis (EAE) is a classical preclinical animal model of MS. In …
View article: Rotating magnetic field delays human umbilical vein endothelial cell aging and prolongs the lifespan of Caenorhabditis elegans
Rotating magnetic field delays human umbilical vein endothelial cell aging and prolongs the lifespan of Caenorhabditis elegans Open
The biological effects of magnetic fields are a research hotspot in the field of biomedical engineering. In this study, we further investigated the effects of a rotating magnetic field (RMF; 0.2 T, 4 Hz) on the growth of human umbilical ve…
View article: Loss of hnRNP A1 in murine skeletal muscle exacerbates high-fat diet-induced onset of insulin resistance and hepatic steatosis
Loss of hnRNP A1 in murine skeletal muscle exacerbates high-fat diet-induced onset of insulin resistance and hepatic steatosis Open
Impairment of glucose (Glu) uptake and storage by skeletal muscle is a prime risk factor for the development of metabolic diseases. Heterogeneous nuclear ribonucleoprotein A1 (hnRNP A1) is a highly abundant RNA-binding protein that has bee…