Tong Zhang
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View article: Bifidobacterium longum CCFM760 combined with lactulose alleviates loperamide-induced constipation by regulating the gut microbiota and improving short-chain fatty acid metabolism
Bifidobacterium longum CCFM760 combined with lactulose alleviates loperamide-induced constipation by regulating the gut microbiota and improving short-chain fatty acid metabolism Open
View article: Depressive disorders are associated with brain structural injury in HIV-positive men who have sex with men
Depressive disorders are associated with brain structural injury in HIV-positive men who have sex with men Open
View article: Simultaneous Quantification of Bictegravir and Emtricitabine Using a Simple and Economical Liquid Chromatography–Ultraviolet Method for Therapeutic Drug Monitoring in Patients with Human Immunodeficiency Virus
Simultaneous Quantification of Bictegravir and Emtricitabine Using a Simple and Economical Liquid Chromatography–Ultraviolet Method for Therapeutic Drug Monitoring in Patients with Human Immunodeficiency Virus Open
Background: Biktarvy is an effective antiviral drug for patients with HIV. However, owing to its long-term use and poor patient adherence, sustained and effective Biktarvy treatment is consistently limited by insufficient in vivo drug conc…
View article: From comfortable to conflicted: a three-year longitudinal symptom evolution of problematic Internet use among junior high school students
From comfortable to conflicted: a three-year longitudinal symptom evolution of problematic Internet use among junior high school students Open
Background Problematic Internet use (PIU) is frequently regarded as a potential mental health concern and poses significant risks to the well-being of adolescents. Previous studies have predominantly focused on the influencing factors and …
View article: Efficacy and safety of warming Yang and dredging intestines method in metastatic colon cancer maintenance
Efficacy and safety of warming Yang and dredging intestines method in metastatic colon cancer maintenance Open
BACKGROUND There is a lack of integrated Chinese and Western medicine treatment regimens supported by high-level evidence-based medicine in the maintenance therapy phase of metastatic colorectal cancer (mCRC). Based on the traditional Chin…
View article: Genetic dissection and validation of a new dominant QTL associated with chlorophyll content and its regulatory networks analysis in soybean
Genetic dissection and validation of a new dominant QTL associated with chlorophyll content and its regulatory networks analysis in soybean Open
Leaf-color mutants have proven valuable for studying chlorophyll metabolism, photosynthesis, and yield improvement. In this study, we identified a yellow-leaf (yl) mutant in soybean (Glycine max), characterized by reduced chlorophyll accum…
View article: Electrochemical oxidation enabled HAT approach for the synthesis of quinolinones
Electrochemical oxidation enabled HAT approach for the synthesis of quinolinones Open
View article: IGF-1 secreted by mesenchymal stem cells affects the function of lymphatic endothelial progenitor cells: a potential strategy for the treatment of lymphedema
IGF-1 secreted by mesenchymal stem cells affects the function of lymphatic endothelial progenitor cells: a potential strategy for the treatment of lymphedema Open
Mesenchymal stem cells (MSCs) can participate in lymphangiogenesis through paracrine effects, while lymphatic endothelial progenitor cells (LEPCs), a subpopulation of endothelial progenitor cells (EPCs), can differentiate into mature lymph…
View article: Role of lifestyle factors in mediating the effect of mood swings on cardiovascular diseases: A mediation Mendelian randomization study
Role of lifestyle factors in mediating the effect of mood swings on cardiovascular diseases: A mediation Mendelian randomization study Open
It has been found that individuals with psychiatric illnesses are predisposed to an elevated risk of cardiovascular diseases (CVDs). Mood swing is a clinically relevant characteristic linked to psychiatric disorders. This study examined th…
View article: Spatiotemporal patterns and influencing factors of genotypic resistance testing utilization among people living with HIV: A 10-year retrospective analysis at a tertiary care hospital in Beijing, China (2014–2023)
Spatiotemporal patterns and influencing factors of genotypic resistance testing utilization among people living with HIV: A 10-year retrospective analysis at a tertiary care hospital in Beijing, China (2014–2023) Open
Prior research indicated low genotypic resistance testing (GRT) for human immunodeficiency virus (HIV) utilization in China due to partial cost coverage under national antiretroviral therapy policies, limited testing accessibility, and fin…
View article: Spatiotemporal trends in hernia disease burden and health workforce correlations in aging populations: a global analysis with projections to 2050
Spatiotemporal trends in hernia disease burden and health workforce correlations in aging populations: a global analysis with projections to 2050 Open
Despite declining age-standardized rates for inguinal, femoral, and abdominal wall hernias, absolute disease burden continues increasing due to demographic factors. Socioeconomic development significantly impacts disease patterns, with hig…
View article: A case report of chronic abdominal pain caused by non digestive or psychological disorders
A case report of chronic abdominal pain caused by non digestive or psychological disorders Open
View article: Impaired immune reconstitution in HIV infection: the role of CD4+ T-cell-associated NKG2D ligands, CD4+ T-cell subsets imbalance, and immune function deficiency
Impaired immune reconstitution in HIV infection: the role of CD4+ T-cell-associated NKG2D ligands, CD4+ T-cell subsets imbalance, and immune function deficiency Open
Objective The role of natural killer (NK) cells, which mediate innate immunity, in the immune reconstitution of people living with HIV (PLWH) remains unclear. Our previous research indicated that early activation of CD56 dim CD16 dim/- NK …
View article: Mortality risk prediction model in AIDS patients with pneumocystis pneumonia in China
Mortality risk prediction model in AIDS patients with pneumocystis pneumonia in China Open
Introduction Pneumocystis pneumonia (PCP) is a common and serious complication of HIV/AIDS, with a higher prevalence in patients not receiving antiretroviral therapy. Due to the high mortality rate of PCP, accurate prediction of its case f…
View article: Somatosensory‐Thalamic Functional Dysconnectivity Associated With Poststroke Motor Function Rehabilitation: A Resting‐State fMRI Study
Somatosensory‐Thalamic Functional Dysconnectivity Associated With Poststroke Motor Function Rehabilitation: A Resting‐State fMRI Study Open
Background The thalamus plays a pivotal role in functional brain networks, yet its contribution to motor function recovery following stroke remains elusive. We aim to explore changes in thalamocortical functional connectivity poststroke an…
View article: P024: Updated efficacy and safety of SHR-A1811, an anti-HER2 antibodydrug conjugate, in heavily pretreated advanced solid tumors with HER2-expression or mutations: a global, multicenter, phase 1 study
P024: Updated efficacy and safety of SHR-A1811, an anti-HER2 antibodydrug conjugate, in heavily pretreated advanced solid tumors with HER2-expression or mutations: a global, multicenter, phase 1 study Open
View article: Case report: Spontaneous renal hemorrhage in anti-neutrophil cytoplasmic antibody-associated vasculitis
Case report: Spontaneous renal hemorrhage in anti-neutrophil cytoplasmic antibody-associated vasculitis Open
Anti-neutrophil cytoplasmic antibody (ANCA)-associated vasculitis (AAV) is a systemic necrotizing vasculitis that predominantly affects small vessels. In this report, we present a typical case of granulomatosis with polyangiitis (GPA) comp…
View article: Brain function abnormalities and inflammation in HIV-positive men who have sex with men with depressive disorders
Brain function abnormalities and inflammation in HIV-positive men who have sex with men with depressive disorders Open
Background Depressive disorders are highly prevalent among people with HIV (PWH) and are related to aberrant inflammation and immune responses. However, there is currently a lack of investigation into the neurological, inflammatory, endocr…
View article: Stability Switching and Chaotic Dynamics in a Heterogeneous Population-Based Disease Model with Infection Delay
Stability Switching and Chaotic Dynamics in a Heterogeneous Population-Based Disease Model with Infection Delay Open
View article: Experimental Study on Clustering Characteristics of Flame Spatiotemporal Evolution During Ignition Process Induced by Ignitor Position in a Central Sudden Expansion Supersonic Combustor
Experimental Study on Clustering Characteristics of Flame Spatiotemporal Evolution During Ignition Process Induced by Ignitor Position in a Central Sudden Expansion Supersonic Combustor Open
View article: Memory stem CD8+T cells in HIV/Mtb mono- and co-infection: characteristics, implications, and clinical significance
Memory stem CD8+T cells in HIV/Mtb mono- and co-infection: characteristics, implications, and clinical significance Open
Human immunodeficiency Virus (HIV) and Mycobacterium tuberculosis ( Mtb ) co-infection presents a significant public health challenge worldwide. Comprehensive assessment of the immune response in HIV/ Mtb co-infection is complex and challe…
View article: Cohort study on the treatment of <i>BRAF V600E</i> mutant metastatic colorectal cancer with integrated Chinese and western medicine
Cohort study on the treatment of <i>BRAF V600E</i> mutant metastatic colorectal cancer with integrated Chinese and western medicine Open
BACKGROUND Patients with BRAF V600E mutant metastatic colorectal cancer (mCRC) have a low incidence rate, poor biological activity, suboptimal response to conventional treatments, and a poor prognosis. In the previous cohort study on mCRC …
View article: MYC-dependent upregulation of the de novo serine and glycine synthesis pathway is a targetable metabolic vulnerability in group 3 medulloblastoma
MYC-dependent upregulation of the de novo serine and glycine synthesis pathway is a targetable metabolic vulnerability in group 3 medulloblastoma Open
Background Group 3 medulloblastoma (MBGRP3) represents around 25% of medulloblastomas and is strongly associated with c-MYC (MYC) amplification, which confers significantly worse patient survival. Although elevated MYC expression is a sign…
View article: Prevalence, incidence, and case fatality of tuberculous meningitis in adults living with HIV: a systematic review and meta-analysis
Prevalence, incidence, and case fatality of tuberculous meningitis in adults living with HIV: a systematic review and meta-analysis Open
PROSPERO; No: CRD42022338586.
View article: Comprehensive analysis of GINS subunit expression, prognostic value, and immune infiltration in clear cell renal cell carcinoma
Comprehensive analysis of GINS subunit expression, prognostic value, and immune infiltration in clear cell renal cell carcinoma Open
BACKGROUND: In recent decades, there has been increasing evidence that Go-Ichi-Nii-San (GINS) subunits play an important role in the development and progression of various tumors. However, little research has been conducted on the role of …
View article: Population pharmacokinetics of Ainuovirine and exposure–response analysis in human immunodeficiency virus-infected individuals
Population pharmacokinetics of Ainuovirine and exposure–response analysis in human immunodeficiency virus-infected individuals Open
Background: Ainuovirine (ANV) is a new generation of non-nucleoside reverse transcriptase inhibitor for the treatment of human immunodeficiency virus (HIV) type 1 infection. This study aimed to evaluate the population pharmacokinetic (PopP…
View article: Traditional Chinese Medicine JianPiHuaTan formula improving quality of life and survival in patients with colorectal cancer through RAS/RAF downstream signaling pathways
Traditional Chinese Medicine JianPiHuaTan formula improving quality of life and survival in patients with colorectal cancer through RAS/RAF downstream signaling pathways Open
Objective JianPiHuaTan Formula (JPHTF), a traditional Chinese medicine (TCM), has been utilized as an adjunctive therapy for colorectal cancer (CRC). The study aims to evaluate the potential clinical benefits of JPHTF and its effectiveness…
View article: MDB-74. SERINE/GLYCINE METABOLISM REPRESENTS A NOVEL TARGETABLE THERAPEUTIC VULNERABILITY IN MYC-AMPLIFIED MEDULLOBLASTOMA
MDB-74. SERINE/GLYCINE METABOLISM REPRESENTS A NOVEL TARGETABLE THERAPEUTIC VULNERABILITY IN MYC-AMPLIFIED MEDULLOBLASTOMA Open
BACKGROUND Medulloblastoma is the most frequent malignant brain tumour of childhood. Whilst advances in risk-stratification and upfront multimodal therapy have led to five-year survival rates around 70%, a subset of tumours remain refracto…
View article: Faster Sampling via Stochastic Gradient Proximal Sampler
Faster Sampling via Stochastic Gradient Proximal Sampler Open
Stochastic gradients have been widely integrated into Langevin-based methods to improve their scalability and efficiency in solving large-scale sampling problems. However, the proximal sampler, which exhibits much faster convergence than L…
View article: Single-cell profiling of small molecule-genomic interactions and epigenetic states
Single-cell profiling of small molecule-genomic interactions and epigenetic states Open
We present scEpiChem, a unique method to jointly measure the genomic interactions of small molecules and epigenetic states, such as histone modifications and chromatin accessibility, within single cells. scEpiChem utilizes split-pool barco…