Explanipedia

The sustainability payoff of AI: Revisiting TFP in corporate and societal performance Open

Jian Wang, Hang Lu, Zimo Yang, Ziqi Zhong · 2025

Optogenetic control of T cells for immunomodulation. Open

Brendan McKee, Siyao Liu, Peng Cai, Zimo Yang, Tien‐Hung Lan , et al. · 2025

Cellular immunotherapy has transformed cancer treatment by harnessing T cells to target malignant cells. However, its broader adoption is hindered by challenges such as efficacy loss, limited persistence, tumor heterogeneity, an immunosupp…

ECHS1: pathogenic mechanisms, experimental models, and emerging therapeutic strategies Open

Qiang Fu, Rui Qiu, Li Shang, Yuxiang Qin, Ziyi Lu , et al. · 2025

Variability in Long COVID Definitions and Validation of Published Prevalence Rates Open

Lauren E. Wisk, Michelle L’Hommedieu, Kate Diaz Roldan, Imtiaz Ebna Mannan, Erica S. Spatz , et al. · 2025

Importance Long COVID definitions vary widely, and no consensus exists on how to accurately measure its prevalence, complicating both clinical care and research. Objective To assess long COVID prevalence using various definitions from publ…

Work Impairment and Financial Outcomes Among Adults With vs Without Long COVID Open

Michael Gottlieb, Ji Chen, Huihui Yu, Michelle Santangelo, Erica S. Spatz , et al. · 2025

Importance While much of the focus on long COVID (LC; defined as developing new, persistent symptoms lasting 3 months or longer after SARS-CoV-2 infection) has been on health status and quality of life, the impact on individual work produc…

Assessment of health conditions from patient electronic health record portals vs self-reported questionnaires: an analysis of the INSPIRE study Open

Rohan Khera, Mitsuaki Sawano, Frederick Warner, Andreas Coppi, Aline F Pedroso , et al. · 2025

Objectives Direct electronic access to multiple electronic health record (EHR) systems through patient portals offers a novel avenue for decentralized research. Given the critical value of patient characterization, we sought to compare com…

Development of Highly Selective Aldosterone Synthase Inhibitors Open

Gong Shen, Zimo Yang, Yi Lv, Huisi Liu, Xiaopian Tian , et al. · 2025

PROTAC for Bruton’s tyrosine kinase degradation alleviates inflammation in autoimmune diseases Open

Can Zhu, Zimo Yang, Yu‐Xiao Zhang, Zhenjun Li, Guangchen Li , et al. · 2024

Myalgic Encephalomyelitis/Chronic Fatigue Syndrome After SARS-CoV-2 Infection Open

Elizabeth R. Unger, Jin-Mann S. Lin, Lauren E. Wisk, Huihui Yu, Michelle L’Hommedieu , et al. · 2024

Importance Chronic symptoms reported following an infection with SARS-CoV-2, such as cognitive problems, overlap with symptoms included in the definition of myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS). Objective To evaluate…

Prevalence of Symptoms ≤12 Months After Acute Illness, by COVID-19 Testing Status Among Adults — United States, December 2020–March 2023 Open

Juan Carlos C. Montoy, James H. Ford, Huihui Yu, Michael Gottlieb, Dana Morse , et al. · 2023

To further the understanding of post-COVID conditions, and provide a more nuanced description of symptom progression, resolution, emergence, and reemergence after SARS-CoV-2 infection or COVID-like illness, analysts examined data from the …

Severe Fatigue and Persistent Symptoms at 3 Months Following Severe Acute Respiratory Syndrome Coronavirus 2 Infections During the Pre-Delta, Delta, and Omicron Time Periods: A Multicenter Prospective Cohort Study Open

Michael Gottlieb, Ralph C. Wang, Huihui Yu, Erica S. Spatz, Juan Carlos C. Montoy , et al. · 2023

Background Most research on severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) variants focuses on initial symptomatology with limited longer-term data. We characterized prevalences of prolonged symptoms 3 months post–SARS-CoV-2 …

Design, synthesis, and evaluation of BTK-targeting PROTACs with optimized bioavailability <i>in vitro</i> and <i>in vivo</i> Open

Yonghui Sun, Zimo Yang, Zhimin Zhang, Zhen Li, Liubin Guo , et al. · 2023

Development of a novel PROTAC molecule targeting BTK protein with better PK properties in vivo .

Information cocoons in online navigation Open

Lei Hou, Xue Pan, Kecheng Liu, Zimo Yang, Jian-Guo Liu , et al. · 2022

Social media and online navigation bring us enjoyable experiences in accessing information, and simultaneously create information cocoons (ICs) in which we are unconsciously trapped with limited and biased information. We provide a formal …

Enabling Multiple Intercavity Polariton Coherences by Adding Quantum Confinement to Cavity Molecular Polaritons Open

Zimo Yang, Harsh H. Bhakta, Wei Xiong · 2022

The data, figure, code for manuscript of "Enabling Multiple Intercavity Polariton Coherences by Adding Quantum Confinement to Cavity Molecular Polaritons"

Tumor Cell-Derived Microparticles Packaging Fluvastatin Suppress Lung Adenocarcinoma by Blocking Transmembrane Monocarboxylate Transporter4 Open

Wenjuan Chen, Qi Tan, Mengfei Guo, ting liao, Yumei Li , et al. · 2022

Recent Progress in Synthesis of Polysubstituted Imidazoles by Cyclization Reaction Open

Mi‐Na Zhao, Zimo Yang, De‐Suo Yang · 2022

Information Cocoons in Online Navigation Open

Lei Hou, Xue Pan, Kecheng Liu, Zimo Yang, Jian-Guo Liu , et al. · 2021

Social media and online navigation bring us enjoyable experience in accessing information, and simultaneously create information cocoons (ICs) in which we are unconsciously trapped with limited and biased information. We provide a formal d…

Merging PROTAC and molecular glue for degrading BTK and GSPT1 proteins concurrently Open

Zimo Yang, Yonghui Sun, Zhihao Ni, Celi Yang, Tong Yan , et al. · 2021

Ultrafast Coherence Delocalization in Real Space Simulated by Polaritons Open

Bo Xiang, Zimo Yang, Yi‐Zhuang You, Wei Xiong · 2021

We investigated coherence delocalization on a coupled-cavity molecular polariton platform in time, frequency, and spatial domains, enabled by ultrafast two-dimensional infrared hyperspectral imaging. Unidirectional coherence delocalization…

Radiology residency training in China: results from the first retrospective nationwide survey Open

Jingfeng Zhang, Xinxin Han, Zhenghan Yang, Zhenchang Wang, Jianjun Zheng , et al. · 2021

Objectives This was the first study to systematically landscape and examine China’s nationwide standardized residency training in radiology. Methods In this retrospective cross-sectional study, we used data from the 2019 national survey of…

Preliminary prediction of the basic reproduction number of the Wuhan novel coronavirus 2019‐nCoV Open

Tao Zhou, Quan-Hui Liu, Zimo Yang, Jingyi Liao, Kexin Yang , et al. · 2020

Objectives To estimate the basic reproduction number of the Wuhan novel coronavirus (2019‐nCoV). Methods Based on the susceptible‐exposed‐infected‐removed (SEIR) compartment model and the assumption that the infectious cases with symptoms …

Synthesis of Quaternary Carbon-Centered Benzoindolizidinones via Novel Photoredox-Catalyzed Alkene Aminoarylation: Facile Access to Tylophorine and Analogues Open

Chao Zhang, Yi Wang, Yugang Song, Hongying Gao, Yonghui Sun , et al. · 2019

Open AccessCCS ChemistryRESEARCH ARTICLE1 Oct 2019Synthesis of Quaternary Carbon-Centered Benzoindolizidinones via Novel Photoredox-Catalyzed Alkene Aminoarylation: Facile Access to Tylophorine and Analogues Chao Zhang, Yi Wang, Yugang Son…

Potent and Preferential Degradation of CDK6 via Proteolysis Targeting Chimera Degraders Open

Shang Su, Zimo Yang, Hongying Gao, Haiyan Yang, Songbiao Zhu , et al. · 2019

A focused PROTAC library hijacking cancer therapeutic target CDK6 was developed. A design principle as "match/mismatch" was proposed for understanding the degradation profile differences in these PROTACs. Notably, potent PROTACs with speci…

Early Detection of the Risk of Developing Psychiatric Disorders: A Study of 461 Chinese University Students under Chronic Stress Open

Meng Zhang, René Bridler, Christine Möhr, Inés Moragrega, Ningning Sun , et al. · 2019

Chronic stress, a characteristic of modern time, has a significant impact on general health. In the context of psychiatric disorders, insufficient coping behavior under chronic stress has been linked to higher rates of (1) depressive sympt…

Synthesis, Evaluation, and Structure–Activity Relationship Study of Lanosterol Derivatives To Reverse Mutant-Crystallin-Induced Protein Aggregation Open

Xinglin Yang, Xiangjun Chen, Zimo Yang, Yibo Xi, Liguo Wang , et al. · 2018

We describe here the development of potent synthetic analogues of the naturally occurring triterpenoid lanosterol to reverse protein aggregation in cataracts. Lanosterol showed superiority to other scaffolds in terms of efficacy and genera…

Synthesis and evaluation of osimertinib derivatives as potent EGFR inhibitors Open

Hongying Gao, Zimo Yang, Xinglin Yang, Yu Rao · 2017

Bounds of memory strength for power-law series Open

Fangjian Guo, Dan Yang, Zimo Yang, Zhi-Dan Zhao, Tao Zhou · 2017

Many time series produced by complex systems are empirically found to follow power-law distributions with different exponents α. By permuting the independently drawn samples from a power-law distribution, we present nontrivial bounds on th…

Indigenization of urban mobility Open

Zimo Yang, Defu Lian, Nicholas Jing Yuan, Xing Xie, Rui Yong , et al. · 2016

Memory Constraints for Power-Law Series Open

Fangjian Guo, Zimo Yang, Zhi-Dan Zhao, Tao Zhou · 2015

Many time series produced by complex systems are empirically found to follow power-law distributions with different exponents $\alpha$. By permuting the independently drawn samples from a power-law distribution, we present non-trivial boun…

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