Ziping Jiang
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View article: The recurrence or metastasis related gene predicts the prognosis of extremity and trunk soft tissue sarcoma
The recurrence or metastasis related gene predicts the prognosis of extremity and trunk soft tissue sarcoma Open
Background Relapsed soft tissue sarcomas (STS) have poor prognosis and limited treatment options. However, the molecular mechanism underlying recurrence and the prognostic predictor for STS are unclear. Methods We enrolled 35 extremity and…
View article: Neutrophil diversity and function in health and disease
Neutrophil diversity and function in health and disease Open
Neutrophils, the most abundant type of granulocyte, are widely recognized as one of the pivotal contributors to the acute inflammatory response. Initially, neutrophils were considered the mobile infantry of the innate immune system, tasked…
View article: CRISPR technology in human diseases
CRISPR technology in human diseases Open
Gene editing is a growing gene engineering technique that allows accurate editing of a broad spectrum of gene‐regulated diseases to achieve curative treatment and also has the potential to be used as an adjunct to the conventional treatmen…
View article: On Neuron Activation Pattern and Applications
On Neuron Activation Pattern and Applications Open
As various deep learning applications have been deployed in diverse areas, the explainability of neural networks is becoming increasingly important in the research field. Besides being desirable on its own account, explainability also ofte…
View article: On Explaining Neural Network Robustness with Activation Path
On Explaining Neural Network Robustness with Activation Path Open
ICLR submission. This work is supported in part by the Huawei Technologies Co., Ltd under Grant HIRP2019041002010, the Horizon Europe: European Lighthouse on Secure and Safe AI – ELSA, the UK EPSRC under Grant EP/P009727/1, and the Leverhu…
View article: On Explaining Neural Network Robustness with Activation Path
On Explaining Neural Network Robustness with Activation Path Open
ICLR submission. This work is supported in part by the Huawei Technologies Co., Ltd under Grant HIRP2019041002010, the Horizon Europe: European Lighthouse on Secure and Safe AI – ELSA, the UK EPSRC under Grant EP/P009727/1, and the Leverhu…
View article: Corrigendum: Compounds purified from edible fungi fight against chronic inflammation through oxidative stress regulation
Corrigendum: Compounds purified from edible fungi fight against chronic inflammation through oxidative stress regulation Open
[This corrects the article DOI: 10.3389/fphar.2022.974794.].
View article: Interferon and interferon-stimulated genes in HBV treatment
Interferon and interferon-stimulated genes in HBV treatment Open
Human hepatitis B virus (HBV) is a small enveloped DNA virus with a complex life cycle. It is the causative agent of acute and chronic hepatitis. HBV can resist immune system responses and often causes persistent chronic infections. HBV is…
View article: Advances of hydrogel combined with stem cells in promoting chronic wound healing
Advances of hydrogel combined with stem cells in promoting chronic wound healing Open
Wounds can be divided into two categories, acute and chronic. Acute wounds heal through the normal wound healing process. However, chronic wounds take longer to heal, leading to inflammation, pain, serious complications, and an economic bu…
View article: Corrigendum: Applications of chitosan and its derivatives in skin and soft tissue diseases
Corrigendum: Applications of chitosan and its derivatives in skin and soft tissue diseases Open
[This corrects the article DOI: 10.3389/fbioe.2022.894667.].
View article: Modulation of immunosuppressive cells and noncoding RNAs as immunotherapy in osteosarcoma
Modulation of immunosuppressive cells and noncoding RNAs as immunotherapy in osteosarcoma Open
The most common bone cancer is osteosarcoma (OS), which mostly affects children and teenagers. Early surgical resection combined with chemotherapy significantly improves the prognosis of patients with OS. Existing chemotherapies have poor …
View article: Local Application of Krill Oil Accelerates the Healing of Artificially Created Wounds in Diabetic Mice
Local Application of Krill Oil Accelerates the Healing of Artificially Created Wounds in Diabetic Mice Open
Diabetes mellitus (DM) impairs the wound healing process, seriously threatening the health of the diabetic population. To date, few effective approaches have been developed for the treatment of diabetic wounds. Krill oil (KO) contains bioa…
View article: The application of collagen in the repair of peripheral nerve defect
The application of collagen in the repair of peripheral nerve defect Open
Collagen is a natural polymer expressed in the extracellular matrix of the peripheral nervous system. It has become increasingly crucial in peripheral nerve reconstruction as it was involved in regulating Schwann cell behaviors, maintainin…
View article: Compounds purified from edible fungi fight against chronic inflammation through oxidative stress regulation
Compounds purified from edible fungi fight against chronic inflammation through oxidative stress regulation Open
Chronic inflammation is associated with various chronic diseases, including cardiovascular disease, neurodegenerative disease, and cancer, which severely affect the health and quality of life of people. Oxidative stress induced by unbalanc…
View article: Non-coding RNAs in diabetes mellitus and diabetic cardiovascular disease
Non-coding RNAs in diabetes mellitus and diabetic cardiovascular disease Open
More than 10% of the world’s population already suffers from varying degrees of diabetes mellitus (DM), but there is still no cure for the disease. Cardiovascular disease (CVD) is one of the most common and dangerous of the many health com…
View article: Tanshinone IIA Inhibits Liver Fibrosis by Regulating COL1A1 Expression Through H19<i>/</i>let-7a in Mice
Tanshinone IIA Inhibits Liver Fibrosis by Regulating COL1A1 Expression Through H19<i>/</i>let-7a in Mice Open
Liver fibrosis is a serious health problem and may lead to advanced liver cirrhosis and hepatocellular carcinoma if left untreated. In this study, a mouse liver fibrosis model was established by the administration of 3,5-diethoxycarbonyl-1…
View article: Review on Social Behavior Analysis of Laboratory Animals: From Methodologies to Applications
Review on Social Behavior Analysis of Laboratory Animals: From Methodologies to Applications Open
As the bridge between genetic and physiological aspects, animal behaviour analysis is one of the most significant topics in biology and ecological research. However, identifying, tracking and recording animal behaviour are labour intensive…
View article: Review on Social Behavior Analysis of Laboratory Animals: From Methodologies to Applications
Review on Social Behavior Analysis of Laboratory Animals: From Methodologies to Applications Open
As the bridge between genetic and physiological aspects, animal behaviour analysis is one of the most significant topics in biology and ecological research. However, identifying, tracking and recording animal behaviour are labour intensive…
View article: Applications of Chitosan and its Derivatives in Skin and Soft Tissue Diseases
Applications of Chitosan and its Derivatives in Skin and Soft Tissue Diseases Open
Chitosan and its derivatives are bioactive molecules that have recently been used in various fields, especially in the medical field. The antibacterial, antitumor, and immunomodulatory properties of chitosan have been extensively studied. …
View article: Flavonoids Inhibit Cancer by Regulating the Competing Endogenous RNA Network
Flavonoids Inhibit Cancer by Regulating the Competing Endogenous RNA Network Open
Flavonoids are present in a wide range of plants. They have been used in the treatment of cancer, but the mechanism underlying this activity is unclear. In recent years, microRNA (miRNA) and long non-coding RNA (lncRNA) levels have been ob…
View article: Calcium Signaling Regulated by Cellular Membrane Systems and Calcium Homeostasis Perturbed in Alzheimer’s Disease
Calcium Signaling Regulated by Cellular Membrane Systems and Calcium Homeostasis Perturbed in Alzheimer’s Disease Open
Although anything that changes spatiotemporally could be a signal, cells, particularly neurons, precisely manipulate calcium ion (Ca 2+ ) to transmit information. Ca 2+ homeostasis is indispensable for neuronal functions and survival. The …
View article: Role of N6-methyl-adenosine modification in mammalian embryonic development
Role of N6-methyl-adenosine modification in mammalian embryonic development Open
N6-methyl-adenosine (m6A) methylation is one of the most common and abundant modifications of RNA molecules in eukaryotes. Although various biological roles of m6A methylation have been elucidated, its role in embryonic development is stil…
View article: Identification of immune-related biomarkers associated with tumorigenesis and prognosis in skin cutaneous melanoma.
Identification of immune-related biomarkers associated with tumorigenesis and prognosis in skin cutaneous melanoma. Open
Skin cutaneous melanoma (SKCM) is one of the most malignant and aggressive forms of cancer. Investigating the mechanisms of carcinogenesis further could lead to the discovery of prognostic biomarkers that could be used to guide cancer trea…
View article: Chrysin Induced Cell Apoptosis Through H19/let-7a/COPB2 Axis in Gastric Cancer Cells and Inhibited Tumor Growth
Chrysin Induced Cell Apoptosis Through H19/let-7a/COPB2 Axis in Gastric Cancer Cells and Inhibited Tumor Growth Open
Background Chrysin is a natural flavone that is present in honey and has exhibited anti-tumor properties. It has been widely studied as a therapeutic agent for the treatment of various types of cancers. The objectives of this present study…
View article: Role of N6-methyl-adenosine modification in mammalian embryonic development
Role of N6-methyl-adenosine modification in mammalian embryonic development Open
N6-methyl-adenosine (m6A) methylation is one of the most common and abundant modifications of RNA molecules in eukaryotes. Although various biological roles of m6A methylation have been elucidated, its role in embryonic development is stil…
View article: Chrysin Induced Cell Apoptosis and Inhibited Invasion Through Regulation of TET1 Expression in Gastric Cancer Cells [Corrigendum]
Chrysin Induced Cell Apoptosis and Inhibited Invasion Through Regulation of TET1 Expression in Gastric Cancer Cells [Corrigendum] Open
[This corrects the article DOI: 10.2147/OTT.S246031.].
View article: Protective role of NRF2 in macrovascular complications of diabetes
Protective role of NRF2 in macrovascular complications of diabetes Open
Macrovascular complications develop in over a half of the diabetic individuals, resulting in high morbidity and mortality. This poses a severe threat to public health and a heavy burden to social economy. It is therefore important to devel…
View article: Galangin promotes cell apoptosis through suppression of <i>H19</i> expression in hepatocellular carcinoma cells
Galangin promotes cell apoptosis through suppression of <i>H19</i> expression in hepatocellular carcinoma cells Open
Background Galangin has been extensively studied as the antitumor agent in various cancers. However, the effect of galangin in hepatocellular carcinoma (HCC) remains elusive. Methods Using RNA sequencing, the differential expression of lnc…