Zikai Zhou
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View article: IL-6 Inhibition Partially Ameliorates Maternal Immune Activation-Induced Autism-Like Behavioral Abnormalities in Mice
IL-6 Inhibition Partially Ameliorates Maternal Immune Activation-Induced Autism-Like Behavioral Abnormalities in Mice Open
Prenatal maternal immune activation (MIA) has been implicated in autism spectrum disorder (ASD) pathogenesis, with interleukin-6 (IL-6) identified as a key inflammatory mediator. We investigated the therapeutic potential of IL-6 inhibition…
View article: Value of ctDNA in surveillance of adjuvant chemosensitivity and regimen adjustment in stage III colon cancer: a protocol for phase II multicentre randomised controlled trial (REVISE trial)
Value of ctDNA in surveillance of adjuvant chemosensitivity and regimen adjustment in stage III colon cancer: a protocol for phase II multicentre randomised controlled trial (REVISE trial) Open
Introduction The standard of care for stage III colon cancer is 3 or 6 months of double-drug regimen chemotherapy following radical surgery. However, patients with positive circulating tumour DNA (ctDNA) exhibit a high risk of recurrence r…
View article: Zigzag Diffusion Sampling: Diffusion Models Can Self-Improve via Self-Reflection
Zigzag Diffusion Sampling: Diffusion Models Can Self-Improve via Self-Reflection Open
Diffusion models, the most popular generative paradigm so far, can inject conditional information into the generation path to guide the latent towards desired directions. However, existing text-to-image diffusion models often fail to maint…
View article: Golden Noise for Diffusion Models: A Learning Framework
Golden Noise for Diffusion Models: A Learning Framework Open
Text-to-image diffusion model is a popular paradigm that synthesizes personalized images by providing a text prompt and a random Gaussian noise. While people observe that some noises are ``golden noises'' that can achieve better text-image…
View article: IV-Mixed Sampler: Leveraging Image Diffusion Models for Enhanced Video Synthesis
IV-Mixed Sampler: Leveraging Image Diffusion Models for Enhanced Video Synthesis Open
The multi-step sampling mechanism, a key feature of visual diffusion models, has significant potential to replicate the success of OpenAI's Strawberry in enhancing performance by increasing the inference computational cost. Sufficient prio…
View article: The rebalancing of the immune system at the maternal-fetal interface ameliorates autism-like behavior in adult offspring
The rebalancing of the immune system at the maternal-fetal interface ameliorates autism-like behavior in adult offspring Open
Maternal immune activation (MIA) is critical for imparting neuropathology and altered behaviors in offspring; however, maternal-fetal immune cell populations have not been thoroughly investigated in MIA-induced autism spectrum disorders (A…
View article: Value of brain tissue oxygen saturation in neonatal respiratory distress syndrome: a clinical study
Value of brain tissue oxygen saturation in neonatal respiratory distress syndrome: a clinical study Open
Neonatal respiratory distress syndrome (NRDS) is one of the major causes of pre-term mortality and morbidity among very-low-birth-weight infants (VLBWI) in low- and middle-income countries (LMIC). Some of the neonates pass away despite adm…
View article: Brain Resident Ly6Chi Monocytes Are Necessary for Maintaining Adult Hippocampal Neurogenesis
Brain Resident Ly6Chi Monocytes Are Necessary for Maintaining Adult Hippocampal Neurogenesis Open
Adult hippocampal neurogenesis (AHN) is crucial to various brain functions. Neurodegeneration, neuroinflammation and stress can impair AHN, contributing to the development of neurological and psychiatric disorders. Stress is known to exten…
View article: Maternal immune activation and neuropsychiatric disease in offspring: Pathogen's perspective
Maternal immune activation and neuropsychiatric disease in offspring: Pathogen's perspective Open
Neuropsychiatric disorders (NDDs) have been associated with maternal immune activation (MIA) in epidemiologic studies, such as prospective birth cohort studies. There is evidence linking maternal infectious pathogens and inflammation to a …
View article: The development and application of ornithopter and the study of ornithopter aerodynamics
The development and application of ornithopter and the study of ornithopter aerodynamics Open
Ornithopter, in the past, was a vehicle that appeared in science fiction movies and novels. However, due to advances in materials science and human research into aerodynamics, this fantasy is becoming increasingly possible. In this paper, …
View article: Characterizing neurotrophic factor-induced synaptic growth in primary mouse neuronal cultures
Characterizing neurotrophic factor-induced synaptic growth in primary mouse neuronal cultures Open
Neurotrophic factors and their signaling cascades play important roles in synaptic growth, which can be investigated in cultured primary neurons to better control the concentrations and timing of neurotrophic factor treatment. Here, we pro…
View article: Prediction of Metro Train‐Induced Tunnel Vibrations Using Machine Learning Method
Prediction of Metro Train‐Induced Tunnel Vibrations Using Machine Learning Method Open
The tunnel vibration level is usually employed as a vibration source intensity of the empirical prediction method. Currently, the analogy test and data base are two main means to determine the vibration source intensity. To improve the acc…
View article: NGPF2 triggers synaptic scaling up through ALK-LIMK-cofilin-mediated mechanisms
NGPF2 triggers synaptic scaling up through ALK-LIMK-cofilin-mediated mechanisms Open
Synaptic scaling is an extensively studied form of homeostatic plasticity critically involved in various brain functions. Although it is accepted that synaptic scaling is expressed through the postsynaptic accumulation of AMPA receptors (A…
View article: Transcriptome Regulation by Oncogenic ALK Pathway in Mammalian Cortical Development Revealed by Single-Cell RNA Sequencing
Transcriptome Regulation by Oncogenic ALK Pathway in Mammalian Cortical Development Revealed by Single-Cell RNA Sequencing Open
Precise regulation of embryonic neurodevelopment is crucial for proper structural organization and functioning of the adult brain. The key molecular machinery orchestrating this process remains unclear. Anaplastic lymphoma kinase (ALK) is …
View article: P21 activated kinase‐1 (PAK1) in macrophages is required for promotion of Th17 cell response during helminth infection
P21 activated kinase‐1 (PAK1) in macrophages is required for promotion of Th17 cell response during helminth infection Open
CD4 + T cells differentiate into distinct functional effector and inhibitory subsets are facilitated by distinct cytokine cues present at the time of antigen recognition. Maintaining a balance between T helper 17 (Th17) and regulatory T (T…
View article: Deletion of Limk1 and Limk2 in mice does not alter cochlear development or auditory function
Deletion of Limk1 and Limk2 in mice does not alter cochlear development or auditory function Open
Inherited hearing loss is associated with gene mutations that result in sensory hair cell (HC) malfunction. HC structure is defined by the cytoskeleton, which is mainly composed of actin filaments and actin-binding partners. LIM motif-cont…
View article: Structural Analysis of Piezo1 Ion Channel Reveals the Relationship between Amino Acid Sequence Mutations and Human Diseases
Structural Analysis of Piezo1 Ion Channel Reveals the Relationship between Amino Acid Sequence Mutations and Human Diseases Open
Since first identified in 2010, Piezo proteins have been found to perform as poreforming mechanosensitive ion channels across a wide range of animals. As a Piezo ortholog primarily expressed in mammalian systems, Piezo1 has been observed t…
View article: Hippocampal Long-Term Depression in the Presence of Calcium-Permeable AMPA Receptors
Hippocampal Long-Term Depression in the Presence of Calcium-Permeable AMPA Receptors Open
The GluA2 subunit of AMPA glutamate receptors (AMPARs) has been shown to be critical for the expression of NMDA receptor (NMDAR)-dependent long-term depression (LTD). However, in young GluA2 knockout (KO) mice, this form of LTD can still b…
View article: PAK2 Haploinsufficiency Results in Synaptic Cytoskeleton Impairment and Autism-Related Behavior
PAK2 Haploinsufficiency Results in Synaptic Cytoskeleton Impairment and Autism-Related Behavior Open
Synaptic cytoskeleton dysfunction represents a common pathogenesis in neurodevelopmental disorders, such as autism spectrum disorder (ASD). The serine/threonine kinase PAK2 is a critical regulator of cytoskeleton dynamics. However, its fun…
View article: Accumulation of Dense Core Vesicles in Hippocampal Synapses Following Chronic Inactivity
Accumulation of Dense Core Vesicles in Hippocampal Synapses Following Chronic Inactivity Open
The morphology and function of neuronal synapses are regulated by neural activity, as manifested in activity-dependent synapse maturation and various forms of synaptic plasticity. Here we employed cryo-electron tomography (cryo-ET) to visu…
View article: Cdk7 Is Required for Activity-Dependent Neuronal Gene Expression, Long-Lasting Synaptic Plasticity and Long-Term Memory
Cdk7 Is Required for Activity-Dependent Neuronal Gene Expression, Long-Lasting Synaptic Plasticity and Long-Term Memory Open
In the brain, de novo gene expression driven by learning-associated neuronal activities is critical for the formation of long-term memories. However, the signaling machinery mediating neuronal activity-induced gene expression, especially t…
View article: Mutations of <i>PQBP1</i> in Renpenning syndrome promote ubiquitin-mediated degradation of FMRP and cause synaptic dysfunction
Mutations of <i>PQBP1</i> in Renpenning syndrome promote ubiquitin-mediated degradation of FMRP and cause synaptic dysfunction Open
Renpenning syndrome is a group of X-linked intellectual disability syndromes caused by mutations in human polyglutamine-binding protein 1 (PQBP1) gene. Little is known about the molecular pathogenesis of the various mutations that cause th…