Zengqiang Yuan
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View article: Ferroptosis‐Mediated Hippocampal Neuronal Loss Post‐mTBI: Chromatin Accessibility Profiling and Single‐Nucleus Transcriptomics
Ferroptosis‐Mediated Hippocampal Neuronal Loss Post‐mTBI: Chromatin Accessibility Profiling and Single‐Nucleus Transcriptomics Open
Neuronal death in the hippocampus following mild traumatic brain injury (mTBI) is a hallmark of cognitive dysfunction, yet the underlying molecular mechanisms remain poorly understood. To address this issue, the hippocampus of eCCI‐modeled…
View article: A novel brain-derived peptide inhibits microglial pyroptosis through MBTPS1 in neonatal hypoxic-ischemic brain damage
A novel brain-derived peptide inhibits microglial pyroptosis through MBTPS1 in neonatal hypoxic-ischemic brain damage Open
HIBDAP inhibits microglial pyroptosis by combining with MBTPS1 to inhibit the expression of the NLRP-3/ASC/Caspase-1/GSDMD N-terminus, IL-1β and IL-18 and significantly improves motor, learning and memory-related abilities in neonatal HIBD…
View article: Microglial Prrc2a regulates microglia-neuron interaction in cerebellum and motor functions in mice
Microglial Prrc2a regulates microglia-neuron interaction in cerebellum and motor functions in mice Open
Summary: The crosstalk between microglia and neuron has been recognized as a crucial process in the development and disorders of the central nervous system. The present study probes into the role of Prrc2a—a post-transcriptional regulator …
View article: High Glucose Aggravates Cerebral Ischemia/Reperfusion via Truncated <scp>NLRP3</scp> ‐Mediated Hexokinase‐2 Translocation
High Glucose Aggravates Cerebral Ischemia/Reperfusion via Truncated <span>NLRP3</span> ‐Mediated Hexokinase‐2 Translocation Open
Background High blood glucose is a well‐established risk factor for poor outcomes in ischemic stroke. However, the underlying molecular mechanisms linking high blood glucose to worsened stroke outcomes remain unclear. Objectives Previous s…
View article: Hypoxia-mediated regulation of mRNA metabolism: from transcription to stability
Hypoxia-mediated regulation of mRNA metabolism: from transcription to stability Open
Background Hypoxia plays a critical role in both physiological and pathological processes. Cells adapt to hypoxia through the extensive reprogramming of gene expression. While the transcriptional regulations of hypoxia-inducible factors (H…
View article: Innovating transcranial magnetic stimulation treatment for post-traumatic stress disorder: Zapping away the bad memory
Innovating transcranial magnetic stimulation treatment for post-traumatic stress disorder: Zapping away the bad memory Open
View article: Neuromodulatory role and therapeutic potential of N6-methyladenosine RNA methylation in neurodegenerative diseases
Neuromodulatory role and therapeutic potential of N6-methyladenosine RNA methylation in neurodegenerative diseases Open
N 6 -methyladenosine RNA methylation, an essential post-transcriptional modification, dynamically regulates RNA metabolism and plays a crucial role in neuronal function. Growing evidence suggests that dysregulated N 6 -methyladenosine modi…
View article: RACK1 promotes the development and function of alveolar macrophages through directly binding to and stabilizing PPARγ
RACK1 promotes the development and function of alveolar macrophages through directly binding to and stabilizing PPARγ Open
Alveolar macrophages (AMs) are indispensable to prevent pulmonary alveolar proteinosis and clear inhaled pathogens. Receptor for activated C kinase 1 (RACK1) is a versatile adaptor protein that regulates multiple signaling pathways. Whethe…
View article: Biomarkers of Specific Brain Changes in Adolescents with Anxiety Disorder Based on MRI Multimodal Data
Biomarkers of Specific Brain Changes in Adolescents with Anxiety Disorder Based on MRI Multimodal Data Open
Anxiety disorders are among the most prevalent mental illnesses, particularly among adolescents. Those adolescents experience chronic, persistent, excessive, and uncontrollable worry, as well as irrational fears, across various aspects of …
View article: Correction: Conductive single-wall carbon nanotubes/extracellular matrix hybrid hydrogels promote the lineage-specific development of seeding cells for tissue repair through reconstructing an integrin-dependent niche
Correction: Conductive single-wall carbon nanotubes/extracellular matrix hybrid hydrogels promote the lineage-specific development of seeding cells for tissue repair through reconstructing an integrin-dependent niche Open
View article: Left Frontoparietal Control Network Connectivity Moderates the Effect of Amyloid on Cognitive Decline in Preclinical Alzheimer's Disease: The A4 Study
Left Frontoparietal Control Network Connectivity Moderates the Effect of Amyloid on Cognitive Decline in Preclinical Alzheimer's Disease: The A4 Study Open
View article: Extracellular Matrix Remodeling Alleviates Memory Deficits in Alzheimer's Disease by Enhancing the Astrocytic Autophagy‐Lysosome Pathway
Extracellular Matrix Remodeling Alleviates Memory Deficits in Alzheimer's Disease by Enhancing the Astrocytic Autophagy‐Lysosome Pathway Open
Extracellular matrix (ECM) remodeling is strongly linked to Alzheimer's disease (AD) risk; however, the underlying mechanisms are not fully understood. Here, it is found that the injection of chondroitinase ABC (ChABC), mimicking ECM remod…
View article: Roles of microglial calcium channels in neurodegenerative diseases
Roles of microglial calcium channels in neurodegenerative diseases Open
Microglia are crucial for neurodevelopment, and the maintenance of central nervous system functions. Calcium signals in microglia regulate the neuronal plasticity critical for learning, memory, and neuron survival. Growing evidence highlig…
View article: PRRC2B modulates oligodendrocyte progenitor cell development and myelination by stabilizing Sox2 mRNA
PRRC2B modulates oligodendrocyte progenitor cell development and myelination by stabilizing Sox2 mRNA Open
Oligodendrocyte progenitor cells (OPCs) differentiate into myelin-producing cells and modulate neuronal activity. Defects in OPC development are associated with neurological diseases. N6-methyladenosine (m6A) contribu…
View article: Tim-3 Knockout Exacerbates Chronic Restraint Stress Induced Depression by Enhancing Neuroinflammation
Tim-3 Knockout Exacerbates Chronic Restraint Stress Induced Depression by Enhancing Neuroinflammation Open
View article: Acute ischemia induces spatially and transcriptionally distinct microglial subclusters
Acute ischemia induces spatially and transcriptionally distinct microglial subclusters Open
Background Damage in the ischemic core and penumbra after stroke affects patient prognosis. Microglia immediately respond to ischemic insult and initiate immune inflammation, playing an important role in the cellular injury after stroke. H…
View article: Noncanonical contribution of microglial transcription factor NR4A1 to post-stroke recovery through TNF mRNA destabilization
Noncanonical contribution of microglial transcription factor NR4A1 to post-stroke recovery through TNF mRNA destabilization Open
Microglia-mediated neuroinflammation is involved in various neurological diseases, including ischemic stroke, but the endogenous mechanisms preventing unstrained inflammation is still unclear. The anti-inflammatory role of transcription fa…
View article: The Role of PRRC2B in Cerebral Vascular Remodeling Under Acute Hypoxia in Mice
The Role of PRRC2B in Cerebral Vascular Remodeling Under Acute Hypoxia in Mice Open
High altitude exposure leads to various cognitive impairments. The cerebral vasculature system plays an integral role in hypoxia‐induced cognitive defects by reducing oxygen and nutrition supply to the brain. RNA N6‐methyladenosine (m6A) i…
View article: Dlg1 deletion in microglia ameliorates chronic restraint stress induced mice depression-like behavior
Dlg1 deletion in microglia ameliorates chronic restraint stress induced mice depression-like behavior Open
Background: Major depression is one of the most common psychiatric disorders worldwide, inflicting suffering, significant reduction in life span, and financial burdens on families and society. Mounting evidence implicates that exposure to …
View article: Additional file 1 of Acute ischemia induces spatially and transcriptionally distinct microglial subclusters
Additional file 1 of Acute ischemia induces spatially and transcriptionally distinct microglial subclusters Open
Additional file 1: Table S1. Quality control data for scRNA-seq and ST.
View article: Deletion of Calhm2 alleviates MPTP-induced Parkinson's disease pathology by inhibiting EFHD2-STAT3 signaling in microglia
Deletion of Calhm2 alleviates MPTP-induced Parkinson's disease pathology by inhibiting EFHD2-STAT3 signaling in microglia Open
Background: Neuroinflammation is involved in the development of Parkinson's disease (PD). Calhm2 plays an important role in the development of microglial inflammation, but whether Calhm2 is involved in PD and its regulatory mechanis…
View article: Author Correction: Microglial hexokinase 2 deficiency increases ATP generation through lipid metabolism leading to β-amyloid clearance
Author Correction: Microglial hexokinase 2 deficiency increases ATP generation through lipid metabolism leading to β-amyloid clearance Open
View article: The role and regulatory mechanism of m6A methylation in the nervous system
The role and regulatory mechanism of m6A methylation in the nervous system Open
N6-methyladenosine (m 6 A) modification regulates RNA translation, splicing, transport, localization, and stability at the post-transcriptional level. The m 6 A modification has been reported to have a wide range of effects on the nervous …
View article: The XPO1 Inhibitor KPT-8602 Ameliorates Parkinson’s Disease by Inhibiting the NF-κB/NLRP3 Pathway
The XPO1 Inhibitor KPT-8602 Ameliorates Parkinson’s Disease by Inhibiting the NF-κB/NLRP3 Pathway Open
Exportin 1 (XPO1) is an important transport receptor that mediates the nuclear export of various proteins and RNA. KPT-8602 is a second-generation inhibitor of XPO1, demonstrating the lowest level of side effects, and is currently in clini…
View article: High, in Contrast to Low Levels of Acute Stress Induce Depressive-like Behavior by Involving Astrocytic, in Addition to Microglial P2X7 Receptors in the Rodent Hippocampus
High, in Contrast to Low Levels of Acute Stress Induce Depressive-like Behavior by Involving Astrocytic, in Addition to Microglial P2X7 Receptors in the Rodent Hippocampus Open
Extracellular adenosine 5′-triphosphate (ATP) in the brain is suggested to be an etiological factor of major depressive disorder (MDD). It has been assumed that stress-released ATP stimulates P2X7 receptors (Rs) at the microglia, thereby c…
View article: Astrocytes in depression and Alzheimer’s disease
Astrocytes in depression and Alzheimer’s disease Open
Astrocytes are an abundant subgroup of cells in the central nervous system (CNS) that play a critical role in controlling neuronal circuits involved in emotion, learning, and memory. In clinical cases, multiple chronic brain diseases may c…
View article: Dlg1 Knockout Inhibits Microglial Activation and Alleviates Lipopolysaccharide-Induced Depression-Like Behavior in Mice
Dlg1 Knockout Inhibits Microglial Activation and Alleviates Lipopolysaccharide-Induced Depression-Like Behavior in Mice Open
View article: The mechanism behind activation of the Nod-like receptor family protein 3 inflammasome in Parkinson’s disease
The mechanism behind activation of the Nod-like receptor family protein 3 inflammasome in Parkinson’s disease Open
Previous studies have shown that the ATP-P2X4 receptor signaling pathway mediates the activation of the Nod-like receptor family protein 3 (NLRP3) inflammasome. The NLRP3 inflammasome may promote renal interstitial inflammation in diabetic…
View article: Microglial Calhm2 regulates neuroinflammation and contributes to Alzheimer’s disease pathology
Microglial Calhm2 regulates neuroinflammation and contributes to Alzheimer’s disease pathology Open
Calhm2 has an important role in microglial activation and contributes to Alzheimer’s disease pathology.
View article: Conductive single-wall carbon nanotubes/extracellular matrix hybrid hydrogels promote the lineage-specific development of seeding cells for tissue repair through reconstructing an integrin-dependent niche
Conductive single-wall carbon nanotubes/extracellular matrix hybrid hydrogels promote the lineage-specific development of seeding cells for tissue repair through reconstructing an integrin-dependent niche Open
Background The niche of tissue development in vivo involves the growth matrix, biophysical cues and cell-cell interactions. Although natural extracellular matrixes may provide good supporting for seeding cells in vitro, it is evitable to d…