Zhiai Xu
YOU?
Author Swipe
View article: High-resolution X-ray imaging technologies for non-destructive testing of integrated circuits
High-resolution X-ray imaging technologies for non-destructive testing of integrated circuits Open
View article: Igniting VLMs toward the Embodied Space
Igniting VLMs toward the Embodied Space Open
While foundation models show remarkable progress in language and vision, existing vision-language models (VLMs) still have limited spatial and embodiment understanding. Transferring VLMs to embodied domains reveals fundamental mismatches b…
View article: Effects of aerobic exercise on executive function in children and adolescents with attention deficit hyperactivity disorder: a systematic review and meta-analysis of randomized controlled trials
Effects of aerobic exercise on executive function in children and adolescents with attention deficit hyperactivity disorder: a systematic review and meta-analysis of randomized controlled trials Open
Aerobic exercise interventions can significantly improve the executive functions of children and adolescents with ADHD. To achieve the best intervention effects, it is recommended to engage in chronic aerobic exercise, with a period lastin…
View article: Engineering STING Nanoadjuvants for spatiotemporally-tailored innate immunity stimulation and cancer vaccination therapy
Engineering STING Nanoadjuvants for spatiotemporally-tailored innate immunity stimulation and cancer vaccination therapy Open
Spatiotemporally-tailored activation of dendritic cells (DC) in lymph nodes (LN) remains a critical challenge for effective cancer vaccination therapy. In this study, we show that photo/sonodynamic effect can trigger the nuclear transcript…
View article: Effects of Aerobic Exercise on Executive Function in Children and Adolescents with Attention Deficit Hyperactivity Disorder: A Systematic Review and Meta-Analysis of Randomized Controlled Trials
Effects of Aerobic Exercise on Executive Function in Children and Adolescents with Attention Deficit Hyperactivity Disorder: A Systematic Review and Meta-Analysis of Randomized Controlled Trials Open
Background The benefits of aerobic exercise interventions on the executive function of children and adolescents have been fully confirmed. However, the effects of such interventions on the executive function of children and adolescents wit…
View article: Self‐Oxygenating PROTAC Microneedle for Spatiotemporally‐Confined Protein Degradation and Enhanced Glioblastoma Therapy
Self‐Oxygenating PROTAC Microneedle for Spatiotemporally‐Confined Protein Degradation and Enhanced Glioblastoma Therapy Open
Glioblastoma (GBM) is the most aggressive subtype of primary brain tumors, which marginally respond to standard chemotherapy due to the blood‐brain barrier (BBB) and the low tumor specificity of the therapeutics. Herein, a double‐layered m…
View article: Tumor-specific delivery of clickable inhibitor for PD-L1 degradation and mitigating resistance of radioimmunotherapy
Tumor-specific delivery of clickable inhibitor for PD-L1 degradation and mitigating resistance of radioimmunotherapy Open
Achieving selective and durable inhibition of programmed death ligand 1 (PD-L1) in tumors for T cell activation remains a major challenge in immune checkpoint blockade therapy. We herein presented a set of clickable inhibitors for spatiall…
View article: A Self-Immobilizing Photosensitizer with Long-Term Retention for Hypoxia Imaging and Enhanced Photodynamic Therapy
A Self-Immobilizing Photosensitizer with Long-Term Retention for Hypoxia Imaging and Enhanced Photodynamic Therapy Open
The precise theranostic strategy of fluorescence imaging-guided photodynamic therapy (PDT) can effectively mitigate the adverse effect of photosensitizers in normal cells and tissues. However, low tumor enrichment and high diffusivity of p…
View article: A region-confined PROTAC nanoplatform for spatiotemporally tunable protein degradation and enhanced cancer therapy
A region-confined PROTAC nanoplatform for spatiotemporally tunable protein degradation and enhanced cancer therapy Open
View article: Tumor-targeted PROTAC prodrug nanoplatform enables precise protein degradation and combination cancer therapy
Tumor-targeted PROTAC prodrug nanoplatform enables precise protein degradation and combination cancer therapy Open
View article: From structural design to delivery: mRNA therapeutics for cancer immunotherapy
From structural design to delivery: mRNA therapeutics for cancer immunotherapy Open
mRNA therapeutics have emerged as powerful tools for cancer immunotherapy in accordance with their superiority in expressing all sequence‐known proteins in vivo. In particular, with a small dosage of delivered mRNA, antigen‐presenting cell…
View article: Nanovesicles loaded with a TGF-β receptor 1 inhibitor overcome immune resistance to potentiate cancer immunotherapy
Nanovesicles loaded with a TGF-β receptor 1 inhibitor overcome immune resistance to potentiate cancer immunotherapy Open
View article: Photochemically controlled activation of STING by CAIX-targeting photocaged agonists to suppress tumor cell growth
Photochemically controlled activation of STING by CAIX-targeting photocaged agonists to suppress tumor cell growth Open
A photo-caged STING agonist featuring a tumor-targeting carbonic anhydrase warhead was designed and synthesized for photo-controllable activation of STING signaling.
View article: Self‐Cooperative Prodrug Nanovesicles Migrate Immune Evasion to Potentiate Chemoradiotherapy in Head and Neck Cancer
Self‐Cooperative Prodrug Nanovesicles Migrate Immune Evasion to Potentiate Chemoradiotherapy in Head and Neck Cancer Open
Chemoradiotherapy is the standard of care for the clinical treatment of locally advanced head and neck cancers. However, the combination of ion radiation with free chemotherapeutics yields unsatisfactory therapeutic output and severe side …
View article: Author Correction: Engineered bioorthogonal POLY-PROTAC nanoparticles for tumour-specific protein degradation and precise cancer therapy
Author Correction: Engineered bioorthogonal POLY-PROTAC nanoparticles for tumour-specific protein degradation and precise cancer therapy Open
View article: Engineered bioorthogonal POLY-PROTAC nanoparticles for tumour-specific protein degradation and precise cancer therapy
Engineered bioorthogonal POLY-PROTAC nanoparticles for tumour-specific protein degradation and precise cancer therapy Open
View article: Dual-targeting prodrug nanotheranostics for NIR-Ⅱ fluorescence imaging-guided photo-immunotherapy of glioblastoma
Dual-targeting prodrug nanotheranostics for NIR-Ⅱ fluorescence imaging-guided photo-immunotherapy of glioblastoma Open
Glioblastoma (GBM) therapy is severely impaired by the blood-brain barrier (BBB) and invasive tumor growth in the central nervous system. To improve GBM therapy, we herein presented a dual-targeting nanotheranostic for second near-infrared…
View article: Engineering POLYTAC Nanoparticles for Bioorthogonal Click Reaction-Enforced Protein Degradation and Breast Cancer Therapy
Engineering POLYTAC Nanoparticles for Bioorthogonal Click Reaction-Enforced Protein Degradation and Breast Cancer Therapy Open
PROteolysis TArgeting Chimeras (PROTACs) have been extensively explored for targeted protein degradation and cancer therapy. However, clinic translation of the conventional small molecular PROTACs is challenged by their unfavorable pharmac…
View article: High-performance self-supporting AgCoPO<sub>4</sub>/CFP for hydrogen evolution reaction under alkaline conditions
High-performance self-supporting AgCoPO<sub>4</sub>/CFP for hydrogen evolution reaction under alkaline conditions Open
The synthesis of AgCoPO 4 /CFP for high performance hydrogen evolution reaction in an alkaline environment.
View article: Design of an activatable NIR-II nanoprobe for the <i>in vivo</i> elucidation of Alzheimer's disease-related variations in methylglyoxal concentrations
Design of an activatable NIR-II nanoprobe for the <i>in vivo</i> elucidation of Alzheimer's disease-related variations in methylglyoxal concentrations Open
A biocompatible Fe 3 O 4 nanoparticle integrating methylglyoxal-activatable NIR-II fluorescent probe and brain-targeting peptide was developed for visualizing Alzheimer's disease (AD)-related methylglyoxal variation in vivo .
View article: Bispecific prodrug nanoparticles circumventing multiple immune resistance mechanisms for promoting cancer immunotherapy
Bispecific prodrug nanoparticles circumventing multiple immune resistance mechanisms for promoting cancer immunotherapy Open
View article: Regulating Glucose Metabolism with Prodrug Nanoparticles for Promoting Photoimmunotherapy of Pancreatic Cancer
Regulating Glucose Metabolism with Prodrug Nanoparticles for Promoting Photoimmunotherapy of Pancreatic Cancer Open
The low immunogenicity, insufficient infiltration of T lymphocytes, and dismal response to immune checkpoint blockade therapy pose major difficulties in immunotherapy of pancreatic cancer. Photoimmunotherapy by photodynamic therapy (PDT) c…
View article: Multifunctional peptide-assembled micelles for simultaneously reducing amyloid-β and reactive oxygen species
Multifunctional peptide-assembled micelles for simultaneously reducing amyloid-β and reactive oxygen species Open
Multifunctional micelles based on a peptide–polymer for simultaneously targeting Aβ degradation and ROS scavenging for AD therapy.
View article: Ultrasensitive Detection of RNA Biomarkers Using Portable Sensing Platforms Based on Organic Electrochemical Transistors
Ultrasensitive Detection of RNA Biomarkers Using Portable Sensing Platforms Based on Organic Electrochemical Transistors Open
View article: Overcoming immune resistance by sequential prodrug nanovesicles for promoting chemoimmunotherapy of cancer
Overcoming immune resistance by sequential prodrug nanovesicles for promoting chemoimmunotherapy of cancer Open
View article: Supramolecular Prodrug Nanovectors for Active Tumor Targeting and Combination Immunotherapy of Colorectal Cancer
Supramolecular Prodrug Nanovectors for Active Tumor Targeting and Combination Immunotherapy of Colorectal Cancer Open
Immunotherapy aiming to harness the exquisite power of the immune system has emerged as a crucial part of clinical cancer management. However, only a subset of cancer patients responds to current immunotherapy because of low immunogenicity…
View article: Exploration and Practice of Student-Centered Online and Offline Blended Teaching Mode in Instrumental Analysis Experiment
Exploration and Practice of Student-Centered Online and Offline Blended Teaching Mode in Instrumental Analysis Experiment Open
View article: Supplementary Material for: Effect of Transcranial Alternating Current Stimulation for the Treatment of Chronic Insomnia: A Randomized, Double-Blind, Parallel-Group, Placebo-Controlled Clinical Trial
Supplementary Material for: Effect of Transcranial Alternating Current Stimulation for the Treatment of Chronic Insomnia: A Randomized, Double-Blind, Parallel-Group, Placebo-Controlled Clinical Trial Open
Background: Not all adults with chronic insomnia respond to the recommended therapeutic options of cognitive behavioral therapy and approved hypnotic drugs. Transcranial alternating current stimulation (tACS) may offer a nove…
View article: MICROFLUIDIC MICROALGAL BIOREACTOR FOR HIGH-THROUGHPUT SCREENING OF CO2 CONCENTRATION CONDITIONS ON MICROALGAE GROWTH
MICROFLUIDIC MICROALGAL BIOREACTOR FOR HIGH-THROUGHPUT SCREENING OF CO2 CONCENTRATION CONDITIONS ON MICROALGAE GROWTH Open
This paper presents a high-throughput microfluidic bioreactor capable of culturing and screening microalgal strains under different CO2 envionmental conditions.The present bioreactor consists of a microfluidic microalgae culture unit, a CO…