Zheng He
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View article: Employersâ perspectives on recruiting and retaining pharmacists in regional and rural Victoria, Australia
Employersâ perspectives on recruiting and retaining pharmacists in regional and rural Victoria, Australia Open
This study identified that remuneration, work conditions and policy aspects, as well as workplace and role satisfaction and social factors, are the major challenges for employers in recruiting and retaining pharmacists in regional or rural…
View article: Rat retinal function attenuation with IOP elevation is impacted by both blood pressure and intracranial pressure
Rat retinal function attenuation with IOP elevation is impacted by both blood pressure and intracranial pressure Open
Introduction To consider how blood pressure and intracranial pressure modify the way that retinal function responds to intraocular pressure elevation in rats. Methods Six groups of adult Long–Evans rats (n = 7–11 eyes/group, total animals …
View article: Getting the full picture: what are the enablers and barriers to a rural pharmacy workforce for employers and employees? A critical review of literature from 2002–2022
Getting the full picture: what are the enablers and barriers to a rural pharmacy workforce for employers and employees? A critical review of literature from 2002–2022 Open
Purpose of review Geographical maldistribution of pharmacists to regional and rural areas in Australia is well documented in a similar fashion to other health professions. This narrative review aimed to identify the enablers and barriers t…
View article: Monte Carlo simulation to optimize polymyxin B dosing regimens for the treatment of Gram-negative bacteremia
Monte Carlo simulation to optimize polymyxin B dosing regimens for the treatment of Gram-negative bacteremia Open
Objective This study aimed to predict and evaluate the efficacy of various polymyxin B dosing regimens for Gram-negative bacteremia using Monte Carlo simulation, with a specific focus on assessing the efficacy in patients receiving continu…
View article: Efficient OpAmp Adaptation for Zoom Attention to Golden Contexts
Efficient OpAmp Adaptation for Zoom Attention to Golden Contexts Open
Large language models (LLMs) have shown significant promise in question-answering (QA) tasks, particularly in retrieval-augmented generation (RAG) scenarios and long-context applications. However, their performance is hindered by noisy ref…
View article: Lipid on stroke in intracranial artery atherosclerotic stenosis: a mediation role of glucose
Lipid on stroke in intracranial artery atherosclerotic stenosis: a mediation role of glucose Open
Objective Expanding on previous investigations, this study aims to elucidate the role of lipid metabolism disorders in the development of intracranial atherosclerotic stenosis (ICAS) and the determination of stroke risk. The primary object…
View article: Hypertensive disorders of pregnancy and adverse outcomes of twins
Hypertensive disorders of pregnancy and adverse outcomes of twins Open
Background Hypertensive disorders of pregnancy (HDP) can significantly impact infant outcomes. However, research on the effects of HDP on twin pregnancies is limited and has not been well understood. Methods Data were collected from 22 med…
View article: Cytosine–phosphate–guanine oligodeoxynucleotides alleviate radiation-induced kidney injury in cervical cancer by inhibiting DNA damage and oxidative stress through blockade of PARP1/XRCC1 axis
Cytosine–phosphate–guanine oligodeoxynucleotides alleviate radiation-induced kidney injury in cervical cancer by inhibiting DNA damage and oxidative stress through blockade of PARP1/XRCC1 axis Open
Background Radiotherapy can cause kidney injury in patients with cervical cancer. This study aims to investigate the possible molecular mechanisms by which CpG-ODNs (Cytosine phosphate guanine-oligodeoxynucleotides) regulate the PARP1 (pol…
View article: <strong>Diet-related Lipidomic Signatures and Changed Type 2 Diabetes Risk in A Randomized Controlled Feeding Study with Mediterranean Diet and Traditional Chinese or Transitional diets</strong>
<strong>Diet-related Lipidomic Signatures and Changed Type 2 Diabetes Risk in A Randomized Controlled Feeding Study with Mediterranean Diet and Traditional Chinese or Transitional diets</strong> Open
Objective: Few trials studied the links of food components in different diets with their induced lipidomic changes and related metabolic outcomes. Thus, we investigated specific lipidomic signatures with habitual diets and modified diabete…
View article: <strong>Diet-related Lipidomic Signatures and Changed Type 2 Diabetes Risk in A Randomized Controlled Feeding Study with Mediterranean Diet and Traditional Chinese or Transitional diets</strong>
<strong>Diet-related Lipidomic Signatures and Changed Type 2 Diabetes Risk in A Randomized Controlled Feeding Study with Mediterranean Diet and Traditional Chinese or Transitional diets</strong> Open
Objective: Few trials studied the links of food components in different diets with their induced lipidomic changes and related metabolic outcomes. Thus, we investigated specific lipidomic signatures with habitual diets and modified diabete…
View article: Numerical simulation of plasma gasification of oil-based drilling cuttings
Numerical simulation of plasma gasification of oil-based drilling cuttings Open
In this paper, ASPEN PLUS commercial software is used to simulate the plasma gasification process of oil-based drilling cuttings, and the numerical simulation results are analyzed in detail. The conclusions can provide theoretical guidance…
View article: Fractalkine-induced microglial vasoregulation occurs within the retina and is altered early in diabetic retinopathy
Fractalkine-induced microglial vasoregulation occurs within the retina and is altered early in diabetic retinopathy Open
Significance This work identifies a role for microglia, the innate immune cells of the CNS, in the local control of the retinal vasculature and identifies deficits early in diabetes. Microglia contact neurons and vasculature and express se…
View article: Transcriptome analysis of the effect of a novel human serine protease inhibitor SPINK13 on gene expression in MHCC97-H cells
Transcriptome analysis of the effect of a novel human serine protease inhibitor SPINK13 on gene expression in MHCC97-H cells Open
This study showed that SPINK13 inhibits hepatocellular carcinoma cell development by regulating the JNK, p53, and the IKK/NF-κB pathways, its potential targets for antitumor drugs may be JUN, GADD45A, GADD45B, TNFRSF1A, FOS, CDKN1B, NFKBIA…
View article: Retinal Functional and Structural Changes in the 5xFAD Mouse Model of Alzheimer’s Disease
Retinal Functional and Structural Changes in the 5xFAD Mouse Model of Alzheimer’s Disease Open
Alzheimer's disease is characterized by the aberrant deposition of protein in the brain and is the leading cause of dementia worldwide. Increasingly, there have been reports of the presence of these protein hallmarks in the retina. In this…
View article: Fractalkine-induced microglial vasoregulation occurs within the retina and is altered early in diabetic retinopathy
Fractalkine-induced microglial vasoregulation occurs within the retina and is altered early in diabetic retinopathy Open
Local blood flow control within the CNS is critical to proper function and is dependent on coordination between neurons, glia and blood vessels. Macroglia such as astrocytes and Müller cells, contribute to this neurovascular unit within th…
View article: Remdesivir may not be a magic bullet for COVID-19 from pharmaceutical perspective
Remdesivir may not be a magic bullet for COVID-19 from pharmaceutical perspective Open
Coronavirus disease 2019 (COVID-19) caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has become the global pandemic and caused hundreds of thousands of people died in the world, which is in urgent need to develop …
View article: Blocking endothelial apoptosis revascularizes the retina in a model of ischemic retinopathy
Blocking endothelial apoptosis revascularizes the retina in a model of ischemic retinopathy Open
Aberrant, neovascular retinal blood vessel growth is a vision-threatening complication in ischemic retinal diseases. It is driven by retinal hypoxia frequently caused by capillary nonperfusion and endothelial cell (EC) loss. We investigate…
Response of the Trilaminar Retinal Vessel Network to Intraocular Pressure Elevation in Rat Eyes Open
These data show that the intermediate and deep vascular plexus in the rat retina have a greater capacity for autoregulation against mild IOP elevation but are more affected at high IOP.
View article: <p>RGS4 Regulates Proliferation And Apoptosis Of NSCLC Cells Via microRNA-16 And Brain-Derived Neurotrophic Factor</p>
RGS4 Regulates Proliferation And Apoptosis Of NSCLC Cells Via microRNA-16 And Brain-Derived Neurotrophic Factor Open
This study revealed that RGS4 overexpression positively correlated with the development of NSCLC. TDownstream RGS4 targets (eg, miR-16 and BDNF) might be involved in the development of NSCLC and may serve as potential therapeutic targets f…
View article: MicroRNA-30b is involved in the pathological process of diabetes mellitus induced by pancreatic cancer by regulating plasminogen activator inhibitor-1
MicroRNA-30b is involved in the pathological process of diabetes mellitus induced by pancreatic cancer by regulating plasminogen activator inhibitor-1 Open
This study investigated the expression of plasminogen activator inhibitor-1 (PAI-1) and microRNA (miRNA or miR)-30b in tumor tissues, blood and urine from pancreatic cancer (PC) patients with diabetes mellitus. The effect of culture supern…
View article: A Model of Glaucoma Induced by Circumlimbal Suture in Rats and Mice
A Model of Glaucoma Induced by Circumlimbal Suture in Rats and Mice Open
The circumlimbal suture is a technique for inducing experimental glaucoma in rodents by chronically elevating intraocular pressure (IOP), a well-known risk factor for glaucoma. This protocol demonstrates a step-by-step guide on this techni…