Zijun Zhou
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View article: Delayed diagnosis of pituitary LCH with BRAFV600E mutation: A case report and literature review
Delayed diagnosis of pituitary LCH with BRAFV600E mutation: A case report and literature review Open
Rationale: This case report highlights the diagnostic challenges and clinical complexities of adult-onset pituitary Langerhans Cell Histiocytosis (LCH), a rare entity with a prolonged and indolent progression. This underscores the critical…
View article: Information-Constrained Retrieval for Scientific Literature via Large Language Model Agents
Information-Constrained Retrieval for Scientific Literature via Large Language Model Agents Open
This study addresses the problems of insufficient semantic understanding, interference from redundant information, and limited reliability of results in scientific literature retrieval by proposing a retrieval algorithm based on informatio…
View article: Lactate-to-albumin ratio and 28 day mortality in hypertensive patients with atrial fibrillation: a retrospective cohort study
Lactate-to-albumin ratio and 28 day mortality in hypertensive patients with atrial fibrillation: a retrospective cohort study Open
View article: Mitochondrial dysfunction drives ZBP1-mediated PANoptosis to increase the susceptibility of heart failure with preserved ejection fraction-associated atrial fibrillation
Mitochondrial dysfunction drives ZBP1-mediated PANoptosis to increase the susceptibility of heart failure with preserved ejection fraction-associated atrial fibrillation Open
These findings identify ZBP1 as a molecular bridge between mitochondrial dysfunction and PANoptosis by sensing mitochondrial Z-DNA, highlighting its central role in HFpEF-associated AF pathogenesis. Targeting this axis may provide a promis…
View article: Identifying priority control factors for heavy metal pollution in urban agricultural soils of the Chengdu Plain: An integrated multi-model approach
Identifying priority control factors for heavy metal pollution in urban agricultural soils of the Chengdu Plain: An integrated multi-model approach Open
View article: APOE deficiency triggers anti-tumour activity of macrophages in liver cancer
APOE deficiency triggers anti-tumour activity of macrophages in liver cancer Open
Macrophage infiltration correlates with poor prognosis in patients with liver cancer and resistance to immunotherapy. However, it is difficult to target tumour-associated macrophages (TAMs) because of their inherent heterogeneity. Specific…
View article: Ultra-rapid meningeal metastasis in triple-negative breast cancer: A case report
Ultra-rapid meningeal metastasis in triple-negative breast cancer: A case report Open
For high - risk triple - negative breast cancer patients, the risk of brain metastasis should be closely monitored.
View article: Matrine Inhibits the Wnt3a/β‐Catenin Signalling to Attenuate Pressure Overload‐Induced Atrial Remodelling and Vulnerability to Atrial Fibrillation
Matrine Inhibits the Wnt3a/β‐Catenin Signalling to Attenuate Pressure Overload‐Induced Atrial Remodelling and Vulnerability to Atrial Fibrillation Open
Atrial fibrillation (AF) is closely associated with atrial electrical and structural remodelling, yet effective drug strategies remain limited. Matrine (MAT), the active compound in Sophora flavescens , has shown anti‐AF effects, but its m…
View article: Chronic mild stress exacerbates atrial fibrillation and neutrophil extracellular traps formation through S100A8/A9 signaling
Chronic mild stress exacerbates atrial fibrillation and neutrophil extracellular traps formation through S100A8/A9 signaling Open
View article: Comparison of Ethanol-Iohexol Mixture and Ethanol-Lipiodol Suspension in Rabbit Renal Artery Embolization
Comparison of Ethanol-Iohexol Mixture and Ethanol-Lipiodol Suspension in Rabbit Renal Artery Embolization Open
Objective To evaluate the efficacy and safety of an ethanol-iohexol mixture (EIM) as an endovascular embolic agent using a rabbit renal artery embolization model. Methods Thirty rabbits were randomly assigned to the EIM group or the ethano…
View article: Association between METTL14 gene polymorphisms and risk of ovarian endometriosis
Association between METTL14 gene polymorphisms and risk of ovarian endometriosis Open
Background Endometriosis, a prevalent chronic gynecological condition, is frequently associated with infertility and pelvic pain. Despite numerous studies indicating a correlation between epigenetic regulation and endometriosis, its precis…
View article: Novel <i>STAT3</i> Y360C Gain-of-function Variant Underlies Immune Dysregulation and Aberrancy in Mitochondrial Dynamics
Novel <i>STAT3</i> Y360C Gain-of-function Variant Underlies Immune Dysregulation and Aberrancy in Mitochondrial Dynamics Open
The STAT3 is an important regulator in a wide range of different cell types. Human STAT3 variants are associated with several immune dysregulation diseases. The current study investigated the clinical, genetic, and immunobiological …
View article: A pilot study examining periodontally healthy middle-aged humans and monkeys display different levels of alveolar bone resorption, gingival inflammatory infiltrate, and salivary microbiota profile
A pilot study examining periodontally healthy middle-aged humans and monkeys display different levels of alveolar bone resorption, gingival inflammatory infiltrate, and salivary microbiota profile Open
Background Monkeys are an appropriate model for periodontal research owing to their similar dental anatomy and physiology unlike humans. Extensive literature exists on pathological periodontitis in monkeys and humans, although concerns reg…
View article: Cellular and molecular biology of posttranslational modifications in cardiovascular disease
Cellular and molecular biology of posttranslational modifications in cardiovascular disease Open
Cardiovascular disease (CVD) has now become the leading cause of death worldwide, and its high morbidity and mortality rates pose a great threat to society. Although numerous studies have reported the pathophysiology of CVD, the exact path…
View article: A patient-based murine model recapitulates human STAT3 gain-of-function syndrome
A patient-based murine model recapitulates human STAT3 gain-of-function syndrome Open
STAT3 gain-of-function (GOF) variants results in a heterogeneous clinical syndrome characterized by early onset immunodeficiency, multi-organ autoimmunity, and lymphoproliferation. While 191 documented cases with STAT3 GOF variants have be…
View article: Chaperonin-containing TCP-1 subunit genes are potential prognostic biomarkers and are correlated with Th2 cell infiltration in lung adenocarcinoma: An observational study
Chaperonin-containing TCP-1 subunit genes are potential prognostic biomarkers and are correlated with Th2 cell infiltration in lung adenocarcinoma: An observational study Open
A family of molecular chaperone complexes called chaperonin-containing T-complex protein 1 (TCP-1) subunit genes (CCTs) aids in the folding of numerous proteins. With regard to lung adenocarcinoma (LUAD), this study provided a thorough und…
View article: Dexrazoxane inhibits the growth of esophageal squamous cell carcinoma by attenuating SDCBP/MDA-9/syntenin-mediated EGFR-PI3K-Akt pathway activation
Dexrazoxane inhibits the growth of esophageal squamous cell carcinoma by attenuating SDCBP/MDA-9/syntenin-mediated EGFR-PI3K-Akt pathway activation Open
Syndecan-binding protein (SDCBP) was reported to stimulate the advancement of esophageal squamous cell carcinoma (ESCC) and could potentially be a target for ESCC treatment. There is a growing corpus of research on the anti-tumor effects o…
View article: Understanding The Impact of Culture as A Destination Image Attribute on Sustainable Tourism
Understanding The Impact of Culture as A Destination Image Attribute on Sustainable Tourism Open
This study aims to underscore the pivotal role of cultural attributes in shaping destination image and examines their implications for sustainable tourism. Through a comprehensive review of relevant literature, the study proposes a concept…
View article: Thyroid Hormone Biomonitoring: A Review on Their Metabolism and Machine-Learning Based Analysis on Effects of Endocrine Disrupting Chemicals
Thyroid Hormone Biomonitoring: A Review on Their Metabolism and Machine-Learning Based Analysis on Effects of Endocrine Disrupting Chemicals Open
The thyroid is an essential endocrine organ in human body, and thyroid hormones (THs) are pivotal signaling molecules and mediators in various physiological processes. THs, particularly in their free form, play a critical role in regulatin…
View article: Effect of Ph, Protein/Polysaccharide Ratio and Preparation Method on the Properties of Lactoferrin-Polysaccharide Complexes
Effect of Ph, Protein/Polysaccharide Ratio and Preparation Method on the Properties of Lactoferrin-Polysaccharide Complexes Open
View article: Potential efficacy and mechanism of medicinal plants on chronic kidney disease-associated vascular calcification: a review
Potential efficacy and mechanism of medicinal plants on chronic kidney disease-associated vascular calcification: a review Open
View article: Efficacy of activating blood and resolving stasis therapy for IgA nephropathy: a systematic review and meta-analysis
Efficacy of activating blood and resolving stasis therapy for IgA nephropathy: a systematic review and meta-analysis Open
View article: Polygonum Cuspidatum Alcohol Extract Exerts Analgesic Effects via the MAPK/ERK Signaling Pathway
Polygonum Cuspidatum Alcohol Extract Exerts Analgesic Effects via the MAPK/ERK Signaling Pathway Open
PC alcohol extract can inhibit inflammation and alleviate pain, which is related to its inhibition of the MAPK/ERK signaling pathway in spinal cord. Thus, PC alcohol extract is a promising candidate for pain treatment.
View article: Chaperonin containing TCP-1 subunit genes are potential prognostic biomarkers and correlate with Th2 cell infiltration in lung adenocarcinoma
Chaperonin containing TCP-1 subunit genes are potential prognostic biomarkers and correlate with Th2 cell infiltration in lung adenocarcinoma Open
Background Chaperonin containing TCP-1 (T-complex protein 1) subunit genes (CCTs) is a family of molecular chaperone complex that assists the folding of multiple proteins. However, there is no comprehensive analysis of CCTs in lung adenoca…
View article: Bioinformatics and experimental validation of an AURKA/TPX2 axis as a potential target in esophageal squamous cell carcinoma
Bioinformatics and experimental validation of an AURKA/TPX2 axis as a potential target in esophageal squamous cell carcinoma Open
Aurora kinase A (AURKA), a serine/threonine kinase that regulates mitotic processes, has garnered significant interest given its association with the development of several types of cancer. In the present study, it was shown that AURKA exp…
View article: Did variants in inborn errors of immunity genes contribute to the extinction of Neanderthals?
Did variants in inborn errors of immunity genes contribute to the extinction of Neanderthals? Open
Although the exact functional impact of these three variants needs further elucidation, we speculate that they could have resulted in an increased susceptibility to severe diseases and may have contributed to the extinction of Neanderthals…
View article: Did variants in inborn errors of immunity genes contribute to the extinction of Neanderthals?
Did variants in inborn errors of immunity genes contribute to the extinction of Neanderthals? Open
Neanderthals were a species of archaic human that became extinct around 40,000 years ago. Modern humans have inherited 1-6% of Neanderthal DNA as a result of interbreeding with the Neanderthals. These inherited Neanderthal genes have parad…
View article: Activation of cannabinoid receptor 2 attenuates Angiotensin II-induced atrial fibrillation via a potential NOX/CaMKII mechanism
Activation of cannabinoid receptor 2 attenuates Angiotensin II-induced atrial fibrillation via a potential NOX/CaMKII mechanism Open
Background Atrial fibrillation (AF) is the most frequent arrythmia managed in clinical practice. Several mechanisms have been proposed to contribute to the occurrence and persistence of AF, in which oxidative stress plays a non-negligible …
View article: Three patients with defects in interferon gamma receptor signaling: A challenging diagnosis
Three patients with defects in interferon gamma receptor signaling: A challenging diagnosis Open
Three patients with defects in interferon gamma receptor signaling: A challenging diagnosisTo the Editor, Mendelian susceptibility to mycobacterial disease (MSMD) is a rare inherited disorder characterized by infections with weakly virulen…
View article: Author response for "Three patients with defects in interferon gamma receptor signaling: A challenging diagnosis"
Author response for "Three patients with defects in interferon gamma receptor signaling: A challenging diagnosis" Open